A System Framework For Managing Learner Autonomy

The need to connect information systems studies with other concentrations in business school curricula requires the development of integral courses comprised of several knowledge domains. Students with different prior knowledge, skills and learning focus (e.g., business development, technology management, or programming) should be able to enroll in the same course. The resulting difficulties of such personalized classroom management techniques could be largely overcome through special learning designs and proper technological architecture. Presented results could be generalized for other complex non-linear course organizations

Partikeldetektion in mikrofluidischen Systemen

Die Analyse von Mikropartikeln hat in Medizin, Biologie und Chemie eine große Bedeutung. Neue Analysesysteme sollen per Drucktechnologie hergestellt werden. Unter diesem Hinblick werden in dieser Arbeit neuartige optische Partikeldetektionssysteme auf Basis von Mikrofluidik und planaren Optiken entwickelt und untersucht. Da sich die Funktionsweise von etablierten Partikeldetektionssystemen deutlich unterscheidet, erfolgt eine detaillierte Untersuchung der Signaleigenschaften und Fehlerstatistik

Partikeldetektion in mikrofluidischen Systemen

Analysis of microparticles is an important tool in medicine, biology and chemistry. In order to address future application areas, new systems will be produced by printing technology. In this work new microfluidic particle detection systems which employ planar optics are developed and analyzed. Because the characteristic of these new systems differs greatly from established particle detection systems the signals and statistics are analyzed in depth

Upscaling from single- to multi-filament dielectric barrier discharges in pulsed operation

A study on the scalability of discharge characteristics of a single-filament dielectric barrier discharge (DBD) to a spatially one-dimensional multi-filament arrangement driven by the same high-voltage (HV) pulses was performed for a gas mixture of 0.1 vol% O2 in N2 at 1 bar. Both arrangements feature a 1 mm gap with dielectric-covered electrodes featuring two hemispherical alumina caps for the single-filament and two parallel alumina-tubes for the multi-filament arrangement. The DBDs were characterised by electrical measurements (for peak current, energy, and power) accompanied by iCCD and streak imaging to determine the filament number and the discharge development in the gas gap and on the surfaces. It was found that the electrical quantities scale with a constant factor between the single- and multi-filament arrangement, which is expected to be related to the filament number. In the multi-filament arrangement, the pulsed operation leads to filament formation in the entire gap in lateral direction within less than 2 ns. Furthermore, particular breakdown or discharge inception regimes were identified for the multi-filament DBDs. These regimes could be generated at the falling slope of asymmetrical HV pulses featuring e.g. a double-streamer propagation, which was previously reported for single-filament DBDs. Consequently, it was proven that the discharge manipulation by varying the HV pulse widths obtained for single-filament DBDs can also be applied in a one-dimensional multi-filament arrangement, i.e. an upscaling based on the knowledge for single-filament DBDs seems to be generally possible

The Intrinsic Connectome of the Rat Amygdala

The connectomes of nervous systems or parts there of are becoming important subjects of study as the amount of connectivity data increases. Because most tract-tracing studies are performed on the rat, we conducted a comprehensive analysis of the amygdala connectome of this species resulting in a meta-study. The data were imported into the neuroVIISAS system, where regions of the connectome are organized in a controlled ontology and network analysis can be performed. A weighted digraph represents the bilateral intrinsic (connections of regions of the amygdala) and extrinsic (connections of regions of the amygdala to non-amygdaloid regions) connectome of the amygdala. Its structure as well as its local and global network parameters depend on the arrangement of neuronal entities in the ontology. The intrinsic amygdala connectome is a small-world and scale-free network. The anterior cortical nucleus (72 in- and out-going edges), the posterior nucleus (45), and the anterior basomedial nucleus (44) are the nuclear regions that posses most in- and outdegrees. The posterior nucleus turns out to be the most important nucleus of the intrinsic amygdala network since its Shapley rate is minimal. Within the intrinsic amygdala, regions were determined that are essential for network integrity. These regions are important for behavioral (processing of emotions and motivation) and functional (memory) performances of the amygdala as reported in other studies

Impact of the electrode proximity on the streamer breakdown and development of pulsed dielectric barrier discharges

The impact of the electrode proximity on the streamer breakdown and development of pulsed-driven dielectric barrier discharges (DBDs) in a single-filament arrangement has been investigated in a gas mixture of 0.1 vol% O2 in N2 at 0.6 bar and 1.0 bar. The gap distance was varied from 0.5 mm to 1.5 mm, and the applied voltage was adapted correspondingly to create comparable breakdown conditions in the gap. The development of the DBDs was recorded by an iCCD and a streak camera system, while fast electrical measurements provided insight into discharge characteristics such as the transferred charge and consumed energy. The results demonstrate that breakdown in a smaller gap is characterised by a slower streamer propagation but a significantly higher acceleration. It can therefore be concluded that the proximity of the cathode has a strong impact on the characteristics of the streamer breakdown. However, after the streamer has crossed the gap, the discharge structure in front of the anode was found to be the same independent of the actual gap distance

Effect of a high-voltage mesh electrode on the volume and surface characteristics of pulsed dielectric barrier discharges

Electrical breakdown in a pulsed asymmetric dielectric barrier discharge between a glass-covered mesh electrode and a grounded metal electrode in the air at atmospheric pressure is investigated. Volume discharge forms between the metal tip and the dielectric surface and spreads over the dielectric surface. Breakdown and discharge behaviors depend on the polarity of the charged electrode covered with glass compared to the metal rod electrode. In the case of the dielectric cathode (covered mesh), volume discharge features a stronger and longer-lasting emission. Volume discharge is weaker with outstretched surface discharge developing on the opposite glass electrode sustained by the embedded mesh when the metal rod functions as a cathode. The development and spatial distribution of the surface discharge depend on the relative polarity of the dielectrics caused by the charge deposition of the preceding discharge and is independent of the polarity of the applied high voltage. The discharge emission is brighter for the metal cathode and dielectric anode than for the metal anode, with a branching discharge developing and spreading in a star-like structure along the embedded grid, while a ring-like structure was observed for the metal anode and dielectric cathode. The duty cycle influences the discharge development and properties through the effects of the gas phase and surface pre-ionization

Inactivation of airborne bacteria by plasma treatment and ionic wind for indoor air cleaning

Airborne bacteria are a general problem in medical or health care facilities with a high risk for nosocomial infections. Rooms with a continuous airflow, such as operation theaters, are of particular importance due to a possible dissemination and circulation of pathogens including multidrug-resistant microorganisms. In this regard, a cold atmospheric-pressure plasma (CAP) may be a possibility to support usual disinfection procedures due to its decontaminating properties. The aim of this study was to determine the antimicrobial efficacy of a plasma decontamination module that included a dielectric barrier discharge for plasma generation. Experimental parameters such as an airflow velocity of 4.5 m/s and microbial contaminations of approximately 6,000 colony-forming units (cfu)/m3 were used to simulate practical conditions of a ventilation system in an operating theater. The apathogenic microorganism Escherichia coli K12 DSM 11250/NCTC 10538 and the multidrug-resistant strains E. coli 21181 and 21182 (isolated from patients) were tested to determine the antimicrobial efficacy. In summary, the number of cfu was reduced by 31–89% for the tested E. coli strains, whereby E. coli K12 was the most susceptible strain toward inactivation by the designed plasma module. A possible correlation between the number or kind of resistances and susceptibility against plasma was discussed. The inactivation of microorganisms was affected by plasma intensity and size of the plasma treatment area. In addition, the differences of the antimicrobial efficacies caused through the nebulization of microorganisms in front (upstream) or behind (downstream) the plasma source were compared. The presence of ionic wind had no influence on the reduction of the number of cfu for E. coli K12, as the airflow velocity was too high for a successful precipitation, which would be a prerequisite for an increased antimicrobial efficacy. The inactivation of the tested microorganisms confirms the potential of CAP for the improvement of air quality. The scale-up of this model system may provide a novel tool for an effective air cleaning process

Das Konnektom der Basalganglien der Ratte

Der Begriff Konnektom umfasst die Gesamtheit aller neuronalen Verbindungen innerhalb des Nervensystems in einem Organismus. Tract-Tracing-Studien, bezogen auf die Kerngebiete der Basalganglien der Ratte, wurden ausgewertet und mit Hilfe des Programmes neuroVIISAS umfassend analysiert. Bei der Auswertung wurden neben ipsi- auch kontralaterale Konnektivitäten auf mehreren hierarchischen Ebenen berücksichtigt. Besondere Bedeutung kommt den Kerngebieten der Substantia nigra pars compacta und des Caudatus-Putamen-Komplexes zu