1,264 research outputs found
TOKAT YÖRESiNDEKi SÜNNi VE ALEVi TOPLULUKLARlNDA HALK DiNDARLIGININ BiR BOYUTUNU OLUŞTURAN ZiYARET iNANÇ VE UYGULAMALARINDAKi BENZER VE FARKLILIKLAR
Anadolu'nun en eski kültür ve uygarlık merkezlerinden birisi olan
Tokat'ın Türkleşmesi ve İslamlaşmasmda, hiç şüphesiz adına daha çok,
Horasan Eren/eri, Gazi-Alperenler veya Veliler dediğimiz şahıslarm rolü
oldukça büyüktür. Yöre halkı, bölgeyi Türkleştirip İslarrıJaştırırken, burada
bulıman ve çoğunun adı bilinmeyen mezar ve türbelerin her birisini bu
ısımsiz kalıramanlara atfetmek suretiyle onlara karşı vicdanİ
soruınlululdannı yerine getirmekle kalmamış, bu yeni coğrafyadaki bir takını
dağlar, ağaçlar, sular ve kayalan da -daha çok İslam öncesi inançlarmdan
kalan ahşkanlıklanyla- kutsayarak bölgenin her kanşma kendi dini-kültürel
damgalarını vurınuşlardır. Tokat yöresinde bu şekilde oluşmuş pek çok
ziyaret yeri mevcuttur
Reduced differential transform method for solving (1 + n) – Dimensional Burgers' equation
AbstractThis paper discusses a recently developed semi-analytic technique so called the reduced differential transform method (RDTM) for solving the (1 + n) – dimensional Burgers' equation. The method considers the use of the appropriate initial or boundary conditions and finds the solution without any discretization, transformation, or restrictive assumptions. Four numerical examples are provided in order to validate the efficiency and reliability of the method and furthermore to compare its computational effectiveness with other analytical methods available in the literature
A wideband linear tunable CDTA and its application in field programmable analogue array
This document is the Accepted Manuscript version of the following article: Hu, Z., Wang, C., Sun, J. et al. ‘A wideband linear tunable CDTA and its application in field programmable analogue array’, Analog Integrated Circuits and Signal Processing, Vol. 88 (3): 465-483, September 2016. Under embargo. Embargo end date: 6 June 2017. The final publication is available at Springer via https://link.springer.com/article/10.1007%2Fs10470-016-0772-7 © Springer Science+Business Media New York 2016In this paper, a NMOS-based wideband low power and linear tunable transconductance current differencing transconductance amplifier (CDTA) is presented. Based on the NMOS CDTA, a novel simple and easily reconfigurable configurable analogue block (CAB) is designed. Moreover, using the novel CAB, a simple and versatile butterfly-shaped FPAA structure is introduced. The FPAA consists of six identical CABs, and it could realize six order current-mode low pass filter, second order current-mode universal filter, current-mode quadrature oscillator, current-mode multi-phase oscillator and current-mode multiplier for analog signal processing. The Cadence IC Design Tools 5.1.41 post-layout simulation and measurement results are included to confirm the theory.Peer reviewedFinal Accepted Versio
A study on dual square free modules
Let M be an H-supplemented coatomic module with FIEP. Then we prove that M is dual square free if and only if every maximal submodule ofM is fully invariant. Let M = ⊕ i∈I Mi be a direct sum, such that M is coatomic. Then we prove that M is dual square free if and only if each Mi is dual square free for all i ∈ I and, Mi and ⊕ j̸≠i Mj are dual orthogonal. Finally we study the endomorphism rings of dual square free modules. Let M be a quasi-projective module. If EndR(M) is right dual square free, then M is dual square free. In addition, if M is finitely generated, then EndR(M) is right dual square free whenever M is dual square free. We give several examples illustrating our hypotheses
Social welfare and profit maximization from revealed preferences
Consider the seller's problem of finding optimal prices for her
(divisible) goods when faced with a set of consumers, given that she can
only observe their purchased bundles at posted prices, i.e., revealed
preferences. We study both social welfare and profit maximization with revealed
preferences. Although social welfare maximization is a seemingly non-convex
optimization problem in prices, we show that (i) it can be reduced to a dual
convex optimization problem in prices, and (ii) the revealed preferences can be
interpreted as supergradients of the concave conjugate of valuation, with which
subgradients of the dual function can be computed. We thereby obtain a simple
subgradient-based algorithm for strongly concave valuations and convex cost,
with query complexity , where is the additive
difference between the social welfare induced by our algorithm and the optimum
social welfare. We also study social welfare maximization under the online
setting, specifically the random permutation model, where consumers arrive
one-by-one in a random order. For the case where consumer valuations can be
arbitrary continuous functions, we propose a price posting mechanism that
achieves an expected social welfare up to an additive factor of
from the maximum social welfare. Finally, for profit maximization (which may be
non-convex in simple cases), we give nearly matching upper and lower bounds on
the query complexity for separable valuations and cost (i.e., each good can be
treated independently)
Explaining spatial variation in housing construction activity in Turkey
In Turkey, there has been a strong policy narrative that has emphasized the importance of construction activity as a driver of economic growth. This has given shape to a central state-led policy regime that has sought to ensure that planners and other urban policy makers develop plans and strategies that support construction activity. Against this backdrop, and a recent history of uneven spatial development, this paper seeks to understand what this policy imperative might mean for housing construction activity in different provinces. It seeks to reflect on both the relationship between the state and the market, and the interaction between state policies, economic drivers and levels of construction activity. The evidence presented in the paper suggests that uneven spatial development might be explained in different ways in different provinces. Although, in many cases, patterns of construction activity are consistent with economic fundamentals, there are important exceptions in some regions where arguably activity levels are at odds with prior expectations
Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia
Extramedullary hematopoiesis associated with thalassemia causing spinal cord compression is an extremely rare event in the course of the disease. Documentation with an imaging technique, such as MRI, is mandatory. A patient with thalassemia intermedia, who developed paraparesis in spite of transfusion, underwent surgical decompression. Rapid neurological improvement was observed postoperatively and this neurological condition was protected with adequate hemoglobin level. Management of these patients remains controversial. Various modes of therapy such as surgical decompression, radiotherapy, and transfusion are discussed and the related literature is reviewed
Composite structural motifs of binding sites for delineating biological functions of proteins
Most biological processes are described as a series of interactions between
proteins and other molecules, and interactions are in turn described in terms
of atomic structures. To annotate protein functions as sets of interaction
states at atomic resolution, and thereby to better understand the relation
between protein interactions and biological functions, we conducted exhaustive
all-against-all atomic structure comparisons of all known binding sites for
ligands including small molecules, proteins and nucleic acids, and identified
recurring elementary motifs. By integrating the elementary motifs associated
with each subunit, we defined composite motifs which represent
context-dependent combinations of elementary motifs. It is demonstrated that
function similarity can be better inferred from composite motif similarity
compared to the similarity of protein sequences or of individual binding sites.
By integrating the composite motifs associated with each protein function, we
define meta-composite motifs each of which is regarded as a time-independent
diagrammatic representation of a biological process. It is shown that
meta-composite motifs provide richer annotations of biological processes than
sequence clusters. The present results serve as a basis for bridging atomic
structures to higher-order biological phenomena by classification and
integration of binding site structures.Comment: 34 pages, 7 figure
Specialized dynamical properties of promiscuous residues revealed by simulated conformational ensembles
The ability to interact with different partners is one of the most important features in proteins. Proteins that bind a large number of partners (hubs) have been often associated with intrinsic disorder. However, many examples exist of hubs with an ordered structure, and evidence of a general mechanism promoting promiscuity in ordered proteins is still elusive. An intriguing hypothesis is that promiscuous binding sites have specific dynamical properties, distinct from the rest of the interface and pre-existing in the protein isolated state. Here, we present the first comprehensive study of the intrinsic dynamics of promiscuous residues in a large protein data set. Different computational methods, from coarse-grained elastic models to geometry-based sampling methods and to full-atom Molecular Dynamics simulations, were used to generate conformational ensembles for the isolated proteins. The flexibility and dynamic correlations of interface residues with a different degree of binding promiscuity were calculated and compared considering side chain and backbone motions, the latter both on a local and on a global scale. The study revealed that (a) promiscuous residues tend to be more flexible than nonpromiscuous ones, (b) this additional flexibility has a higher degree of organization, and (c) evolutionary conservation and binding promiscuity have opposite effects on intrinsic dynamics. Findings on simulated ensembles were also validated on ensembles of experimental structures extracted from the Protein Data Bank (PDB). Additionally, the low occurrence of single nucleotide polymorphisms observed for promiscuous residues indicated a tendency to preserve binding diversity at these positions. A case study on two ubiquitin-like proteins exemplifies how binding promiscuity in evolutionary related proteins can be modulated by the fine-tuning of the interface dynamics. The interplay between promiscuity and flexibility highlighted here can inspire new directions in protein-protein interaction prediction and design methods. © 2013 American Chemical Society
Protein Docking by the Interface Structure Similarity: How Much Structure Is Needed?
The increasing availability of co-crystallized protein-protein complexes provides an opportunity to use template-based modeling for protein-protein docking. Structure alignment techniques are useful in detection of remote target-template similarities. The size of the structure involved in the alignment is important for the success in modeling. This paper describes a systematic large-scale study to find the optimal definition/size of the interfaces for the structure alignment-based docking applications. The results showed that structural areas corresponding to the cutoff values <12 Å across the interface inadequately represent structural details of the interfaces. With the increase of the cutoff beyond 12 Å, the success rate for the benchmark set of 99 protein complexes, did not increase significantly for higher accuracy models, and decreased for lower-accuracy models. The 12 Å cutoff was optimal in our interface alignment-based docking, and a likely best choice for the large-scale (e.g., on the scale of the entire genome) applications to protein interaction networks. The results provide guidelines for the docking approaches, including high-throughput applications to modeled structures
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