Framing Brexit: the role, and the impact, of the national newspapers on the EU Referendum

This article examines the significance of frames used in the national newspapers during the campaign leading up to the Referendum on June 23, 2016 on whether or not the UK should remain a member of the European Union. Through a contextual research, this study identified three major frames persistently used by the leading proponents of the 'Leave campaign' and was widely reflected in the most popular national newspapers

Pull-off bond strength of novel wide rounded ends fiber and impact of fiber stretching on fiber/matrix frictional-slip bond strength

This paper presents a study about fiber slippage behavior under direct pull-out and assessment of fiber/matrix pull-off bond strength. This study was prepared through theoretical calculations validated by experimental tests. Theoretically, the study shows a general solution for the fiber-slip mechanism in a general matrix using a new frictional-shear-lag model and an analytical model for pull-off bond strength. Experimentally, pull-out tests were conducted for selected types of single fiber in micro-level (glass, carbon, and short-steel fiber); and macro-level (straight steel fiber). The results showed significant improvements in the pull-off bond strength using novel shape of fiber with wide rounded ends-WESF. The pull-off bond strength in normal-weight concrete was found lower than in lightweight concrete, and the matrix with higher compressive strength improves the pull-off bond strength. Also, the steel fiber showed higher pull-off bond strength compared to glass and carbon fiber; whereas the efficiency of short-steel fiber was higher than the long one. All types of fiber showed that the higher aspect ratio reduces the pull-off bond strength. Using the novel-WESF, the performance of fiber-slip improved 52.65% in normal-weight concrete. Moreover, the fiber-slip performance improved 61.79% in sand-lightweight concrete, and 70.20% in all other types of light-weight concrete

The Mediation Role of Marketing Orientation in Relationship between Environmental Friendliness with Customer Green Intention Buying

As green marketing becomes an essential tool for sustainable business strategy, companies are adopting green marketing practices to achieve better business performance. However, no research has yet operationalized all the organizational facets that are necessary to become a green marketing oriented company. The main purpose of this study is evaluating the impact of environmental friendliness on customer green intention buying with regarding marketing orientation. 12 Hypotheses were generated based on conceptual model. The sample includes 390 customers of Kalleh Company in Iran. The research is based on structural equation modeling (SEM) based on variation (partial least square) and path analysis. The collected data were analyzed by PLS software. The result revealed that there are positive and significant relationship between variables except tactical green marketing orientation and green satisfaction which is not significant. This researchs findings guide managers to develop their business and performance strategies and results and help them to improve the level of customers behaviors. KeyWords marketing orientation, Environmental, customer green intention buying, green trust, green satisfactio

Connection Between Microscopic Dynamics And Macroscopic Properties Of Soft Particle Glasses

The heterogeneous dynamics of jammed suspensions of soft particles is analyzed using three-dimensional particle dynamic simulations. Our results reveal how particle softness determines the dynamics at different length scales. The long-time shear-induced diffusion coefficient, the structural relaxation time, the shear stress and the normal stress differences are found to be universal functions of the same non-dimensional shear rate that depends on the solvent viscosity, particle elasticity and volume fraction. They are interconnected through simple relationships that predict the macroscopic rheology from microscopic dynamics. Please click Additional Files below to see the full abstract

Fiberconcrete non-linear fracture control through fresh concrete flow numerical simulation

The use of fiber (steel or synthetic) reinforced concrete (FRC) had a considerable increase during the last decades mainly due to its higher resistance to crack formation and simplified casting technique. At the same time fiberconcrete strength properties are non-linear with a high scatter. The paper presents results for fiberconcrete post-cracking behavior control by means of fresh FRC flow numerical simulations and prediction of internal structure (fiber orientation and distribution) formatio

GLUT 1 expression is a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma

Objectives: This study will investigate the phenotype of Glucose transporter 1 (GLUT1) in endometrial cancer and the association of its expression with tumor’s clinicopathological factors. Material and methods: Standard immunohistochemistry (IHC) staining protocol was utilized to identify the location and expression pattern of GLUT1 in a panel of 71 endometrial carcinomas compared to 30 normal tissues using tissue microarrays. Results: High scores of GLUT1 staining are more frequent in cancer cases, it was recognized in 64 (90%) endometrial cancers and 12 (40%) control cases. Tissue histotype (cancer versus non-cancerous) was associated with IHC staining of GLUT1 (p = 0.000). Significant association between strong GLUT1 staining of malignant epithelial cells and stage of tumor (p = 0.000) was observed, advanced disease stages were more prevalent with high GLUT1 staining in malignant epithelial cells. There is also a significant association between high scores of GLUT1 staining and location of expression in transformed epithelium, cytoplasmic and membranous (p = 0.000), 100% of cases with cytoplasmic and membranous expression showed high GLUT1 staining scores. Considerable varied survival models were observed with positive GLUT 1 neoplasm regarding diagnosis, grade, stage, differentiation, and recurrence (p-values 0.000, 0.000, 0.000, 0.002, and 0.000 respectively). Survival estimates are considerably healthier in positive GLUT1 staining cases of endometrial carcinoma, which have low grade, low stage and no recurrence. Conclusions: GLUT1 expression has been found upregulated in endometrial carcinoma. IHC staining of GLUT1 can be a supportive mean in predicting prognosis and survival estimates of endometrial carcinoma with specific clinical factors

Glycophenotype of prostatic carcinomas.

The factors that affect the progression of prostatic carcinoma are poorly understood, but it is known that carbohydrate antigens on the tumour cell surface play a role in the transforming and metastatic processes. The present report aimed to perform a comparative, lectin-histochemical study of benign and carcinomatous prostates, using a battery of lectins, in combination with monoclonal antibodies against Lewis antigens, and a semi quantitative study, to investigate the changes in glycosylation patterns that occur in prostatic carcinoma. Blocks from 27 necropsy cases of prostatic carcinoma were sectioned and stained with H+E, fifteen biotinylated lectins chosen to probe for a wide range of oligosaccharide sequences within several categories of glycoprotein glycans, using a lectin-biotin avidin-peroxidase method, and monoclonal antibodies against Lewisa, sialyl Lewisa and sialyl Lewisx antigens. The glycophenotype of prostatic carcinoma differed from that of the noncancerous prostate in revealing more intense staining with the following lectins (AAA, UEA-1, DBA, WFA, VVA, HPA, BSA-1B4, MPA, ECA, AHA, and CTA), while the binding patterns of (GNA and NPA) were almost similar in both prostatic carcinoma and the noncancerous prostate. Lewis antigens are found to be expressed in prostatic carcinomas but not in the noncancerous prostate. The observations of this study suggest that the gylcophenotype of transformed prostatic cells was modified. It showed a moderate increase in, and changing patterns of, fucosylation and galactosylation, increased branching of side chains and sharp rise in 2 deoxy, 2 acetamido galactosylation and masking process by sialylation, especially by Îą2-3 and Îą2-6 linkages. All these changes in the glycosylation pattern of the transformed prostatic cells were observed on O-glycans, no changes were observed on N-glycans