La perversión como estrategia subjetiva en Amor, curiosidad prozac y dudas por Lucía Etxebarria

Ana, Rosa y Cristina son protagonistas que desesperadamente buscan la Ley y una manera de abordar el deseo y El Otro. Amor, curiosidad, prozac y dudas, por Lucía Etxebarria, es una novela sobre las hermanas Gaena que demuestra la necesidad de mujeres para una estrategia que se puede implementar para avenirse con el deseo y la suspensión del Maestro, cuando El Otro está suspendido, en la España pos-Franco. Un análisis psicoanalítico, específicamente de Lacan, es apropiado para esta novela como sus estructuras sugieren este tipo de lectura. Lucía Etxebarria presenta a tres hermanas que viven en la España pos-Franco y que forman una sujeta compuesta, la cual le provee a la lectora española con un modelo de cómo abordar el deseo y El Otro.Abstract: Ana, Rosa, and Cristina are protagonists in a desperate search for the Law and a way to deal with desire and the Other. Amor, curiosidad, prozac, y dudas, by Lucía Etxebarria, is a novel about the Gaena sisters that demonstrates the need for a strategy for women to implement in order to come to terms with desire and the suspension of the Master, when the Other is in abeyance, in post-Franco Spain. A psychoanalytic, specifically a Lacanian, analysis is appropriate for this novel as its structures suggest such a reading. Lucía Etxebarria presents three sisters living in post-Franco Spain who form a composite subject, which in turn provides the Spanish reader with a model of how to deal with desire and the Other

Managerial job satisfaction:a longitudinal study

The study examines the job satisfaction of supervisors and managers in four organisations over time. It also considers the importance which they attached to different facets of their job. The major objectives were: To examine the constituent dimensions of job satisfaction at intervals over one year. To examine reasons for change inthe level of job satisfaction at intervals over one year. To provide information on job satisfaction for those concerned with job satisfaction policies. The sample consisted of one hundred and eight people. Each was interviewed on at least three occasions over the course of a year. Interviews took place at predetermined time intervals. The study shows that job satisfaction is dynamic over a relatively short period of time. The ratings which supervisors and managers gave to aspects of their job did not, however, all change by equal amounts or in the same direction. Changes in job satisfaction were associated with events experienced but it was the meaning of those events to correspondents which appeared to be particularly important. People tended to adopt a localised frame of reference when considering their work situation. Certain job variables, such as variety, were consistently and positively correlated with job satisfaction. With some other variables, the relationship varied across time. Frequently, age and job level moderated the association between independent variables and job satisfaction. Links were found between the quality of life and job satisfaction. There was a consistent positive association between job satisfaction and life satisfaction. However, the job was rarely considered to be the main factor contributing to a person's quality of life. The research highlights the difficulties and desirability of introducing standardised job satisfaction policies in the light of individual differences. In addition, it demonstrates that merely correlating variables with job satisfaction at one point in time may conceal complex relationships and meanings. A new measure of job satisfaction - whereby facets are assessed and rated relative to each other was also developed as part of this study

Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide

The NF-κB transcriptional response is tightly regulated by a number of processes including the phosphorylation, ubiquitination, and subsequent proteasomal degradation of NF-κB subunits. The IκB family protein BCL-3 stabilizes a NF-κB p50 homodimer·DNA complex through inhibition of p50 ubiquitination. This complex inhibits the binding of the transcriptionally active NF-κB subunits p65 and c-Rel on the promoters of NF-κB target genes and functions to suppress inflammatory gene expression. We have previously shown that the direct interaction between p50 and BCL-3 is required for BCL-3-mediated inhibition of pro-inflammatory gene expression. In this study we have used immobilized peptide array technology to define regions of BCl-3 that mediate interaction with p50 homodimers. Our data show that BCL-3 makes extensive contacts with p50 homodimers and in particular with ankyrin repeats (ANK) 1, 6, and 7, and the N-terminal region of Bcl-3. Using these data we have designed a BCL-3 mimetic peptide based on a region of the ANK1 of BCL-3 that interacts with p50 and shares low sequence similarity with other IκB proteins. When fused to a cargo carrying peptide sequence this BCL-3-derived peptide, but not a mutated peptide, inhibited Toll-like receptor-induced cytokine expression in vitro. The BCL-3 mimetic peptide was also effective in preventing inflammation in vivo in the carrageenan-induced paw edema mouse model. This study demonstrates that therapeutic strategies aimed at mimicking the functional activity of BCL-3 may be effective in the treatment of inflammatory disease

Small Business Enterprise and Development: Consultation Modes

By  means  of four   illustrative  case studies,  consultation  interventions  in small  and  medium sized  (SMEs)  enterprises  are  explored     Recognized  consultation  intervention  modes  of 'expert ',  'doctor-patient' and  'process  consultation'  are found  to fluctuate  rapidly  within each case st11dy, making apparent the need for  consultants to be flexible  and adopt an appropriate stance for  client and contingencies of the situation.  The permeability  of the boundaries between content and process issues, with diagnosis and intervention inter-woven, is also apparent. The article concludes with a consideration of the conditions for success for different consultation modes with small businesses and implications for small businesses and enterprise development in their use of consultants

A Call to Arms: Revisiting Database Design

Good database design is crucial to obtain a sound, consistent database, and - in turn - good database design methodologies are the best way to achieve the right design. These methodologies are taught to most Computer Science undergraduates, as part of any Introduction to Database class. They can be considered part of the "canon", and indeed, the overall approach to database design has been unchanged for years. Moreover, none of the major database research assessments identify database design as a strategic research direction. Should we conclude that database design is a solved problem? Our thesis is that database design remains a critical unsolved problem. Hence, it should be the subject of more research. Our starting point is the observation that traditional database design is not used in practice - and if it were used it would result in designs that are not well adapted to current environments. In short, database design has failed to keep up with the times. In this paper, we put forth arguments to support our viewpoint, analyze the root causes of this situation and suggest some avenues of research.Comment: Removed spurious column break. Nothing else was change

Organizing Compression of Hyperspectral Imagery to Allow Efficient Parallel Decompression

family of schemes has been devised for organizing the output of an algorithm for predictive data compression of hyperspectral imagery so as to allow efficient parallelization in both the compressor and decompressor. In these schemes, the compressor performs a number of iterations, during each of which a portion of the data is compressed via parallel threads operating on independent portions of the data. The general idea is that for each iteration it is predetermined how much compressed data will be produced from each thread