Intergalactic HI in the NGC5018 group

The cold interstellar and intergalactic medium is in the small group of galaxies whose brightest member is the elliptical galaxy NGC5018. Researchers' attention was first drawn to this galaxy as possibly containing cold interstellar gas by the detection by the Infrared Astronomy Satellite (IRAS) of emission at lambda 60 microns and lambda 100 microns at an intensity of about 1 Jy (Knapp et al. 1989), which is relatively strong for an elliptical (Jura et al. 1987). These data showed that the temperature of the infrared emission is less than 30K and that its likely source is therefore interstellar dust. A preliminary search for neutral hydrogen (HI) emission from this galaxy using the Very Large Array (VLA) showed that there appears to be HI flowing between NGC5018 and the nearby Sc galaxy NGC5022 (Kim et al. 1988). Since NGC5018 has a well-developed system of optical shells (cf. Malin and Carter 1983; Schweizer 1987) this observation suggests that NGC5018 may be in the process of forming its shell system by the merger of a cold stellar system with the elliptical, as suggested by Quinn (1984). Researchers describe follow-up HI observations of improved sensitivity and spatial resolution, and confirm that HI is flowing between NCG5022 and NGC5018, and around NGC5018. The data show, however, that the HI bridge actually connects NGC5022 and another spiral in the group, MCG03-34-013, both spatially and in radial velocity, and that in doing so it flows through and around NGC5018, which lies between the spiral galaxies. This is shown by the total HI map, with the optical positions of the above three galaxies labelled

On Grouping Hospitals for Cost Analysis

Ik-Whan Kwon is Chairman of the Department of Management Science at St. Louis University. Jacqueline D. Frasca is Director of Medical Records Services at Cardinal Glennon Memorial Hospital for Children in St. Louis. Joe H. Kim is an Associate Professor of Marketing at Rider College

Using virtual reality for science mission planning: A Mars Pathfinder case

NASA's Mars Pathfinder Project requires a Ground Data System (GDS) that supports both engineering and scientific payloads with reduced mission operations staffing, and short planning schedules. Also, successful surface operation of the lander camera requires efficient mission planning and accurate pointing of the camera. To meet these challenges, a new software strategy that integrates virtual reality technology with existing navigational ancillary information and image processing capabilities. The result is an interactive workstation based applications software that provides a high resolution, 3-dimensial, stereo display of Mars as if it were viewed through the lander camera. The design, implementation strategy and parametric specification phases for the development of this software were completed, and the prototype tested. When completed, the software will allow scientists and mission planners to access simulated and actual scenes of Mars' surface. The perspective from the lander camera will enable scientists to plan activities more accurately and completely. The application will also support the sequence and command generation process and will allow testing and verification of camera pointing commands via simulation

Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphomas: reappraisal of a provisional entity in the 2016 WHO classification of cutaneous lymphomas.

Primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma is a rare and poorly characterized variant of cutaneous lymphoma still considered a provisional entity in the latest 2016 World Health Organization Classification of Cutaneous lymphomas. We sought to better characterize and provide diagnostic and therapeutic guidance of this rare cutaneous lymphoma. Thirty-four patients with a median age of 77 years (range 19-89 years) presented primarily with extensive annular necrotic plaques or tumor lesions with frequent mucous membrane involvement. The 5-year survival was 32% with a median survival of 12 months. A subset of 17 patients had a prodrome of chronic patches prior to the development of aggressive ulcerative lesions. We identified cases with lack of CD8 or αβ T-cell receptor expression yet with similar clinical and pathological presentation. Allogeneic stem cell transplantation provided partial or complete remissions in 5/6 patients. We recommend the term primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma as this more broad designation better describes this clinical-pathologic presentation, which allows the inclusion of cases with CD8 negative and/or αβ/γδ T-cell receptor chain double-positive or double-negative expression. We have identified early skin signs of chronic patch/plaque lesions that are often misdiagnosed as eczema, psoriasis, or mycosis fungoides. Our experience confirms the poor prognosis of this entity and highlights the inefficacy of our standard therapies with the exception of allogeneic stem cell transplantation in selected cases

Combinations of idelalisib with rituximab and/or bendamustine in patients with recurrent indolent non-Hodgkin lymphoma

Key Points Combining phosphatidylinositol-3-kinase δ inhibition with rituximab, bendamustine, or both is feasible and active in relapsed iNHL. The safety of novel combinations should be proven in phase 3 trials before adoption in clinical practice.</jats:p

Screening and management of viral hepatitis and hepatocellular carcinoma in Mongolia: results from a survey of Mongolian physicians from all major provinces of Mongolia

published_or_final_versio

Deep CO(1–0) Observations of z = 1.62 Cluster Galaxies with Substantial Molecular Gas Reservoirs and Normal Star Formation Efficiencies

We present an extremely deep CO(1–0) observation of a confirmed z = 1.62 galaxy cluster. We detect two spectroscopically confirmed cluster members in CO(1–0) with signal-to-noise ratio $\gt 5$. Both galaxies have log(${{ \mathcal M }}_{\star }$/${{ \mathcal M }}_{\odot }$) > 11 and are gas rich, with ${{ \mathcal M }}_{\mathrm{mol}}$/(${{ \mathcal M }}_{\star }$+${{ \mathcal M }}_{\mathrm{mol}}$) ~ 0.17–0.45. One of these galaxies lies on the star formation rate (SFR)–${{ \mathcal M }}_{\star }$ sequence, while the other lies an order of magnitude below. We compare the cluster galaxies to other SFR-selected galaxies with CO measurements and find that they have CO luminosities consistent with expectations given their infrared luminosities. We also find that they have gas fractions and star formation efficiencies (SFE) comparable to what is expected from published field galaxy scaling relations. The galaxies are compact in their stellar light distribution, at the extreme end for all high-redshift star-forming galaxies. However, their SFE is consistent with other field galaxies at comparable compactness. This is similar to two other sources selected in a blind CO survey of the HDF-N. Despite living in a highly quenched protocluster core, the molecular gas properties of these two galaxies, one of which may be in the process of quenching, appear entirely consistent with field scaling relations between the molecular gas content, stellar mass, star formation rate, and redshift. We speculate that these cluster galaxies cannot have any further substantive gas accretion if they are to become members of the dominant passive population in $z\lt 1$ clusters

Global Analysis of Predicted G Protein-Coupled Receptor Genes in the Filamentous Fungus, Neurospora crassa.

G protein-coupled receptors (GPCRs) regulate facets of growth, development, and environmental sensing in eukaryotes, including filamentous fungi. The largest predicted GPCR class in these organisms is the Pth11-related, with members similar to a protein required for disease in the plant pathogen Magnaporthe oryzae. However, the Pth11-related class has not been functionally studied in any filamentous fungal species. Here, we analyze phenotypes in available mutants for 36 GPCR genes, including 20 Pth11-related, in the model filamentous fungus Neurospora crassa. We also investigate patterns of gene expression for all 43 predicted GPCR genes in available datasets. A total of 17 mutants (47%) possessed at least one growth or developmental phenotype. We identified 18 mutants (56%) with chemical sensitivity or nutritional phenotypes (11 uniquely), bringing the total number of mutants with at least one defect to 28 (78%), including 15 mutants (75%) in the Pth11-related class. Gene expression trends for GPCR genes correlated with the phenotypes observed for many mutants and also suggested overlapping functions for several groups of co-transcribed genes. Several members of the Pth11-related class have phenotypes and/or are differentially expressed on cellulose, suggesting a possible role for this gene family in plant cell wall sensing or utilization

A review on boiling heat transfer enhancement with nanofluids

There has been increasing interest of late in nanofluid boiling and its use in heat transfer enhancement. This article covers recent advances in the last decade by researchers in both pool boiling and convective boiling applications, with nanofluids as the working fluid. The available data in the literature is reviewed in terms of enhancements, and degradations in the nucleate boiling heat transfer and critical heat flux. Conflicting data have been presented in the literature on the effect that nanofluids have on the boiling heat-transfer coefficient; however, almost all researchers have noted an enhancement in the critical heat flux during nanofluid boiling. Several researchers have observed nanoparticle deposition at the heater surface, which they have related back to the critical heat flux enhancement