Mathematical modeling of thermal power plant's boiler air-gas flow path regulation modes

В работе предлагаются математические модели газовоздушного тракта котла и механизмов собственных нужд ТЭС. С использованием табличных и графических представлений напорных характеристик серийных вентиляторов и дымососов получены эквивалентные соотношения для сети механизмов. Исследована задача нахождения оптимальных параметров управления для группы центробежных механизмов, обеспечивающих работу газовоздушного тракта котла. Исследовано влияние разрежения в топке котла на режим работы его вспомогательных механизмов. Приводятся результаты моделирования для типичных последовательно-параллельных соединений механизмов в гидравлических сетях ТЭС.The paper presents a mathematical model for thermal power plant's boiler air-gas flow paths and auxiliaries. With application of production fans' and flue gas extractor fans' head-capacity curves and tables, equivalent relations for the net of the mechanisms are obtained. A problem of determining the optimal control parameters for a group of centrifugal mechanisms in the air-gas path is studied. The effect of the boiler furnace draft on its auxiliaries operation is analyzed. The results of mathematical modeling for typical serial and parallel connections of the mechanisms in the thermal power plant hydraulic network are given

Significant benefits of AIP testing and clinical screening in familial isolated and young-onset pituitary tumors

Context Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs). Objective To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients. Design 12-year prospective, observational study. Participants & Setting We studied probands and family members of FIPA kindreds and sporadic patients with disease onset ≤18 years or macroadenomas with onset ≤30 years (n = 1477). This was a collaborative study conducted at referral centers for pituitary diseases. Interventions & Outcome AIP testing and clinical screening for pituitary disease. Comparison of characteristics of prospectively diagnosed (n = 22) vs clinically presenting AIPmut PitNET patients (n = 145), and AIPmut (n = 167) vs AIPneg PitNET patients (n = 1310). Results Prospectively diagnosed AIPmut PitNET patients had smaller lesions with less suprasellar extension or cavernous sinus invasion and required fewer treatments with fewer operations and no radiotherapy compared with clinically presenting cases; there were fewer cases with active disease and hypopituitarism at last follow-up. When comparing AIPmut and AIPneg cases, AIPmut patients were more often males, younger, more often had GH excess, pituitary apoplexy, suprasellar extension, and more patients required multimodal therapy, including radiotherapy. AIPmut patients (n = 136) with GH excess were taller than AIPneg counterparts (n = 650). Conclusions Prospectively diagnosed AIPmut patients show better outcomes than clinically presenting cases, demonstrating the benefits of genetic and clinical screening. AIP-related pituitary disease has a wide spectrum ranging from aggressively growing lesions to stable or indolent disease course

Landscape of Familial Isolated and Young-Onset Pituitary Adenomas: Prospective Diagnosis in AIP Mutation Carriers.

Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete penetrance. Clinical screening of apparently unaffected AIP mutation (AIPmut) carriers could identify previously unrecognized disease.This article is freely available via PubMed Central. Click on the 'Additional Link' above to access the full text