Perceiving concealment in relationships between parents and adolescents: links with parental behavior

Item does not contain fulltextAlthough concealment in relationships is commonplace, little is known about its implications for the target of concealment. Two large-scale studies among adolescents and their parents tested the central hypothesis that parents' perception of child concealment predicts poorer parenting behaviors toward their child. Further, we investigated whether actual child concealment adds to the prediction of parenting behaviors through an interaction with parental perception of concealment. Study 1 yielded evidence for the hypothesized link, which was independent of actual concealment. Study 2 largely replicated these results for perceptions of both concealment and lying while controlling for perceptions of disclosure. Overall, these results suggest that parents' perception of child concealment coincides with poorer parenting behaviors, regardless of actual child concealment.20 p

Examining the Diagnostic Yield of Tumour Testing and Qualifying Germline Concordance for Hereditary Cancer Variants in Patients with High-Grade Serous Carcinoma

Despite advances in treatment, prognosis for most patients with high-grade serous carcinoma (HGSC) remains poor. Genomic alterations in the homologous recombination (HR) pathway are used for cancer risk assessment and render tumours sensitive to platinum-based chemotherapy and poly (ADP-ribose) polymerase inhibitors (PARPi), which can be associated with more favourable outcomes. In addition to patients with tumours containing BRCA1 or BRCA2 pathologic variants, there is emerging evidence that patients with tumours harbouring pathologic variants in other HR genes may also benefit from PARPi therapy. The objective of this study is to assess the feasibility of primary-tumour testing by examining the concordance of variant detection between germline and tumour-variant status using a custom hereditary cancer gene panel (HCP). From April 2019 to November 2020, HCP variant testing was performed on 146 HGSC formalin-fixed, paraffin-embedded tissue samples using next-generation sequencing. Of those, 78 patients also underwent HCP germline testing using blood samples. A pathogenic variant was detected in 41.1% (60/146) of tumours tested, with 68.3% (41/60) having either a BRCA1 or BRCA2 variant (n = 36), or BRCA1/2 plus a second variant (n = 5), and 31.2% (19/60) carrying a pathogenic variant in another HCP gene. The overall variant rate among the paired germline and tumour samples was 43.6% (34/78), with the remaining 56% (44/78) having no pathogenic variant detected in the germline or tumour. The overall BRCA1/2 variant rate for paired samples was 33.3% (26/78), with germline variants detected in 11.5% (9/78). A non-BRCA1/2 germline variant in another HCP gene was detected in 9.0% (7/78). All germline variants were detected in the tumour, demonstrating 100% concordance. These data provide evidence supporting the feasibility of primary-tumour testing for detecting germline and somatic variants in HCP genes in patients with HGSC, which can be used to guide clinical decision-making, and may provide opportunity for improving patient triage and clinical genetic referral practices

Resident Gut Microbiota Mediates Exercise Capacity and Tissue Metabolomes in Mice

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Design of the muscles in motion study: a randomized controlled trial to evaluate the efficacy and feasibility of an individually tailored home-based exercise training program for children and adolescents with juvenile dermatomyositis

BACKGROUND: Juvenile dermatomyositis (JDM) is a rare, often chronic, systemic autoimmune disease of childhood, characterized by inflammation of the microvasculature of the skeletal muscle and skin. Prominent clinical features include significant exercise intolerance, muscle weakness, and fatigue. Despite pharmacological improvements, these clinical features continue to affect patients with JDM, even when the disease is in remission. Exercise training is increasingly utilized as a non-pharmacological intervention in the clinical management of (adult) patients with chronic inflammatory conditions; however no randomized controlled trials (RCT) have been performed in JDM. In the current study, the efficacy and feasibility of an exercise training program in patients with JDM will be examined. METHODS/DESIGN: Subjects (n = 30) will include 8–18 year olds diagnosed with JDM. The intervention consists of an individually tailored 12-weeks home-based exercise training program in which interval training on a treadmill is alternated with strength training during each session. The program is based on previous literature and designed with a defined frequency, intensity, time, and type of exercise (FITT principles). Primary outcome measures include aerobic exercise capacity, isometric muscle strength, and perception of fatigue. The study methodology has been conceived according to the standards of the CONSORT guidelines. The current study will be a multi-center (4 Dutch University Medical Centers) RCT, with the control group also entering the training arm directly after completion of the initial protocol. Randomization is stratified according to age and gender. DISCUSSION: The current study will provide evidence on the efficacy and feasibility of an individually tailored 12-week home-based exercise training program in youth with JDM. TRIAL REGISTRATION: Medical Ethics Committee of the University Medical Center Utrecht, the Netherlands: 11–336; Netherlands Trial Register (NTR): NTR 3184

On the Maxwell-Stefan approach to multicomponent diffusion

We consider the system of Maxwell-Stefan equations which describe multicomponent diffusive fluxes in non-dilute solutions or gas mixtures. We apply the Perron-Frobenius theorem to the irreducible and quasi-positive matrix which governs the flux-force relations and are able to show normal ellipticity of the associated multicomponent diffusion operator. This provides local-in-time wellposedness of the Maxwell-Stefan multicomponent diffusion system in the isobaric, isothermal case.Comment: Based on a talk given at the Conference on Nonlinear Parabolic Problems in Bedlewo, Mai 200

Performance Benefits of Pre- and Per-cooling on Self-paced Versus Constant Workload Exercise:A Systematic Review and Meta-analysis

BACKGROUND AND OBJECTIVE: Exercise in hot environments impairs endurance performance. Cooling interventions can attenuate the impact of heat stress on performance, but the influence of an exercise protocol on the magnitude of performance benefit remains unknown. This meta-analytical review compared the effects of pre- and per-cooling interventions on performance during self-paced and constant workload exercise in the heat.METHODS: The study protocol was preregistered at the Open Science Framework ( https://osf.io/wqjb3 ). A systematic literature search was performed in PubMed, Web of Science, and MEDLINE from inception to 9 June, 2023. We included studies that examined the effects of pre- or per-cooling on exercise performance in male individuals under heat stress (&gt; 30 °C) during self-paced or constant workload exercise in cross-over design studies. Risk of bias was assessed using the Cochrane Risk of Bias Tool for randomized trials.RESULTS: Fifty-nine studies (n = 563 athletes) were identified from 3300 records, of which 40 (n = 370 athletes) used a self-paced protocol and 19 (n = 193 athletes) used a constant workload protocol. Eighteen studies compared multiple cooling interventions and were included more than once (total n = 86 experiments and n = 832 paired measurements). Sixty-seven experiments used a pre-cooling intervention and 19 used a per-cooling intervention. Average ambient conditions were 34.0 °C [32.3-35.0 °C] and 50.0% [40.0-55.3%] relative humidity. Cooling interventions attenuated the performance decline in hot conditions and were more effective during a constant workload (effect size [ES] = 0.62, 95% confidence interval [CI] 0.44-0.81) compared with self-paced exercise (ES = 0.30, 95% CI 0.18-0.42, p = 0.004). A difference in performance outcomes between protocols was only observed with pre-cooling (ES = 0.74, 95% CI 0.50-0.98 vs ES = 0.29, 95% CI 0.17-0.42, p = 0.001), but not per-cooling (ES = 0.45, 95% CI 0.16-0.74 vs ES = 0.35, 95% CI 0.01-0.70, p = 0.68).CONCLUSIONS: Cooling interventions attenuated the decline in performance during exercise in the heat, but the magnitude of the effect is dependent on exercise protocol (self-paced vs constant workload) and cooling type (pre- vs per-cooling). Pre-cooling appears to be more effective in attenuating the decline in exercise performance during a constant workload compared with self-paced exercise protocols, whereas no differences were found in the effectiveness of per-cooling.</p

Принципи реалізму і теорії націоналізму

Статтю присвячено порівняльному аналізові теорій націоналізму й теорії політичного реалізму. Здійснена спроба синтезу цих двох теоретичних формацій з метою вдосконалення пізнавального апарату політології міжнародних відносин. На підставі базових положень реалізму, розглянуто роль націоналізму, як глобальної соціальної сили в світовій політиці, а також реалістські теоретичні інтерпретації цієї сили. Особливу увагу надано витлумаченню націоналізму як фактору міжнародних конфліктів та наслідкам для систем міжнародних відносин національних державотворчих процесів.Статья посвящена сравнительному анализу теорий национализма и теории политического реализма. С целью усовершенствования познавательного аппарата политологии международных отношений, осуществлена попытка синтеза этих двух теоретических систем. На основании базовых положений реализма рассмотрена роль национализма в мировой политике, а также реалистские интерпретации этой определяющей силы современности. Особое внимание уделено интерпретации роли национализма в международных конфликтах и последствиям для международных систем процессов образования новых государств.The article deals with comparative analysis of the theories of nationalism and theory of political realism. This study aimed at methodological synthesis of these two groups of theories in order to improve a cognitive potential of political science in the sphere of its application to international relations. The role of nationalism as a global social factor and interpretation of this factor by realism is regarded. The special research attention is paid to the ways modern international conflicts and state1building processes are inspired by nationalism