Cardiovascular safety of celecoxib in acute myocardial infarction patients: a nested case-control study

The objective was to measure the impact of exposure to coxibs and non-steroidal antiinflammatory drugs (NSAID) on morbidity and mortality in older patients with acute myocardial infarction (AMI). A nested case-control study was carried out using an exhaustive population-based cohort of patients aged 66 years and older living in Quebec (Canada) who survived a hospitalization for AMI (ICD-9 410) between 1999 and 2002. The main variables were all-cause and cardiovascular (CV) death, subsequent hospital admission for AMI, and a composite end-point including recurrent AMI or CV death. Conditional logistic regressions were used to estimate the risk of mortality and morbidity. A total of 19,823 patients aged 66 years and older survived hospitalization for AMI in the province of Quebec between 1999 and 2002. After controlling for covariables, the risk of subsequent AMI and the risk of composite end-point were increased by the use of rofecoxib. The risk of subsequent AMI was particularly high for new rofecoxib users (HR 2.47, 95% CI 1.57–3.89). No increased risk was observed for celecoxib users. No increased risk of CV death was observed for patients exposed to coxibs or NSAIDs. Patients newly exposed to NSAIDs were at an increased risk of death (HR 2.22, 95% CI 1.30–3.77) and of composite end-point (HR 2.28, 95% CI 1.35–3.84). Users of rofecoxib and NSAIDs, but not celecoxib, were at an increased risk of recurrent AMI and of composite end-point. Surprisingly, no increased risk of CV death was observed. Further studies are needed to better understand these apparently contradictory results

Satellite Dwarf Galaxies in a Hierarchical Universe: Infall Histories, Group Preprocessing, and Reionization

In the Local Group (LG), almost all satellite dwarf galaxies that are within the virial radius of the Milky Way (MW) and Andromeda (M31) exhibit strong environmental influence. The orbital histories of these satellites provide the key to understanding the role of the MW/M31 halo, lower-mass groups, and cosmic reionization on the evolution of dwarf galaxies. We examine the virial-infall histories of satellites with M_star = 10^{3-9} M_sun using the ELVIS suite of cosmological zoom-in dissipationless simulations of 48 MW/M31-like halos. Satellites at z = 0 fell into the MW/M31 halos typically 5 - 8 Gyr ago at z = 0.5 - 1. However, they first fell into any host halo typically 7 - 10 Gyr ago at z = 0.7 - 1.5. This difference arises because many satellites experienced "group preprocessing" in another host halo, typically of M_vir ~ 10^{10-12} M_sun, before falling into the MW/M31 halos. Satellites with lower mass and/or those closer to the MW/M31 fell in earlier and are more likely to have experienced group preprocessing; half of all satellites with M_star 6), and only < 4% were satellites of any other host halo during reionization. Thus, effects of cosmic reionization versus host-halo environment on the formation histories of surviving dwarf galaxies in the LG occurred at distinct epochs, separated typically by 2 - 4 Gyr, so they are separable theoretically and, in principle, observationally

Satellites of LMC-mass dwarfs: close friendships ruined by Milky Way mass haloes

Motivated by the recent discovery of several dwarfs near the Large Magellanic Cloud (LMC), we study the accretion of massive satellites onto Milky Way (MW)/M31-like haloes using the ELVIS suite of N-body simulations. We identify 25 surviving LMC-mass subhaloes, and investigate the lower-mass satellites that were associated with these subhaloes before they fell into the MW/M31 haloes. Typically, 7 per cent of the overall z = 0 satellite population of MW/M31 haloes were in a surviving LMC-group before falling into the MW/M31 halo. This fraction can vary between 1 and 25 per cent, being higher for groups with higher mass and/or more recent infall times. Groups of satellites disperse rapidly in phase space after infall, and their distances and velocities relative to the group centre become statistically similar to the overall satellite population after 4–8 Gyr. We quantify the likelihood that satellites were associated with an LMC-mass group as a function of both distance and velocity relative to the LMC at z = 0. The close proximity in distance of the nine Dark Energy Survey candidate dwarf galaxies to the LMC suggest that ∼2–4 are likely associated with the LMC. Furthermore, if several of these dwarfs are genuine members, then the LMC-group probably fell into the MW very recently, ≲2 Gyr ago. If the connection with the LMC is established with follow-up velocity measurements, these ‘satellites of satellites’ represent prime candidates to study the effects of group pre-processing on lower mass dwarfs

A variational approach for object contour tracking

International audienceIn this paper we describe a new framework for the tracking of closed curves described through implicit surface modeling. The approach proposed here enables a continuous tracking along an image sequence of deformable object contours. Such an approach is formalized through the minimization of a global spatio-temporal continuous cost functional stemming from a Bayesian Maximum a posteriori estimation of a Gaussian probability distribution. The resulting minimization sequence consists in a forward integration of an evolution law followed by a backward integration of an adjoint evolution model. This latter pde include also a term related to the discrepancy between the curve evolution law and a noisy observation of the curve. The efficiency of the approach is demonstrated on image sequences showing deformable objects of different natures