My Journey From Farquhar College of Arts and Science To The Field Of Dentistry

Pursuing advanced education leading to a professional degree of any kind is a long and challenging endeavor, yielding great reward and fulfillment. As a dentist and current orthodontic resident, I have experienced this firsthand. Before any of that was possible, however, I needed an educational foundation that I could utilize and build upon at the next level. I am a proud alumnus of the Farquhar College of Arts and Sciences, where I received my undergraduate degree in biology. It was here that I was given the opportunity and provided with the essential tools to succeed at the next level. This presentation will highlight some insights and experiences I have had on my journey from biology major to dental professional and key lessons I learned along the way to reaching my career goals. I majored in biology with the sole intent of entry into a graduate program in the medical field. After shadowing different healthcare professionals and holding a number of related jobs, I narrowed my decision to dentistry. This was the career that felt like the best match and one that I was genuinely excited about. Shortly after acceptance into NSU CDM, I explored ways to fund my education. I discovered the Armed Forces Health Professions Scholarship. This seemed like a great opportunity to serve the country, travel, and hone my skills as a dentist. And so I joined the Navy. After graduating dental school, I was off to Naval Officer Development School in Newport, Rhode Island for 6 weeks of indoctrination. From there, I was permanently stationed with the 1st Marine Logistics Group at Camp Pendleton in San Diego, CA. Here I continued to develop my aptitude as a dentist and Naval Officer. My interest grew in specialization and once again, I found a profession that I was elated about. This time it was orthodontics. Upon fulfilling my contractual obligation with the Navy, I applied to orthodontics and dentofacial orthopedics and matched at Montefiore Medical Center in the Bronx, NY. I am currently finishing up the first of a three-year residency at MMC

Proprioceptive perception of phase variability

Previous work has established that judgments of relative phase variability of 2 visually presented oscillators covary with mean relative phase. Ninety degrees is judged to be more variable than 0° or 180°, independently of the actual level of phase variability. Judged levels of variability also increase at 180°. This pattern of judgments matches the pattern of movement coordination results. Here, participants judged the phase variability of their own finger movements, which they generated by actively tracking a manipulandum moving at 0°, 90°, or 180°, and with 1 of 4 levels of Phase Variability. Judgments covaried as an inverted U-shaped function of mean relative phase. With an increase in frequency, 180° was judged more variable whereas 0° was not. Higher frequency also reduced discrimination of the levels of Phase Variability. This matching of the proprioceptive and visual results, and of both to movement results, supports the hypothesized role of online perception in the coupling of limb movements. Differences in the 2 cases are discussed as due primarily to the different sensitivities of the systems to the information

A Study of Dark Matter and QCD-Charged Mediators in the Quasi-Degenerate Regime

We study a scenario in which the only light new particles are a Majorana fermion dark matter candidate and one or more QCD-charged scalars, which couple to light quarks. This scenario has several interesting phenomenological features if the new particles are nearly degenerate in mass. In particular, LHC searches for the light scalars have reduced sensitivity, since the visible and invisible products tend to be softer. Moreover, dark matter-scalar co-annihilation can allow even relatively heavy dark matter candidates to be consistent thermal relics. Finally, the dark matter nucleon scattering cross section is enhanced in the quasi-degenerate limit, allowing direct detection experiments to use both spin-independent and spin-dependent scattering to probe regions of parameter space beyond those probed by the LHC. Although this scenario has broad application, we phrase this study in terms of the MSSM, in the limit where the only light sparticles are a bino-like dark matter candidate and light-flavored squarks.Comment: 24 pages, 5 figures; as published in PRD with significant revision

Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation

The Drosophila kelch gene encodes a member of a protein superfamily defined by the presence of kelch repeats. In Drosophila, Kelch is required to maintain actin organization in ovarian ring canals. We set out to study the actin cross-linking activity of Kelch and how Kelch function is regulated. Biochemical studies using purified, recombinant Kelch protein showed that full-length Kelch bundles actin filaments, and kelch repeat 5 contains the actin binding site. Two-dimensional electrophoresis demonstrated that Kelch is tyrosine phosphorylated in a src64-dependent pathway. Site-directed mutagenesis determined that tyrosine residue 627 is phosphorylated. A Kelch mutant with tyrosine 627 changed to alanine (KelY627A) rescued the actin disorganization phenotype of kelch mutant ring canals, but failed to produce wild-type ring canals. Electron microscopy demonstrated that phosphorylation of Kelch is critical for the proper morphogenesis of actin during ring canal growth, and presence of the nonphosphorylatable KelY627A protein phenocopied src64 ring canals. KelY627A protein in ring canals also dramatically reduced the rate of actin monomer exchange. The phenotypes caused by src64 mutants and KelY627A expression suggest that a major function of Src64 signaling in the ring canal is the negative regulation of actin cross-linking by Kelch

Exact synthesis of multiqubit Clifford-cyclotomic circuits

Let $n\geq 8$ be an integer divisible by 4. The Clifford-cyclotomic gate set $\mathcal{G}_n$ is the universal gate set obtained by extending the Clifford gates with the $z$-rotation $T_n = \mathrm{diag}(1,\zeta_n)$, where $\zeta_n$ is a primitive $n$-th root of unity. In this note, we show that, when $n$ is a power of 2, a multiqubit unitary matrix $U$ can be exactly represented by a circuit over $\mathcal{G}_n$ if and only if the entries of $U$ belong to the ring $\mathbb{Z}[1/2,\zeta_n]$. We moreover show that $\log(n)-2$ ancillas are always sufficient to construct a circuit for $U$. Our results generalize prior work to an infinite family of gate sets and show that the limitations that apply to single-qubit unitaries, for which the correspondence between Clifford-cyclotomic operators and matrices over $\mathbb{Z}[1/2,\zeta_n]$ fails for all but finitely many values of $n$, can be overcome through the use of ancillas

Exploratory Pollen Analysis of the Ditch of the 1665 Turf Fort, Jamestown, Virginia

Pollen analysis of subsoil, slopewash, episodic fill, plowzone, and archaeological backdirt deposits in a core from a ditch associated with the 1665 Turf (earthwork) Fort at Jamestown, Virginia, record bare, slightly weedy local conditions around 17th-century artisan dwellings on the Jamestown waterfront and register the Virginia forest in the background before construction of the fort. Goosefoot dominated the earthwork slope; close relatives of the goldenrods were initially the most prominent plants in the open-ditch period. Pollen percolation rates adjusted for plowing and applied to ragweed-type (Ambrosia-type) percentages suggest that cultivation over the ditch began ca. 1729. Cultural matrix depostition, slopewash, and pollen percolation were crticial to the preservation of this record, and serve to emphasize the importance of evaluating pollen record formation processes in cultural landscape studies

Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological evidence of joint damage. Mice heterozygous for PAR-2 gene disruption showed an intermediate phenotype. PAR-2 expression, normally limited to endothelial cells in small arterioles, was substantially upregulated 2 weeks after induction of inflammation, both in synovium and in other periarticular tissues. PAR-2 agonists showed potent proinflammatory effects as intra-articular injection of ASKH95, a novel synthetic PAR-2 agonist, induced prolonged joint swelling and synovial hyperemia. Given the absence of the chronic inflammatory response in the PAR-2-deficient mice, our findings demonstrate a key role for PAR-2 in mediating chronic inflammation, thereby identifying a novel and important therapeutic target for the management of chronic inflammatory diseases such as rheumatoid arthritis

ViCTree: an automated framework for taxonomic classification from protein sequences

Motivation: The increasing rate of submission of genetic sequences into public databases is providing a growing resource for classifying the organisms that these sequences represent. To aid viral classification, we have developed ViCTree, which automatically integrates the relevant sets of sequences in NCBI GenBank and transforms them into an interactive maximum likelihood phylogenetic tree that can be updated automatically. ViCTree incorporates ViCTreeView, which is a JavaScript-based visualisation tool that enables the tree to be explored interactively in the context of pairwise distance data. Results: To demonstrate utility, ViCTree was applied to subfamily Densovirinae of family Parvoviridae. This led to the identification of six new species of insect virus. Availability: ViCTree is open-source and can be run on any Linux- or Unix-based computer or cluster. A tutorial, the documentation and the source code are available under a GPL3 license, and can be accessed at http://bioinformatics.cvr.ac.uk/victree_web/

Nature, Virginia\u27s Economy, and the Climate Threat

The Commission\u27s charge is to propose solutions to you for climate-related issues facing the Commonwealth. Our Symposium today also takes up that challenge. In this booklet you will find research and recommendations for you -- and all of Virginia\u27s governing bodies – for how best to protect our state\u27s priceless and economically essential natural heritage as climate changes disrupt our ecosystems. Paper prepared for Environmental Studies Senior Seminar. Faculty advisers: Dr. Peter D. Smallwood and Stephen P. Nas