Constraints on the Persistent Radio Source Associated with FRB 20190520B Using the European VLBI Network

We present very long baseline interferometry (VLBI) observations of a continuum radio source potentially associated with the fast radio burst source FRB 20190520B. Using the European VLBI network, we find the source to be compact on VLBI scales with an angular size of <2.3 mas (3σ). This corresponds to a transverse physical size of <9 pc (at the z = 0.241 redshift of the host galaxy), confirming it to be as fast radio burst (FRB) persistent radio source (PRS) like that associated with the first-known repeater FRB 20121102A. The PRS has a flux density of 201 ± 34 μJy at 1.7 GHz and a spectral radio luminosity of L1.7 GHz = (3.0 ± 0.5) × 1029 erg s−1 Hz−1 (also similar to the FRB 20121102A PRS). Compared to previous lower-resolution observations, we find that no flux is resolved out on milliarcsecond scales. We have refined the PRS position, improving its precision by an order of magnitude compared to previous results. We also report the detection of the FRB 20190520B burst at 1.4 GHz and find the burst position to be consistent with the PRS position, at ≲20 mas. This strongly supports their direct physical association and the hypothesis that a single central engine powers both the bursts and the PRS. We discuss the model of a magnetar in a wind nebula and present an allowed parameter space for its age and the radius of the putative nebula powering the observed PRS emission. Alternatively, we find that an accretion-powered hypernebula model also fits our observational constraints

Constraints on the persistent radio source associated with FRB 20190520B using the European VLBI Network

We present very-long-baseline interferometry (VLBI) observations of a continuum radio source potentially associated with the fast radio burst source FRB 20190520B. Using the European VLBI network (EVN), we find the source to be compact on VLBI scales with an angular size of $<2.3$ mas ($3\sigma$). This corresponds to a transverse physical size of $<9$ pc (at the $z=0.241$ redshift of the host galaxy), confirming it to be an FRB persistent radio source (PRS) like that associated with the first-known repeater FRB 20121102A. The PRS has a flux density of $201 \pm 34 \rm{\mu Jy}$ at 1.7 GHz and a spectral radio luminosity of $L_{1.7 \rm GHz} = (3.0 \pm 0.5) \times 10^{29}\,\mathrm{erg s^{-1} Hz^{-1}}$ (also similar to the FRB 20121102A PRS). Comparing to previous lower-resolution observations, we find that no flux is resolved out on milliarcsecond scales. We have refined the PRS position, improving its precision by an order of magnitude compared to previous results. We also report the detection of a FRB 20190520B burst at 1.4 GHz and find the burst position to be consistent with the PRS position, at $\lesssim20$ mas. This strongly supports their direct physical association and the hypothesis that a single central engine powers both the bursts and the PRS. We discuss the model of a magnetar in a wind nebula and present an allowed parameter space for its age and the radius of the putative nebula powering the observed PRS emission. Alternatively, we find that an accretion-powered 'hypernebula' model also fits our observational constraints.Comment: 13 pages, 6 figures, Submitted to ApJ

Hepatitis E in England and Wales

In 2005, 329 cases of hepatitis E virus infection were confirmed in England and Wales; 33 were confirmed indigenous infections, and a further 67 were estimated to be indigenous infections. Hepatitis E should be considered in the investigation of patients with hepatitis even if they have no history of travel

Milliarcsecond Localization of the Repeating FRB 20201124A

Very long baseline interferometric (VLBI) localizations of repeating fast radio bursts (FRBs) have demonstrated a diversity of local environments: from nearby star-forming regions to globular clusters. Here we report the VLBI localization of FRB 20201124A using an ad hoc array of dishes that also participate in the European VLBI Network (EVN). In our campaign, we detected 18 bursts from FRB 20201124A at two separate epochs. By combining the visibilities from both epochs, we were able to localize FRB 20201124A with a 1 sigma uncertainty of 2.7 mas. We use the relatively large burst sample to investigate astrometric accuracy and find that for greater than or similar to 20 baselines (greater than or similar to 7 dishes) we can robustly reach milliarcsecond precision even using single-burst data sets. Subarcsecond precision is still possible for single bursts, even when only similar to 6 baselines (four dishes) are available. In such cases, the limited uv coverage for individual bursts results in very high side-lobe levels. Thus, in addition to the peak position from the dirty map, we also explore smoothing the structure in the dirty map by fitting Gaussian functions to the fringe pattern in order to constrain individual burst positions, which we find to be more reliable. Our VLBI work places FRB 20201124A 710 +/- 30 mas (1 sigma uncertainty) from the optical center of the host galaxy, consistent with originating from within the recently discovered extended radio structure associated with star formation in the host galaxy. Future high-resolution optical observations, e.g., with Hubble Space Telescope, can determine the proximity of FRB 20201124A\u27s position to nearby knots of star formation

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

One-Step Preservation of Phosphoproteins and Tissue Morphology at Room Temperature for Diagnostic and Research Specimens

BACKGROUND: There is an urgent need to measure phosphorylated cell signaling proteins in cancer tissue for the individualization of molecular targeted kinase inhibitor therapy. However, phosphoproteins fluctuate rapidly following tissue procurement. Snap-freezing preserves phosphoproteins, but is unavailable in most clinics and compromises diagnostic morphology. Formalin fixation preserves tissue histomorphology, but penetrates tissue slowly, and is unsuitable for stabilizing phosphoproteins. We originated and evaluated a novel one-step biomarker and histology preservative (BHP) chemistry that stabilizes signaling protein phosphorylation and retains formalin-like tissue histomorphology with equivalent immunohistochemistry in a single paraffin block. RESULTS: Total protein yield extracted from BHP-fixed, routine paraffin-embedded mouse liver was 100% compared to snap-frozen tissue. The abundance of 14 phosphorylated proteins was found to be stable over extended fixation times in BHP fixed paraffin embedded human colon mucosa. Compared to matched snap-frozen tissue, 8 phosphoproteins were equally preserved in mouse liver, while AMPKβ1 Ser108 was slightly elevated after BHP fixation. More than 25 tissues from mouse, cat and human specimens were evaluated for preservation of histomorphology. Selected tissues were evaluated in a multi-site, independent pathology review. Tissue fixed with BHP showed equivalent preservation of cytoplasmic and membrane cytomorphology, with significantly better nuclear chromatin preservation by BHP compared to formalin. Immunohistochemical staining of 13 non-phosphorylated proteins, including estrogen receptor alpha, progesterone receptor, Ki-67 and Her2, was equal to or stronger in BHP compared to formalin. BHP demonstrated significantly improved immunohistochemical detection of phosphorylated proteins ERK Thr202/Tyr204, GSK3-α/β Ser21/Ser9, p38-MAPK Thr180/Tyr182, eIF4G Ser1108 and Acetyl-CoA Carboxylase Ser79. CONCLUSION: In a single paraffin block BHP preserved the phosphorylation state of several signaling proteins at a level comparable to snap-freezing, while maintaining the full diagnostic immunohistochemical and histomorphologic detail of formalin fixation. This new tissue fixative has the potential to greatly facilitate personalized medicine, biobanking, and phospho-proteomic research