Time Series Analysis of Key Societal Events as Reflected in Complex Social Media Data Streams

Social media platforms hold valuable insights, yet extracting essential information can be challenging. Traditional top-down approaches often struggle to capture critical signals in rapidly changing events. As global events evolve swiftly, social media narratives, including instances of disinformation, become significant sources of insights. To address the need for an inductive strategy, we explore a niche social media platform GAB and an established messaging service Telegram, to develop methodologies applicable on a broader scale. This study investigates narrative evolution on these platforms using quantitative corpus-based discourse analysis techniques. Our approach is a novel mode to study multiple social media domains to distil key information which may be obscured otherwise, allowing for useful and actionable insights. The paper details the technical and methodological aspects of gathering and preprocessing GAB and Telegram data for a keyness (Log Ratio) metric analysis, identifying crucial nouns and verbs for deeper exploration. Empirically, this approach is applied to a case study of a well defined event that had global impact: the 2023 Wagner mutiny. The main findings are: (1) the time line can be deconstructed to provide useful data features allowing for improved interpretation; (2) a methodology is applied which provides a basis for generalization. The key contribution is an approach, that in some cases, provides the ability to capture the dynamic narrative shifts over time with elevated confidence. The approach can augment near-real-time assessment of key social movements, allowing for informed governance choices. This research is important because it lays out a useful methodology for time series relevant info-culling, which can enable proactive modes for positive social engagement.Comment: AAAI2024 Workshop on AI for Time Series Analysis (AI4TS

Locke on Substance

In the Essay, Locke refers to the ordinary-sized natural things as ‘particular sorts of Substances’ (2.23), whereas the ‘three sorts of Substances’ (2.27) are more metaphysically laden sorts: God, finite spirits, and fundamental material particles. He posits the much-contested ‘substratum’ in each particular sort of substance but not any of the three sorts. It should also be noted that his list of the particular sorts includes ‘men’. In regard to this nobler sort, he refers to a further classification – viz., ‘the Substance of spirit’ and ‘the Substance of the body’ – only in terms of their nominal essence. A naturalistic, nominalist approach is deeply entrenched in his account of the human-related sorts as well. In this chapter, I shall explore how Locke develops a theory of substance in the Essay that is less metaphysical and more naturalistic and epistemically humble than those of his rationalist contemporaries

Exploring the Impact of ChatGPT on Student Interactions in Computer-Supported Collaborative Learning

The growing popularity of generative AI, particularly ChatGPT, has sparked both enthusiasm and caution among practitioners and researchers in education. To effectively harness the full potential of ChatGPT in educational contexts, it is crucial to analyze its impact and suitability for different educational purposes. This paper takes an initial step in exploring the applicability of ChatGPT in a computer-supported collaborative learning (CSCL) environment. Using statistical analysis, we validate the shifts in student interactions during an asynchronous group brainstorming session by introducing ChatGPT as an instantaneous question-answering agent.Comment: AAAI2024 Workshop on AI for Education (AI4ED

A wearable multiplexed silicon nonvolatile memory array using nanocrystal charge confinement

Strategies for efficient charge confinement in nanocrystal floating gates to realize high-performance memory devices have been investigated intensively. However, few studies have reported nanoscale experimental validations of charge confinement in closely packed uniform nanocrystals and related device performance characterization. Furthermore, the system-level integration of the resulting devices with wearable silicon electronics has not yet been realized. We introduce a wearable, fully multiplexed silicon nonvolatile memory array with nanocrystal floating gates. The nanocrystal monolayer is assembled over a large area using the Langmuir-Blodgett method. Efficient particle-level charge confinement is verified with the modified atomic force microscopy technique. Uniform nanocrystal charge traps evidently improve the memory window margin and retention performance. Furthermore, the multiplexing of memory devices in conjunction with the amplification of sensor signals based on ultrathin silicon nanomembrane circuits in stretchable layouts enables wearable healthcare applications such as long-term data storage of monitored heart rates.

Graves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child

Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have an human leukocyte antigen-matched sibling, he was treated with rabbit ATG (3.5 mg/kg/day for 5 days) and cyclosporine. Five months later, he became transfusion independent. However, 23 months after IST, he complained of mild hand tremors, sweating, weight loss, palpitations, and goiter. Results of thyroid function tests revealed hyperthyroidism (free thyroxine, 3.42 ng/dL; thyroid stimulating hormone [TSH], <0.01 nIU/mL; triiodothyronine, 3.99 ng/mL). Results of tests for autoantibodies were positive for the antimicrosome antibody and TSH-binding inhibitory immunoglobulin, but negative for the antithyroglobulin antibody and antinuclear antibody. He was treated with methimazole, and his symptoms improved. The patient has been disease free for 39 months after IST and 9 months after methimazole treatment. This case report suggests that although rare, rabbit ATG may have implications in the pathogenesis of autoimmune hyperthyroidism. Our findings suggest that thyroid function tests should be incorporated in the routine follow-up of SAA patients treated with ATG

Mineralocorticoid receptors modulate vascular endothelial function in human obesity

Abstract Obesity increases linearly with age and is associated with impaired vascular endothelial function and increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to impaired vascular endothelial function in cardiovascular disease; however, their role in uncomplicated human obesity is unknown. Because plasma aldosterone levels are elevated in obesity and adipocytes may be a source of aldosterone, we hypothesized that MRs modulate vascular endothelial function in older adults in an adiposity-dependent manner. To test this hypothesis, we administered MR blockade (eplerenone; 100 mg/day) for 1 month in a balanced randomized double-blind placebo-controlled cross-over study to 22 older adults (ten men, 55--79 years) varying widely in adiposity [BMI (body mass index): 20--45 kg/m 2 ], but who were free from overt cardiovascular disease. We evaluated vascular endothelial function [brachial artery FMD (flow-mediated dilation)] via ultrasonography) and oxidative stress (plasma F 2 -isoprostanes and vascular endothelial cell protein expression of nitrotyrosine and NADPH oxidase p47 phox ) during placebo and MR blockade. In the whole group, oxidative stress (P &gt; 0.05) and FMD did not change with MR blockade (6.39 + − 0.67 compared with 6.23 + − 0.73 %; P = 0.7). However, individual improvements in FMD in response to eplerenone were associated with higher total body fat (BMI: r = 0.45, P = 0.02; and dual-energy X-ray absorptiometry-derived percentage body fat: r = 0.50, P = 0.009) and abdominal fat (total: r = 0.61, P = 0.005; visceral: r = 0.67, P = 0.002; and subcutaneous: r = 0.48, P = 0.03). In addition, greater improvements in FMD with eplerenone were related to higher baseline fasting glucose (r = 0.53, P = 0.01). MRs influence vascular endothelial function in an adiposity-dependent manner in healthy older adults

Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high level of expression of the IL-6 receptor (IL-6R). The purpose of this study was to investigate the effect of anticancer drugs on the expression of the drug resistance-related cancer stem cell markers, ABCG2, IL-6R, and CD133 in non-small cell lung cancer (NSCLC) cell lines. A549, H460, and H23 NSCLC cell lines were treated with the anticancer drugs 5-fluorouracil (5-FU; 25 µg/ml) and methotrexate (MTX; 50 µg/ml), and the expression of putative CSC markers was analyzed by fluorescent activated cell sorter (FACS) and the gene expression level of abcg2, il-6r and cd133 by reverse transcriptasepolymerase chain reaction (RT-PCR). We found that the fraction of ABCG2-positive(+) cells was significantly increased by treatment with both 5-FU and MTX in NSCLC cells, and the elevation of abcg2, il-6r and cd133 expressions in response to these drugs was also confirmed using RT-PCR. Also, the number of IL-6R(+) cells was increased by MTX in the 3 cell lines mentioned and increased by 5-FU in the H460 cell line. The number of CD133(+) cells was also significantly increased by both 5-FU and MTX treatment in all of the cell lines tested. These results indicate that 5-FU and MTX considerably enhance the expression of drug-resistance related CSC markers in NSCLC cell lines. Thus, we suggest that antimetabolite cancer drugs, such as 5-FU and MTX, can lead to the propagation of CSCs through altering the expression of CSC markers

A pathogen-derived metabolite induces microglial activation via odorant receptors

Microglia (MG), the principal neuroimmune sentinels in the brain, continuously sense changes in their environment and respond to invading pathogens, toxins, and cellular debris, thereby affecting neuroinflammation. Microbial pathogens produce small metabolites that influence neuroinflammation, but the molecular mechanisms that determine whether pathogen-derived small metabolites affect microglial activation of neuroinflammation remain to be elucidated. We hypothesized that odorant receptors (ORs), the largest subfamily of G protein-coupled receptors, are involved in microglial activation by pathogen-derived small metabolites. We found that MG express high levels of two mouse ORs, Olfr110 and Olfr111, which recognize a pathogenic metabolite, 2-pentylfuran, secreted by Streptococcus pneumoniae. These interactions activate MG to engage in chemotaxis, cytokine production, phagocytosis, and reactive oxygen species generation. These effects were mediated through the G(alpha s)-cyclic adenosine monophosphate-protein kinase A-extracellular signal-regulated kinase and G(beta gamma)-phospholipase C-Ca2+ pathways. Taken together, our results reveal a novel interplay between the pathogen-derived metabolite and ORs, which has major implications for our understanding of microglial activation by pathogen recognition. Database Model data are available in the PMDB database under the accession number PM0082389.N

The Supposed but Unknown: A Functionalist Account of Locke's Substratum

The world is occupied by many and varied things. What constitutes their thingness? In the Essay, Locke addresses this question in Book II, Chapter xxiii, titled ‘Of our Complex Ideas of Substance’, wherein the much-contested definition of ‘substratum’ appears—‘a supposed but unknown support of the Qualities’. Most significant in this definition are the dual qualifiers that Locke uses: ‘supposed’ and ‘unknown’. This paper examines this two-qualifier definition, illuminating the historical and philosophical significance it may have. There have been two rival readings. The first takes Locke’s substratum to be a bare substratum; and the second identifies it with what Locke terms as ‘real essence’—i.e. ‘a real Constitution of the insensible Parts’. Critically reviewing these two major interpretations, I attribute to Locke a type of functionalism, according to which the status of a substratum is determined by its functional role of ‘uniting’ a bundle of qualities into an individual substance

Przyczyny i Charakterystyka Kompleksowych Umów w Dziedzinie Obronności Zawartych Pomiędzy Polską a Koreą Południową w 2022r.

Zakończenie zimnej wojny oraz globalizacja współczesnego świata wpłynęły na wzrost handlu oraz współpracy pomiędzy odległymi państwami. Dzięki globalizacji relacje pomiędzy Polską i Koreą Południową, państwami o przeciwstawnych politycznych ideologiach w czasie zimnej wojny, po roku 1990 rozwinęły się zarówno na płaszczyźnie ekonomicznej jak i dyplomatycznej. Co więcej, w 2022 r., który przyniósł atak Rosji na Ukrainę, polski rząd zawarł kompleksowe umowy w dziedzinie obronności z rządem i przedsiębiorstwami sektora obronnego Korei Południowej. Niniejsza praca licencjacka skupia się na analizie przyczyn, dla których polski rząd zdecydował się na współpracę z Koreą Południową. Praca podejmuje próbę wyjaśnienia ich poprzez aplikację teorii racjonalnego wyboru oraz teorii globalizacji. Praca oparta jest na źródłach pierwotnych i wtórnych oraz na dwóch wywiadach eksperckich.The end of the Cold War and globalization in the modern world have increased trade and cooperation between distant nations. Due to globalization, the relationship between Poland and South Korea, countries with opposite political ideologies during the Cold War, has developed economically and diplomatically since the 1990s. Furthermore, at the beginning of 2022, after the Russian invasion of Ukraine, the Polish government signed large-scale defense arms contracts with the South Korean government and South Korean defense companies. This bachelor’s dissertation analyzes the causes of the Polish government’s decision to cooperate with South Korea. The thesis explains them by employing the rational choice theory and globalization theory. It is based on primary and secondary sources as well as two expert interviews