503 research outputs found
The Development of a Universally Accepted Sacral Fracture Classification: A Survey of AOSpine and AOTrauma Members.
Study Design Survey study. Objective To determine the global perspective on controversial aspects of sacral fracture classifications. Methods While developing the AOSpine Sacral Injury Classification System, a survey was sent to all members of AOSpine and AOTrauma. The survey asked four yes-or-no questions to help determine the best way to handle controversial aspects of sacral fractures in future classifications. Chi-square tests were initially used to compare surgeons\u27 answers to the four key questions of the survey, and then the data was modeled through multivariable logistic regression analysis. Results A total of 474 surgeons answered all questions in the survey. Overall 86.9% of respondents felt that the proposed hierarchical nature of injuries was appropriate, and 77.8% of respondents agreed that that the risk of neurologic injury is highest in a vertical fracture through the foramen. Almost 80% of respondents felt that the separation of injuries based on the integrity of L5-S1 facet was appropriate, and 83.8% of surgeons agreed that a nondisplaced sacral U fracture is a clinically relevant entity. Conclusion This study determines the global perspective on controversial areas in the injury patterns of sacral fractures and demonstrates that the development of a comprehensive and universally accepted sacral classification is possible
Like-charge attraction through hydrodynamic interaction
We demonstrate that the attractive interaction measured between like-charged
colloidal spheres near a wall can be accounted for by a nonequilibrium
hydrodynamic effect. We present both analytical results and Brownian dynamics
simulations which quantitatively capture the one-wall experiments of Larsen and
Grier (Nature 385, p. 230, 1997).Comment: 10 pages, 4 figure
Optimally adapted multi-state neural networks trained with noise
The principle of adaptation in a noisy retrieval environment is extended here
to a diluted attractor neural network of Q-state neurons trained with noisy
data. The network is adapted to an appropriate noisy training overlap and
training activity which are determined self-consistently by the optimized
retrieval attractor overlap and activity. The optimized storage capacity and
the corresponding retriever overlap are considerably enhanced by an adequate
threshold in the states. Explicit results for improved optimal performance and
new retriever phase diagrams are obtained for Q=3 and Q=4, with coexisting
phases over a wide range of thresholds. Most of the interesting results are
stable to replica-symmetry-breaking fluctuations.Comment: 22 pages, 5 figures, accepted for publication in PR
Sacral Fractures and Associated Injuries.
STUDY DESIGN: Literature review.
OBJECTIVE: The aim of this review is to describe the injuries associated with sacral fractures and to analyze their impact on patient outcome.
METHODS: A comprehensive narrative review of the literature was performed to identify the injuries associated with sacral fractures.
RESULTS: Sacral fractures are uncommon injuries that result from high-energy trauma, and that, due to their rarity, are frequently underdiagnosed and mistreated. Only 5% of sacral fractures occur in isolation. Injuries most often associated with sacral fractures include neurologic injuries (present in up to 50% of sacral fractures), pelvic ring disruptions, hip and lumbar spine fractures, active pelvic/ abdominal bleeding and the presence of an open fracture or significant soft tissue injury. Diagnosis of pelvic ring fractures and fractures extending to the lumbar spine are key factors for the appropriate management of sacral fractures. Importantly, associated systemic (cranial, thoracic, and abdominopelvic) or musculoskeletal injuries should be promptly assessed and addressed. These associated injuries often dictate the management and eventual outcome of sacral fractures and, therefore, any treatment algorithm should take them into consideration.
CONCLUSIONS: Sacral fractures are complex in nature and often associated with other often-missed injuries. This review summarizes the most relevant associated injuries in sacral fractures and discusses on their appropriate management
Fortnightly Fluctuations in the O-C Diagram of CS 1246
Dominated by a single, large-amplitude pulsation mode, the rapidly-pulsating
hot subdwarf B star CS 1246 is a prime candidate for a long-term O-C diagram
study. We collected nearly 400 hours of photometry with the PROMPT telescopes
over a time span of 14 months to begin looking for secular variations in the
pulse timings. Interestingly, the O-C diagram is dominated by a strong
sinusoidal pattern with a period of 14.1 days and an amplitude of 10.7
light-seconds. Underneath this sine wave is a secular trend implying a decrease
in the 371.7-s pulsational period of Pdot = -1.9 x 10^-11, which we attribute
to the evolution of the star through the H-R diagram. The sinusoidal variation
could be produced by the presence of a low-mass companion, with m sin i ~ 0.12
Msun, orbiting the subdwarf B star at a distance of 20 Rsun. An analysis of the
combined light curve reveals the presence of a low-amplitude first harmonic to
the main pulsation mode.Comment: Accepted for publication in MNRAS. 11 pages, 8 figures, 5 table
A canonical ensemble approach to graded-response perceptrons
Perceptrons with graded input-output relations and a limited output precision
are studied within the Gardner-Derrida canonical ensemble approach. Soft non-
negative error measures are introduced allowing for extended retrieval
properties. In particular, the performance of these systems for a linear and
quadratic error measure, corresponding to the perceptron respectively the
adaline learning algorithm, is compared with the performance for a rigid error
measure, simply counting the number of errors. Replica-symmetry-breaking
effects are evaluated.Comment: 26 pages, 10 ps figure
Strong Attraction between Charged Spheres due to Metastable Ionized States
We report a mechanism which can lead to long range attractions between
like-charged spherical macroions, stemming from the existence of metastable
ionized states. We show that the ground state of a single highly charged
colloid plus a few excess counterions is overcharged. For the case of two
highly charged macroions in their neutralizing divalent counterion solution we
demonstrate that, in the regime of strong Coulomb coupling, the counterion
clouds are very likely to be unevenly distributed, leading to one overcharged
and one undercharged macroion. This long-living metastable configuration in
turn leads to a long range Coulomb attraction.Comment: REVTEX-published versio
Optimality of mutation and selection in germinal centers
The population dynamics theory of B cells in a typical germinal center could
play an important role in revealing how affinity maturation is achieved.
However, the existing models encountered some conflicts with experiments. To
resolve these conflicts, we present a coarse-grained model to calculate the B
cell population development in affinity maturation, which allows a
comprehensive analysis of its parameter space to look for optimal values of
mutation rate, selection strength, and initial antibody-antigen binding level
that maximize the affinity improvement. With these optimized parameters, the
model is compatible with the experimental observations such as the ~100-fold
affinity improvements, the number of mutations, the hypermutation rate, and the
"all or none" phenomenon. Moreover, we study the reasons behind the optimal
parameters. The optimal mutation rate, in agreement with the hypermutation rate
in vivo, results from a tradeoff between accumulating enough beneficial
mutations and avoiding too many deleterious or lethal mutations. The optimal
selection strength evolves as a balance between the need for affinity
improvement and the requirement to pass the population bottleneck. These
findings point to the conclusion that germinal centers have been optimized by
evolution to generate strong affinity antibodies effectively and rapidly. In
addition, we study the enhancement of affinity improvement due to B cell
migration between germinal centers. These results could enhance our
understandings to the functions of germinal centers.Comment: 5 figures in main text, and 4 figures in Supplementary Informatio
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