Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015

The XXIIIrd World Congress of Psychiatric Genetics meeting, sponsored by the International Society of Psychiatric Genetics, was held in Toronto, ON, Canada, on 16-20 October 2015. Approximately 700 participants attended to discuss the latest state-of-the-art findings in this rapidly advancing and evolving field. The following report was written by trainee travel awardees. Each was assigned one session as a rapporteur. This manuscript represents the highlights and topics that were covered in the plenary sessions, symposia, and oral sessions during the conference, and contains major notable and new findings. © 2016 Wolters Kluwer Health, Inc

Outcome of DSM-5 attenuated psychosis syndrome over follow-up: Six years follow-up study in a large general population-based population

32nd Congress of the European-College-of-Neuropsychopharmacology (ECNP) -- SEP 07-10, 2019 -- Copenhagen, DENMARKWOS: 000502657501022[No abstract available]European Coll Neuropsychopharmaco

A survey of second-life batteries based on techno-economic perspective and applications-based analysis

Abstract The penetration of electrical vehicles (EVs) is exponentially rising to decarbonize the transport sector resulting in the research problem regarding the future of their retired batteries. Landfill disposal poses an environmental hazard, therefore, recycling or reusing them as second-life batteries (SLBs) are the inevitable options. Reusing the EV batteries with significant remaining useful life in stationary storage applications maximizes the economic benefits while extending the useful lifetime before recycling. Following a critical review of the research in SLBs, the key areas were identified as accurate State of Health (SOH) estimation, optimization of health indicators, battery life cycle assessment including repurposing, End-Of-Life (EOL) extension techniques and significance of first-life degradation data on ageing in second-life applications. The inconsistencies found in the reviewed literature showed that the absence of degradation data from first as well as second life, has a serious impact on accurate remaining useful life (RUL) prediction and SOH estimation. This review, for the first time, critically surveyed the recent studies in the field of identification, selection and control of application-based health indicators in relation to the accurate SOH estimation, offering future research directions in this emerging research area. In addition to the technical challenges, this paper also analyzed the economic perspective of SLBs, highlighting the impact of accuracy in second-life SOH estimation and RUL extension on their projected revenue in stationary storage applications. Lack of standard business model based on future market trends of energy and battery pricing and governing policies for SLBs are identified as urgent research gaps

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈ 1000 from Xenopus oocytes and >1050 from human cells. In addition, we quantified the partitioning of ≈5000 unique proteins between nucleus and cytoplasm of Xenopus oocytes. The data suggest new CRM1 functions in spatial control of vesicle coat-assembly, centrosomes, autophagy, peroxisome biogenesis, cytoskeleton, ribosome maturation, translation, mRNA degradation, and more generally in precluding a potentially detrimental action of cytoplasmic pathways within the nuclear interior. There are also numerous new instances where CRM1 appears to act in regulatory circuits. Altogether, our dataset allows unprecedented insights into the nucleocytoplasmic organisation of eukaryotic cells, into the contributions of an exceedingly promiscuous exportin and it provides a new basis for NES prediction

Quitting cannabis decreases but does not eliminate psychosis risk: evidence from a 7 years large populationbased cohort

ECNP Workshop for Junior Scientists in Europe -- MAR 17-20, 2016 -- Nice, FRANCEWOS: 000398564500059ECNPScientific and Technological Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112S476]This work is funded by the Scientific and Technological Council of Turkey 1001 programme, project no: 112S476

A 6-year follow-up study in a community-based population: Is neighbourhood-level social capital associated with the risk of emergence and persistence of psychotic experiences and transition to psychotic disorder?

Background Social capital is thought to represent an environmental factor associated with the risk of psychotic disorder (PD). This study aims to investigate the association between neighbourhood-level social capital and clinical transitions within the spectrum of psychosis. Methods In total, 2175 participants, representative of a community-based population, were assessed twice (6 years apart) to determine their position within an extended psychosis spectrum: no symptoms, subclinical psychotic experiences (PE), clinical PE, PD. A variable representing change between baseline (T1) and follow-up (T2) assessment was constructed. Four dimensions of social capital (informal social control, social disorganisation, social cohesion and trust, cognitive social capital) were assessed at baseline in an independent sample, and the measures were aggregated to the neighbourhood level. Associations between the variable representing psychosis spectrum change from T1 to T2 and the social capital variables were investigated. Results Lower levels of neighbourhood-level social disorganisation, meaning higher levels of social capital, reduced the risk of clinical PE onset (OR 0.300; z = -2.75; p = 0.006), persistence of clinical PE (OR 0.314; z = -2.36; p = 0.018) and also the transition to PD (OR 0.136; z = -2.12; p = 0.034). The other social capital variables were not associated with changes from T1 to T2. Conclusions Neighbourhood-level social disorganisation may be associated with the risk of psychosis expression. Whilst replication of this finding is required, it may point to level of social disorganisation as a public health target moderating population psychosis risk