Mapping 2007-08 Tuition And Fees In Higher Education

Using data sets from US News & World Report and the Association to Advance Collegiate Schools of Business, this paper isolates 10 factors that account for 90 percent of the variation in tuition and fees across 523 institutions of higher learning in the United States.  It is hoped that the results will give guidance to schools by quantifying the costs and benefits of making a given change to their tuition and fee structure.&nbsp

Moral Attributes In A Dictator Game

This paper investigates whether or not the moral factors captured in an emotional intelligence assessment matter in the economic decisions made by subjects in a dictator game.  We find a statistically significant relationship between the amount of the dictator’s contribution and a few of the factors of the Intrapersonal Dimension of the EQ-i. We also find a significant relationship between dictator contributions and an adjusted EQ-i score, measures of independence, know-my-own and empathy. Our results may be relevant to researchers interested in understanding the preference set of economic decision-makers.  Moreover, for those interested in refining experimental design protocols, we show the EQ-i to be a useful resource to control for a few of the moral attributes Levitt et al. (2006) suggest are so very important in understanding laboratory and field experiments.

Establishment of Innovative Shared Departments to Advance Interdisciplinary Education

More and more universities are pursuing interdisciplinary academic activities that span across department and college boundaries. Administrative structures to facilitate such programs are difficult to establish within traditional university frameworks consisting of disciplinary departments and colleges. Often interdisciplinary programs are housed in a traditional disciplinary department or college, or in a standalone center reporting to a college dean or the provost. The difficulty of these structures is obtaining broad buy-in from faculty across departments and having disciplinary degree programs include interdisciplinary coursework. To overcome the difficulties described above, an innovative shared department structure that fosters collaborations to advance interdisciplinary education has been deployed at the University of New Haven. Three shared departments have been established over the last two years: (1) a college-wide department to support interdisciplinary coursework in the first two years of engineering programs; (2) a university-wide department to support entrepreneurship and innovation; and (3) a university-wide department to support health sciences. The shared departments typically have faculty whose tenure home is a traditional disciplinary department. Faculty membership is based on interest and activity level in teaching interdisciplinary courses, participating in interdisciplinary co-curricular activities, and performing interdisciplinary research. A few faculty members may be appointed full-time in a shared department. Like traditional departments, the shared departments have chairs to lead and coordinate activities. Faculty membership can vary from year-to-year depending on their level of activity in the shared department. The shared departments are responsible for approving interdisciplinary courses within their jurisdiction. The chairs of the departments are responsible for reviewing the performance of instructors teaching the interdisciplinary courses, and for providing feedback to disciplinary department chairs on the performance of faculty who are members of the shared department. To date the shared departments have facilitated the following: (1) an Entrepreneurial Engineering Living-Learning Community (LLC) for freshmen; (2) an Innovation and Entrepreneurship LLC for sophomores; (3) an integrated technical communications program across all engineering and computer science programs; (4) an integrated approach to developing entrepreneurial thinking in students across all engineering and computer science programs; (5) the development and teaching of courses on entrepreneurship; and (6) startup weekends and a business plan competition with students drawn from across the university. The detailed structure of the two shared departments and the lessons learned in establishing and operating them is described in this paper

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors1,2, yet the relevant antigens remain unknown. Here we use genetic, immunohistochemical and transcriptional immunoprofiling, computational biophysics, and functional assays to identify T-cell antigens in long-term survivors of pancreatic cancer. Using whole-exome sequencing and in silico neoantigen prediction, we found that tumours with both the highest neoantigen number and the most abundant CD8+ T-cell infiltrates, but neither alone, stratified patients with the longest survival. Investigating the specific neoantigen qualities promoting T-cell activation in long-term survivors, we discovered that these individuals were enriched in neoantigen qualities defined by a fitness model, and neoantigens in the tumour antigen MUC16 (also known as CA125). A neoantigen quality fitness model conferring greater immunogenicity to neoantigens with differential presentation and homology to infectious disease-derived peptides identified long-term survivors in two independent datasets, whereas a neoantigen quantity model ascribing greater immunogenicity to increasing neoantigen number alone did not. We detected intratumoural and lasting circulating T-cell reactivity to both high-quality and MUC16 neoantigens in long-term survivors of pancreatic cancer, including clones with specificity to both high-quality neoantigens and predicted cross-reactive microbial epitopes, consistent with neoantigen molecular mimicry. Notably, we observed selective loss of high-quality and MUC16 neoantigenic clones on metastatic progression, suggesting neoantigen immunoediting. Our results identify neoantigens with unique qualities as T-cell targets in pancreatic ductal adenocarcinoma. More broadly, we identify neoantigen quality as a biomarker for immunogenic tumours that may guide the application of immunotherapies

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Background and aims: Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC. Methods: We interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids. Results: Patient-derived cell lines faithfully recapitulate the epithelial component of pancreatic tumors including previously described molecular subtypes. Biomarkers of DDR deficiency, including a novel signature of homologous recombination deficiency, co-segregates with response to platinum (P < 0.001) and PARP inhibitor therapy (P < 0.001) in vitro and in vivo. We generated a novel signature of replication stress with which predicts response to ATR (P < 0.018) and WEE1 inhibitor (P < 0.029) treatment in both cell lines and human PC organoids. Replication stress was enriched in the squamous subtype of PC (P < 0.001) but not associated with DDR deficiency. Conclusions: Replication stress and DDR deficiency are independent of each other, creating opportunities for therapy in DDR proficient PC, and post-platinum therapy

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Three essays on making electric power markets

Technological change over the past three decades has altered most of the basic conditions in the electric power industry. Because of technical progress, the dominant paradigm has shifted from the provision of electric power by regulated and vertically integrated local natural monopolies to competition and vertical separation. In the first essay I provide a historical context of the electric industry\u27s power current deregulation debate. Then a dynamic model of induced institutional change is used to investigate how endogenous technological advancements have induced radical institutional change in the generation and transmission segments of the electric power industry. ^ Because the Federal Energy Regulatory Commission (FERC) ordered regulated utilities to provide open access to their transmission networks and to separate their generation and transmission functions, transmission networks have been used more intensively and in much different ways then in the past. The second essay tests experimentally the predictions of neoclassical theory for a radial electric power market under two alternative deregulated transmission institutions: financial transmission rights and physical transmission rights. Experimental evidence presented there demonstrates that an electric power market with physical transmission rights governing its transmission network generates more “right” market signals relative to a transmission network governed by financial transmission rights. ^ The move to a greater reliance on markets for electric power is an idea that has animated sweeping and dramatic changes in the traditional business of electric power. The third essay examines two of the most innovative and complex initiatives of making electric power markets in the United States: California and PJM. As those markets mature and others are made, they must revise their governance mechanisms to eliminate rules that create inefficiency and adopt rules that work efficiently elsewhere. I argue that restructured electric power markets in the United States we should consider adopting an integrated procurement approach for electric power and ancillary services, binding forward markets for those commodities, and a market for physical transmission rights.

Of Altruists and Thieves

We replicate List's &lsqb;2007&rsqb; baseline dictator game (DG) with subjects earning their endowment, evaluate the effect of decreasing the stakes of the DG, conduct a DG in which taking is the only option, measure dictators’ ex post perceptions, and impose a social distance framing effect. Dictator behavior is influenced when they earn their endowment and when the stakes of the game are changed, but not when a social distance framing effect is imposed. Our results suggest that dictators have been nudged into demonstrating altruistic tendencies in the standard DG, just as our taking treatment has nudged dictators to become thieves.

Phosphorylated Akt expression is a prognostic marker in early-stage non-small cell lung cancer

Aims: To determine the prognostic significance of pAkt expression in order to identify high-risk stage IB patients with non-small cell lung cancer (NSCLC) in an exploratory study. Methods: We identified 471 consecutive patients with stage IB primary NSCLC according to the American Joint Commission on Cancer 6th edition tumour-node-metastasis (TNM) staging system, who underwent surgical resection between 1990 and 2008. Patients who received neoadjuvant or adjuvant treatments were excluded. Pathology reports were reviewed, and pathological characteristics were extracted. Expression of phosphorylated Akt (pAkt) in both cytoplasmic and nuclear locations was assessed by immunohistochemistry, and clinicopathological factors were analysed against 10-year overall survival using Kaplan-Meier and Cox proportional hazards model. Results: 455 (96.6%) cancers were adequate for pAkt immunohistochemical analysis. The prevalence of pAkt expression in the cytoplasm and nucleus of the cancers was 60.7% and 43.7%, respectively. Patients whose cancers expressed higher levels of cytoplasmic pAkt had a trend towards longer overall survival than those with lower levels (p=0.06). Conversely, patients whose cancers expressed higher levels of nuclear pAkt had a poorer prognosis than those with lower levels of expression (p=0.02). Combined low cytoplasmic/high nuclear expression of pAkt was an independent predictor of overall survival (HR=2.86 (95% CI 1.35 to 6.04); p=0.006) when modelled with age (HR=1.05 (95% CI 1.03 to 1.07); p0.05). Conclusions: Level of expression of pAkt in the cytoplasm and nucleus is an independent prognostic factor that may help to select patients with high-risk disease