{\it Ab initio} calculations of magnetic structure and lattice dynamics of Fe/Pt multilayers

The magnetization distribution, its energetic characterization by the interlayer coupling constants and lattice dynamics of (001)-oriented Fe/Pt multilayers are investigated using density functional theory combined with the direct method to determine phonon frequencies. It is found that ferromagnetic order between consecutive Fe layers is favoured, with the enhanced magnetic moments at the interface. The bilinear and biquadratic coupling coefficients between Fe layers are shown to saturate fast with increasing thickness of nonmagnetic Pt layers which separate them. The phonon calculations demonstrate a rather strong dependence of partial iron phonon densities of states on the actual position of Fe monolayer in the multilayer structure.Comment: 7 pages, 8 figure

Can Gravitational Waves Prevent Inflation?

To investigate the cosmic no hair conjecture, we analyze numerically 1-dimensional plane symmetrical inhomogeneities due to gravitational waves in vacuum spacetimes with a positive cosmological constant. Assuming periodic gravitational pulse waves initially, we study the time evolution of those waves and the nature of their collisions. As measures of inhomogeneity on each hypersurface, we use the 3-dimensional Riemann invariant ${\cal I}\equiv {}~^{(3)\!}R_{ijkl}~^{(3)\!}R^{ijkl}$ and the electric and magnetic parts of the Weyl tensor. We find a temporal growth of the curvature in the waves' collision region, but the overall expansion of the universe later overcomes this effect. No singularity appears and the result is a ``no hair" de Sitter spacetime. The waves we study have amplitudes between $0.020\Lambda \leq {\cal I}^{1/2} \leq 125.0\Lambda$ and widths between $0.080l_H \leq l \leq 2.5l_H$, where $l_H=(\Lambda/3)^{-1/2}$, the horizon scale of de Sitter spacetime. This supports the cosmic no hair conjecture.Comment: LaTeX, 11 pages, 3 figures are available on request <To [email protected] (Hisa-aki SHINKAI)>, WU-AP/29/9

Intermediate inflation and the slow-roll approximation

It is shown that spatially homogeneous solutions of the Einstein equations coupled to a nonlinear scalar field and other matter exhibit accelerated expansion at late times for a wide variety of potentials $V$. These potentials are strictly positive but tend to zero at infinity. They satisfy restrictions on $V'/V$ and $V''/V'$ related to the slow-roll approximation. These results generalize Wald's theorem for spacetimes with positive cosmological constant to those with accelerated expansion driven by potentials belonging to a large class.Comment: 19 pages, results unchanged, additional backgroun

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells

Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid organs is essential for limiting CLL progression and ultimately developing a cure. Experimental Design: We assessed the potency of cyclin-dependent kinase (CDK) inhibitor CR8, a roscovitine analog, to induce apoptosis in primary CLL from distinct prognostic subsets using flow cytometry–based assays. CLL cells were cultured in in vitro prosurvival and proproliferative conditions to mimic microenvironmental signals in the lymphoid organs, to elucidate the mechanism of action of CR8 in quiescent and proliferating CLL cells using flow cytometry, Western blotting, and quantitative real-time PCR. Results: CR8 was 100-fold more potent at inducing apoptosis in primary CLL cells than roscovitine, both in isolated culture and stromal-coculture conditions. Importantly, CR8 induced apoptosis in CD40-ligated CLL cells and preferentially targeted actively proliferating cells within these cultures. CR8 treatment induced downregulation of the antiapoptotic proteins Mcl-1 and XIAP, through inhibition of RNA polymerase II, and inhibition of NF-κB signaling at the transcriptional level and through inhibition of the inhibitor of IκB kinase (IKK) complex, resulting in stabilization of IκBα expression. Conclusions: CR8 is a potent CDK inhibitor that subverts pivotal prosurvival and proproliferative signals present in the tumor microenvironment of CLL patient lymphoid organs. Our data support the clinical development of selective CDK inhibitors as novel therapies for CLL

Bianchi type IX asymptotical behaviours with a massive scalar field: chaos strikes back

We use numerical integrations to study the asymptotical behaviour of a homogeneous but anisotropic Bianchi type IX model in General Relativity with a massive scalar field. As it is well known, for a Brans-Dicke theory, the asymptotical behaviour of the metric functions is ruled only by the Brans-Dicke coupling constant with respect to the value -3/2. In this paper we examine if such a condition still exists with a massive scalar field. We also show that, contrary to what occurs for a massless scalar field, the singularity oscillatory approach may exist in presence of a massive scalar field having a positive energy density.Comment: 31 pages, 7 figures (low resolution

Energy Density of Non-Minimally Coupled Scalar Field Cosmologies

Scalar fields coupled to gravity via $\xi R {\Phi}^2$ in arbitrary Friedmann-Robertson-Walker backgrounds can be represented by an effective flat space field theory. We derive an expression for the scalar energy density where the effective scalar mass becomes an explicit function of $\xi$ and the scale factor. The scalar quartic self-coupling gets shifted and can vanish for a particular choice of $\xi$. Gravitationally induced symmetry breaking and de-stabilization are possible in this theory.Comment: 18 pages in standard Late

Accelerated cosmological expansion due to a scalar field whose potential has a positive lower bound

In many cases a nonlinear scalar field with potential $V$ can lead to accelerated expansion in cosmological models. This paper contains mathematical results on this subject for homogeneous spacetimes. It is shown that, under the assumption that $V$ has a strictly positive minimum, Wald's theorem on spacetimes with positive cosmological constant can be generalized to a wide class of potentials. In some cases detailed information on late-time asymptotics is obtained. Results on the behaviour in the past time direction are also presented.Comment: 16 page

Study of blind thrust faults underlying Tokyo and Osaka urban areas using a combination of high-resolution seismic reflection profiling and continuous coring

We acquired high-resolution seismic reflection profiles and continuously cored boreholes to evaluate active flexures produced by major blind thrust fault systems within two densely populated Neogene-Quaternary sedimentary basins in Japan: the Fukaya Fault System near Tokyo in the Kanto Basin and the Uemachi Fault System in the Osaka Basin. The high-resolution seismic reflection survey made clear the length, geometry and growth history of fault-related folds, or flexures formed above the two blind thrusts. Continuously cored boreholes linked with high-resolution seismic profiles enabled us to estimate the uplift rate as defined by shallow stratigraphic horizons and constrain the age of the most recent growth of the flexures during earthquakes on the Fukaya and Uemachi fault systems. Even with the high quality of the data we collected, it is still not possible to exactly constrain the age of the most recent blind thrust earthquake recorded by flexure of these fault-related folds. Data presented in this paper form the basis for future efforts aimed at mechanical and kinematic models for fault growth to evaluate the activity of blind thrusts underlying urban areas

Magnetic and Structural Studies of the Quasi-Two-Dimensional Spin-Gap System (CuCl)LaNb2O7

We report magnetization, nuclear magnetic resonance (NMR), nuclear quadrupole resonance (NQR), and transmission electron microscopy (TEM) studies on the quasi-two-dimensional spin-gap system (CuCl)LaNb2O7, a possible candidate for the J1-J2 model on a square lattice. A sharp single NQR line is observed at the Cu and Cl sites, indicating that both Cu and Cl atoms occupy a unique site. However, the electric field gradient tensors at the Cu, Cl, and La sites do not have axial symmetry. This is incompatible with the reported crystal structure. Thus the J1-J2 model has to be modified. We propose alternative two-dimensional dimer models based on the NMR, NQR, and TEM results. The value of the hyperfine coupling constant at the Cu sites indicates that the spin density is mainly on the d(3z2-r2) orbital (z parallel c). At 1.5 K, Cu- and Nb-NMR signals disappear above the critical field Bc1 = 10.3 T determined from the onset of the magnetization, indicating a field-induced magnetic phase transition at Bc1.Comment: 9 pages, 16 figure

Scalar field in cosmology: Potential for isotropization and inflation

The important role of scalar field in cosmology was noticed by a number of authors. Due to the fact that the scalar field possesses zero spin, it was basically considered in isotropic cosmological models. If considered in an anisotropic model, the linear scalar field does not lead to isotropization of expansion process. One needs to introduce scalar field with nonlinear potential for the isotropization process to take place. In this paper the general form of scalar field potentials leading to the asymptotic isotropization in case of Bianchi type-I cosmological model, and inflationary regime in case of isotropic space-time is obtained. In doing so we solved both direct and inverse problem, where by direct problem we mean to find metric functions and scalar field for the given potential, whereas, the inverse problem means to find the potential and scalar field for the given metric function. The scalar field potentials leading to the inflation and isotropization were found both for harmonic and proper synchronic time.Comment: 10 page