Sunny

[Verse 1]Here you come a running back in to my me’ry’s eye, Little playmate once my gaymate in a day gone by.Ragged dresses, tangled tresses flying over the hill,Heaven bless us!You’ve no less a share of Jack than Jill. You funny little will-o-wispy,Sassy little lispy, That describes her to a T. She is full of fun, he Sunny. Named the lady perfectly, She is bright and sunny. Never comb your hair Sunny!Leave the breeze there Sunny! Let your stocking fall down, For shocking the town is all that you do.Smiling all the while,Tomboy, where’d you get your smile from boy?Little sunny girl, Be my honey girl, I’m for you

Ranking local climate policy: assessing the mitigation and adaptation activities of 104 German cities

Climate mitigation and climate adaptation are crucial tasks for urban areas and can involve synergies as well as trade-offs. However, few studies have examined how mitigation and adaptation efforts relate to each other in a large number of differently sized cities, and therefore we know little about whether forerunners in mitigation are also leading in adaptation or if cities tend to focus on just one policy field. This article develops an internationally applicable approach to rank cities on climate policy that incorporates multiple indicators related to (1) local commitments on mitigation and adaptation, (2) urban mitigation and adaptation plans and (3) climate adaptation and mitigation ambitions. We apply this method to rank 104 differently sized German cities and identify six clusters: climate policy leaders, climate adaptation leaders, climate mitigation leaders, climate policy followers, climate policy latecomers and climate policy laggards. The article seeks explanations for particular cities’ positions and shows that coping with climate change in a balanced way on a high level depends on structural factors, in particular city size, the pathways of local climate policies since the 1990s and funding programmes for both climate mitigation and adaptation

Gasping in Response to Basic Resuscitation Efforts: Observation in a Swine Model of Cardiac Arrest

Objective. To analyze the effect of basic resuscitation efforts on gasping and of gasping on survival. Methods. This is secondary analysis of a previously reported study comparing continuous chest compressions (CCC CPR) versus chest compressions plus ventilation (30:2 CPR) on survival. 64 swine were randomized to 1 of these 2 basic CPR approaches after either short (3 or 4 minutes) or long (5 or 6 minutes) durations of untreated VF. At 12 minutes of VF, all received the same Guidelines 2005 Advanced Cardiac Life Support. Neurologically status was evaluated at 24 hours. A score of 1 is normal, 2 is abnormal, such as not eating or drinking normally, unsteady gait, or slight resistance to restraint, 3 severely abnormal, where the animal is recumbent and unable to stand, 4 is comatose, and 5 is dead. For this analysis a neurological outcome score of 1 or 2 was classified as “good”, and a score of 3, 4, or 5 was classified as “poor.” Results. Gasping was more likely to continue or if absent, to resume in the animals with short durations of untreated VF before basic resuscitation efforts. With long durations of untreated VF, the frequency of gasping and survival was better in swine receiving CCC CPR. In the absence of frequent gasping, intact survival was rare in the long duration of untreated VF group. Conclusions. Gasping is an important phenomenon during basic resuscitation efforts for VF arrest and in this model was more frequent with CCC-CPR

ADAMTS9, a member of the ADAMTS family, in Xenopus development

Extracellular matrix (ECM) remodeling by metalloproteinases is crucial during development. The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin type I motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling. The human family includes 19 members. In this study we identified the 19 members of the ADAMTS family in Xenopus laevis and Xenopus tropicalis. Gene identification and a phylogenetic study revealed strong conservation of the ADAMTS family and contributed to a better annotation of the Xenopus genomes. Expression of the entire ADAMTS family was studied from early stages to tadpole stages of Xenopus, and detailed analysis of ADAMTS9 revealed expression in many structures during organogenesis such as neural crest (NC) derivative tissues, the pronephros and the pancreas. Versican, a matrix component substrate of ADAMTS9 shows a similar expression pattern suggesting a role of ADAMTS9 in the remodeling of the ECM in these structures by degradation of versican

Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites

Di-(2-ethylhexyl)-phthalate (DEHP), an ubiquitous environmental contaminant, has been shown to cause adverse effects on glucose homeostasis and insulin sensitivity in epidemiological studies, but the underlying mechanisms are still unknown. We therefore tested the hypothesis that chronic DEHP exposure causes impaired insulin sensitivity, affects body weight, adipose tissue (AT) function and circulating metabolic parameters of obesity resistant 129S6 mice in vivo. An obesity-resistant mouse model was chosen to reduce a potential obesity bias of DEHP effects on metabolic parameters and AT function. The metabolic effects of 10-weeks exposure to DEHP were tested by insulin tolerance tests and quantitative assessment of 183 metabolites in mice. Furthermore, 3T3-L1 cells were cultured with DEHP for two days, differentiated into mature adipocytes in which the effects on insulin stimulated glucose and palmitate uptake, lipid content as well as on mRNA/protein expression of key adipocyte genes were investigated.We observed in female mice that DEHP treatment causes enhanced weight gain, fat mass, impaired insulin tolerance, changes in circulating adiponectin and adipose tissue Pparg, adiponectin and estrogen expression. Serum metabolomics indicated a general increase in phospholipid and carnitine concentrations. In vitro, DEHP treatment increases the proliferation rate and alters glucose uptake in adipocytes. Taken together, DEHP has significant effects on adipose tissue (AT) function and alters specific serum metabolites. Although, DEHP treatment led to significantly impaired insulin tolerance, it did not affect glucose tolerance, HOMA-IR, fasting glucose, insulin or triglyceride serum concentrations. This may suggest that DEHP treatment does not cause impaired glucose metabolism at the whole body level

Narrado por un mito: Felix Krull, de Thomas Mann

This article proposes an approach to the novel Bekenntnisse des Hochstaplers Felix Krull by Thomas Mann from the point of view of the imaginal psychology of James Hillman. From this perspective the novel seems to illustrate the most innovative thesis of that psychology, which is especially relevant for having been written prior to the formulation of Hillman’s theories. The unplanned correspondence between both ways of thinking furnishes a valuable argument that supports the new conception of human psyche introduced by Carl Gustav Jung and developed in this way by James Hillman.El presente artículo propone una lectura de la novela de Thomas Mann desde la óptica de la psicología imaginal de James Hillman. En esta perspectiva la novela parece ofrecer una ilustración de las tesis más innovadoras de dicha psicología, lo que resulta especialmente relevante por haber sido escrita con antelación a la formulación de las teorías del pensador estadounidense. La impremeditada correspondencia entre ambos pensamientos suministra un argumento digno de tenerse en cuenta a favor de la innovadora concepción de la psique humana inaugurada por Carl Gustav Jung y desarrollada en esta línea por James Hillman

Instrumente und Maßnahmen der kommunalen Klimaanpassung: Empirische Befunde für einen erfolgreichen Transfer

Der vorliegende Bericht untersucht Lern- und Transferprozesse zwischen sowie innerhalb von Städten sowie das Transferpotenzial konkreter Wissenstransfer-Medien, Instrumente und Maßnahmen. Damit wird das Ziel verfolgt, ein besseres Verständnis dieser Prozesse zu entwickeln und einen Beitrag zur Verbesserung des Transfers von kommunalen Klimaanpassungsaktivitäten zu leisten. Er baut dabei auf einer vorangegangenen Analyse des Forschungsstands zum Transfer von Policies durch Haupt et al. (2021) auf und versucht, den bereits generierten Wissensstand auf der Ebene von Policies nun um die Ebene konkreter Instrumente und Maßnahmen zu ergänzen sowie durch empirische Befunde zu ausgewählten Maßnahmen zu untermauern. Die Wissens- und Datengrundlage dieses Berichts umfasst einen Mix aus verschiedenen (Online)-Befragungen und Interviews mit Vertreter:innen relevanter Akteursgruppen, vor allem Vertreter:innen von Stadtverwaltungen, sowie den Erfahrungswerten der drei Projekt-Fallstudienstädte Potsdam, Remscheid und Würzburg

Urbane Resilienz gegenüber extremen Wetterereignissen: Gemeinsamer Verbundabschlussbericht des Forschungsprojektes ExTrass

Das Projekt ExTrass hatte zwei Ziele: Das erste Ziel war es, Klimaresilienz in den drei Fallstudienstädten Potsdam, Remscheid und Würzburg messbar zu stärken. Das zweite Ziel war es, Transferpotenziale zwischen Groß- und Mittelstädten in Deutschland zu identifizieren und besser nutzbar zu machen, sodass die Wirkung von Pilotvorhaben über die direkt involvierten Städte hinausgehen kann. Dies sollte in enger Zusammenarbeit mit den Stadtverwaltungen sowie zivilgesellschaftlichen Akteur:innen des Katastrophenschutzes erfolgen. Dabei standen folgende Leitfragen im Fokus: • Wie verbreitet sind Klimaanpassungsaktivitäten in Großstädten und größeren kreisfreien Mittelstädten in Deutschland? • Welche hemmenden und begünstigenden Faktoren beeinflussen die Klimaanpassung? • Welche Maßnahmen der Klimaanpassung werden tatsächlich umgesetzt, und wie kann die Umsetzung verbessert werden? Was behindert? • Inwiefern lassen sich Beispiele guter Praxis auf andere Städte übertragen, adaptieren oder weiterentwickeln

Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome

Chromosome 22q11.2 deletion syndrome (22q11DS) is the most common microdeletion syndrome in humans. It is typified by highly variable symptoms, which might be explained by epigenetic regulation of genes in the interval. Using computational algorithms, our laboratory previously predicted that DiGeorge critical region 6 (DGCR6), which lies within the deletion interval, is imprinted in humans. Expression and epigenetic regulation of this gene have not, however, been examined in 22q11DS subjects. The purpose of this study was to determine if the expression levels of DGCR6 and its duplicate copy DGCR6L in 22q11DS subjects are associated with the parent-of-origin of the deletion and childhood psychopathologies. Our investigation showed no evidence of parent-of-origin-related differences in expression of both DGCR6 and DGCR6L. However, we found that the variability in DGCR6 expression was significantly greater in 22q11DS children than in age and gender-matched control individuals. Children with 22q11DS who had anxiety disorders had significantly lower DGCR6 expression, especially in subjects with the deletion on the maternal chromosome, despite the lack of imprinting. Our findings indicate that epigenetic mechanisms other than imprinting contribute to the dysregulation of these genes and the associated childhood psychopathologies observed in individuals with 22q11DS. Further studies are now needed to test the usefulness of DGCR6 and DGCR6L expression and alterations in the epigenome at these loci in predicting childhood anxiety and associated adult-onset pathologies in 22q11DS subjects