Proto-Genbun Itchi Discourse and the Philology of Itō Jinsai

Early Modern Japan Networ

Teaching the biography of Laura Ingalls Wilder: fostering a media literacy approach for multilingual writers

In creating this thesis, the culmination of writings from teaching English composition to multilingual writers, contributed to my research. This action research study focuses on how to foster a media literacy approach when teaching multilingual writers. The literature focus unit was based on the biography of Laura Ingalls Wilder using the book, Laura Ingalls Wilder: A Photographic Story of a Life (Stone, 2009). The research conducted for this study took place during the winter quarter of 2015 within English 112, which is a composition class offered at Eastern Washington University (EWU) for multilingual writers. During this time, questionnaires, journal responses, student sample essays and assignments were collected. Within these pages, several student samples will be provided to demonstrate the effectiveness and importance of giving students an opportunity to express their voice through the use of media literacy . By honoring and preserving their culture they became active participants and were engaged within their learning. The goal of this study was to analyze and synthesize how media literacy can be fostered through a vast array of topics to assist the multilingual writer in gaining knowledge about U.S. history during the 19th and 20th century --Leaf iv

Message from the President

Newsletter published on March 10, 2017 detailing the multiple studies being undertaken by the faculty of Jiann-Ping Hsu College of Public Healthhttps://digitalcommons.georgiasouthern.edu/pubhlth-bee-facmedia/1037/thumbnail.jp

Effects of ambient temperature and transportation distances on the resulting pork quality

Factors beyond the farm gate can affect the quality pork product, among them temperature and amount of time for transport. This study examines how these factors affect producers selling in the niche pork market

User-initialized active contour segmentation and golden-angle real-time cardiovascular magnetic resonance enable accurate assessment of LV function in patients with sinus rhythm and arrhythmias.

BackgroundData obtained during arrhythmia is retained in real-time cardiovascular magnetic resonance (rt-CMR), but there is limited and inconsistent evidence to show that rt-CMR can accurately assess beat-to-beat variation in left ventricular (LV) function or during an arrhythmia.MethodsMulti-slice, short axis cine and real-time golden-angle radial CMR data was collected in 22 clinical patients (18 in sinus rhythm and 4 patients with arrhythmia). A user-initialized active contour segmentation (ACS) software was validated via comparison to manual segmentation on clinically accepted software. For each image in the 2D acquisitions, slice volume was calculated and global LV volumes were estimated via summation across the LV using multiple slices. Real-time imaging data was reconstructed using different image exposure times and frame rates to evaluate the effect of temporal resolution on measured function in each slice via ACS. Finally, global volumetric function of ectopic and non-ectopic beats was measured using ACS in patients with arrhythmias.ResultsACS provides global LV volume measurements that are not significantly different from manual quantification of retrospectively gated cine images in sinus rhythm patients. With an exposure time of 95.2 ms and a frame rate of > 89 frames per second, golden-angle real-time imaging accurately captures hemodynamic function over a range of patient heart rates. In four patients with frequent ectopic contractions, initial quantification of the impact of ectopic beats on hemodynamic function was demonstrated.ConclusionUser-initialized active contours and golden-angle real-time radial CMR can be used to determine time-varying LV function in patients. These methods will be very useful for the assessment of LV function in patients with frequent arrhythmias

Consanguinity and rare mutations outside of MCCC genes underlie nonspecific phenotypes of MCCD.

Purpose3-Methylcrotonyl-CoA carboxylase deficiency (MCCD) is an autosomal recessive disorder of leucine catabolism that has a highly variable clinical phenotype, ranging from acute metabolic acidosis to nonspecific symptoms such as developmental delay, failure to thrive, hemiparesis, muscular hypotonia, and multiple sclerosis. Implementation of newborn screening for MCCD has resulted in broadening the range of phenotypic expression to include asymptomatic adults. The purpose of this study was to identify factors underlying the varying phenotypes of MCCD.MethodsWe performed exome sequencing on DNA from 33 cases and 108 healthy controls. We examined these data for associations between either MCC mutational status, genetic ancestry, or consanguinity and the absence or presence/specificity of clinical symptoms in MCCD cases.ResultsWe determined that individuals with nonspecific clinical phenotypes are highly inbred compared with cases that are asymptomatic and healthy controls. For 5 of these 10 individuals, we discovered a homozygous damaging mutation in a disease gene that is likely to underlie their nonspecific clinical phenotypes previously attributed to MCCD.ConclusionOur study shows that nonspecific phenotypes attributed to MCCD are associated with consanguinity and are likely not due to mutations in the MCC enzyme but result from rare homozygous mutations in other disease genes.Genet Med 17 8, 660-667

Gustav Mahler’s Symphonies (Gustav Mahlers Sinfonien) by Paul Bekker (1921): A Translation with Commentary

Gustav Mahlers Sinfonien by Paul Bekker was published in 1921, just ten years after the composer’s death. Bekker presents critical readings of all nine completed symphonies and Das Lied von der Erde. His “Symphonic Style” chapter sets the stage by considering Mahler’s place in the 19th-century symphonic tradition, which he traces from Beethoven through Schubert and Bruckner. A main concern in Bekker’s introductory chapter and throughout the book is the “finale problem” that had challenged composers ever since Beethoven’s Ninth. He also calls attention to the “dangerous power” of the Adagio as manifested in Bruckner’s symphonies. Bekker argues that Mahler had solved these and other problems of the “modern” symphony, and he revisits questions of form along with other critical concerns throughout the book. The following ten analytical chapters fall into two main parts. The first part considers topics such as the problematic status of the “program” in Mahler, the changing influence of Mahler’s songs on his symphonies, the fundamental importance of the melodic impulse in Mahler, and aspects of formal design, orchestration, and counterpoint. Bekker’s introductory reflections are often surprising and original. The second part of each analytical chapter is a more traditional hermeneutic narrative that discusses the symphony movement by movement, with copious notated musical excerpts by way of illustration. The present translation presents new digital versions of Bekker’s 888 examples, noting errors in the original edition and adding for each example measure numbers and details about instrumentation. In addition to presenting the first complete English translation of Bekker’s landmark study, the dissertation introduces the historical and critical context for his work. Bekker’s contemporaries Ernst Kurth and August Halm are considered, among others. Unlike many twentieth-century writers on Mahler, Bekker remains closely focused on musical analysis, with only incidental reference to biographical and documentary details. The translator’s extensive commentary highlights special problems in interpreting Bekker’s German and also traces Bekker’s significant influence upon later Mahler scholarship. Theodor W. Adorno’s debt to Bekker is of particular interest, and one is surprised to discover that Adorno does not consistently acknowledge Bekker’s precedence

LSF small molecule inhibitors phenocopy LSF-targeted siRNAs causing mitotic defects and senescence in cancer cells

The oncogene LSF has been proposed as a novel target with therapeutic potential for multiple cancers. LSF overexpression correlates with poor prognosis for both liver and colorectal cancers, for which there are currently limited therapeutic treatment options. In particular, molecularly targeted therapies for hepatocellular carcinoma targeting cellular receptors and kinases have yielded disappointing clinical results, providing an urgency for targeting distinct mechanisms. LSF small molecule inhibitors, Factor Quinolinone Inhibitors (FQIs), have exhibited robust anti-tumor activity in multiple pre-clinical models of hepatocellular carcinoma, with no observable toxicity. To understand how the inhibitors impact cancer cell proliferation, we characterized the cellular phenotypes that result from loss of LSF activity. Phenotypically, inhibition of LSF activity induced a mitotic delay with condensed, but unaligned, chromosomes. This mitotic disruption resulted in improper cellular division leading to multiple outcomes: multi-nucleation, apoptosis, and cellular senescence. The cellular phenotypes observed upon FQI1 treatment were due specifically to the loss of LSF activity, as siRNA specifically targeting LSF produced nearly identical phenotypes. Taken together, these findings confirm that LSF is a promising therapeutic target for cancer treatment.First author draf