Use of Aspergillus wentii for biosorption of methylene blue from aqueous solution

In this study, Aspergillus wentii was used as a biosorbent for the adsorption of methylene blue from aqueous solution. The effects of contact time, initial dye concentration, solution pH and temperature on biosorption were investigated. The contact time required (that is, the equilibrium time) for maximum dye biosorption was found to be 120 min. The amount of the dye biosorbed increased with increasing initial dye concentrations and solution pH, while it was decreasing with an increase in temperature. Percent biosorption was changed between 14.86 and 85.04 under all conditions studied. Desorption studies were performed by changing of the value pH among 3 - 10. Desorption was considerably affected by lower pH. The maximum percentage of desorption was found to be 29.51 at pH 3. Biosorption isotherm from equilibrium values followed Freundlich model

Are Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio Related with Hepatosteatosis in Obese Children?

Objective: Obesity is an important health problem, which affects children and adolescents and is highly prevalent throughout the world. Non-alcoholic fatty liver disease is fattening that occurs due to non-alcohol causes, and it is associated with obesity in most of the cases. We investigated the relation of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) to hepatosteatosis in obese children in our study.Material and Methods: 104 obese children aged between 4-16 years, who were determined to have a body mass index (BMI) of 95th percentile or higher according to age and gender, were examined retrospectively. The genders, ages, and examination findings of the patients were recorded. In obese children, leukocyte, hemoglobin, platelet, mean platelet volume, neutrophil and lymphocyte levels were assessed in the complete blood count performed during the first application. Neutrophil-to-lymphocyte ratio was calculated. Fasting blood glucose (FBG) and fasting insulin, serum aminotransferase values, ultrasonographic results of patients were recorded.Results: Hepatosteatosis was determined in 64 of 104 patients (61.53%) while it was not determined in 40 patients (38.47%). The BMI, fasting insulin, HOMA-IR, ALT levels were higher in obese children with hepatosteatosis than patients without hepatosteatosis. The average MPV of the group with hepatosteatosis was 7.78±1.57, and the average MPV of the group without hepatosteatosis was 7.42±1.43, no statistical difference was observed between the groups (p=0.236). The average NLR was 1.62±1.06 in the group with hepatosteatosis and 1.38±0.59 in the group without hepatosteatosis. There was no statistical difference between the NLR averages of both groups (p=0.200).Conclusion: No relation was determined between MPV and NLR and liver fattening in obese children

Fundamental characterization, photophysics and photocatalysis of a base metal iron(II)-cobalt(III) dyad

A new base metal iron-cobalt dyad has been obtained by connection between a heteroleptic tetra-NHC iron(II) photosensitizer combining a 2,6-bis[3-(2,6-diisopropylphenyl)imidazol-2-ylidene]pyridine with 2,6-bis(3-methyl-imidazol-2-ylidene)-4,4′-bipyridine ligand, and a cobaloxime catalyst. This novel iron(II)-cobalt(III) assembly has been extensively characterized by ground- and excited-state methods like X-ray crystallography, X-ray absorption spectroscopy, (spectro-)electrochemistry, and steady-state and time-resolved optical absorption spectroscopy, with a particular focus on the stability of the molecular assembly in solution and determination of the excited-state landscape. NMR and UV/Vis spectroscopy reveal dissociation of the dyad in acetonitrile at concentrations below 1 mM and high photostability. Transient absorption spectroscopy after excitation into the metal-to-ligand charge transfer absorption band suggests a relaxation cascade originating from hot singlet and triplet MLCT states, leading to the population of the $^{3}$MLCT state that exhibits the longest lifetime. Finally, decay into the ground state involves a $^{3}$MC state. Attachment of cobaloxime to the iron photosensitizer increases the $^{3}$MLCT lifetime at the iron centre. Together with the directing effect of the linker, this potentially makes the dyad more active in photocatalytic proton reduction experiments than the analogous two-component system, consisting of the iron photosensitizer and Co(dmgH)$_2$(py)Cl. This work thus sheds new light on the functionality of base metal dyads, which are important for more efficient and sustainable future proton reduction systems

Development of knitted and woven fabric for medical textiles

Bu çalışmada, yeterli antimikrobiyallik özelliğine sahip kullanım performansı yüksek örme ve dokuma tekstil yüzeylerinin geliştirilmesi amaçlanmıştır. Çalışma kapsamında bu özellikler kazandırılmak için hem elyaflardan gelen özelliklerden hem de kimyasallardan gelen antimikrobiyal özelliklerden faydalanılmıştır. Buna göre, çalışma kapsamında, üç farklı iplik numarasından (Ne 40/1, Ne 30/1 ve Ne 17/1) iki farklı eğirme yöntemi (Ring ve Vortex) kullanılarak farklı elyaflardan (pamuk, gümüş, tencel, bambu, poliester, kanallı poliester ve antibakteriyel poliester) iplikler üretilmiştir. Üretilen ipliklerden ise örme ve dokuma kumaş üretimleri gerçekleştirilmiştir. Örme kumaşlar üç farklı konstrüksiyonda (süprem, interlok ve iki iplik) üretilmiştir. Dokuma kumaşlar ise, iki farklı konstrüksiyonda (1/1 bez ayağı ve saten) farklı atkı ve çözgü ipliği kullanılarak üretilmiştir. Üretilen örme ve dokuma kumaşlara emdirme ve çektirme yöntemi ile Antibakteriyel ve su itici bitim işlemi uygulanmıştır. Geliştirilen kumaşlara fiziksel performans testleri, ısıl konfor testleri ve Antibakteriyel Aktivite, Bakteri Filtrasyon Etkinlik Testi, Nefes Alabilirlik (Basınç Farkı) ve Mikrobiyal Temizlik (Biyoyük) ölçümleri yapılmıştır. Elde edilen sonuçlar incelendiğinde, antibakteriyel apre uygulanmış örme kumaş (A) ve gümüş elyaf içeren örme kumaş (B1) numunelerin TSE K 599 standardına göre ve performans testlerine göre en uygun kumaşlar oldukları görülmüştür.In this project, it is aimed to develop technical textiles with sufficient antimicrobial properties with high usage performance. Within the scope of the study, both antimicrobial fibers and silver-added chemicals were used to gain these properties. Accordingly, within the scope of the project, yarns are spun from cotton, silver fiber, tencel, bamboo, polyester, polyester coolmax and polyester antibacterial fibers. In this project we used two different spinning methods (Ring and Vortex) from three different yarn counts (Ne 40/1, Ne 30/1 and Ne 17/1). Knitted and woven fabrics were produced from these yarns. Knitted fabrics have been produced in three different constructions (single jersey, interlock and 2-thread) and with different yarn mixtures. Woven fabrics, on the other hand, are produced in two different constructions (1/1 plain and satin) and using different weft and warp yarns. Antibacterial and water- repellent finishing processes 6 Carbon was applied to the knitted and woven fabrics. Performance tests, thermal comfort measurment and antibacterial activity, bacterial filtration efficiency, breathability (Pressure Difference) and Bioburden tests were performed on the developed fabrics. When the results obtained were examined, the knitted fabric (A) and knitted fabric with silver fiber (B1) sample completed all the measurements successfully

A rare cause of thyrotoxicosis: TSH-secreting pituitary adenoma

Bu çalışma,18-22 Mayıs 2022 tarihlerinde Antalya’da düzenlenen 43. Türkiye Endokrinoloji ve Metabolizma Hastalıkları Kongresi‘nde bildiri olarak sunulmuştur.Tiroid stimüle edici hormon (TSH) salgılayan hipofiz adenomu (TSHoma) tirotoksikozun nadir görülen sebeplerinden biridir. Tanı genellikle uygunsuz TSH yüksekliğinin araştırılması ya da hipofizer insidentalomanın tetkiki sırasında konulmaktadır. Olgumuz bilinen poliskistik over sendromu olan 26 yaşında kadın hasta olup altı aydır olan titreme, terleme ve baş ağrısı yakınmalarıyla kliniğimize başvurdu. Laboratuvar analizlerinde serum serbest T3 ve T4 düzeyi yüksek iken TSH düzeyi normal sınırlarda saptandı. Seks hormonu bağlayıcı globülin (SHBG) düzeyi normal sınırlardaydı Manyetik rezonans görüntüleme sonucunda hipofiz bezinde makradenom izlendi. TRH uyarı testine TSH yanıtı saptanmadı. TSHoma tanısı alan hastada preoperatif oktreotid ve metimazol tedavisi ile ötiroidizm sağlandıktan sonra hipofiz cerrahisi uygulandı. Cerrahi materyalin histopatolojik incelemesinde fibrotik değişikliklerle birlikte prolaktin ile pozitif, TSH ile negatif boyanma izlendi. Bu olgu sunumunda SHBG düzeyi normal ve TSH boyaması negatif olmasına rağmen uygunsuz TSH salınımı nedeniyle TSHoma tanısı alan bir hastayı sunmayı amaçladık.Thyroid-stimulating hormone (TSH) secreting pituitary adenoma (TSHoma) is one of the rare causes of thyrotoxicosis. The diagnosis is usually made during investigating inappropriate TSH elevation or pituitary incidentaloma. Our patient, a 26-year-old female patient, known to have polycystic ovary syndrome, was admitted to our clinic with complaints of tremor, sweating, and headache for six months. Laboratory analysis showed serum free T3 and T4 levels were elevated, while TSH levels were within normal limits. Sex hormone binding globulin (SHBG) level was within normal limits. Macroadenoma was observed in the pituitary gland at magnetic resonance imaging. TSH secretion did not increase much in response to the thyrotropin-releasing hormone. The patient was diagnosed with TSHoma, and pituitary surgery was performed after euthyroidism was achieved with preoperative octreotide and methimazole treatment. Positive staining with prolactin and negative staining with TSH were observed along with fibrotic changes in the histopathological examination of the surgical material. We aimed to present a patient diagnosed with TSHoma due to inappropriate TSH secretion, although her SHBG level was normal and TSH staining was negative in the current case report

ERYTHROPOIETIN FOR THE TREATMENT OF SUBARACHNOID HEMORRAGE: A FEASIBLE INGREDIENT FOR A SUCCESS MEDICAL RECIPE

Subaracnhoid hemorrage (SAH) following aneurysm bleeding accounts for 6% to 8% of all cerebrovascular accidents. Althoug an aneurysm can be effectively managed by surgery or endovascular therapy, delayed cerebral ischemia is diagnosed in a high percentage of patients resulting in significant morbility and mortality. Cerebral vasospasm occurs in more than half of all patients after aneurysm rupture and is recognized as the leading cause of delayed cerebral ischemia after SAH. Hemodynamic strategies and endovascular procedures may be considered fo the treatment of cerebral vasospasm. In recent years, the mechanism contributing to the development of vasospasm, abnormal reactivity of cerebral arteries and cerebral ischemia following SAH, have been intensively investigated. A number of pathological processes have been identified in the pathogenesis of vasospasm including endothelial injury, smooth muscle cell contraction from spasmogenic substances produced by the subarachnoid blood clots, changes in vascular responsiveness and inflammatory response of the vascular endothelium. to date, the current therapeutic interventions remain ineffective being limited to the manipulation os systemic blood pressure, variation of blood volume and viscosity, and control of arterial carbon dioxide tension. In this scenario, the hormone erythropoietin (EPO), has been found to exert neuroprotective action during experimental SAH when its recombinant form (rHuEPO) is systematically administered. However, recent translation of experimental data into clinical trials has suggested an unclear role of recombinant human EPO in the setting of SAH. In this context, the aim of the recurrent review is to present current evidence on the potential role of EPO in cerebrovascular dysfunction following aneurysmal subarachnoid hemorrage