The use of basic fibroblast growth factor to improve vocal function: A systematic review and meta-analysis

OBJECTIVES: This systematic review and meta-analysis examines if intralaryngeal injection of basic fibroblast growth factor 2 (FGF2) can improve voice outcomes in those with vocal disability. DESIGN: A Systematic review of original human studies reporting voice outcomes following intra-laryngeal injection of basic fibroblast growth factor 2 in those with vocal dysfunction. Databases searched were Medline (1946-July 2022), Embase (1947-July 2022), Cochrane database and Google Scholar. SETTING: Secondary or tertiary care centres that undertook the management of voice pathology Hospital. PARTICIPANTS: Inclusion criteria were original human studies reporting voice outcome measurements following intralaryngeal injection of FGF2 to treat vocal fold atrophy, vocal fold scarring, vocal fold sulcus or vocal fold palsy. Articles not written in English, studies that did not include human subjects and studies where voice outcome measures were not recorded before and after FGF2 injection were excluded from the review. MAIN OUTCOME MEASURES: The primary outcome measure was maximum phonation time. Secondary outcome measures included acoustic analysis, glottic closure, mucosal wave formation, voice handicap index and GRBAS scale. RESULTS: Fourteen articles were included out of a search of 1023 and one article was included from scanning reference lists. All studies had a single arm design without control groups. Conditions treated were vocal fold atrophy (n = 186), vocal cord paralysis (n = 74), vocal fold fibrosis (n = 74) and vocal fold sulcus (n = 56). A meta-analysis of six articles reporting on the use of FGF2 in patients with vocal fold atrophy showed a significant increase of mean maximum phonation time of 5.2 s (95% CI: 3.4-7.0) at 3-6 months following injection. A significant improvement in maximum phonation time, voice handicap index and glottic closure was found following injection in most studies assessed. No major adverse events were reported following injection. CONCLUSIONS: To date, intralaryngeal injection of basic FGF2 appears to be safe and it may be able to improve voice outcomes in those with vocal dysfunction, especially vocal fold atrophy. Randomised controlled trials are needed to further evaluate efficacy and support the wider use of this therapy

Bayesian modeling of pilot belief and visual misperception in helicopter overland navigation

This paper aims to provide a framework to model human belief and misperception in helicopter overland navigation. Helicopter overland navigation is known to be a challenging cognitive task, and understanding the cognitive processes associated with it is non-trivial. Twelve military personnel participated in the study and statistical analysis showed that their gaze parameters can be predicted by their level of expertise. Some pilots showed common visual misperception during the navigation task, which can be explained by the following errors: 1) confusion between inference and evidence, 2) incorrect mutually exclusive assumptions on the data, and 3) biased sampling. Simulation results on two cases observed in the experiments are given. Quantitative differences in dynamic perceptions between a Bayesian agent and misperceiving humans are presented with the suggested modeling framework

Hierarchical and nonhierarchical features of the mouse visual cortical network

Neocortical computations underlying vision are performed by a distributed network of functionally specialized areas. Mouse visual cortex, a dense interareal network that exhibits hierarchical properties, comprises subnetworks interconnecting distinct processing streams. To determine the layout of the mouse visual hierarchy, we have evaluated the laminar patterns formed by interareal axonal projections originating in each of ten areas. Reciprocally connected pairs of areas exhibit feedforward/feedback relationships consistent with a hierarchical organization. Beta regression analyses, which estimate a continuous hierarchical distance measure, indicate that the network comprises multiple nonhierarchical circuits embedded in a hierarchical organization of overlapping levels. Single-unit recordings in anaesthetized mice show that receptive field sizes are generally consistent with the hierarchy, with the ventral stream exhibiting a stricter hierarchy than the dorsal stream. Together, the results provide an anatomical metric for hierarchical distance, and reveal both hierarchical and nonhierarchical motifs in mouse visual cortex

Designing and Evaluating Presentation Strategies for Fact-Checked Content

With the rapid growth of online misinformation, it is crucial to have reliable fact-checking methods. Recent research on finding check-worthy claims and automated fact-checking have made significant advancements. However, limited guidance exists regarding the presentation of fact-checked content to effectively convey verified information to users. We address this research gap by exploring the critical design elements in fact-checking reports and investigating whether credibility and presentation-based design improvements can enhance users' ability to interpret the report accurately. We co-developed potential content presentation strategies through a workshop involving fact-checking professionals, communication experts, and researchers. The workshop examined the significance and utility of elements such as veracity indicators and explored the feasibility of incorporating interactive components for enhanced information disclosure. Building on the workshop outcomes, we conducted an online experiment involving 76 crowd workers to assess the efficacy of different design strategies. The results indicate that proposed strategies significantly improve users' ability to accurately interpret the verdict of fact-checking articles. Our findings underscore the critical role of effective presentation of fact reports in addressing the spread of misinformation. By adopting appropriate design enhancements, the effectiveness of fact-checking reports can be maximized, enabling users to make informed judgments.Comment: Accepted to the 32nd ACM International Conference on Information and Knowledge Management (CIKM '23

Modeling Planetary System Formation with N-Body Simulations: Role of Gas Disk and Statistics Comparing to Observations

During the late stage of planet formation when Mars-size cores appear, interactions among planetary cores can excite their orbital eccentricities, speed their merges and thus sculpture the final architecture of planet systems. This series of work contributes to the final assembling of planet systems with N-body simulations, including the type I and II migration of planets, gas accretion of massive cores in a viscous disk. In this paper, the standard formulations of type I and II migrations are adopted to investigate the formation of planet systems around solar mass stars. Statistics on the final distributions of planetary masses, semi-major axes and eccentricities are derived, which are comparable to those of the observed systems. Our simulations predict some orbital signatures of planet systems around solar mass stars: 36% of the survival planets are giant planets (Mp>10Me). Most of the massive giant planets (Mp>30Me) locate at 1-10AU. Terrestrial planets distribute more or less evenly at <1-2 AU. Planets in inner orbits (<1 AU) may accumulate at the inner edges of either the protostellar disk (3-5 days) or its MRI dead zone (30-50 days). There is a planet desert in the mass-eccecntricity diagram, i.e., lack of planets with masses 0.005 - 0.08 MJ in highly eccentric orbits (e > 0.3 - 0.4). The average eccentricity (~ 0.15) of the giant planets (Mp>10Me) are bigger than that (~ 0.05) of the terrestrial planets (Mp< 10Me). A planet system with more planets tends to have smaller planet masses and orbital eccentricities on average.Comment: receiveded by Ap

Mining Primary Care Electronic Health Records for Automatic Disease Phenotyping: A Transparent Machine Learning Framework

(1) Background: We aimed to develop a transparent machine-learning (ML) framework to automatically identify patients with a condition from electronic health records (EHRs) via a parsimonious set of features. (2) Methods: We linked multiple sources of EHRs, including 917,496,869 primary care records and 40,656,805 secondary care records and 694,954 records from specialist surgeries between 2002 and 2012, to generate a unique dataset. Then, we treated patient identification as a problem of text classification and proposed a transparent disease-phenotyping framework. This framework comprises a generation of patient representation, feature selection, and optimal phenotyping algorithm development to tackle the imbalanced nature of the data. This framework was extensively evaluated by identifying rheumatoid arthritis (RA) and ankylosing spondylitis (AS). (3) Results: Being applied to the linked dataset of 9657 patients with 1484 cases of rheumatoid arthritis (RA) and 204 cases of ankylosing spondylitis (AS), this framework achieved accuracy and positive predictive values of 86.19% and 88.46%, respectively, for RA and 99.23% and 97.75% for AS, comparable with expert knowledge-driven methods. (4) Conclusions: This framework could potentially be used as an efficient tool for identifying patients with a condition of interest from EHRs, helping clinicians in clinical decision-support process

Square-lattice s=1/2 XY model and the Jordan-Wigner fermions: The ground-state and thermodynamic properties

Using the 2D Jordan-Wigner transformation we reformulate the square-lattice s=1/2 XY (XZ) model in terms of noninteracting spinless fermions and examine the ground-state and thermodynamic properties of this spin system. We consider the model with two types of anisotropy: the spatial anisotropy interpolating between 2D and 1D lattices and the anisotropy of the exchange interaction interpolating between isotropic XY and Ising interactions. We compare the obtained (approximate) results with exact ones (1D limit, square-lattice Ising model) and other approximate ones (linear spin-wave theory and exact diagonalization data for finite lattices of up to N=36 sites supplemented by finite-size scaling). We discuss the ground-state and thermodynamic properties in dependence on the spatial and exchange interaction anisotropies. We pay special attention to the quantum phase transition driven by the exchange interaction anisotropy as well as to the appearance/disappearance of the zero-temperature magnetization in the quasi-1D limit.Comment: 28 pages, 7 figures include

Rapid, energy-efficient synthesis of the layered carbide, Al₄C₃

The phase-pure binary aluminium carbide, Al4C3 can be synthesised in vacuo from the elements in 30 minutes via microwave heating in a multimode cavity reactor. The success of the reaction is dependent on the use of finely divided aluminium and graphite starting materials, both of which couple effectively to the microwave field. The yellow-brown powder product was characterised by powder X-ray diffraction, scanning electron microscopy/energy dispersive X-ray spectroscopy thermogravimetric-differential thermal analysis and Raman spectroscopy. Powders were composed of hexagonal single crystallites tens of microns in diameter (rhombohedral space group R[3 with combining macron]m; Z = 3; a = 3.33813(5) Å, c = 25.0021(4) Å) and were stable to 1000 °C in air, argon and nitrogen. Equivalent microwave reactions of the elements in air led to the formation of the oxycarbide phases Al2OC and Al4O4C

Polymorphous low-grade adenocarcinoma of the tongue: a case report

<p>Abstract</p> <p>Introduction</p> <p>Polymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions. Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of 'terminal duct carcinoma'. Most patients present with an asymptomatic mass in the hard palate. In rare cases, the mass can also occur in the tongue. We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.</p> <p>Case presentation</p> <p>A 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa. There were no other associated complaints. The lesion was excised and subjected to histopathological examination that revealed an interesting and unusual morphology of polymorphous low-grade adenocarcinoma.</p> <p>Conclusion</p> <p>Polymorphous low-grade adenocarcinoma is a well-defined entity in the minor salivary glands. Its occurrence in the tongue is rare with very few cases reported in the literature. It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.</p

Papillary Thyroglossal Duct Cyst Carcinoma with Synchronous Occult Papillary Thyroid Microcarcinoma

This is a case report on papillary thyroglossal duct cyst (TGDC) carcinoma along with synchronous occult papillary thyroid microcarcinoma. A 46-year-old woman visited our hospital because she had an anterior midline neck mass below her hyoid bone. Preoperative ultrasound-guided fine-needle aspiration cytology revealed signs of papillary TGDC carcinoma. We performed a Sistrunk operation and a total thyroidectomy. Histopathological examination of the specimen revealed papillary carcinoma arising in the TGDC and papillary microcarcinoma of the thyroid gland without extrathyroidal extension. Surgeons should be aware of TGDC carcinoma during surgical planning and postoperative treatment and should differentiate this carcinoma from an anterior midline neck mass