Approach to wild-type gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GISTs) arise from the intestinal pacemaker cells of Cajal. Wild-type gastrointestinal stromal tumors (WT-GIST) are a unique and uncommon subtype of GISTs that lack activating mutations in the tyrosine kinase c-KIT or platelet derived growth factor receptor alpha (PDGFRA) receptors. The lack of these growth-stimulating mutations renders tyrosine kinase receptor inhibitors, such as imatinib mesylate, relatively ineffective against these tumors. WT-GIST arises most commonly due to underlying alternate proliferative signals associated with germ-line, genetic mutations. WT-GIST frequently arises in patients with BRAF mutations, Carney’s Triad or neurofibromatosis type-1 (NF-1). All patients with WT-GIST require a careful examination for germ-line mutations and very close observation for recurrent tumors. Surgery remains a mainstay therapy for these patients. This review aims to discuss the most recent data available on the diagnosis and treatment of WT-GIST

The Globular Cluster System of M60 (NGC 4649). II. Kinematics of the Globular Cluster System

We present a kinematic analysis of the globular cluster (GC) system in the giant elliptical galaxy (gE) M60 in the Virgo cluster. Using the photometric and spectroscopic database of 121 GCs (83 blue GCs and 38 red GCs), we have investigated the kinematics of the GC system. We have found that the M60 GC system shows a significant overall rotation. The rotation amplitude of the blue GCs is slightly smaller than or similar to that of the red GCs, and their angles of rotation axes are similar. The velocity dispersions about the mean velocity and about the best fit rotation curve for the red GCs are marginally larger than those for the blue GCs. Comparison of observed stellar and GC velocity dispersion profiles with those calculated from the stellar mass profile shows that the mass-to-light ratio should be increased as the galactocentric distance increases, indicating the existence of an extended dark matter halo. The entire sample of GCs in M60 is found to have a tangentially biased velocity ellipsoid unlike the GC systems in other gEs. Two subsamples appear to have different velocity ellipsoids. The blue GC system has a modest tangentially biased velocity ellipsoid, while the red GC system has a modest radially biased or an isotropic velocity ellipsoid. From the comparison of the kinematic properties of the M60 GC system to those of other gEs (M87, M49, NGC 1399, NGC 5128, and NGC 4636), it is found that the velocity dispersion of the blue GC system is similar to or larger than that of the red GC system except for M60, and the rotation of the GC system is not negligible. The entire sample of each GC system shows an isotropic velocity ellipsoid except for M60, while the subsamples show diverse velocity ellipsoids. We discuss the implication of these results for the formation models of the GC system in gEs.Comment: 48 pages, 16 figures. To appear in Ap

Emergence of robust 2D skyrmions in SrRuO3 ultrathin film without the capping layer

Magnetic skyrmions have fast evolved from a novelty, as a realization of topologically protected structure with particle-like character, into a promising platform for new types of magnetic storage. Significant engineering progress was achieved with the synthesis of compounds hosting room-temperature skyrmions in magnetic heterostructures, with the interfacial Dzyaloshinskii-Moriya interactions (DMI) conducive to the skyrmion formation. Here we report findings of ultrathin skyrmion formation in a few layers of SrRuO3 grown on SrTiO3 substrate without the heavy-metal capping layer. Measurement of the topological Hall effect (THE) reveals a robust stability of skyrmions in this platform, judging from the high value of the critical field 1.57 Tesla (T) at low temperature. THE survives as the field is tilted by as much as 85 degrees at 10 Kelvin, with the in-plane magnetic field reaching up to 6.5 T. Coherent Bragg Rod Analysis, or COBRA for short, on the same film proves the rumpling of the Ru-O plane to be the source of inversion symmetry breaking and DMI. First-principles calculations based on the structure obtained from COBRA find significant magnetic anisotropy in the SrRuO3 film to be the main source of skyrmion robustness. These features promise a few-layer SRO to be an important new platform for skyrmionics, without the necessity of introducing the capping layer to boost the spin-orbit coupling strength artificially.Comment: Supplementary Information available upon reques

The immediate upstream region of the 5 '-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana

The nucleotide sequence around the translational initiation site is an important cis-acting element for post-transcriptional regulation. However, it has not been fully understood how the sequence context at the 5'-untranslated region (5'-UTR) affects the translational efficiency of individual mRNAs. In this study, we provide evidence that the 5'-UTRs of Arabidopsis genes showing a great difference in the nucleotide sequence vary greatly in translational efficiency with more than a 200-fold difference. Of the four types of nucleotides, the A residue was the most favourable nucleotide from positions -1 to -21 of the 5'-UTRs in Arabidopsis genes. In particular, the A residue in the 5'-UTR from positions -1 to -5 was required for a high-level translational efficiency. In contrast, the T residue in the 5'-UTR from positions -1 to -5 was the least favourable nucleotide in translational efficiency. Furthermore, the effect of the sequence context in the -1 to -21 region of the 5'-UTR was conserved in different plant species. Based on these observations, we propose that the sequence context immediately upstream of the AUG initiation codon plays a crucial role in determining the translational efficiency of plant genes.ope

Emergence of robust 2D skyrmions in SrRuO3 ultrathin film without the capping layer

Magnetic skyrmions have fast evolved from a novelty, as a realization of topologically protected structure with particle-like character, into a promising platform for new types of magnetic storage. Significant engineering progress was achieved with the synthesis of compounds hosting room-temperature skyrmions in magnetic heterostructures, with the interfacial Dzyaloshinskii-Moriya interactions (DMI) conducive to the skyrmion formation. Here we report findings of ultrathin skyrmion formation in a few layers of SrRuO3 grown on SrTiO3 substrate without the heavy-metal capping layer. Measurement of the topological Hall effect (THE) reveals a robust stability of skyrmions in this platform, judging from the high value of the critical field 1.57 Tesla (T) at low temperature. THE survives as the field is tilted by as much as 85 degrees at 10 Kelvin, with the in-plane magnetic field reaching up to 6.5 T. Coherent Bragg Rod Analysis, or COBRA for short, on the same film proves the rumpling of the Ru-O plane to be the source of inversion symmetry breaking and DMI. First-principles calculations based on the structure obtained from COBRA find significant magnetic anisotropy in the SrRuO3 film to be the main source of skyrmion robustness. These features promise a few-layer SRO to be an important new platform for skyrmionics, without the necessity of introducing the capping layer to boost the spin-orbit coupling strength artificially.Comment: Supplementary Information available upon reques

The Globular Cluster System of M60 (NGC 4649). I. CFHT MOS Spectroscopy and Database

We present the measurement of radial velocities for globular clusters in M60, giant elliptical galaxy in the Virgo cluster. Target globular cluster candidates were selected using the Washington photometry based on the deep 16\arcmin \times 16\arcmin images taken at the KPNO 4m and using the $VI$ photometry derived from the HST/WFPC2 archive images. The spectra of the target objects were obtained using the Multi-Object Spectrograph (MOS) at the Canada-France-Hawaii Telescope (CFHT). We have measured the radial velocity for 111 objects in the field of M60: 93 globular clusters (72 blue globular clusters with $1.0\le(C-T_1)<1.7$ and 21 red globular clusters with $1.7\le(C-T_1)<2.4$), 11 foreground stars, 6 small galaxies, and the nucleus of M60. The measured velocities of the 93 globular clusters range from $\sim 500$ km s$^{-1}$ to $\sim 1600$ km s$^{-1}$, with a mean value of $1070_{-25}^{+27}$ km s$^{-1}$, which is in good agreement with the velocity of the nucleus of M60 ($v_{\rm gal}=1056$ km s$^{-1}$). Combining our results with data in the literature, we present a master catalog of radial velocities for 121 globular clusters in M60. The velocity dispersion of the globular clusters in the master catalog is found to be $234_{-14}^{+13}$ km s$^{-1}$ for the entire sample, $223_{-16}^{+13}$ km s$^{-1}$ for 83 blue globular clusters, and $258_{-31}^{+21}$ km s$^{-1}$ for 38 red globular clusters.Comment: 29 pages, 8 figures. To appear in Ap

Brain Structural Networks Associated with Intelligence and Visuomotor Ability

Increasing evidence indicates that multiple structures in the brain are associated with intelligence and cognitive function at the network level. The association between the grey matter (GM) structural network and intelligence and cognition is not well understood. We applied a multivariate approach to identify the pattern of GM and link the structural network to intelligence and cognitive functions. Structural magnetic resonance imaging was acquired from 92 healthy individuals. Source-based morphometry analysis was applied to the imaging data to extract GM structural covariance. We assessed the intelligence, verbal fluency, processing speed, and executive functioning of the participants and further investigated the correlations of the GM structural networks with intelligence and cognitive functions. Six GM structural networks were identified. The cerebello-parietal component and the frontal component were significantly associated with intelligence. The parietal and frontal regions were each distinctively associated with intelligence by maintaining structural networks with the cerebellum and the temporal region, respectively. The cerebellar component was associated with visuomotor ability. Our results support the parieto-frontal integration theory of intelligence by demonstrating how each core region for intelligence works in concert with other regions. In addition, we revealed how the cerebellum is associated with intelligence and cognitive functions

Physico-chemical properties of Arabidopsis Ca 2+ /H + antiporter transgenic rice grain

In this study, calcium contents, physico-chemical compositions, and grain related cytological &amp; agronomic traits of CAX1 (CAtione Xange) transgenic rice plants were examined. The average content of calcium in brown seeds of transgenic plants was 183.3ppm, which was elevated to 71% more than that of the parental cultivar &apos;Ilpum&apos;. CLMS analysis revealed that the starch granule compound was more compact and dense in the endosperm of the CAX1 transgenic grain. Green fluorescence was observed having strong signals in the cell and the vacuolar membranes, respectively. The grain size of CAX1 transgenic rice was similar to the parental cultivar; however, one thousand grain weight was reduced to 21.8g from that of 25.9g in the parental cultivar &apos;Ilpum&apos;. Physico-chemical properties of the endosperm such as amylose, protein and lipid content were similar to the parental cultivar &apos;Ilpum&apos;. The results indicate that Arabidopsis CAX1 is successfully expressed in rice and found to increase calcium contents in the endosperm. Among the transgenic plants, elite plants can be selected with elevated calcium content of about 2.4 times more than parental cultivar, &apos;Ilpum&apos;. These lines can be used as a good genetic resource for releasing calcium fortified rice in the future

Near-Infrared Properties of Metal-poor Globular Clusters in the Galactic Bulge Direction

Aims. J, H, and K' images obtained from the near-infrared imager CFHTIR on the Canada-France-Hawaii Telescope are used to derive the morphological parameters of the red giant branch (RGB) in the near-infrared color-magnitude diagrams for 12 metal-poor globular clusters in the Galactic bulge direction. Using the compiled data set of the RGB parameters for the observed 12 clusters, in addition to the previously studied 5 clusters, we discuss the properties of the RGB morphology for the clusters and compare them with the calibration relations for the metal-rich bulge clusters and the metal-poor halo clusters. Methods. The photometric RGB shape indices such as colors at fixed magnitudes of MK = MH = (-5.5, -5, -4, and -3), magnitudes at fixed colors of (J - K)o = (J - H)o = 0.7, and the RGB slope are measured from the fiducial normal points defined in the near- infrared color-magnitude diagrams for each cluster. The magnitudes of RGB bump and tip are also estimated from the differential and cumulative luminosity functions of the selected RGB stars. The derived RGB parameters have been used to examine the overall behaviors of the RGB morphology as a function of cluster metallicity. Results. The correlations between the near-infrared photometric RGB shape indices and the cluster metallicity for the programme clusters compare favorably with the previous observational calibration relations for metal-rich clusters in the Galactic bulge and the metal-poor halo clusters. The observed near-infrared magnitudes of the RGB bump and tip for the investigated clusters are also in accordance with the previous calibration relations for the Galactic bulge clusters.Comment: 12 pages, 9 figures, accepted for publication in Astronomy & Astrophysic