Resection and resolution of bone marrow lesions associated with an improvement of pain after total knee replacement: a novel case study using a 3-Tesla metal artefact reduction MRI sequence

We present our case report using a novel metal artefact reduction magnetic resonance imaging (MRI) sequence to observe resolution of subchondral bone marrow lesions (BMLs), which are strongly associated with pain, in a patient after total knee replacement surgery. Large BMLs were seen preoperatively on the 3-Tesla MRI scans in a patient with severe end stage OA awaiting total knee replacement surgery. Twelve months after surgery, using a novel metal artefact reduction MRI sequence, we were able to visualize the bone-prosthesis interface and found complete resection and resolution of these BMLs. This is the first reported study in the UK to use this metal artefact reduction MRI sequence at 3-Tesla showing that resection and resolution of BMLs in this patient were associated with an improvement of pain and function after total knee replacement surgery. In this case it was associated with a clinically significant improvement of pain and function after surgery. Failure to eradicate these lesions may be a cause of persistent postoperative pain that is seen in up to 20% of patients following TKR surgery

Results from the Advance Power Technology Experiment on the Starshine 3 Satellite

The Starshine 3 satellite was put into orbit on September 30, 2001 as part of the Kodiak Star mission. Starshine 3’s primary mission is to measure the atmospheric density of the thermosphere and serve as a learning outreach tool for primary and secondary school age children. Starshine 3 also carries a power technology experiment. Starshine 3 has a small, 1 Watt power system using state-of-the-art components. Eight small clusters of solar cells are distributed across the surface. Each cluster consists of a 6-cell string of 2 cm x 2 cm, GaInP/GaAs/Ge, triple-junction solar cells. These cells have twice the power-to-area ratio as traditional silicon solar cells and 25% more power than GaAs cells. Starshine 3 also carries novel integrated microelectronic power supplies (IMPS). The idea behind an IMPS unit is to allow greater flexibility in circuit design with a power source not tied to a central bus. Each IPS is used to provide 50 microwatts of continuous power throughout the mission. Early results show that this design can be used to provide continuous power under very adverse operating conditions

Diagnostic accuracy of MRI for identifying posterior element bone stress injury in athletes with low back pain: a systematic review and narrative synthesis

Objective To investigate the diagnostic accuracy of MRI for identifying posterior element bone stress injury (PEBSI) in the athletic population with low back pain (LBP).Study Design A systematic review searched for published sources up until July 2020. Eligibility criteria: prospective cohort design, MRI diagnosis, adolescents/young adults, chief symptoms of LBP, PEBSI as the clinical diagnosis and SPECT-CT as reference standard. Risk of bias and overall quality were assessed using QUADAS-2 and GRADE, respectively. A narrative synthesis was conducted.Results Four studies were included, with three included in the quantitative synthesis. Compared with SPECT-CT, two studies involving MRI demonstrated sensitivity and specificity of 80% and 100%, and 88% and 97%, respectively. Compared with CT, one study involving MRI demonstrated sensitivity and specificity of 97% and 91%, respectively. Risk of bias was moderate to high although consistency across studies was noted.Conclusion Findings support further research to consider MRI as the modality of choice for diagnosing PEBSI. MRI was consistent with SPECT-CT for ruling-in PEBSI, but the clinical value of cases where MRI had false negatives remains uncertain due to possible over-sensitivity by SPECT-CT.PROSPERO registration number CRD42015023979

Options Studied for Managing Space Station Solar Array Electrical Hazards for Sequential Shunt Unit Replacement

The U.S. solar array strings on the International Space Station are connected to a sequential shunt unit (SSU). The job of the SSU is to shunt, or short, the excess current from the solar array, such that just enough current is provided downstream to maintain the 160-V bus voltage while meeting the power load demand and recharging the batteries. Should an SSU fail on-orbit, it would be removed and replaced with the on-orbit spare during an astronaut space walk or extravehicular activity (EVA) (see the photograph). However, removing an SSU during an orbit Sun period with input solar array power connectors fully energized could result in substantial hardware damage and/or safety risk to the EVA astronaut. The open-circuit voltage of cold solar-array strings can exceed 320 V, and warm solar-array strings could feed a short circuit with a total current level exceeding 240 A

Advance Power Technology Experiment for the Starshine 3 Satellite

The Starshine 3 satellite will carry several power technology demonstrations. Since Starshine 3 is primarily a passive experiment and does not need electrical power to successfully complete its mission, the requirement for a highly reliable power system is greatly reduced. This creates an excellent opportunity to test new power technologies. Several government and commercial interests have teamed up to provide Starshine 3 with a small power system using state-of-the-art components. Starshine 3 will also fly novel integrated microelectronic power supplies (IMPS) for evaluation

Feasibility of Large High-Powered Solar Electric Propulsion Vehicles: Issues and Solutions

Human exploration beyond low Earth orbit will require the use of enabling technologies that are efficient, affordable, and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as an option to achieve human exploration missions to near Earth objects (NEOs) because of its favorable mass efficiency as compared to traditional chemical systems. This paper describes the unique challenges and technology hurdles associated with developing a large high-power SEP vehicle. A subsystem level breakdown of factors contributing to the feasibility of SEP as a platform for future exploration missions to NEOs is presented including overall mission feasibility, trip time variables, propellant management issues, solar array power generation, array structure issues, and other areas that warrant investment in additional technology or engineering development

International Space Station Electric Power System Performance Code-SPACE

The System Power Analysis for Capability Evaluation (SPACE) software analyzes and predicts the minute-by-minute state of the International Space Station (ISS) electrical power system (EPS) for upcoming missions as well as EPS power generation capacity as a function of ISS configuration and orbital conditions. In order to complete the Certification of Flight Readiness (CoFR) process in which the mission is certified for flight each ISS System must thoroughly assess every proposed mission to verify that the system will support the planned mission operations; SPACE is the sole tool used to conduct these assessments for the power system capability. SPACE is an integrated power system model that incorporates a variety of modules tied together with integration routines and graphical output. The modules include orbit mechanics, solar array pointing/shadowing/thermal and electrical, battery performance, and power management and distribution performance. These modules are tightly integrated within a flexible architecture featuring data-file-driven configurations, source- or load-driven operation, and event scripting. SPACE also predicts the amount of power available for a given system configuration, spacecraft orientation, solar-array-pointing conditions, orbit, and the like. In the source-driven mode, the model must assure that energy balance is achieved, meaning that energy removed from the batteries must be restored (or balanced) each and every orbit. This entails an optimization scheme to ensure that energy balance is maintained without violating any other constraints

Concept Design of High Power Solar Electric Propulsion Vehicles for Human Exploration

Human exploration beyond low Earth orbit will require enabling capabilities that are efficient, affordable and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as one option to achieve human exploration missions beyond Earth orbit because of its favorable mass efficiency compared to traditional chemical propulsion systems. This paper describes the unique challenges associated with developing a large-scale high-power (300-kWe class) SEP vehicle and design concepts that have potential to meet those challenges. An assessment of factors at the subsystem level that must be considered in developing an SEP vehicle for future exploration missions is presented. Overall concepts, design tradeoffs and pathways to achieve development readiness are discussed

Thin film solar cell inflatable ultraviolet rigidizable deployment hinge

A flexible inflatable hinge includes curable resin for rigidly positioning panels of solar cells about the hinge in which wrap around contacts and flex circuits are disposed for routing power from the solar cells to the power bus further used for grounding the hinge. An indium tin oxide and magnesium fluoride coating is used to prevent static discharge while being transparent to ultraviolet light that cures the embedded resin after deployment for rigidizing the inflatable hinge

Finance and Climate Change: A Progressive Green Finance Strategy for the UK

The rapid decarbonization of the UK economy requires a wider range of policies, from fiscal interventions to a green industrial strategy, a green plan for a National Investment Bank and environmental regulations that will restrict carbon-intensive consumption. These policies need to be accompanied by a rapid transformation of the UK financial system. The UK’s official Green Finance Strategy, published by the Conservative government in July 2019, does not go far enough. It offers a market-led, too much carrot, too little stick, deregulated decarbonisation approach. Yet an ambitious transition to low-carbon will not take place via the market because of a series of market failures that include incompatible time horizons between private finance and climate crisis, incomplete capital markets, corporate market power, and subjective private classifications of green assets. To climate-align private finance, we offer a set of recommendations that aim to (i) establish a robust institutional framework, (ii) green Bank of England/commercial banking and (iii) green shadowbanking/market-based finance (see Figure 1). Recommendation I: Develop a Green Public Taxonomy. An ambitious green finance agenda needs a clear description of what counts as green and what does not. The increasingly popular Environmental, Social and Governance (ESG) private sector approaches suffer from significant shortcomings that open the door to greenwashing. Instead, we suggest a public taxonomy, developed by a UK Technical Expert Group and building on the European Commission’s taxonomy, that identifies economic activities with different degrees of greenness and brownness. The analysis of climate-related financial risks and climate stress-tests should continue in parallel with the development of the Taxonomy. Recommendation II: Make firms disclose the climate impact and risks of their activities. There are two types of information that should be disclosed. First, the degree of greenness and brownness of the financial assets held by financial and non financial corporations should be disclosed based on the Green Public Taxonomy. Second, it is important that disclosure extends to the transition and physical climate risks facing institutions. These risks could be disclosed based on methodologies that are being developed by TCFD and NGFS. Recommendation III: Set up the Green Finance TaskForce (GFAT). Working towards a path of net-zero emissions by 2030 is a challenging task. Green finance policies should be coordinated with other climate policies (green fiscal, industrial) such that the reduction of emissions will be maximised and the economic disruptions caused by decarbonisation will be minimal. The Green Finance Task Force will closely monitor progress in greening private finance, take actions to tackle transition risks and respond dynamically to obstacles that stand in the way of reorienting private finance towards green activities