Recent changes in U.S. family finances: evidence from the 1998 and 2001 Survey of Consumer Finances

Data from the Federal Reserve Board's Survey of Consumer Finances show a striking pattern of growth in family income and net worth between 1998 and 2001. Inflation-adjusted incomes of families rose broadly, although growth was fastest among the group of families whose income was higher than the median. The median value of family net worth grew faster than that of income, but as with income, the growth rates of net worth were fastest for groups above the median. The years between 1998 and 2001 also saw a rise in the proportion of families that own corporate equities either directly or indirectly (such as through mutual funds or retirement accounts); by 2001 the proportion exceeded 50 percent. The growth in the value of equity holdings helped push up financial assets as a share of total family assets despite a decline in the overall stock market that began in the second half of 2000. ; The level of debt carried by families rose over the period, but the expansion in equities and the increased values of principal residences and other assets were sufficient to reduce debt as a proportion of family assets. The typical share of family income devoted to debt repayment also fell over the period. For some groups, however--particularly those with relatively low levels of income and wealth--a concurrent rise in the frequency of late debt payments indicated that their ability to service their debts had deteriorated.Consumer behavior ; Saving and investment ; Income

Recent changes in U.S. family finances: evidence from the 2001 and 2004 Survey of Consumer Finances

Reviews changes in the income and wealth of U.S. families between 2001 and 2004. The discussion draws on data from the Federal Reserve Board's triennial Survey of Consumer Finances for those years and also uses evidence from earlier years of the survey to place the 2001-04 changes in a broader context.Consumers ; Consumption (Economics)

Changes in U.S. family finances from 2004 to 2007: evidence from the Survey of Consumer Finances

The Federal Reserve Board's Survey of Consumer Finances for 2007 provides insights into changes in family income and net worth since the 2004 survey. The survey shows that, over the 2004-07 period, the median value of real (inflation-adjusted) family income before taxes was little changed, while mean income climbed 8.5 percent. Unlike family income over this period, both median and mean net worth increased; the median rose 17.7 percent, and the mean rose 13.0 percent. This article reviews these and other changes in the financial condition of U.S. families, including developments in assets, liabilities, and debt payments.Consumer surveys ; Households - Economic aspects

Viruses as co-factors for the initiation or exacerbation of lung fibrosis

Idiopathic pulmonary fibrosis (IPF) remains exactly that. The disease originates from an unknown cause, and little is known about the mechanisms of pathogenesis. While the disease is likely multi-factorial, evidence is accumulating to implicate viruses as co-factors (either as initiating or exacerbating agents) of fibrotic lung disease. This review summarizes the available clinical and experimental observations that form the basis for the hypothesis that viral infections may augment fibrotic responses. We review the data suggesting a link between hepatitis C virus, adenovirus, human cytomegalovirus and, in particular, the Epstein-Barr gammaherpesvirus, in IPF. In addition, we highlight the recent associations made between gammaherpesvirus infection and lung fibrosis in horses and discuss the various murine models that have been used to investigate the contribution of gammaherpesviruses to fibrotic progression. We review the work demonstrating that gammaherpesvirus infection of Th2-biased mice leads to multi-organ fibrosis and highlight studies showing that gammaherpesviral infections of mice either pre- or post-fibrotic challenge can augment the development of fibrosis. Finally, we discuss potential mechanisms whereby viral infections may amplify the development of fibrosis. While none of these studies prove causality, we believe the evidence suggests that viral infections should be considered as potential initiators or exacerbating agents in at least some cases of IPF and thereby justify further study

Ab initio molecular dynamics calculations of ion hydration free energies

We apply ab initio molecular dynamics (AIMD) methods in conjunction with the thermodynamic integration or "lambda-path" technique to compute the intrinsic hydration free energies of Li+, Cl-, and Ag+ ions. Using the Perdew-Burke-Ernzerhof functional, adapting methods developed for classical force field applications, and with consistent assumptions about surface potential (phi) contributions, we obtain absolute AIMD hydration free energies (Delta G(hyd)) within a few kcal/mol, or better than 4%, of Tissandier 's [J. Phys. Chem. A 102, 7787 (1998)] experimental values augmented with the SPC/E water model phi predictions. The sums of Li+/Cl- and Ag+/Cl- AIMD Delta G(hyd), which are not affected by surface potentials, are within 2.6% and 1.2 % of experimental values, respectively. We also report the free energy changes associated with the transition metal ion redox reaction Ag++Ni+-> Ag+Ni2+ in water. The predictions for this reaction suggest that existing estimates of Delta G(hyd) for unstable radiolysis intermediates such as Ni+ may need to be extensively revised.Comment: 18 pages, 8 figures. This version is essentially the one published in J. Chem. Phy

IgG antibody production and persistence to 6 months following SARS-CoV-2 vaccination: a Northern Ireland observational study

BACKGROUND: This study evaluates spike protein IgG antibody response following Oxford-AstraZeneca COVID-19 vaccination using the AbC-19™ lateral flow device. METHODS: Plasma samples were collected from n=111 individuals from Northern Ireland. The majority were >50 years old and/or clinically vulnerable. Samples were taken at five timepoints from pre-vaccination until 6-months post-first dose. RESULTS: 20.3% of participants had detectable IgG responses pre-vaccination, indicating prior COVID-19. Antibodies were detected in 86.9% of participants three weeks after the first vaccine dose, falling to 74.7% immediately prior to the second dose, and rising to 99% three weeks post-second vaccine. At 6-months post-first dose, this decreased to 90.5%. At all timepoints, previously infected participants had significantly higher antibody levels than those not previously infected. CONCLUSION: This study demonstrates that strong anti-spike protein antibody responses are evoked in almost all individuals that receive two doses of Oxford-AstraZeneca vaccine, and largely persist beyond six months after first vaccination

Characteristics and transformation of Pacific winter water on the Chukchi Sea shelf in late spring

Author Posting. © American Geophysical Union, 2019. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research-Oceans 124 (2019): 7153– 7177, doi: 10.1029/2019JC015261.Data from a late spring survey of the northeast Chukchi Sea are used to investigate various aspects of newly ventilated winter water (NVWW). More than 96% of the water sampled on the shelf was NVWW, the saltiest (densest) of which tended to be in the main flow pathways on the shelf. Nearly all of the hydrographic profiles on the shelf displayed a two‐layer structure, with a surface mixed layer and bottom boundary layer separated by a weak density interface (on the order of 0.02 kg/m3). Using a polynya model to drive a one‐dimensional mixing model, it was demonstrated that, on average, the profiles would become completely homogenized within 14–25 hr when subjected to the March and April heat fluxes. A subset of the profiles would become homogenized when subjected to the May heat fluxes. Since the study domain contained numerous leads within the pack ice—many of them refreezing—and since some of the measured profiles were vertically uniform in density, this suggests that NVWW is formed throughout the Chukchi shelf via convection within small openings in the ice. This is consistent with the result that the salinity signals of the NVWW along the central shelf pathway cannot be explained solely by advection from Bering Strait or via modification within large polynyas. The local convection would be expected to stir nutrients into the water column from the sediments, which explains the high nitrate concentrations observed throughout the shelf. This provides a favorable initial condition for phytoplankton growth on the Chukchi shelf.The authors are indebted to Commanding Officer John Reeves, Executive Officer Gregory Stanclik, Operations Officer Jacob Cass, and the entire crew of the USCGC Healy for their hard work and dedication in making the SUBICE cruise a success. We also acknowledge Scott Hiller for his assistance with Healy's meteorological data. We thank an anonymous reviewer for helpful input that improved the paper. Funding for A. P., R. P., C. N., and F. B. was provided by the National Science Foundation (NSF) under grant PLR‐1303617. K. M. was funded by the Natural Sciences and Engineering Research Council of Canada. K. V. acknowledges the Bergen Research Foundation under Grant BFS2016REK01. K. A. was supported by the NSF grant PLR‐1304563. The CTD and shipboard ADCP data are available from https://www.rvdata.us/search/cruise/HLY1401, and the nutrient data can be accessed from https://arcticdata.io/catalog/view/doi:10.18739/A2RG3Z and http://ocean.stanford.edu/subice/. The shipboard meteorological data reside at http://ocean.stanford.edu/subice/.2020-04-1

Pure iterative reconstruction improves image quality in computed tomography of the abdomen and pelvis acquired at substantially reduced radiation doses in patients with active Crohn disease

Objective: We assessed diagnostic accuracy and image quality of modified protocol (MP) computed tomography (CT) of the abdomen and pelvis reconstructed using pure iterative reconstruction (IR) in patients with Crohn disease (CD). Methods: Thirty-four consecutive patients with CD were referred with suspected extramural complications. Two contemporaneous CT datasets were acquired in all patients: standard protocol (SP) and MP. The MP and SP protocols were designed to impart radiation exposures of 10% to 20% and 80% to 90% of routine abdominopelvic CT, respectively. The MP images were reconstructed with model-based IR (MBIR) and adaptive statistical IR (ASIR). Results: The MP-CT and SP-CT dose length product were 88 (58) mGy.cm (1.27 [0.87] mSv) and 303 [204] mGy.cm (4.8 [2.99] mSv), respectively (P < 0.001). Median diagnostic acceptability, spatial resolution, and contrast resolution were significantly higher and subjective noise scores were significantly lower on SP-ASIR 40 compared with all MP datasets. There was perfect clinical agreement between MP-MBIR and SP-ASIR 40 images for detection of extramural complications. Conclusions: Modified protocol CT using pure IR is feasible for assessment of active CD

Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts

<p>Abstract</p> <p>Background</p> <p>Simian Virus 40 (SV40) immortalization followed by treatment of cells with 3-methylcholanthrene (3-MC) has been used to elicit tumors in athymic mice. 3-MC carcinogenesis has been thoroughly studied, however gene-level interactions between 3-MC and SV40 that could have produced the observed tumors have not been explored. The commercially-available human uroepithelial cell lines were either SV40-immortalized (HUC) or SV40-immortalized and then 3-MC-transformed (HUC-TC).</p> <p>Results</p> <p>To characterize the SV40 - 3MC interaction, we compared human gene expression in these cell lines using a human cancer array and confirmed selected changes by RT-PCR. Many viral Large T Antigen (Tag) expression-related changes occurred in HUC-TC, and it is concluded that SV40 and 3-MC may act synergistically to transform cells. Changes noted in <it>IFP 9-27, 2'-5' OAS, IF 56, MxA </it>and <it>MxAB </it>were typical of those that occur in response to viral exposure and are part of the innate immune response. Because interferon is crucial to innate immune host defenses and many gene changes were interferon-related, we explored cellular growth responses to exogenous IFN-γ and found that treatment impeded growth in tumor, but not immortalized HUC on days 4 - 7. Cellular metabolism however, was inhibited in <it>both </it>cell types. We conclude that IFN-γ <it>metabolic </it>responses were functional in both cell lines, but IFN-γ <it>anti-proliferative </it>responses functioned only in tumor cells.</p> <p>Conclusions</p> <p>Synergism of SV40 with 3-MC or other environmental carcinogens may be of concern as SV40 is now endemic in 2-5.9% of the U.S. population. In addition, SV40-immortalization is a generally-accepted method used in many research materials, but the possibility of off-target effects in studies carried out using these cells has not been considered. We hope that our work will stimulate further study of this important phenomenon.</p