26 research outputs found
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.
- Author
- Abdulhakim E
- Agous I
- Allegar N
- Alvarado O
- Amalyan W
- Andersen J
- Andor M
- Andrei L
- Anspach R
- Asbill B
- Averna M
- Averna M
- Awasty V
- Balaji H
- Balthazar Y
- Barna O
- Basart D
- Becher P
- Beke E
- Bellingar B
- Bergeron J
- Bergeron J
- Biro J
- Blach E
- Black R
- Blair Britt L
- Blumberg V
- Bolster E
- Bondarchuk O
- Bonnet J
- Borgencrantz B
- Boye A
- Breedt J
- Briones Ir
- Broker R
- Bruckert E
- Bucci M
- Butuk D
- Caccavo A
- Cadinot D
- Caixas A
- Campos Pf
- Capiau L
- Cardenas Sp
- Carvalho D
- Casanova R
- Cañon Co
- Cesar M
- Ceska R
- Chaudhari U
- Chaykin L
- Cheung D
- Chizhov P
- Chuang R
- Chumakova G
- Codutti O
- Cohen K
- Cohen L
- Collins G
- Collins H
- Conrad G
- Constance C
- Contzen C
- Cure Cc
- D'Ignazio G
- da Silva Pm
- Dabrowska M
- David W
- Davis B
- De Cesare N
- De Pellegrin Am
- de Salazar Dm
- Degtyareva E
- Derezinski T
- Devedzhiev T
- Dimov B
- Dohad S
- Doig F
- Donnachie H
- Dunn F
- Dyadyk O
- Dzongowski P
- East C
- Ebrahim I
- Egelhof R
- Egstrup K
- El Shahawy M
- El Shahawy M
- Elias M
- Elkin G
- Elle S
- Ellery A
- Elliott T
- Ellis G
- Eriksson M
- Espinosa Ev
- Farnier M
- Farnier M
- Feld L
- Fernandez Cruz A
- Fraile B
- Francis A
- Fuentes F
- Fulat M
- Fuller G
- Furusho Lc
- García Lr
- Gatien L
- Gavish D
- Gawron A
- Gelersztein E
- Gen M
- Gerber J
- Ghitis A
- Gil Extremera B
- Gislason G
- Glover R
- Golden G
- Goloschekin B
- Gomez Ji
- Gotchev D
- Graff A
- Greenwald J
- Grijalvo Om
- Gronkova N
- Gunstone A
- Hart R
- Harvey P
- Hassanin H
- Haught H
- Heaton K
- Heitner J
- Henderson D
- Herrman J
- Herrod J
- Himpel Boenninghoff Aa
- Hoag G
- Hoivik H
- Hoogendijk J
- Horacek T
- Horvathova V
- Huffman C
- Hunter J
- Høivik Ho
- Isermann B
- Jain R
- Jansky P
- Junggeburth J
- Kadr H
- Kanakaridisz N
- Kantaros L
- Karpenko O
- Kassas S
- Kastelein Jj
- Kaye W
- Kekki S
- Kentgens S
- Kerrane J
- Khan N
- Kimmel M
- Kinzfogl G
- Kivitz A
- Klausen Ib
- Kolettis E
- Kondagunta V
- Konieczny M
- Kooy A
- Koren M
- Koren Mj
- Kotzé H
- Koval O
- Kovalyov O
- Koziolova N
- Krempf M
- Krempf M
- Krolick M
- Kumar M
- Kushnir M
- Kuusela M
- König Hj
- Köse V
- Lakin G
- Landman C
- Langslet G
- Langslet G
- Lappo M
- Larnefeldt H
- Lebeis M
- Lejay D
- Lembo G
- Lepor N
- Lepor Ne
- Levinsky D
- Libov I
- Lingan Gr
- Lip G
- Lo E
- Loayza Ms
- Lomholdt J
- Lopez Rb
- Lorch D
- Lorenzato C
- Luc G
- Luc G
- Madder R
- Majul C
- Malik A
- Marple R
- Marten I
- Martinho V
- Massalski W
- Matias F
- Matoltsy A
- Maus O
- Maw K
- Mccullough P
- Mcknight T
- Meissner G
- Meli J
- Mendonca I
- Mendoza Ja
- Mezzetti A
- Miekus P
- Mincheva V
- Mollod M
- Moriarty P
- Moulin P
- Murray A
- Naccarato T
- Nadar V
- Nagy K
- Narvaez Nc
- Nevins B
- Nieminen S
- Nikolaeva A
- Norheim P
- Nseir W
- Nyirati G
- O'Dea D
- O'Mahony M
- Ogorek M
- Olsson Önerud Å
- Olvera I
- Oyesile B
- Paillard F
- Palatnik M
- Paltsman Z
- Pandey S
- Paragh G
- Patel R
- Patron A
- Pavel Knox I
- Pawa R
- Peeters M
- Phaneuf Dc
- Piechatzek R
- Plana N
- Plevin S
- Podoleanu C
- Pop C
- Pordy R
- Poulsen S
- Pozzi C
- Prashad R
- Pritchard J
- Prokhorov O
- Pudi K
- Raal F
- Raal Fj
- Radin D
- Ranganath L
- Reddy R
- Reichman A
- Reis G
- Revol T
- Reyes H
- Rinke A
- Risberg K
- Roberts J
- Robinson J
- Robinson Jg
- Rohlf J
- Rosas El
- RUBBA PAOLO OSVALDO FEDERICO
- Rubino J
- Ruiz Ab
- Salazar Ma
- Salvioni A
- Sarker A
- Schaupp T
- Schear M
- Schmidt L
- Schnabel R
- Schramm R
- Schulze Ed
- Shaw H
- Shealy N
- Sherman H
- Shockey G
- Shore K
- Shu D
- Sidor M
- Singh N
- Soran H
- Stanciu D
- Stich M
- Stroes E
- Stroes Es
- Strutinskiy A
- Stößel J
- Svintsitskiy A
- Szymkowiak K
- Talreja D
- Tashchuk V
- Tayob M
- Tellier G
- Tengmark Bo
- Theis E
- Thew S
- Thomas H
- Thompson P.
- Timmis H
- Todorov G
- Torp Pedersen C
- Torres D
- Toth P
- Treasure C
- Troquay R
- Tumbev H
- Tuomilehto J
- Tzekova M
- Uusinarkaus K
- Valdivielso P
- Vally T
- van den Berg R
- van der Walt E
- van Dyk C
- van Kempen W
- van Rensburg Dj
- Vardi G
- Velazquez F
- Vermeersch P
- Vico M
- Voors Pette C
- Voyce S
- Vrolix M
- Waxler A
- Wayne J
- Weinstein D
- Weiss D
- West J
- Wong Yk
- Zaidman C
- Zarich S
- Zidkova E
- Zilahi Z
- Zimlichman R
- Züchner D
- Zühlke M
- Publication venue
- Publication date
- 01/01/2015
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
- Arif I
- Armaganijan L
- Aroney C
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Aylward P
- Aylward PE
- Aylward PE
- Azizad MM
- Badreddine E
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barraud P
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Bejuit R
- Bekkouche M
- Belhassane A
- Beltran P
- Benbernou F
- Bencic ML
- Benecke JLA
- Benedicto A
- Bengrait N
- Bengus CM
- Benov HO
- Berdan L
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berthou C
- Berti S
- Bezault M
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bouancheau C
- Bougon N
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Bravo Mannucci JE
- Breedveld RW
- Bregeault M-F
- Bregeault M-F
- Brennan JM
- Brigui I
- Brocklehurst M
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Butters J
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Calderon Ticona JR
- Camacho Cosavalente LA
- Camp A
- Camprubi Potau M
- Camsari A
- Car S
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carrion Chambilla JM
- Carroll PA
- Cartasegna LR
- Carter L
- Caruso OC
- Cassimjee S
- Castadot M
- Castillo Leon RP
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez Ayala CA
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chizhov P
- Chopda M
- Chopra VK
- Chotnoparatpat P
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Cianciarulo J
- Cioranu RS
- Citron B
- Civeira Murillo F
- Claeys M
- Claxton E
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
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- Coca Payeras A
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- Colombo HR
- Colquhoun D
- Coman I
- Commerford PJ
- Conrad G
- Constantine G
- Constantinescu MCA
- Convens C
- Cools F
- Corbett C
- Cornel JH
- Correa Flores RM
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- Cosin Sales J
- Costa F
- Costamagna O
- Coste P
- Cotruta R
- Cottin Y
- Coufal Z
- Coulange A
- Coverdale SGM
- Cristian G
- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
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- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
- Davidson L
- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Leon ERR
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- De Santos MON
- De Silva HA
- De Souza JA
- De Wolf L
- Delarche N
- Deloatch S
- Demirtas M
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- Devarapalli SK
- Devaul D
- DeVore AD
- Diamantis S
- Diaz Fernandez JF
- Diaz A
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- Dilic M
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- Dimov BI
- Dimulescu D
- Dincic DV
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- Domokos S
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- Dorobantu M
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- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
- Duran ROG
- Durand Velasquez JR
- Duronto EA
- Dzupina A
- Dzyak G
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- East C
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- Ebrahim IO
- Edelberg JM
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- Egorova L
- Egydio F
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- Escudier JM
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- Fairlamb J
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- Feitosa GS
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- Fernandez Portales J
- Fernandez M
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- Ferrolino A
- Filardi PP
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- Fishberg R
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- Forgosh L
- Foster M
- Foster R
- Fournie-Lloret D
- Francis A
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- French WJ
- Friedman D
- Frost L
- Fu G
- Fuchs S
- Fujii K
- Fujimoto K
- Fujimoto K
- Fujinaga H
- Fulop P
- Fulwani MC
- Furukawa Y
- Gache C
- Galski T
- Galvani M
- Gapon L
- Garcia Brasca DF
- Garcia Castillo A
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- Gardner G
- Garrahy PJ
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- Gavish D
- Ge J
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- Gerber J
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- Giesler G
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- Gilbert JM
- Gillespie E
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- Giordano JA
- Giorgeto FE
- Gislason G
- Giuliano ME
- Gniot J
- Gobillot C
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- Goodman SG
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- Gordienko A
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- Gosselink ATM
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- Hagstrom E
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- Halle B
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- Harding S
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- Harrington RA
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- Hattler B
- Hatzitolios A
- Healy J
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- Hedman A
- Heidenreich L
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- Hemetsberger R
- Henderson D
- Henkin Y
- Hepditch A
- Herath JI
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- Heredia Landeo J
- Hermans K
- Hermans WRM
- Hernandez Zuniga JD
- Herrman JPR
- Hersbach FMRJ
- Herzog W
- Hess CN
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- Higuera JD
- Hii CLS
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- Hoppe U
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- Hsieh I-C
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- Huang T-Y
- Huang W
- Huber K
- Huidobro L
- Huikuri H
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- Hussein O
- Hwang J-J
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- Ilieva-Pandeva KA
- Ince C
- Iniguez A
- Iqbal SMR
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- Ivanov IG
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- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Alirocumab and cardiovascular outcomes after acute coronary syndrome
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- Abbas J.
- Abbate A.
- Abdullakutty J.
- Abhyanakar A. D.
- Aboyans V.
- Abrantes J. A. M.
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- Vuurmans T.
- Wada A.
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- Waites J. H.
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- Walichiewicz P. M.
- Waltenberger J.
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- Zahger D.
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- Zainea M.
- Zaman A.
- Zeiher A. M.
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- Zirlik A.
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- Zrazhevsky K.
- Zuniga J. D. H.
- Zurakowski A.
- Zuran I.
- Zweiker R.
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. METHODS We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients who had an acute coronary syndrome 1 to 12 months earlier, had a low-density lipoprotein (LDL) cholesterol level of at least 70 mg per deciliter (1.8 mmol per liter), a non-highdensity lipoprotein cholesterol level of at least 100 mg per deciliter (2.6 mmol per liter), or an apolipoprotein B level of at least 80 mg per deciliter, and were receiving statin therapy at a high-intensity dose or at the maximum tolerated dose. Patients were randomly assigned to receive alirocumab subcutaneously at a dose of 75 mg (9462 patients) or matching placebo (9462 patients) every 2 weeks. The dose of alirocumab was adjusted under blinded conditions to target an LDL cholesterol level of 25 to 50 mg per deciliter (0.6 to 1.3 mmol per liter). The primary end point was a composite of death from coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. RESULTS The median duration of follow-up was 2.8 years. A composite primary end-point event occurred in 903 patients (9.5%) in the alirocumab group and in 1052 patients (11.1%) in the placebo group (hazard ratio, 0.85; 95% confidence interval [CI], 0.78 to 0.93; P<0.001). A total of 334 patients (3.5%) in the alirocumab group and 392 patients (4.1%) in the placebo group died (hazard ratio, 0.85; 95% CI, 0.73 to 0.98). The absolute benefit of alirocumab with respect to the composite primary end point was greater among patients who had a baseline LDL cholesterol level of 100 mg or more per deciliter than among patients who had a lower baseline level. The incidence of adverse events was similar in the two groups, with the exception of local injection-site reactions (3.8% in the alirocumab group vs. 2.1% in the placebo group). CONCLUSIONS Among patients who had a previous acute coronary syndrome and who were receiving highintensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower among those who received alirocumab than among those who received placebo
Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial
- Author
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: After acute coronary syndrome, diabetes conveys an excess risk of ischaemic cardiovascular events. A reduction in mean LDL cholesterol to 1·4–1·8 mmol/L with ezetimibe or statins reduces cardiovascular events in patients with an acute coronary syndrome and diabetes. However, the efficacy and safety of further reduction in LDL cholesterol with an inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) after acute coronary syndrome is unknown. We aimed to explore this issue in a prespecified analysis of the ODYSSEY OUTCOMES trial of the PCSK9 inhibitor alirocumab, assessing its effects on cardiovascular outcomes by baseline glycaemic status, while also assessing its effects on glycaemic measures including risk of new-onset diabetes. Methods: ODYSSEY OUTCOMES was a randomised, double-blind, placebo-controlled trial, done at 1315 sites in 57 countries, that compared alirocumab with placebo in patients who had been admitted to hospital with an acute coronary syndrome (myocardial infarction or unstable angina) 1–12 months before randomisation and who had raised concentrations of atherogenic lipoproteins despite use of high-intensity statins. Patients were randomly assigned (1:1) to receive alirocumab or placebo every 2 weeks; randomisation was stratified by country and was done centrally with an interactive voice-response or web-response system. Alirocumab was titrated to target LDL cholesterol concentrations of 0·65–1·30 mmol/L. In this prespecified analysis, we investigated the effect of alirocumab on cardiovascular events by glycaemic status at baseline (diabetes, prediabetes, or normoglycaemia)—defined on the basis of patient history, review of medical records, or baseline HbA1c or fasting serum glucose—and risk of new-onset diabetes among those without diabetes at baseline. The primary endpoint was a composite of death from coronary heart disease, non-fatal myocardial infarction, fatal or non-fatal ischaemic stroke, or unstable angina requiring hospital admission. ODYSSEY OUTCOMES is registered with ClinicalTrials.gov, number NCT01663402. Findings: At study baseline, 5444 patients (28·8%) had diabetes, 8246 (43·6%) had prediabetes, and 5234 (27·7%) had normoglycaemia. There were no significant differences across glycaemic categories in median LDL cholesterol at baseline (2·20–2·28 mmol/L), after 4 months' treatment with alirocumab (0·80 mmol/L), or after 4 months' treatment with placebo (2·25–2·28 mmol/L). In the placebo group, the incidence of the primary endpoint over a median of 2·8 years was greater in patients with diabetes (16·4%) than in those with prediabetes (9·2%) or normoglycaemia (8·5%); hazard ratio (HR) for diabetes versus normoglycaemia 2·09 (95% CI 1·78–2·46, p<0·0001) and for diabetes versus prediabetes 1·90 (1·65–2·17, p<0·0001). Alirocumab resulted in similar relative reductions in the incidence of the primary endpoint in each glycaemic category, but a greater absolute reduction in the incidence of the primary endpoint in patients with diabetes (2·3%, 95% CI 0·4 to 4·2) than in those with prediabetes (1·2%, 0·0 to 2·4) or normoglycaemia (1·2%, −0·3 to 2·7; absolute risk reduction pinteraction=0·0019). Among patients without diabetes at baseline, 676 (10·1%) developed diabetes in the placebo group, compared with 648 (9·6%) in the alirocumab group; alirocumab did not increase the risk of new-onset diabetes (HR 1·00, 95% CI 0·89–1·11). HRs were 0·97 (95% CI 0·87–1·09) for patients with prediabetes and 1·30 (95% CI 0·93–1·81) for those with normoglycaemia (pinteraction=0·11). Interpretation: After a recent acute coronary syndrome, alirocumab treatment targeting an LDL cholesterol concentration of 0·65–1·30 mmol/L produced about twice the absolute reduction in cardiovascular events among patients with diabetes as in those without diabetes. Alirocumab treatment did not increase the risk of new-onset diabetes. Funding: Sanofi and Regeneron Pharmaceuticals
Lipoprotein(a) and Benefit of PCSK9 Inhibition in Patients With Nominally Controlled LDL Cholesterol
- Author
- Abbas J.
- Abbate A.
- Abdallah M.
- Abdullakutty J.
- Abdullkutty J.
- Abhyanakar A. D.
- Aboyans V.
- Abrantes J. A. M.
- Abu-Fadel M.
- Accini Mendoza J. L.
- Acevedo M.
- Adamkova V.
- Adamo A.
- Adhyapak S.
- Agarwal H.
- Aggarwal R.
- Aggarwal R. K.
- Aguirre A.
- Ahmed H.
- Ahremark U.
- Ahuad Guerrero R. A.
- Aidar Ayoub J. C.
- Aitken D.
- Akatova E.
- Akhter F.
- Ako J.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was 13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUN
Risk categorization using New American College of Cardiology/American Heart Association guidelines for cholesterol management and its relation to alirocumab treatment following acute coronary syndromes
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
- Arif I
- Armaganijan L
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- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Aylward P
- Aylward PE
- Aylward PE
- Azizad MM
- Baccara-Dinet MT
- Badreddine E
- Bagai A
- Bagriy A
- Bahit MC
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- Baldari D
- Balinovac J
- Ball E
- Bang LE
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- Barakovic F
- Baranov E
- Baranova E
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- Zurakowski A
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- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/08/2019
- Field of study
Background: The 2018 US cholesterol management guidelines recommend additional lipid-lowering therapies for secondary prevention in patients with low-density lipoprotein cholesterol ≥70 mg/dL or non−high-density lipoprotein cholesterol ≥100 mg/dL despite maximum tolerated statin therapy. Such patients are considered at very high risk (VHR) based on a history of >1 major atherosclerotic cardiovascular disease (ASCVD) event or a single ASCVD event and multiple high-risk conditions. We investigated the association of US guideline-defined risk categories with the occurrence of ischemic events after acute coronary syndrome and reduction of those events by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor. Methods: In the ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab), patients with recent acute coronary syndrome and residual dyslipidemia despite optimal statin therapy were randomly assigned to alirocumab or placebo. The primary trial outcome (major adverse cardiovascular events, ie, coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina) was examined according to American College of Cardiology/American Heart Association risk category. Results: Of 18 924 participants followed for a median of 2.8 years, 11 935 (63.1%) were classified as VHR: 4450 (37.3%) had multiple prior ASCVD events and 7485 (62.7%) had 1 major ASCVD event and multiple high-risk conditions. Major adverse cardiovascular events occurred in 14.4% of placebo-treated patients at VHR versus 5.6% of those not at VHR. In the VHR category, major adverse cardiovascular events occurred in 20.4% with multiple prior ASCVD events versus 10.7% with 1 ASCVD event and multiple high-risk conditions. Alirocumab was associated with consistent relative risk reductions in both risk categories (hazard ratio=0.84 for VHR; hazard ratio=0.86 for not VHR; Pinteraction=0.820) and by stratification within the VHR group (hazard ratio=0.86 for multiple prior ASCVD events; hazard ratio=0.82 for 1 major ASCVD event and multiple high-risk conditions; Pinteraction=0.672). The absolute risk reduction for major adverse cardiovascular events with alirocumab was numerically greater (but not statistically different) in the VHR group versus those not at VHR (2.1% versus 0.8%; Pinteraction=0.095) and among patients at VHR with multiple prior ASCVD events versus a single prior ASCVD event (2.4% versus 1.8%; Pinteraction=0.661). Conclusions: The US guideline criteria identify patients with recent acute coronary syndrome and dyslipidemia who are at VHR for recurrent ischemic events and who may derive a larger absolute benefit from treatment with alirocumab. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- A A
- Abbott Jd
- Abdullah S
- Abib E Jr
- Ables Lr
- Abrantes Ja
- Acosta R
- Adams A
- Adams F
- Adroer Martori R
- Agafina As
- Agaiby Jm
- Aggarwala G
- Agraou B
- Aguilarsalinas Ca
- Ahmad A
- Ajala B
- Akdeniz B
- Akhtar N
- Akright L
- Aksentiev S
- Al-Zoebi A
- Alappat P
- Albert M
- Alfieri Ad
- Alhakim M
- Allaw Ma
- Alpizar-Salazar M
- Altafullah Im
- Alvarado Op
- Alvarez Ca
- Alvarez Jg
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- Alvarez-Sala Walther La
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- Van Koningsbruggen P
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- van Leendert Rj
- van Nieuwenhuizen E
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- Verwerft J
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- Viklund J
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- Villaman-Bencosme Y
- Vinanska D
- Vincent J.
- Vincent S
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- Violante Ortiz R
- Vishlitzky V
- Vishneva E
- Visser Rp
- Visseren F
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- Vlach Jj
- Vodnansky P
- Voehringer Hf
- Vogel Dr
- Vohnout B
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- Vukotic G
- Wadud K
- Wainstein J
- Wakefield Ph
- Wakeling J
- Walczak M
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- Wei C
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- Weiss R
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- Welty F
- Wenetz Lm
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- Wesson T
- West Sh
- Westerndorp I
- Wetzel T
- White H.
- Whitlock L
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- Williams Dg
- Williams M
- Willis Jg
- Willits Vl
- Winkelmann B
- Witt N
- Wittmann I
- Woehrle J
- Worner Diz F
- Wozniak I
- Wright R. S.
- Wronska D
- Wuerzner G
- Wychota K
- Xu P
- Xue L
- Yakusevich Vv
- Yang P
- Yang X
- Yao Lc
- Yared Z
- Yarows Sa
- Yigit Z
- Yoon J
- Yunis C.
- Zadra R
- Zaidman Cj
- Zamorano Gomez Jl
- Zannad F
- Zarandon Rb
- Zarich Sw
- Zateyshchikov D
- Zavaro Sh
- Zebrack Js
- Zeig S
- Zemek S
- Zemour G
- Zeng X
- Zeno Ml
- Zhang L
- Zhang X
- Zhang Y
- Zhao Y
- Zhou C
- Zhou Y
- Zhu Y
- Zidkova E
- Zieba B
- Zilahi Z
- Zoet-Nugteren Sk
- Zrazhevskiy K
- Zubek V
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of ≥70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of ≥100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients
Alirocumab and cardiovascular outcomes after acute coronary syndrome
- Author
- Abbas Jalal
- Abbate Antonio
- Abdullakutty Jabir
- Abhyanakar Atul D.
- Aboyans Victor
- Abrantes Jose Antonio M.
- Abu-Fadel Mazen
- Acevedo Monica
- Adamkova Vera
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K.
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Aidar Ayoub Jose Carlos
- Airaksinen Juhani K.
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea Y. Y.
- Alan David
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M.
- Alings Marco
- Alonso Martin Joaquin J.
- Alvarisqueta Andres F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Angel Hominal Miguel
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L.
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Arroyo Julian A. Coronel
- Arstall Margaret A.
- Asanin Milika R.
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayala Carlos A. Chavez
- Aylward Philip E.
- Azizad Masoud M.
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Bang Lia E.
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L.
- Barbato Emanuele
- Barna Olga M.
- Barone-Rochette Gilles
- Barr Craig
- Barrucco Robert
- Bartels Gerard L.
- Bashir Riyaz
- Basson Matthys M. de V.
- Bastos Jose Mesquita
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Belhassane Abdelkader
- Benedicto Amparo
- Bengus Cristina M.
- Benov Haralambi O.
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A.
- Berlowitz Michael
- Berman Brett
- Bernan Alisa
- Berti Sergio
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt D. L.
- Binder Ronald
- Birchem Jessica
- Bittner V. A.
- Blicharski Tomasz
- Blok Thomas
- Blumberg Eduardo D. S.
- Boccara Franck
- Bodanese Luiz C.
- Bodi Peris Vicente
- Boecker Dirk
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel J. J. A.
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- Bordonava Anselmo P.
- Borse Rohidas
- Bortnick Anna
- Bos Robert J.
- Botas Rodriguez Javier
- Botelho Ana
- Botelho Roberto V.
- Botia Diana C. Luna
- Bottcher Morten
- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun-Dullaeus Ruediger
- Breedveld Robert W.
- Brennan J. Matthew
- Brodison Adrian
- Bronzwaer Patrick N. A.
- Brueren Bart R. G.
- Bruguera Cortada Jordi
- Budaj Andrzej
- Bugan Viliam
- Busmane Arija
- Bustamante Labarta Miguel H.
- Busz-Papiez Benita
- Butler Rob
- Bystryk Leszek
- Caccavo Alberto
- Caime Guillermo D.
- Calabro Paolo
- Camprubi Potau Mercedes
- Camsari Ahmet
- Caraco Yoseph
- Carey Charles
- Carlson Eric
- Carnero Gabriela S.
- Carranza Madrigal Jaime
- Carrillo Calvillo Jorge
- Carroll Patrick A.
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- Castadot Marc
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- Chang Mark
- Chaudhary Sanjeev
- Chavez Victor E. Rodriguez
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- Chen Jiyan
- Chen Yundai
- Cheng Shi-Chi
- Cheng Xiaoshu
- Chiang Chern-En
- Chiang Chern-En
- Chizhov Petr
- Chopda Manoj
- Chopra Vijay K.
- Christenson Stuart
- Chu Alan
- Chua Terrance
- Chumakova Galina
- Chumburidze Vakhtang
- Civeira Murillo Fernando
- Claeys Marc
- Claxton Edmund
- Clemmensen Peter
- Clerc Jerome
- Cleveland David
- Clifford Piers
- Clifton Shaun
- Coching Raul Martin
- Codutti Oscar R.
- Cohen Steven
- Collins Nicholas
- Colombo Hugo R.
- Colquhoun David
- Commerford Patrick J.
- Concha Yudy M. Roldan
- Conrad Gary
- Constantine Godwin
- Constantinescu Mircea C. A.
- Convens Carl
- Cools Frank
- Corbett Clive
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- Correa Flores Roger M.
- Cosavalente Luis A. Camacho
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- Costa Fernando
- Coste Pierre
- Cottin Yves
- Coufal Zdenek
- Coverdale Steven G. M.
- Cristian Gabriel
- Cruz Fernandez Jose M.
- Cuccia Claudio
- Cui Lan
- Cyster Henry P.
- Czerski Tomasz
- D'Urso Michael
- Daboul Nizar
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- Davidovic Goran
- Davidsen Flemming
- Davies Richard
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- De Berrazueta Fernandez Jose R.
- De Cesare Nicoletta B.
- De Leo Alessandro
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- De Mora Martin Manuel
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- de Souza Juliana A.
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- Delarche Nicolas
- Deloatch Shalonda
- Demirtas Mustafa
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- DeVore Adam D.
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- Diaz Ariel
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- Dickey Sheila
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- Dimkovic Sinisa
- Dimov Bojidar I.
- Dincic Dragan V.
- Ding Chunhua
- Dion Danielle
- Dodds George
- Dodic Slobodan
- Dombrowski Keith
- Doncovska Snezana
- Dong Shaohong
- Dong Yugang
- Dorobantu Maria
- Dorsel Thomas
- Dran Ricardo D.
- Drexel Heinz
- Drzewiecka Anna
- Ducas John
- Ducrocq Gregory
- Duda Norberto
- Dujardin Karl
- Dukat Andrej
- Dulak Elzbieta
- Dupuis Robert
- Durak-Nalbantic Azra
- Duronto Ernesto A.
- Dzupina Andrej
- Dzyak Georgiy
- Eagerton Donald
- Eapen Zubin
- East Cara
- Eaton Charles
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- Edelberg J. M.
- Edes Istvan
- Egorova Liudmila
- Eisenberg Steven
- Ekanayaka Ruvan
- El Shahawy Mahfouz
- El-Ahdab Fadi
- Elias Mazen
- Eliaschewitz Freddy G.
- Elliott John
- Endsley Patricia
- Eppinger Arleen
- Erglis Andrejs
- Ersanli Murat
- Fadlallah Hussein
- Faes Dirk
- Faggiano Pompilio
- Fairlamb James
- Fajardo Campos Pedro
- Falukozy Jozsef
- Fang Chih-Yuan
- Fang Weiyi
- Fanghanel Salmon Guillermo
- Farhat Naim
- Farrar Michael
- Fausto Ovando Sergio R.
- Fazekas Frantisek
- Fazlibegovic Emir
- Feitosa Gilson S.
- Fell David
- Feng Yi
- Fernandes Manenti Euler Roberto F.
- Fernandez Portales Javier
- Fernandez Angela M.
- Fernandez Mauricio
- Fernando Nimali
- Ferrari Emile
- Ferratini Maurizio
- Ferrolino Arthur
- Filardi Pasquale Perrone
- Fischer Stuart
- Fishberg Robert
- Fisher Daniel
- Fisher Nicholas
- Fisher Raewyn
- Florenzano Fernando
- Flores Enrique
- Flores Romulo E. Oqueli
- Fong Peter
- Forgosh Les
- Foster Malcolm
- Foster Robert
- Francis Adi
- Franek Edward
- Fras Zlatko
- French William J.
- Friedman Dennis
- Frost Lars
- Fu Guosheng
- Fuchs Shmuel
- Fuentes Jimenez Francisco
- Fujii Kenshi
- Fujimoto Kazuteru
- Fujinaga Hiroyuki
- Fulop Peter
- Fulwani Mahesh C.
- Furukawa Yutaka
- Galski Thomas
- Galvani Marcello
- Gapon Liudmila
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- Garcia Duran Ruben O.
- Garcia Lledo Jose Alberto
- Garcia-Dorado David
- Gardner Geraldine
- Garrahy Paul J.
- Garrido Marcelo
- Garza Ruiz Jose Angel
- Gavish Dov
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- Gelormini Joseph
- Gerber Jaime
- Gerber Robert
- Ghitis Arnold
- Ghlonti Ramaz
- Gibson Paul
- Gielen Stephan
- Giesler Gregory
- Gil-Extremera Blas
- Gilbert John M.
- Gillespie Eve
- Gilmore Richard
- Gimple Lawrence
- Giordano Jorge A.
- Giorgeto Flavio E.
- Gislason Gunnar
- Giuliano Maria E.
- Gniot Jacek
- Goch Aleksander
- Goloborodko Borys
- Gomez Vilamajo Oscar A.
- Gonsorcik Jozef
- Gonzales Rolando J. Vargas
- Gonzalez Diaz Belinda
- Gonzalez Salas Luis Gerardo
- Gonzalez-Juanatey Carlos
- Gonzalez-Juanatey Jose R.
- Goodman S. G.
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- Gordeev Ivan
- Gordienko Alexander
- Gorny Jerzy
- Gosselin Gilbert
- Gosselink Antonius T. M.
- Gotcheva Nina N.
- Gotcheva Nina N.
- Govinda Ravishankar A.
- Goyal Naresh K.
- Gremmler Uwe
- Grewal Jasprakash Singh
- Griffiths Huw
- Gring Christian
- Groenemeijer Bjorn E.
- Groutars Reginald G. E. J.
- Guardigli Gabriele
- Guerrero De Leon Maria
- Guha Santanu
- Gullestad Lars
- Guneri Sema
- Guneri Sema
- Guo Ying
- Gurevich Victor
- Gusi Tragant Gabriel
- Guzman Pablo N.
- Haddad Tariq
- Hagstrom Emil
- Hagstrom Emil
- Hahalis P. I. Georgios
- Halabi Majdi
- Halcox Julian
- Hald Flemming
- Haldis Thomas
- Hall Jason
- Halvorsen Sigrun
- Hameed Adnan
- Haniffa Ruvaiz
- Hanotin C.
- Hansen Ole
- Haraguchi Takuya
- Harding Scott
- Harkut Pankaj
- Harrington R. A.
- Harris Barry
- Harris Bill
- Hart Hamish
- Hata Yoshiki
- Hattler Brack
- Hedman Anu
- Heidenreich Lothar
- Heinc Petr
- Heitzer Thomas
- Hemetsberger Rayyan
- Henderson David
- Henkin Yaakov
- Herath Jagath I.
- Herazo Aristides Sotomayor
- Hermans Kurt
- Hermans Walter R. M.
- Hernandez Henry A. Anchante
- Herrman Johannes P. R.
- Hersbach Ferry M. R. J.
- Herzog William
- Hess Connie Ng
- Higashikata Toshinori
- Higuera Juan Diego
- Hii Chris L. S.
- Hirayama Atsushi
- Hirooka Keiji
- Hlatky Mark A.
- Hoag Gordon
- Hodes Zachary
- Hoffer Etienne
- Hoffman David
- Hong Taekjong
- Hoogslag Pieter A. M.
- Hoppe Uta
- Horak David
- Horowitz John
- Horvath Ivan
- Horwitz Phillip
- Hove Jens D.
- Hrabar Adrian D.
- Hranai Marian
- Hsieh I-Chang
- Huang Lan
- Huang Shi'An
- Huang Tsuei-Yuan
- Huang Weijian
- Huber Kurt
- Huidobro Laura
- Huikuri Heikki
- Hunter John
- Hurtig Ulf
- Hussein Osamah
- Huynh Thao
- Hwang Juey-Jen
- Ilic Stevan
- Ilieva-Pandeva Katya A.
- Ince Carlos
- Iniguez Andres
- Iqbal Syed M. R.
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- Istratoaie Octavian
- Ito Kashima
- Ivanov Igor G.
- Ivanova Raya
- Ivanovic Nikola
- Iyengar Shamanna S.
- Izzo Mark
- Jacoby Douglas
- Jafar Zubair
- Jaffrani Naseem
- Jain Diwakar
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- Janosik Denise
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- Jaworska Krystyna
- Jayawardena Jayanthimala
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- Jeong Myung Ho
- Jeppesen Jorgen
- Jeserich Michael
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- Johansen Peter Betton
- Jonas Michael
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- Kahali Dhiman
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- Kalil Renato
- Kamensky Gabriel
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- Karalis Ioannis
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- Karpenko Oleksandr
- Karpenko Yuriy
- Karpov Yuri
- Karpov Yuriy
- Kartalis Athanasios
- Kasim Sazzli
- Katona Andras
- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawasaki Tomohiro
- Ke Yuannan
- Keating Friederike
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- Khan Aziz
- Khan Misal
- Khasanov Niiaz
- Khintibidze Irakli
- Khurana Sandeep
- Kibarskis Aleksandras
- Kichukov Kostadin N.
- Killat Holger
- Kim Chongjin
- Kim Hyo Soo
- Kim Moo Hyun
- Kim Sang-Hyun
- Kimmelstiel Carey
- Kimura Kazuo
- Kimura Takeshi
- King Marilyn
- Kinzfogl George
- Kirma Cevat
- Kishi Koichi
- Kiss Robert Gabor
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- Kiviniemi Tuomas
- Kjovkaroski Aleksandar
- Klancke Kim
- Klantsa Andriy
- Klausen Ib C.
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- Knowles Joshua W.
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- Kopytsya Mykola
- Koren Michael
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- Kornder Jan
- Kornowski Ran
- Korol Marek
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- Kosmachova Elena
- Kostarska-Srokosz Edyta
- Kostis John
- Kotha Purushotham
- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Krasowski Wlodzimierz
- Krawczyk Justine
- Krichmar Perry
- Kristensen Kjeld S.
- Kubica Jacek
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- Kultursay Hakan
- Kumar Anil
- Kumar Priya
- Kumbla Mukund
- Kumkumian Greg
- Kuo Jen-Yuan
- Kurian John
- Kushnir Mykola
- Kutniy Oles
- Kyiak Yulian
- Labroo Ajay
- Lai Christopher
- Lai Wen-Ter
- Lambert Charles
- Landzberg Joel
- Larry John
- Larsen John
- Laucevicius Aleksandras
- Laufs Ulrich
- Laxson David
- Lazov Petar V.
- Leaes Paulo E.
- Leclercq Florence
- Lecorps G.
- Lee Kaeng
- Lee Kwan
- Lefevre Thierry
- Leggewie Stefan
- Lehman Sam J.
- Leimbach Wayne
- Lekakis John
- Leon Reynaldo P. Castillo
- Leonardi Sergio
- Leone Attilio
- Lepage Serge
- Lepor Norman
- Leshchuk Oleh
- Lester F. Martin
- Leung Raymond
- Levy Terry
- Li Huanming
- Li Jianping
- Li Xiaodong
- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
- Liberopoulos Evangelos
- Libov Igor
- Licciardello Giovanni
- Lieber Ira
- Liem Anho A. H.
- Liew Houng B.
- Lillis Linda
- Lin Jinxiu
- Lin Wei Hsiang
- Lin Wenhua
- Lin Xuefeng
- Lindsey Jason
- Linhart Ales
- Link Chad
- Lip Gregory Y. H.
- Lipar Luka
- Lipko Jan Andrzej
- Liu Ming-En
- Liu Shaowen
- Llamas Esperon Guillermo Antonio
- Loma-Osorio Rincon Pablo
- Lomakin Nikita V.
- Lomholdt Jens D.
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- Matei Adrian V.
- Mathews Robin
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- Mazur Juraj
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- Morisset Anne
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- Motovska Zuzana
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- Munusamy Vengatesh
- Murin Jan
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- Musumeci Giuseppe
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- Myshanych Halyna
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- Nishibe Akira
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- Norkiene Sigute
- Novaretto Leonardo P.
- Novo Salvatore
- Novoa Federico
- Novotny Vojtech
- Nowins Rosemary
- Nunez Fragoso Juan Carlos
- Nunez Carlos A. Zea
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- Olivares Claudia
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- Omran Heyder
- Ong Hean Yee
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- Ono Yujiro
- Oomen Antonius
- Oomman Abraham
- Orlikova Olga
- Osokina Natalya
- Ostadal Petr
- Paganelli Franck
- Pagava Zurab
- Palimkar Priya
- Palka Juraj
- Palmer Bruce
- Palvarini Michela
- Panchal Vipul
- Pancholy Samir
- Pandey Amritanshu
- Pandurangi Ulhas
- Parada Jeffrey Castellanos
- Parepa Irinel R.
- Park Hun Sik
- Park Hyeun (Tom)
- Parkhomenko Alexander
- Parkhomenko Alexander
- Parthenakis P. I. Frangkiskos
- Pasquini John
- Patange Aparna
- Patel Chetan B.
- Paterlini Gustavo A.
- Patil Sachin N.
- Patki Nitin
- Patocchi Cristian A.
- Patsilinakos Sotiris
- Pawlowicz Lidia
- Pearce Stephen
- Pecin Ivan
- Pella Daniel
- Peng Daoquan
- Penny William
- Pepine Carl
- Pereira Edward
- Pereira Helder H.
- Pereira Sabrina Bernardez
- Perez Rios Jesus Antonio
- Perez Enrique S. Sanabria
- Perez Luis
- Perkins Lynn
- Perlmutter Neal
- Pesant Yves
- Petranov Stanislav L.
- Petrulioniene Zaneta
- Piatti Piermarco
- Picone Mark
- Piepiorka Marek
- Pillay Thayabran
- Pimentel Filho Pedro
- Pincetti Cristian
- Piovaccari Giancarlo
- Pirenne Bruno
- Piyayotai Dilok
- Plaza Perez Ignacio
- Podoleanu Cristian G. C.
- Podpera Ivo
- Poh Kian-Keong
- Pojskic Belma
- Pollock Stewart
- Pontaga Natalija
- Pope Theodore
- Pordy R.
- Porthan Kimmo
- Porwal Sanjay
- Posio Pirjo
- Pothineni Ramesh B.
- Potthoff Sergio
- Poulsen Steen Hvitfeldt
- Povolny Petr
- Povsic Thomas J.
- Povzun Anton
- Precoma Dalton B.
- Premchand Rajendra K.
- Prieto Juan-Carlos
- Probst Vincent
- Proddutur Naveen Reddy
- Prokhorov Alexander
- Puccioni Enrico
- Puri Sanjeev
- Purow Joshua
- Putnikovic Biljana
- Puymirat Etienne
- Qu Baiming
- Quintero K.
- Radin Michael
- Radovanovic Slavica
- Raev Dimitar H.
- Raffel Owen
- Raffo Carlos A.
- Raghuraman Bagirath
- Rahman Aref
- Raisinghani Ajit
- Rajapaksha Ajantha
- Ramos Lopez Gabriel Arturo
- Ranadive Nandkishore
- Ranjith Naresh
- Rao Sunder
- Rasmanis Gundars
- Rauch-Kroehnert Ursula
- Raungaard Bent
- Ray Kausik K.
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- Rech Rafael
- Reiner Zeljko
- Reis Gilmar
- Reis Helder J. L.
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- Reshetko Olga
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- Ristic Arsen D.
- Ritt Luiz Eduardo F.
- Roberts-Thomson Philip
- Robinson Simon
- Rodes-Cabau Josep
- Rodriguez De Leon Edgar R.
- Roe M. T.
- Rogelio Gregorio
- Rogers James F.
- Rogers William
- Rokyta Richard
- Romeo Stefano
- Ronner Eelko
- Roosen John
- Rosenberg Michael
- Rosenschein Uri
- Rosenson Robert
- Rossi Paulo R. F.
- Rossi Peter
- Rosu Doina
- Rouleau Jean-Lucien
- Rozenman Yoseph
- Rubenstein Howard
- Rudenko Anatolii
- Rudenko Leonid
- Ruiz Ricardo L. Fernandez
- Saaiman Jan A.
- Saathe Shireesh
- Saavedra Silvia S.
- Sabatino Kenneth
- Sabbah Eric
- Sader Mark
- Sakagami Satoru
- Sakalyte Gintare
- Sakamoto Tomohiro
- Salcido Vazquez Eduardo
- Salvioni Alessandro
- Saminski Krzysztof
- Sandhu Manjinder
- Sansanayudh Nakarin
- Santharaj Wijeyasingam
- Saporito Wladimir
- Sarkar David
- Sarvan Mahomed
- Sasiela W. J.
- Sassone Sonia A.
- Sastravaha Krisada
- Savard Daniel
- Sawhney Jitendra
- Schaeufele Tim
- Schellenberg Detlev
- Schiavi Lilia B.
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- Schmalfuss Carsten
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- Schwartz Michael
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- Sinnaeve Peter
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- Skonieczny Grzegorz
- Skorski Marcin
- Skoumas Ioannis
- Slapikas Rimvydas
- Smik Rudolf
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- Soopold sllar
- Soots Mai
- Soran Handrean
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- Sotnikova Tatiana
- Sousa Luciano
- Souza Weimar K. S. B.
- Soward Allan
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- Speirs Shawn
- Spinar Jindrich
- Sporn Daniel
- Spriggs Douglas
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- Staneta Pawel
- Stanislavchuk Mykola
- Stankovic Aleksandar
- Starmer Gregory
- Stasek Josef
- Stasiewski Arkadiusz
- Steg P. G.
- Steg Philippe Gabriel
- Steiner Stephan
- Stellbrink Christoph
- Stewart Ralph
- Stojic Stevo
- Stone James
- Storey Robert
- Strader James
- Strain Janet
- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Stryuk Raisa
- Su Guohai
- Su Xi
- Suarez Otero Rodrigo
- Subkovas Eduardas
- Sudnik Wanda
- Sugino Hiroshi
- Suh David
- Sujjavanich Darin
- Sukonthasarn Apichard
- Suligoj Natasa Cernic
- Sumner Andrew
- Sun Yuemin
- Sundelin Torbjorn
- Sundram P. Sandy
- Suryapranata Harry
- Sussex Bruce
- Svab Premysl
- Sy Rody G.
- Sy Rosa Allyn G.
- Sydow Karsten
- Szarek M.
- Szpajer Michal
- Taguchi Shuichi
- Takahashi Toshiyuki
- Takata Theodore
- Takeda Yoshihiro
- Tamby J. -F.
- Tan Edgar
- Tashchuk Viktor
- Tasic Nebojsa
- Taskinen Marja-Riitta
- Taurio Jyrki
- Ternouth Ian
- Terzic Ibrahim
- Tesloianu Dan N.
- Tespili Maurizio
- Teufel Edward
- Thakkar Maitreya
- Thew Stephen
- Ticona Jorge R. Calderon
- Tirador Louie
- Tissera Nirmali
- Todorov Georgi V.
- Toma Mustafa
- Tomala Tadeusz
- Tonnessen Glen
- Torstensson Ingemar
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- Tov Naveh
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- Trevelyan Jasper
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- Tunon Jose
- Turgeman Yoav
- Turi Tibor
- Turk Samir
- Tyrenko Vadim V.
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- Ueda Yasunori
- Uehara Hiroki
- Ueng Kwo-Chang
- Ungi Imre
- Ural Ertan
- Ushakov Olexiy
- Utsu Noriaki
- Vahula Veiko
- Vakaluyk Ihor
- Valgimigli Marco
- Vallejo Gregorio Sanchez
- Vallejos Julio A.
- Van Der Wal Ruud M. A.
- Van Der Zwaan Coenraad C.
- van Diepen Sean F. P.
- Van Huysduynen-Monraats Pascalle S. Hooft
- Van Zyl Louis J.
- Vardi Gil
- Varleta Paola
- Vatutin Mykola
- Vedere Amarnath
- Vejar Margarita
- Velasquez Julio R. Durand
- Velcheva Elena S.
- Verdel Gerardus J. E.
- Vered Zvi
- Vervoort Geert
- Vico Marisa L.
- Vida Manuel
- Videbaek Lars
- Vidotti Maria H.
- Vidovich Mladen
- Viergever Eric P.
- Viigimaa Margus
- Vijay Nampalli
- Vijayaraghavan Ram
- Vikman Saila
- Viktorova Inna
- Violini Roberto
- Vishnevsky Alexander Y.
- Vizel Saul
- Vo Anthony
- Voeller Heinz
- Voevoda Mikhail I.
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
- Voyce Stephen
- Vrolix Mathias C. M.
- Vulic Dusko
- Vuurmans Tycho
- Wada Atsuyuki
- Waider Winfried
- Waisman Gabriel D.
- Waites Jonathon H.
- Wali Andreas
- Walichiewicz Piotr Maria
- Waltenberger Johannes
- Waltman Jonathan
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weissbrodt Matthias
- Welka Stephen
- Welker James
- Wells Terry
- Werner Nikos
- Westerhausen Donald
- Whitaker Jack
- White H. D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J.
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F.
- Wilson Matthew D.
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wright Scott
- Xatzitolios Apostolos
- Xavier Denis
- Xenakis Mark
- Xu Biao
- Xu Dingli
- Xu Xiping
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew Tze-Kay
- Yan Bryan P. Y.
- Yanez Mario
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zeiher A. M.
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Xingsheng
- Zheng Yang
- Zheng Zeqi
- Zhou Yujie
- Zhu Hong
- Zirlik Andreas
- Zizka Jiri
- Zong Wenxia
- Zrazhevsky Konstantin
- Zuniga Jose D. Hernandez
- Zurakowski Aleksander
- Zuran Ivan
- Zweiker Robert
- Publication venue
- Publication date
- 01/01/2018
- Field of study
BACKGROUN
Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
- Author
- Abbas Jalal
- Abbate Antonio
- Abdullakutty Jabir
- Abhyanakar Atul D.
- Aboyans Victor
- Abrantes Jose Antonio M.
- Abu-Fadel Mazen
- Acevedo Monica
- Adamkova Vera
- Adhyapak Srilakshmi
- Agarwal Himanshu
- Aggarwal Rahul
- Aggarwal Rajesh K.
- Aguirre Arnoldo
- Ahmed Hinan
- Ahremark Ulf
- Ahuad Guerrero Rodolfo A.
- Aidar Ayoub Jose Carlos
- Airaksinen Juhani K.
- Aitken Denise
- Akatova Evgenia
- Akhter Faiq
- Ako Junya
- Akright Laura
- Akyea-Djamson Ayim
- Al Joundi Tammam
- Al-Windy Nadea Y. Y.
- Alan David
- Alcocer Gamba Marco Antonio
- Alexander John H.
- Alexander Karen
- Alexandru Tom M.
- Alings Marco
- Alonso Martin Joaquin J.
- Alvarisqueta Andres F.
- Alves De Lima Alberto E.
- Amarasekera Stanley
- Amarasena Naomali
- Amir Offer
- Amlani Mohamadali
- Amosova Ekaterina
- Amuchastegui Marcos
- Andersen Kjell
- Andersen Rolf
- Anderson Jay
- Ando Kenji
- Angel Hominal Miguel
- Annam Sharath
- Anscombe Russell
- Apostolovic Svetlana R.
- Appel Karl-Friedrich
- Arandjelovic Aleksandra
- Araneda Guillermo
- Arango Benecke Juan L.
- Arbel Yaron
- Arif Imran
- Armaganijan Luciana
- Arroyo Julian A. Coronel
- Arstall Margaret A.
- Asanin Milika R.
- Atar Shaul
- Athyros Vasilios
- Auguadro Carla
- Ayala Carlos A. Chavez
- Aylward Philip E.
- Azizad Masoud M.
- Bagai Akshay
- Bagriy Andriy
- Bahit Maria Cecilia
- Bai Feng
- Balaguer Recena Javier
- Baldari Duccio
- Balinovac Jovan
- Ball Eric
- Bang Lia E.
- Banuru Sridhar
- Barakovic Fahir
- Baranov Evgeny
- Baranova Elena
- Barbarash Olga L.
- Barbato Emanuele
- Barna Olga M.
- Barone-Rochette Gilles
- Barr Craig
- Barrucco Robert
- Bartels Gerard L.
- Bashir Riyaz
- Basson Matthys M. de V.
- Bastos Jose Mesquita
- Bata Iqbal
- Batushkin Valeriy
- Bayat Junaid
- Bayram Llamas Edmundo Alfredo
- Bayron Carlos
- Beauloye Christophe
- Bednarski Janusz
- Behrens Steffen
- Belhassane Abdelkader
- Benedicto Amparo
- Bengus Cristina M.
- Benov Haralambi O.
- Berger Rudolf
- Berglund Stefan
- Berk Martin
- Berland Jacques
- Berli Mario A.
- Berlowitz Michael
- Berman Brett
- Bernan Alisa
- Berti Sergio
- Bhagwat Ajit
- Bhagwat Ravi
- Bhansali Prasant
- Bhatt D. L.
- Binder Ronald
- Birchem Jessica
- Bittner V. A.
- Blicharski Tomasz
- Blok Thomas
- Blumberg Eduardo D. S.
- Boccara Franck
- Bodanese Luiz C.
- Bodi Peris Vicente
- Boecker Dirk
- Bojovski Stojko
- Bokarev Igor
- Bokern Marcel J. J. A.
- Bonfanti Alberto J. Cadena
- Bono Julio O. E.
- Bordonava Anselmo P.
- Borse Rohidas
- Bortnick Anna
- Bos Robert J.
- Botas Rodriguez Javier
- Botelho Ana
- Botelho Roberto V.
- Botia Diana C. Luna
- Bottcher Morten
- Bourgeois Ronald
- Brabham David
- Braganza Denise
- Braun-Dullaeus Ruediger
- Breedveld Robert W.
- Brennan J. Matthew
- Brodison Adrian
- Bronzwaer Patrick N. A.
- Brueren Bart R. G.
- Bruguera Cortada Jordi
- Budaj Andrzej
- Bugan Viliam
- Busmane Arija
- Bustamante Labarta Miguel H.
- Busz-Papiez Benita
- Butler Rob
- Bystryk Leszek
- Caccavo Alberto
- Caime Guillermo D.
- Calabro Paolo
- Camprubi Potau Mercedes
- Camsari Ahmet
- Caraco Yoseph
- Carey Charles
- Carlson Eric
- Carnero Gabriela S.
- Carranza Madrigal Jaime
- Carrillo Calvillo Jorge
- Carroll Patrick A.
- Cartasegna Luis R.
- Carter Luther
- Caruso Orlando C.
- Cassimjee Soraya
- Castadot Marc
- Cavallini Claudio
- Cequier Fillat Angel R.
- Cerqueira Maria Jose A. G.
- Cestari Horacio G.
- Cevc Matija
- Cha James
- Chae In-Ho
- Chaitman Bernard
- Chalavarya Gopal
- Chaleff Fred
- Chambilla Jesus M. Carrion
- Chandna Harish
- Chane Majed
- Chang Mark
- Chaudhary Sanjeev
- Chavez Victor E. Rodriguez
- Chen Dandan
- Chen Jiyan
- Chen Yundai
- Cheng Shi-Chi
- Cheng Xiaoshu
- Chiang Chern-En
- Chiang Chern-En
- Chizhov Petr
- Chopda Manoj
- Chopra Vijay K.
- Christenson Stuart
- Chu Alan
- Chua Terrance
- Chumakova Galina
- Chumburidze Vakhtang
- Civeira Murillo Fernando
- Claeys Marc
- Claxton Edmund
- Clemmensen Peter
- Clerc Jerome
- Cleveland David
- Clifford Piers
- Clifton Shaun
- Coching Raul Martin
- Codutti Oscar R.
- Cohen Steven
- Collins Nicholas
- Colombo Hugo R.
- Colquhoun David
- Commerford Patrick J.
- Concha Yudy M. Roldan
- Conrad Gary
- Constantine Godwin
- Constantinescu Mircea C. A.
- Convens Carl
- Cools Frank
- Corbett Clive
- Cornel Jan H.
- Correa Flores Roger M.
- Cosavalente Luis A. Camacho
- Cosin Sales Juan
- Costa Fernando
- Coste Pierre
- Cottin Yves
- Coufal Zdenek
- Coverdale Steven G. M.
- Cristian Gabriel
- Cruz Fernandez Jose M.
- Cuccia Claudio
- Cui Lan
- Cyster Henry P.
- Czerski Tomasz
- D'Urso Michael
- Daboul Nizar
- Dagher Georges
- Dahl Charles
- Dai Kazuoki
- Dalby Anthony J.
- Dalby Anthony J.
- Danchin Nicolas
- Dandillaya Ramprasad
- Daniels Christopher
- Das Srihari
- Davidovic Goran
- Davidsen Flemming
- Davies Richard
- Davis William
- De Berrazueta Fernandez Jose R.
- De Cesare Nicoletta B.
- De Leo Alessandro
- De Luca Giuseppe
- De Mora Martin Manuel
- De Pellegrin Annamaria
- De Salazar Dora I. Molina
- de Santos Mayler O. N.
- de Silva H. Asita
- de Souza Juliana A.
- De Wolf Luc
- Delarche Nicolas
- Deloatch Shalonda
- Demirtas Mustafa
- Denham Douglas
- Devarapalli Sai K.
- DeVore Adam D.
- Diamantis Steve
- Diaz Fernandez Jose Francisco
- Diaz Ariel
- Diaz R.
- Dickey Sheila
- Dilic Mirza
- Dimkovic Sinisa
- Dimov Bojidar I.
- Dincic Dragan V.
- Ding Chunhua
- Dion Danielle
- Dodds George
- Dodic Slobodan
- Dombrowski Keith
- Doncovska Snezana
- Dong Shaohong
- Dong Yugang
- Dorobantu Maria
- Dorsel Thomas
- Dran Ricardo D.
- Drexel Heinz
- Drzewiecka Anna
- Ducas John
- Ducrocq Gregory
- Duda Norberto
- Dujardin Karl
- Dukat Andrej
- Dulak Elzbieta
- Dupuis Robert
- Durak-Nalbantic Azra
- Duronto Ernesto A.
- Dzupina Andrej
- Dzyak Georgiy
- Eagerton Donald
- Eapen Zubin
- East Cara
- Eaton Charles
- Ebrahim Iftikhar O.
- Edelberg J. M.
- Edes Istvan
- Egorova Liudmila
- Eisenberg Steven
- Ekanayaka Ruvan
- El Shahawy Mahfouz
- El-Ahdab Fadi
- Elias Mazen
- Eliaschewitz Freddy G.
- Elliott John
- Endsley Patricia
- Eppinger Arleen
- Erglis Andrejs
- Ersanli Murat
- Fadlallah Hussein
- Faes Dirk
- Faggiano Pompilio
- Fairlamb James
- Fajardo Campos Pedro
- Falukozy Jozsef
- Fang Chih-Yuan
- Fang Weiyi
- Fanghanel Salmon Guillermo
- Farhat Naim
- Farrar Michael
- Fausto Ovando Sergio R.
- Fazekas Frantisek
- Fazlibegovic Emir
- Feitosa Gilson S.
- Fell David
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- Fernandez Portales Javier
- Fernandez Angela M.
- Fernandez Mauricio
- Fernando Nimali
- Ferrari Emile
- Ferratini Maurizio
- Ferrolino Arthur
- Filardi Pasquale Perrone
- Fischer Stuart
- Fishberg Robert
- Fisher Daniel
- Fisher Nicholas
- Fisher Raewyn
- Florenzano Fernando
- Flores Enrique
- Flores Romulo E. Oqueli
- Fong Peter
- Forgosh Les
- Foster Malcolm
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- Franek Edward
- Fras Zlatko
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- Frost Lars
- Fu Guosheng
- Fuchs Shmuel
- Fuentes Jimenez Francisco
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- Goloborodko Borys
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- Groutars Reginald G. E. J.
- Guardigli Gabriele
- Guerrero De Leon Maria
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- Gusi Tragant Gabriel
- Guzman Pablo N.
- Haddad Tariq
- Hagstrom Emil
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- Halabi Majdi
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- Haniffa Ruvaiz
- Hanotin C.
- Hansen Ole
- Haraguchi Takuya
- Harding Scott
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- Harrington R. A.
- Harris Barry
- Harris Bill
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- Hata Yoshiki
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- Hedman Anu
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- Heitzer Thomas
- Hemetsberger Rayyan
- Henderson David
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- Herath Jagath I.
- Herazo Aristides Sotomayor
- Hermans Kurt
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- Hodes Zachary
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- Hoppe Uta
- Horak David
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- Huang Lan
- Huang Shi'An
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- Ito Kashima
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- Jaworska Krystyna
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- Jiang Weihong
- Jintapakorn Woravut
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- Jujjuru Srimannarayana
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- Kaewsuwanna Pinij
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- Kandasamy Balachandran
- Kapin Tibor
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- Karalis Ioannis
- Karlsberg Ronald
- Karna Sunil
- Karpenko Oleksandr
- Karpenko Yuriy
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- Katsuda Yousuke
- Katz Amos
- Kaucak Vladimir
- Kavaliauskiene Roma
- Kawasaki Tomohiro
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- Keating Friederike
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- Kehasukcharoen Wirash
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- Kerkar Prafulla
- Khabeishvili George
- Khaira Ajit S.
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- Khurana Sandeep
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- Kichukov Kostadin N.
- Killat Holger
- Kim Chongjin
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- Kiss Robert Gabor
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- Kiviniemi Tuomas
- Kjovkaroski Aleksandar
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- Kobalava Zhanna
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- Kostarska-Srokosz Edyta
- Kostis John
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- Kouz Simon
- Kovalskyi Ihor
- Kozuma Ken
- Krasowski Wlodzimierz
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- Krichmar Perry
- Kristensen Kjeld S.
- Kubica Jacek
- Kubilius Raimondas
- Kuchar Jiri
- Kuhlman Peter
- Kultursay Hakan
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- Kuo Jen-Yuan
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- Leonardi Sergio
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- Lester F. Martin
- Leung Raymond
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- Li Huanming
- Li Jianping
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- Li Ying
- Lianopoulos Emmanouil
- Liberman Alberto
- Liberopoulos Evangelos
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- Libov Igor
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- Lillis Linda
- Lin Jinxiu
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- Pandey Amritanshu
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- Perez Enrique S. Sanabria
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- Petrulioniene Zaneta
- Piatti Piermarco
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- Pillay Thayabran
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- Piovaccari Giancarlo
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- Pojskic Belma
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- Pontaga Natalija
- Pope Theodore
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- Soopold sllar
- Soots Mai
- Soran Handrean
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- Sotnikova Tatiana
- Sousa Luciano
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- Steiner Stephan
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- Stratmann Matthias
- Strbova Jaroslava
- Strelnieks Aldis
- Striekwold Harry
- Stringfellow Kenya
- Stryuk Raisa
- Su Guohai
- Su Xi
- Suarez Otero Rodrigo
- Subkovas Eduardas
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- Sugino Hiroshi
- Suh David
- Sujjavanich Darin
- Sukonthasarn Apichard
- Suligoj Natasa Cernic
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- Tashchuk Viktor
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- Terzic Ibrahim
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- Tirador Louie
- Tissera Nirmali
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- Torstensson Ingemar
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- Tsai Wei-Chuan
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- Tunon Jose
- Turgeman Yoav
- Turi Tibor
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- Ueng Kwo-Chang
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- Ural Ertan
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- Vizel Saul
- Vo Anthony
- Voeller Heinz
- Voevoda Mikhail I.
- Vogel Robert
- Vohra Rakesh
- Vora Kishor
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- Waltenberger Johannes
- Waltman Jonathan
- Wang Jian'An
- Wang Jianzhong
- Wang Jingfeng
- Wattanakit Keattiyoat
- Wei Meng
- Weidinger Franz
- Weil Joachim
- Weintraub Howard
- Weissbrodt Matthias
- Welka Stephen
- Welker James
- Wells Terry
- Werner Nikos
- Westerhausen Donald
- Whitaker Jack
- White H. D.
- White Lindsey
- White Matthew
- Wiersma Jacobijne J.
- Wilkins Gerard
- Wilkinson Peter
- Willems Frank F.
- Wilson Matthew D.
- Winkelmann Bernhard
- Wiseman Alan
- Witt Nils
- Wlodarczak Adrian
- Wojewoda Pawel
- Wollaert Bart
- Wong Yuk-Ki
- Wongpraparut Nattawut
- Worner Diz Fernando
- Wright Scott
- Xatzitolios Apostolos
- Xavier Denis
- Xenakis Mark
- Xu Biao
- Xu Dingli
- Xu Xiping
- Yagensky Andriy
- Yakushin Sergey
- Yan Andrew Tze-Kay
- Yan Bryan P. Y.
- Yanez Mario
- Yang Eric
- Yang Xiangjun
- Yang Xinchun
- Yao Zhuhua
- Yazdani Shahram
- Yerra Shiv Kumar
- Yin Wei-Hsian
- Yong Huo
- Yoon Jung Han
- Younis Liwa
- Yu Yihua
- Yuan Zuyi
- Yusoff Khalid
- Zahger Doron
- Zaidman Cesar J.
- Zainea Mark
- Zaman Azfar
- Zeiher A. M.
- Zhang Wenwu
- Zhang Xuelian
- Zhang Zheng
- Zhao Xingsheng
- Zheng Yang
- Zheng Zeqi
- Zhou Yujie
- Zhu Hong
- Zirlik Andreas
- Zizka Jiri
- Zong Wenxia
- Zrazhevsky Konstantin
- Zuniga Jose D. Hernandez
- Zurakowski Aleksander
- Zuran Ivan
- Zweiker Robert
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2018
- Field of study
BACKGROUN