Attitude determination and calibration using a recursive maximum likelihood-based adaptive Kalman filter

An adaptive Kalman filter design that utilizes recursive maximum likelihood parameter identification is discussed. At the center of this design is the Kalman filter itself, which has the responsibility for attitude determination. At the same time, the identification algorithm is continually identifying the system parameters. The approach is applicable to nonlinear, as well as linear systems. This adaptive Kalman filter design has much potential for real time implementation, especially considering the fast clock speeds, cache memory and internal RAM available today. The recursive maximum likelihood algorithm is discussed in detail, with special attention directed towards its unique matrix formulation. The procedure for using the algorithm is described along with comments on how this algorithm interacts with the Kalman filter

Neutrons transition densities for the 2+−8+2^+-8^+ multiplet of states in 90^{90}Zr

The neutron transition densities of the $2^+-8^+$ levels in $^{90}$Zr were extracted in the process of analysing ({\bf p},p') scattering at 400 Mev. Its comparison with the proton transition densities for these levels was undertaken. The radial shapes of the experimental neutron and proton transition densities for each state were found to be different.Comment: 9 pages, 4 figure

Tildrakizumab in the treatment of psoriasis: latest evidence and place in therapy.

Psoriasis is a chronic inflammatory disorder that is clinically characterized by scaly cutaneous plaques. New evidence suggests that dysregulation of interleukin (IL)-23, a key cytokine in the T-helper-17 pathway, plays a vital role in the development of psoriatic systemic inflammation. The novel biologic medication tildrakizumab is among the first drugs with specific action against IL-23 that has recently been approved by the United States Food and Drug Administration and the European Medicines Agency for moderate-to-severe psoriasis. Tildrakizumab has been shown in large randomized controlled trials to be effective in improving skin manifestations as well as enhancing quality of life outcomes in patients with psoriasis. Its simple dosing, prolonged duration of action, and mild adverse event profile make it a practical option for patients; however, only a small number of trials have investigated the clinical effectiveness of tildrakizumab, and long-term data regarding the drug's efficacy and safety are currently limited. Hence, further research is needed to better understand the risks and benefits of tildrakizumab. This review summarizes and analyzes phase I, phase II, and phase III clinical trials that investigate the mechanism, pharmacokinetics, efficacy, and safety of tildrakizumab. It also identifies areas in which additional studies are warranted to further elucidate the advantages of tildrakizumab over other biologic therapies

Use of graphene as protection film in biological environments

Corrosion of metal in biomedical devices could cause serious health problems to patients. Currently ceramics coating materials used in metal implants can reduce corrosion to some extent with limitations. Here we proposed graphene as a biocompatible protective film for metal potentially for biomedical application. We confirmed graphene effectively inhibits Cu surface from corrosion in different biological aqueous environments. Results from cell viability tests suggested that graphene greatly eliminates the toxicity of Cu by inhibiting corrosion and reducing the concentration of Cu(2+) ions produced. We demonstrated that additional thiol derivatives assembled on graphene coated Cu surface can prominently enhance durability of sole graphene protection limited by the defects in graphene film. We also demonstrated that graphene coating reduced the immune response to metal in a clinical setting for the first time through the lymphocyte transformation test. Finally, an animal experiment showed the effective protection of graphene to Cu under in vivo condition. Our results open up the potential for using graphene coating to protect metal surface in biomedical application

Keypad mobile phones are associated with a significant increased risk of microbial contamination compared to touch screen phones

The use of mobile phones in the clinical environment by healthcare workers has become widespread. Despite evidence that these devices can harbour pathogenic micro-organisms there is little guidance on how to reduce contamination. Recently touchscreen phones with a single flat surface have been introduced. We hypothesise that bacterial contamination of phones used in hospitals will be lower on touchscreen devices compared to keypad devices. Sixty seven mobile phones belonging to health care workers were sampled. The median colony count for touchscreen phones and keypad devices was 0·09 colony forming units (cfu)/cm2 (interquartile range (IQR) 0.05–0·14) and 0·77 cfu/cm2 (IQR range 0·45–3.52) respectively. Colony counts were significantly higher on the keypad phones (Fisher’s exact test p<0.001). Multivariate analysis showed the type of phone (keypad vs. touch screen) was associated with increased colony counts (F-statistic 14.13: p<0.001). Overall, nine (13%) phones grew either meticillin resistant Staphylococcus aureus or vancomycin resistant enterococci. Eight (24%) keypad phones were contaminated with these organisms compared with one touch screen phone (3%). Our data indicate that touchscreen mobile phones are less contaminated than their keypad counterparts, and they are less likely to harbour pathogenic bacteria in the clinical setting

Collapse analysis, defect sensitivity and load paths in stiffened shell composite structures

An experimental program for collapse of curved stiffened composite shell structures encountered a wide range of initial and deep buckling mode shapes. This paper presents work to determine the significance of the buckling deformations for determining the final collapse loads and to understand the source of the variation. A finite element analysis is applied to predict growth of damage that causes the disbonding of stiffeners and defines a load displacement curve to final collapse. The variability in material properties and geometry is then investigated to identify a range of buckling modes and development of deep postbuckling deformation encountered in the experimental program. Finally the load paths for the damaged panels are used to visualise the load transfer and enhance the physical understanding of the load displacement history

Characterization of the OCO-2 instrument line shape functions using on-orbit solar measurements

Accurately characterizing the instrument line shape (ILS) of the Orbiting Carbon Observatory-2 (OCO-2) is challenging and highly important due to its high spectral resolution and requirement for retrieval accuracy (0. 25 %) compared to previous spaceborne grating spectrometers. On-orbit ILS functions for all three bands of the OCO-2 instrument have been derived using its frequent solar measurements and high-resolution solar reference spectra. The solar reference spectrum generated from the 2016 version of the Total Carbon Column Observing Network (TCCON) solar line list shows significant improvements in the fitting residual compared to the solar reference spectrum currently used in the version 7 Level 2 algorithm in the O₂ A band. The analytical functions used to represent the ILS of previous grating spectrometers are found to be inadequate for the OCO-2 ILS. Particularly, the hybrid Gaussian and super-Gaussian functions may introduce spurious variations, up to 5 % of the ILS width, depending on the spectral sampling position, when there is a spectral undersampling. Fitting a homogeneous stretch of the preflight ILS together with the relative widening of the wings of the ILS is insensitive to the sampling grid position and accurately captures the variation of ILS in the O₂ A band between decontamination events. These temporal changes of ILS may explain the spurious signals observed in the solar-induced fluorescence retrieval in barren areas

Detection and quantification of poliovirus infection using FTIR spectroscopy and cell culture

<p>Abstract</p> <p>Background</p> <p>In a globalized word, prevention of infectious diseases is a major challenge. Rapid detection of viable virus particles in water and other environmental samples is essential to public health risk assessment, homeland security and environmental protection. Current virus detection methods, especially assessing viral infectivity, are complex and time-consuming, making point-of-care detection a challenge. Faster, more sensitive, highly specific methods are needed to quantify potentially hazardous viral pathogens and to determine if suspected materials contain viable viral particles. Fourier transform infrared (FTIR) spectroscopy combined with cellular-based sensing, may offer a precise way to detect specific viruses. This approach utilizes infrared light to monitor changes in molecular components of cells by tracking changes in absorbance patterns produced following virus infection. In this work poliovirus (PV1) was used to evaluate the utility of FTIR spectroscopy with cell culture for rapid detection of infective virus particles.</p> <p>Results</p> <p>Buffalo green monkey kidney (BGMK) cells infected with different virus titers were studied at 1 - 12 hours post-infection (h.p.i.). A partial least squares (PLS) regression method was used to analyze and model cellular responses to different infection titers and times post-infection. The model performs best at 8 h.p.i., resulting in an estimated root mean square error of cross validation (RMSECV) of 17 plaque forming units (PFU)/ml when using low titers of infection of 10 and 100 PFU/ml. Higher titers, from 10³to 10⁶PFU/ml, could also be reliably detected.</p> <p>Conclusions</p> <p>This approach to poliovirus detection and quantification using FTIR spectroscopy and cell culture could potentially be extended to compare biochemical cell responses to infection with different viruses. This virus detection method could feasibly be adapted to an automated scheme for use in areas such as water safety monitoring and medical diagnostics.</p

INSIGHTS INTO GROUNDWATER FLOW PATHS IN AN INTENSIVELY MANAGED CRITICAL ZONE IN NEBRASKA

Glacier Creek, a groundwater-fed stream located in Glacier Creek Preserve (GCP) near Omaha, Nebraska, flows through restored tallgrass prairie and agricultural land (corn-soy rotation) draining a 4 km2 area. The 1 km wide watershed developed on Peoria Loess that overlies Sangamon age glacial till; Glacier Creek itself flows through the glacial till. Previous work concerning land use impacts on solute fluxes indicated a distinct distribution and flux of solutes through restored prairie and agricultural land. Inputs into the subsurface on agricultural land are slow and more concentrated but are diluted by precipitation along shallow flow paths to the north fork of Glacier Creek. In contrast, subsurface flow paths through the restored prairie are more rapid and deeper, leading to less concentrated water in the south fork of Glacier Creek. However, little is known about the subsurface stratigraphy and hydrogeology of the groundwater that provides year-round flow into Glacier Creek. Here we present the initial interpretation of a series of sediment cores and aquifer tests from the ridgetop, midslope, and foot slope topographic positions of agriculture and restored prairie. Sediment cores from the southern, restored prairie portion of GCP show loess overlying glacial till (identified by the appearance of gravel-sized rock fragments). The stratigraphy of the northern, agricultural portion of GCP is much more complex: while loess does overlie glacial till, there are also a series of sandy outwash deposits that cannot be correlated across the landscape. Under both land uses, the local groundwater table lies within the glacial till as referenced by water depth measurements in monitoring wells and gleyed sediments present in cores. Slug tests conducted in ridgetop and foot slope wells indicate that the saturated hydraulic conductivity of the sediments underlying the agricultural land range from two-fold to an order of magnitude greater than those underlying restored prairie, consistent with the presence of sandy layers that conduct water at a quicker rate. Furthermore, the higher flow rates explain why the north fork of Glacier Creek (draining agriculture) produces more water despite being a smaller portion of the watershed. Given these new findings, we modify our conceptual model of subsurface flow at GCP