559 research outputs found
HD101584: Circumstellar characteristics and evolutionary status
We have performed a study of the characteristics of the circumstellar
environment of the binary object HD101584, that provides information on a
likely evolutionary scenario. We have obtained and analysed ALMA observations,
complemented with observations using APEX, of a large number of molecular
lines. An analysis of the spectral energy distribution has also been performed.
Emissions from 12 molecular species (not counting isotopologues) have been
observed, and most of them mapped with angular resolutions in the range 0.1" to
0.6". Four circumstellar components are identified: i) a central compact source
of size 0.15", ii) an expanding equatorial density enhancement (a flattened
density distribution in the plane of the orbit) of size 3", iii) a bipolar
high-velocity outflow (150 km/s), and iv) an hourglass structure. The outflow
is directed almost along the line of sight. There is evidence of a second
bipolar outflow. The mass of the circumstellar gas is 0.5[D/1 kpc]^2 Msun,
about half of it lies in the equatorial density enhancement. The dust mass is
0.01[D/1 kpc]^2 Msun, and a substantial fraction of this is in the form of
large-sized, up to 1 mm, grains. The estimated kinetic age of the outflow is
770[D/1 kpc] yr. The kinetic energy and the scalar momentum of the accelerated
gas are estimated to be 7x10^(45)[D/1 kpc]^2 erg and 10^(39)[D/1 kpc]^2 g cm/s,
respectively. We provide good evidence that the binary system HD101584 is in a
post-common-envelope-evolution phase, that ended before a stellar merger.
Isotope ratios combined with stellar mass estimates suggest that the primary
star's evolution was terminated already on the first red giant branch (RGB).
Most of the energy required to drive the outflowing gas was probably released
when material fell towards the companion.Comment: Accepted for publication in A&
Rotational inhomogeneities from pre-big bang?
The evolution of the rotational inhomogeneities is investigated in the
specific framework of four-dimensional pre-big bang models. While minimal
(dilaton-driven) scenarios do not lead to rotational fluctuations, in the case
of non-minimal (string-driven) models, fluid sources are present in the pre-big
bang phase. The rotational modes of the geometry, coupled to the divergenceless
part of the velocity field, can then be amplified depending upon the value of
the barotropic index of the perfect fluids. In the light of a possible
production of rotational inhomogeneities, solutions describing the coupled
evolution of the dilaton field and of the fluid sources are scrutinized in both
the string and Einstein frames. In semi-realistic scenarios, where the
curvature divergences are regularized by means of a non-local dilaton
potential, the rotational inhomogeneities are amplified during the pre-big bang
phase but they decay later on. Similar analyses can also be performed when a
contraction occurs directly in the string frame metric.Comment: 21 pages, corrected typos, references added; to appear in Class.
Quantum Gra
A phase 1 study assessing the feasibility and safety of intraductal pegylated liposomal doxorubicin (PLD) in women awaiting mastectomy
Post-Hematopoietic Stem Cell Transplantation (HSCT) Outcomes in Patients With AML Transplanted Prior to Achieving Platelet Recovery
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Reduced Intensity Conditioning (RIC) Regimen Followed By Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) In Adult Patients (PTS) With Acute Lymphoblastic Leukemia (ALL)
A high resolution line survey of IRC+10216 with Herschel. First results: Detection of warm silicon dicarbide SiC2
We present the first results of a high-spectral-resolution survey of the
carbon-rich evolved star IRC+10216 that was carried out with the HIFI
spectrometer onboard Herschel. This survey covers all HIFI bands, with a
spectral range from 488 to 1901GHz. In this letter we focus on the band-1b
spectrum, in a spectral range 554.5-636.5GHz, where we identified 130 spectral
features with intensities above 0.03 K and a signal-to-noise ratio >5. Detected
lines arise from HCN, SiO, SiS, CS, CO, metal-bearing species and,
surprisingly, silicon dicarbide (SiC2). We identified 55 SiC2 transitions
involving energy levels between 300 and 900 K. By analysing these rotational
lines, we conclude that SiC2 is produced in the inner dust formation zone, with
an abundance of ~2x10^-7 relative to molecular hydrogen. These SiC2 lines have
been observed for the first time in space and have been used to derive an SiC2
rotational temperature of ~204 K and a source-averaged column density of
~6.4x10^15 cm^-2. Furthermore, the high quality of the HIFI data set was used
to improve the spectroscopic rotational constants of SiC2.Comment: A&A HIFI Special Issue, 201
Atomium:Probing the inner wind of evolved O-rich stars with new, highly excited HO and OH lines
Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear. Here, we report that at early G1 the glycogen synthase kinase (GSK) 3β phosphorylates and stabilizes NM1, allowing for NM1 association with the chromatin. Genomic analysis by ChIP-Seq showed that this mechanism occurs on the rDNA as active GSK3β selectively occupies the gene. ChIP assays and transmission electron microscopy in GSK3β-/- mouse embryonic fibroblasts indicated that at G1 rRNA synthesis is suppressed due to decreased H3K9 acetylation leading to a chromatin state incompatible with transcription. We found that GSK3β directly phosphorylates the endogenous NM1 on a single serine residue (Ser-1020) located within the NM1 C-terminus. In G1 this phosphorylation event stabilizes NM1 and prevents NM1 polyubiquitination by the E3 ligase UBR5 and proteasome-mediated degradation. We conclude that GSK3β-mediated phosphorylation of NM1 is required for pol I transcription activation
Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells
Human T cell lymphotropic virus type 1 (HTLV-1) is a human retrovirus that infects approximately 10–20 million people worldwide and causes an aggressive neoplasia (adult T-cell leukemia/lymphoma - ATL). Therapeutic approaches for the treatment of ATL have variable effectiveness and poor prognosis, thus requiring strategies to identify novel compounds with activity on infected cells. In this sense, we initially screened a small series of 25 1,2,3-triazole derivatives to discover cell proliferation inhibitors and apoptosis inducers in HTLV-1-infected T-cell line (MT-2) for further assessment of their effect on viral tax activity through inducible-tax reporter cell line (Jurkat LTR-GFP). Eight promising compounds (02, 05, 06, 13, 15, 21, 22 and 25) with activity ≥70% were initially selected, based on a suitable cell-based assay using resazurin reduction method, and evaluated towards cell cycle, apoptosis and Tax/GFP expression analyses through flow cytometry. Compound 02 induced S phase cell cycle arrest and compounds 05, 06, 22 and 25 promoted apoptosis. Remarkably, compounds 22 and 25 also reduced GFP expression in an inducible-tax reporter cell, which suggests an effect on Tax viral protein. More importantly, compounds 02, 22 and 25 were not cytotoxic in human hepatoma cell line (Huh-7). Therefore, the discovery of 3 active and non-cytotoxic compounds against HTLV-1-infected cells can potentially contribute, as an initial promising strategy, to the development process of new drugs against ATL
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