Phonon sidebands of color centers in hexagonal boron nitride

Low temperature photoluminescence spectra of a color center in hexagonal boron nitride are analyzed. The acoustic phonon sideband can be described by a deformation coupling proportional to strain to a phonon bath that is effectively two dimensional. The optical phonon band is described by Frohlich coupling to the LO-branches, and a deformation coupling proportional to lattice displacement for the TO-branch. The resonances expressed in the optical band vary from defect to defect, in some emitters, coupling to out-of-plane polarized phonons is reported.Comment: 7 pages, 4 fig

Communications systems technology assessment study. Volume 2: Results

The cost and technology characteristics are examined for providing special satellite services at UHF, 2.5 GHz, and 14/12 GHz. Considered are primarily health, educational, informational and emergency disaster type services. The total cost of each configuration including space segment, earth station, installation operation and maintenance was optimized to reduce the user's total annual cost and establish preferred equipment performance parameters. Technology expected to be available between now and 1985 is identified and comparisons made between selected alternatives. A key element of the study is a survey of earth station equipment updating past work in the field, providing new insight into technology, and evaluating production and test methods that can reduce costs in large production runs. Various satellite configurations were examined. The cost impact of rain attenuation at Ku-band was evaluated. The factors affecting the ultimate capacity achievable with the available orbital arc and available bandwidth were analyzed

Multicentre observational cohort study of NSAIDs as risk factors for postoperative adverse events in gastrointestinal surgery

Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are recommended as postoperative analgesia by the Enhanced Recovery After Surgery Society. Recent studies have raised concerns that NSAID administration following colorectal anastomosis may be associated with increased risk of anastomotic leak. This multicentre study aims to determine NSAIDs' safety profile following gastrointestinal resection. Methods and analysis: This prospective, multicentre cohort study will be performed over a 2-week period utilising a collaborative methodology. Consecutive adults undergoing open or laparoscopic, elective or emergency gastrointestinal resection will be included. The primary end point will be the 30-day morbidity, assessed using the Clavien-Dindo classification. This study will be disseminated through medical student networks, with an anticipated recruitment of at least 900 patients. The study will be powered to detect a 10% increase in complication rates with NSAID use. Ethics and dissemination: Following the Research Ethics Committee Chairperson's review, a formal waiver was received. This study will be registered as a clinical audit or service evaluation at each participating hospital. Dissemination will take place through previously described novel research collaborative networks

CMB Distortions from Superconducting Cosmic Strings

We reconsider the effect of electromagnetic radiation from superconducting strings on cosmic microwave background (CMB) mu- and y-distortions and derive present (COBE-FIRAS) and future (PIXIE) constraints on the string tension, mu_s, and electric current, I. We show that absence of distortions of the CMB in PIXIE will impose strong constraints on mu_s and I, leaving the possibility of light strings (G mu_s < 10^{-18}) or relatively weak currents (I < 10 TeV).Comment: 10pages, 5 figures, Submitted to PRD, v2:References added, replaced to match the PRD versio

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at approximately equal rates. However, the subsequent 17,20 carbon–carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17α-hydroxypregnenlone (OHPREG) versus 17α-hydroxyprogesterone (OHPROG). Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme’s native preference for OHPREG. Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. In a series of resonance Raman experiments, it was observed that, in contrast with the case for the wild-type protein, in the mutant the 17α alcohol of OHPROG tends to form a H-bond with the proximal rather than terminal oxygen of the oxy–ferrous complex. When OHPREG was a substrate, the mutant enzyme was found to have a H-bonding interaction with the proximal oxygen that is substantially weaker than that of the wild type. These results demonstrate that a single-point mutation in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis

Influence of Firms’ Staff and Skills on the Organizational Performance: A Case of the Salt Mining Industry in Tanzania

This study examined the influence of firms’ staff and firms’ skills on the organizational performance of salt mining industry in Coast Region of Tanzania where four salt companies were involved in the study. The study was quantitative, employing a survey design with a sample size of 100 employees obtained conveniently from a pool of 1010 employees from the four selected salt mining companies. The study employed primary data obtained through questionnaire distributed to the sampled respondents. Data was analysed descriptively and with inferential statistics with the help of SPSS to generate frequency tables and multiple regression analysis output. The findings of the study revealed that firms’ staff and firms’ skills influenced the organizational performance of salt mining industry. The study recommends to policy makers and managers of companies in the salt mining industry to reinforce policies, rules and regulations that will ensure low personnel turnover rate. They should appointment employees from diverse backgrounds, recruitment of skilled employees and provide opportunities for advancement. The study also recommends that policy makers should make sure that at organizational level, salt mining companies have career development plans that will enhance skills to employees

Polarographic Study of Zn(II)-Tryptophan System

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Estimating the furrow infiltration characteristic from a single advance point

Management and control of surface irrigation, in particular furrow irrigation, is limited by spatio-temporal soil infiltration variability as well as the high cost and time associated with collecting intensive field data for estimation of the infiltration characteristics. Recent work has proposed scaling the commonly used infiltration function by using a model infiltration curve and a single advance point for every other furrow in an irrigation event. Scaling factors were calculated for a series of furrows at two sites and at four points down the length of the field (0.25 L, 0.5 L, 0.75 L and L). Differences in the value of the scaling factor with distance were found to be a function of the shape of the advance curves. It is concluded that use of points early in the advance results in a substantial loss of accuracy and should be avoided. The scaling factor was also strongly correlated with the furrow-wetted perimeter suggesting that the scaling is an appropriate way of both predicting and accommodating the effect of the hydraulic variability

Surgical outcome with single stage procedure for neglected congenital talipes equinovarus

Background: Congenital talipes equinovarus is one of the commonest congenital anomalies. In developing countries like India especially in the rural population still there are many myths, culture and awareness issues regarding this deformity. Many patients get initial treatment with casting but tend loose follow ups in this prolonged treatment. To give optimal results in these scenarios, the technique for single stage procedure which includes bony and soft tissue repair gives excellent results.Methods: In a retrospective longitudinal study, 13 children with neglected clubfeet were involved. Valid consent, clinical and radiological evaluation was done. Patients underwent single stage (bony and soft tissue) procedure described in the study. Post operatively data was collected and scoring was done as per International clubfoot study group (ICSG) at each follow ups.Results: A total 13 children out of whom 9 were male and 4 females, all having unilateral deformity were studied. The age group was between 5-22 years (mean 13.5). Postoperatively, the children were followed at 6 months intervals. As per ICSG score 10 patients had excellent results, 3 patients had good results and none had poor results. 2 patients had minor complication - delayed wound healing (2-3 weeks).Conclusions: Treatment of neglected clubfoot using single stage procedure dorsal close wedge osteotomy with soft tissue release has a high rate of good and excellent results, with low frequency of complications. It is a good alternative to conventional procedures for management of neglected clubfeet in developing countries, where compliance of patient is a problem

Fast and reliable entanglement distribution with quantum repeaters: principles for improving protocols using reinforcement learning

Future quantum technologies such as quantum communication, quantum sensing, and distributed quantum computation, will rely on networks of shared entanglement between spatially separated nodes. In this work, we provide improved protocols/policies for entanglement distribution along a linear chain of nodes, both homogeneous and inhomogeneous, that take practical limitations such as photon losses, non-ideal measurements, and quantum memories with short coherence times into account. For a wide range of parameters, our policies improve upon previously known policies, such as the ``swap-as-soon-as-possible'' policy, with respect to both the waiting time and the fidelity of the end-to-end entanglement. This improvement is greatest for the most practically relevant cases, namely, for short coherence times, high link losses, and highly asymmetric links. To obtain our results, we model entanglement distribution using a Markov decision process, and then we use the Q-learning reinforcement learning (RL) algorithm to discover new policies. These new policies are characterized by dynamic, state-dependent memory cutoffs and collaboration between the nodes. In particular, we quantify this collaboration between the nodes. Our quantifiers tell us how much ``global'' knowledge of the network every node has. Finally, our understanding of the performance of large quantum networks is currently limited by the computational inefficiency of simulating them using RL or other optimization methods. Thus, in this work, we present a method for nesting policies in order to obtain policies for large repeater chains. By nesting our RL-based policies for small repeater chains, we obtain policies for large repeater chains that improve upon the swap-as-soon-as-possible policy, and thus we pave the way for a scalable method for obtaining policies for long-distance entanglement distribution.Comment: Version 2, title changed, some typos fixed. 27 pages, 18 figures and 3 tables. Comments are welcom