1,325 research outputs found
Analysis of MAGSAT data of the Indian region
Progress in the development of software for reading MAGSAT data tapes and for the reduction of anomaly data, and in the preparation of data for magnetic anomaly maps is reported
'Part'ly first among equals: Semantic part-based benchmarking for state-of-the-art object recognition systems
An examination of object recognition challenge leaderboards (ILSVRC,
PASCAL-VOC) reveals that the top-performing classifiers typically exhibit small
differences amongst themselves in terms of error rate/mAP. To better
differentiate the top performers, additional criteria are required. Moreover,
the (test) images, on which the performance scores are based, predominantly
contain fully visible objects. Therefore, `harder' test images, mimicking the
challenging conditions (e.g. occlusion) in which humans routinely recognize
objects, need to be utilized for benchmarking. To address the concerns
mentioned above, we make two contributions. First, we systematically vary the
level of local object-part content, global detail and spatial context in images
from PASCAL VOC 2010 to create a new benchmarking dataset dubbed PPSS-12.
Second, we propose an object-part based benchmarking procedure which quantifies
classifiers' robustness to a range of visibility and contextual settings. The
benchmarking procedure relies on a semantic similarity measure that naturally
addresses potential semantic granularity differences between the category
labels in training and test datasets, thus eliminating manual mapping. We use
our procedure on the PPSS-12 dataset to benchmark top-performing classifiers
trained on the ILSVRC-2012 dataset. Our results show that the proposed
benchmarking procedure enables additional differentiation among
state-of-the-art object classifiers in terms of their ability to handle missing
content and insufficient object detail. Given this capability for additional
differentiation, our approach can potentially supplement existing benchmarking
procedures used in object recognition challenge leaderboards.Comment: Extended version of our ACCV-2016 paper. Author formatting modifie
Age-Dependence of Femoral Strength in White Women and Men
Although age-related variations in areal bone mineral density (aBMD) and the prevalence of osteoporosis have been well characterized, there is a paucity of data on femoral strength in the population. Addressing this issue, we used finite-element analysis of quantitative computed tomographic scans to assess femoral strength in an age-stratified cohort of 362 women and 317 men, aged 21 to 89 years, randomly sampled from the population of Rochester, MN, and compared femoral strength with femoral neck aBMD. Percent reductions over adulthood were much greater for femoral strength (55% in women, 39% in men) than for femoral neck aBMD (26% in women, 21% in men), an effect that was accentuated in women. Notable declines in strength started in the mid-40s for women and one decade later for men. At advanced age, most of the strength deficit for women compared with men was a result of this decade-earlier onset of strength loss for women, this factor being more important than sex-related differences in peak bone strength and annual rates of bone loss. For both sexes, the prevalence of “low femoral strength” (<3000 N) was much higher than the prevalence of osteoporosis (femoral neck aBMD T-score of −2.5 or less). We conclude that age-related declines in femoral strength are much greater than suggested by age-related declines in femoral neck aBMD. Further, far more of the elderly may be at high risk of hip fracture because of low femoral strength than previously assumed based on the traditional classification of osteoporosis. © 2010 American Society for Bone and Mineral Research
Skin Lesion Analyser: An Efficient Seven-Way Multi-Class Skin Cancer Classification Using MobileNet
Skin cancer, a major form of cancer, is a critical public health problem with
123,000 newly diagnosed melanoma cases and between 2 and 3 million non-melanoma
cases worldwide each year. The leading cause of skin cancer is high exposure of
skin cells to UV radiation, which can damage the DNA inside skin cells leading
to uncontrolled growth of skin cells. Skin cancer is primarily diagnosed
visually employing clinical screening, a biopsy, dermoscopic analysis, and
histopathological examination. It has been demonstrated that the dermoscopic
analysis in the hands of inexperienced dermatologists may cause a reduction in
diagnostic accuracy. Early detection and screening of skin cancer have the
potential to reduce mortality and morbidity. Previous studies have shown Deep
Learning ability to perform better than human experts in several visual
recognition tasks. In this paper, we propose an efficient seven-way automated
multi-class skin cancer classification system having performance comparable
with expert dermatologists. We used a pretrained MobileNet model to train over
HAM10000 dataset using transfer learning. The model classifies skin lesion
image with a categorical accuracy of 83.1 percent, top2 accuracy of 91.36
percent and top3 accuracy of 95.34 percent. The weighted average of precision,
recall, and f1-score were found to be 0.89, 0.83, and 0.83 respectively. The
model has been deployed as a web application for public use at
(https://saketchaturvedi.github.io). This fast, expansible method holds the
potential for substantial clinical impact, including broadening the scope of
primary care practice and augmenting clinical decision-making for dermatology
specialists.Comment: This is a pre-copyedited version of a contribution published in
Advances in Intelligent Systems and Computing, Hassanien A., Bhatnagar R.,
Darwish A. (eds) published by Chaturvedi S.S., Gupta K., Prasad P.S. The
definitive authentication version is available online via
https://doi.org/10.1007/978-981-15-3383-9_1
Dynamical cluster-decay model for hot and rotating light-mass nuclear systems, applied to low-energy S + Mg Ni reaction
The dynamical cluster-decay model (DCM) is developed further for the decay of
hot and rotating compound nuclei (CN) formed in light heavy-ion reactions. The
model is worked out in terms of only one parameter, namely the neck-length
parameter, which is related to the total kinetic energy TKE(T) or effective
Q-value at temperature T of the hot CN, defined in terms of the
both the light-particles (LP), with 4, Z 2, as well as the
complex intermediate mass fragments (IMF), with , is
considered as the dynamical collective mass motion of preformed clusters
through the barrier. Within the same dynamical model treatment, the LPs are
shown to have different characteristics as compared to the IMFs. The systematic
variation of the LP emission cross section , and IMF emission
cross section , calculated on the present DCM match exactly the
statistical fission model predictions. It is for the first time that a
non-statistical dynamical description is developed for the emission of
light-particles from the hot and rotating CN. The model is applied to the decay
of Ni formed in the S + Mg reaction at two incident
energies E = 51.6 and 60.5 MeV. Both the IMFs and average
spectra are found to compare reasonably nicely with the experimental data,
favoring asymmetric mass distributions. The LPs emission cross section is shown
to depend strongly on the type of emitted particles and their multiplicities
Activation and Inhibition of Transglutaminase 2 in Mice
Transglutaminase 2 (TG2) is an allosterically regulated enzyme with transamidating, deamidating and cell signaling activities. It is thought to catalyze sequence-specific deamidation of dietary gluten peptides in the small intestines of celiac disease patients. Because this modification has profound consequences for disease pathogenesis, there is considerable interest in the design of small molecule TG2 inhibitors. Although many classes of TG2 inhibitors have been reported, thus far an animal model for screening them to identify promising celiac drug candidates has remained elusive. Using intraperitoneal administration of the toll-like receptor 3 (TLR3) ligand, polyinosinic-polycytidylic acid (poly(I∶C)), we induced rapid TG2 activation in the mouse small intestine. Dose dependence was observed in the activation of TG2 as well as the associated villous atrophy, gross clinical response, and rise in serum concentration of the IL-15/IL-15R complex. TG2 activity was most pronounced in the upper small intestine. No evidence of TG2 activation was observed in the lung mucosa, nor were TLR7/8 ligands able to elicit an analogous response. Introduction of ERW1041E, a small molecule TG2 inhibitor, in this mouse model resulted in TG2 inhibition in the small intestine. TG2 inhibition had no effect on villous atrophy, suggesting that activation of this enzyme is a consequence, rather than a cause, of poly(I∶C) induced enteropathy. Consistent with this finding, administration of poly(I∶C) to TG2 knockout mice also induced villous atrophy. Our findings pave the way for pharmacological evaluation of small molecule TG2 inhibitors as drug candidates for celiac disease
- …