Dynamical surface structures in multi-particle-correlated surface growths

We investigate the scaling properties of the interface fluctuation width for the $Q$-mer and $Q$-particle-correlated deposition-evaporation models. These models are constrained with a global conservation law that the particle number at each height is conserved modulo $Q$. In equilibrium, the stationary roughness is anomalous but universal with roughness exponent $\alpha=1/3$, while the early time evolution shows nonuniversal behavior with growth exponent $\beta$ varying with models and $Q$. Nonequilibrium surfaces display diverse growing/stationary behavior. The $Q$-mer model shows a faceted structure, while the $Q$-particle-correlated model a macroscopically grooved structure.Comment: 16 pages, 10 figures, revte

Personal digital assistants to collect tuberculosis bacteriology data in Peru reduce delays, errors, and workload, and are acceptable to users: cluster randomized controlled trial

SummaryObjectivesTo evaluate the effectiveness of a personal digital assistant (PDA)-based system for collecting tuberculosis test results and to compare this new system to the previous paper-based system. The PDA- and paper-based systems were evaluated based on processing times, frequency of errors, and number of work-hours expended by data collectors.MethodsWe conducted a cluster randomized controlled trial in 93 health establishments in Peru. Baseline data were collected for 19 months. Districts (n=4) were then randomly assigned to intervention (PDA) or control (paper) groups, and further data were collected for 6 months. Comparisons were made between intervention and control districts and within-districts before and after the introduction of the intervention.ResultsThe PDA-based system had a significant effect on processing times (p<0.001) and errors (p=0.005). In the between-districts comparison, the median processing time for cultures was reduced from 23 to 8 days and for smears was reduced from 25 to 12 days. In that comparison, the proportion of cultures with delays >90 days was reduced from 9.2% to 0.1% and the number of errors was decreased by 57.1%. The intervention reduced the work-hours necessary to process results by 70% and was preferred by all users.ConclusionsA well-designed PDA-based system to collect data from institutions over a large, resource-poor area can significantly reduce delays, errors, and person-hours spent processing data

5D seesaw, flavor structure, and mass textures

In the 5D theory in which only 3 generation right-handed neutrinos are in the bulk, the neutrino flavor mixings and the mass spectrum can be constructed through the seesaw mechanism. The 5D seesaw is easily calculated just by a replacement of the Majorana mass eigenvalues, M_i, by 2 M_*tan(h)[\pi RM_i] (M_*: 5D Planck scale, R: compactification radius). The 5D features appear when the bulk mass, which induces the 4D Majorana mass, is the same as the compactification scale or larger than it. Depending on the type of bulk mass, the seesaw scales of the 3 generations are strongly split (the tan-function case) or degenerate (the tanh-function case). In the split case, the seesaw enhancement is naturally realized. The single right-handed neutrino dominance works in a simple setup, and some specific mass textures, which are just assumptions in the 4D setup, can be naturally obtained in 5 dimensions. The degenerate case is also useful for a suitable neutrino flavor structure.Comment: 15 page

O(d,d;R) Deformations of Complex Structures and Extended Worldsheet Supersymmetry

It is shown that the O(d,d;R) deformations of the superstring vacua and the O(d,d+16;R) deformations of the heterotic string vacua preserve extended worldsheet supersymmetry and, hence, generate superconformal deformations. The transformations of the complex structures are given explicitly and the action of the discrete duality subgroup is discussed. The results are valid when the complex structures are independent of the d coordinates which appear in the transformations. It is shown that generic deformations do not preserve the known superfield formulations of (2,2) extended supersymmetry. The analysis is performed by decomposing the transformations in terms of the metric vielbein and by introducing space-time connections induced due to the non-linear action of the O(d,d;R) and O(d,d+16;R) deformations on the background fields.Comment: 19 pages, Latex, very minor changes (version to appear in Nuclear Physics B

Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish

pVHL is a tumor suppressor. The lack of its function leads to various tumors, among which ccRCC (clear cell renal cell carcinoma) has the most serious outcome due to its resistance to chemotherapies and radiotherapies. Although HIF promotes the progression of ccRCC, the precise mechanism by which the loss of VHL leads to tumor initiation remains unclear. We exploited two zebrafish vhl mutants, vhl and vll, and Tg (phd3:: EGFP)i144 fish to identify crucial functions of Vhl in tumor initiation. Through the mutant analysis, we found that the role of pVHL in DNA repair is conserved in zebrafish Vll. Interestingly, we also discovered that Hif activation strongly suppressed genotoxic stress induced DNA repair defects and apoptosis in vll and brca2 mutants and in embryos lacking ATM activity. These results suggest the potential of HIF as a clinical modulator that can protect cells from accumulating DNA damage and apoptosis which can lead to cancers and neurodegenerative disorders

Deviation of Atmospheric Mixing from Maximal and Structure in the Leptonic Flavor Sector

I attempt to quantify how far from maximal one should expect the atmospheric mixing angle to be given a neutrino mass-matrix that leads, at zeroth order, to a nu_3 mass-eigenstate that is 0% nu_e, 50% nu_mu, and 50% nu_tau. This is done by assuming that the solar mass-squared difference is induced by an "anarchical" first order perturbation, an approach than can naturally lead to experimentally allowed values for all oscillation parameters. In particular, both |cos 2theta_atm| (the measure for the deviation of atmospheric mixing from maximal) and |U_e3| are of order sqrt(Delta m^2_sol/Delta m^2_atm) in the case of a normal neutrino mass-hierarchy, or of order Delta m^2_sol/Delta m^2_atm in the case of an inverted one. Hence, if any of the textures analyzed here has anything to do with reality, next-generation neutrino experiments can see a nonzero cos 2theta_atm in the case of a normal mass-hierarchy, while in the case of an inverted mass-hierarchy only neutrino factories should be able to see a deviation of sin^2 2theta_atm from 1.Comment: 12 pages, no figures, references and acknowledgments adde

Growth model with restricted surface relaxation

We simulate a growth model with restricted surface relaxation process in d=1 and d=2, where d is the dimensionality of a flat substrate. In this model, each particle can relax on the surface to a local minimum, as the Edwards-Wilkinson linear model, but only within a distance s. If the local minimum is out from this distance, the particle evaporates through a refuse mechanism similar to the Kim-Kosterlitz nonlinear model. In d=1, the growth exponent beta, measured from the temporal behavior of roughness, indicates that in the coarse-grained limit, the linear term of the Kardar-Parisi-Zhang equation dominates in short times (low-roughness) and, in asymptotic times, the nonlinear term prevails. The crossover between linear and nonlinear behaviors occurs in a characteristic time t_c which only depends on the magnitude of the parameter s, related to the nonlinear term. In d=2, we find indications of a similar crossover, that is, logarithmic temporal behavior of roughness in short times and power law behavior in asymptotic times

A macroscopic multifractal analysis of parabolic stochastic PDEs

It is generally argued that the solution to a stochastic PDE with multiplicative noise---such as $\dot{u}=\frac12 u"+u\xi$, where $\xi$ denotes space-time white noise---routinely produces exceptionally-large peaks that are "macroscopically multifractal." See, for example, Gibbon and Doering (2005), Gibbon and Titi (2005), and Zimmermann et al (2000). A few years ago, we proved that the spatial peaks of the solution to the mentioned stochastic PDE indeed form a random multifractal in the macroscopic sense of Barlow and Taylor (1989; 1992). The main result of the present paper is a proof of a rigorous formulation of the assertion that the spatio-temporal peaks of the solution form infinitely-many different multifractals on infinitely-many different scales, which we sometimes refer to as "stretch factors." A simpler, though still complex, such structure is shown to also exist for the constant-coefficient version of the said stochastic PDE.Comment: 41 page