Open access – tieteellisen tiedon avoin saatavuus

Tieteellisen tiedon avoimen saatavuuden vaatimus muuttaa tieteellisen julkaisemisen kenttää. Tutkimusmaailman kokonaisuudessaan – tieteellisen tiedon tuottajien ja julkaisijoiden sekä tieteen rahoittajien – on tärkeä yhdessä hahmottaa muutostarpeet sekä sopia pelisäännöistä

D1 protein degradation during photoinhibition of intact leaves a modification of the D1 protein precedes degradation

AbstractIllumination of intact pumpkin leaves with high light led to severe photoinhibition of photosystem II with no net degradation of the D1 protein. Instead, however, a modified form of D1 protein with slightly slower electrophoretic mobility was induced with corresponding loss in the original form of the D1 protein. When the leaves were illuminated in the presence of chloramphenicol the modified form was degraded, which led to a decrease in the total amount of the D1 protein. Subfractionation of the thylakoid membranes further supported the conclusion that the novel form of the D1 protein was not a precursor but a high-light modified form that was subsequently degraded

Virus-specific capping of tobacco mosaic virus RNA: methylation of GTP prior to formation of covalent complex p126-m7GMP

AbstractIn capping cellular mRNAs, a covalent GMP-enzyme intermediate leads to formation of G(5′)ppp(5′)N at the 5′ end of the RNA, which is modified by methylation catalyzed by guanine-7-methyltransferase. Here we show that isolated membranes from tobacco mosaic virus (TMV)-infected plant or insect cells expressing TMV replicase protein p126, synthesized m7GTP using S-adenosylmethionine (AdoMet) as the methyl donor, and catalyzed the formation of a covalent guanylate-p126 complex in the presence of AdoMet. The methyl group from AdoMet was incorporated into p126, suggesting that the complex consisted of m7GMP-p126. Thus, TMV and alphaviruses, despite their evolutionary distance, share the same virus-specific capping mechanism

Väkivaltakäsitteiden sanasto

Denna ordlista över våldsbegrepp har utarbetats i samarbete mellan experter på våld och termino-logi hos Institutet för hälsa och välfärd (THL). Den innehåller definitioner av de begrepp som re-kommenderas att användas i arbetet mot våld. Definierar vi inte tillsammans begreppen kring våldsfenomenet förstår vi inte nödvändigtvis varandra fast vi talar om samma fråga. Ordlistan stöder sakkunniga och professionella så att de kan diskutera våld med enhetliga termer och förstå dem på samma sätt

Väkivaltakäsitteiden sanasto

Tämä väkivaltakäsitteiden sanasto on Terveyden ja hyvinvoinnin laitoksen (THL) väkivalta- ja sanastoasiantuntijoiden yhteistyössä laatima sanasto, joka sisältää määritelmät suositeltavimmille väkivallan vastaisessa työssä käytettäville käsitteille. Jos väkivaltailmiön käsitteitä ei ole yhteisesti määritelty, emme välttämättä ymmärrä toisiamme, vaikka puhuisimme samasta asiasta. Sanaston tarkoituksena on tukea asiantuntijoita ja ammattilaisia keskustelemaan väkivallasta yhdenmukaisin termein ja jakamaan ymmärryksen siitä, mitä niillä tarkoitetaan

The Finnish genetic heritage in 2022 - from diagnosis to translational research

Publisher Copyright: © 2022. Published by The Company of Biologists Ltd.Isolated populations have been valuable for the discovery of rare monogenic diseases and their causative genetic variants. Finnish disease heritage (FDH) is an example of a group of hereditary monogenic disorders caused by single major, usually autosomal-recessive, variants enriched in the population due to several past genetic drift events. Interestingly, distinct subpopulations have remained in Finland and have maintained their unique genetic repertoire. Thus, FDH diseases have persisted, facilitating vigorous research on the underlying molecular mechanisms and development of treatment options. This Review summarizes the current status of FDH, including the most recently discovered FDH disorders, and introduces a set of other recently identified diseases that share common features with the traditional FDH diseases. The Review also discusses a new era for population-based studies, which combine various forms of big data to identify novel genotype-phenotype associations behind more complex conditions, as exemplified here by the FinnGen project. In addition to the pathogenic variants with an unequivocal causative role in the disease phenotype, several risk alleles that correlate with certain phenotypic features have been identified among the Finns, further emphasizing the broad value of studying genetically isolated populations.Peer reviewe

Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells

Peer reviewe

Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells

Peer reviewe