A theoretical and experimental study of propellant combustion phenomena during rapid depressurization Final report

Modified solid propellant combustion model for steady state analyses of burning rate and flame temperatur

Computing Aggregate Properties of Preimages for 2D Cellular Automata

Computing properties of the set of precursors of a given configuration is a common problem underlying many important questions about cellular automata. Unfortunately, such computations quickly become intractable in dimension greater than one. This paper presents an algorithm --- incremental aggregation --- that can compute aggregate properties of the set of precursors exponentially faster than na{\"i}ve approaches. The incremental aggregation algorithm is demonstrated on two problems from the two-dimensional binary Game of Life cellular automaton: precursor count distributions and higher-order mean field theory coefficients. In both cases, incremental aggregation allows us to obtain new results that were previously beyond reach

Evaluation of ozone difluoride as a liquid propellant additive Final report

Ozone difluoride evaluated as liquid propellant additiv

A non-intrusive nonlinear aeroelastic extension of loads packages with application to long range transport aircraft configuration

A new method for constructing geometrically-nonlinear aeroelastic systems from standard linear models is applied to an industry-level aircraft configuration. The new approach seamlessly integrates with current aeroelastic load packages performing linear analysis based on generic finite-element models (FEMs) and aerodynamic influence coefficient matrices (AICs). We generalize the methodology to incorporate control inputs, find the trimmed aircraft state, or generate gusts disturbances, which can be employed separately or combined to obtain a simplified flight dynamics model for load analysis. An initial study of the aeroelastic response of a long range aircraft is presented. Linear and nonlinear results are introduced in static and dynamic computations of manoeuvres, trim, and gust disturbances. These are compared to commercial software calculations, showing the need for geometrically nonlinear analysis in the production environment of airplanes with ultra high aspect ratio wings

A New N-terminal Recognition Domain in Caveolin-1 Interacts with Sterol Carrier Protein-2 (SCP-2)

Although plasma membrane domains, such as caveolae, provide an organizing principle for signaling pathways and cholesterol homeostasis in the cell, relatively little is known regarding specific mechanisms, whereby intracellular lipid-binding proteins are targeted to caveolae. Therefore, the interaction between caveolin-1 and sterol carrier protein-2 (SCP-2), a protein that binds and transfers both cholesterol and signaling lipids (e.g., phosphatidylinositides and sphingolipids), was examined by yeast two-hybrid, in vitro binding and fluorescence resonance energy transfer (FRET) analyses. Results of the in vivo and in vitro assays identified for the first time the N-terminal amino acids (aa) 1−32 amphipathic α helix of SCP-2 functionally interacted with caveolin-1. This interaction was independent of the classic caveolin-1 scaffolding domain, in which many signaling proteins interact. Instead, SCP-2 bound caveolin-1 through a new domain identified in the N-terminal domain of caveolin-1 between aa 34−40. Modeling studies suggested that electrostatic interactions between the SCP-2 N-terminal aa 1−32 amphipathic α-helical domain (cationic, positively charged face) and the caveolin-1 N-terminal aa 33−59 α helix (anionic, negatively charged face) may significantly contribute to this interaction. These findings provide new insights on how SCP-2 enhances cholesterol retention within the cell as well as regulates the distribution of signaling lipids, such as phosphoinositides and sphingolipids, at plasma membrane caveolae