Moving from Cars to People

The twenty-page comic includes a dialogue, taking place in various urban settings, between characters Kelly and Kristi who are based on National Institute for Transportation and Communities (NITC) researchers Kelly Clifton of the University of British Columbia and Kristina Currans of the University of Arizona. The two have a long history of collaboration around the data, methods, and processes used to plan for multimodal transportation impacts of new development. This short graphic synopsis is an engaging, approachable way for anyone – no matter their level of expertise in this topic – to learn about their findings. Illustrated by PSU Master of Fine Arts student Joaquin Golez, the comic was authored by Clifton and Currans and developed in conjunction with Susan Kirtley, director of the Comic Studies Program at Portland State University (PSU), and Portland, OR-based illustrator Ryan Alexander-Tanner, who has worked on academic comics before and drew on his experience to help guide the collaborative process

Barriers to Physical Activity and Healthy Eating in Children as Perceived by Low-Income Parents: A Case Study

During the past three decades the prevalence of childhood obesity has steadily increased in the United States. Causes of childhood obesity are complex and include numerous individual and environmental factors. The purpose of this study was to determine parent perceptions on the social-ecological barriers (community, school, and family) to physical activity and healthy eating, perceived specific to their children. Self-reported data gathered from a 50-item questionnaire and six focus groups were conducted with parents (n=43) enrolled in the Women, Infants, and Children (WIC) Program. Participants (16 to 67 years old) were predominately female (88.4%), Hispanic (67%), low income, and living in or near Lompoc in Santa Barbara County, CA. The social-ecological model (family, school, and community) was utilized to create focus group questions and provide recommendations as part of the Lompoc Community Health Improvement Project (2006-to-the-present). Popular community barriers for physical activity were: disconnected sidewalks, lack of safe bike routes to school, lack of recreational programming at an affordable cost, and language barriers (lack of marketing physical activity programs in Spanish). Two safety barriers involved parks; fear of injury (dilapidated equipment) and fear of gangs (violence). Common school barriers were: teachers do not lead-by-example, lack of healthy food in school cafeteria, and insufficient time for children to purchase food and eat. Family barriers included: grandparents sabotaging healthy eating environments (e.g., spoilingchildren), insufficient nutrition knowledge (both children and parents), and economics (not being able to afford healthy food and a recreation/gym membership)

Accessing Opportunities for Household Provisioning Post-COVID-19

In this project, we used a mixed-methods study to collect critical information to evaluate the extent to which people modified their shopping behavior, either by choice or necessity, to meet their provisioning needs during the COVID-19 crisis and the following recovery. First, four waves of a cross-sectional survey were administered online to a representative sample of households in Arizona, Florida, Michigan, Oregon, and Washington. This longitudinal, comparative study responded directly to a critical research gap and advanced behavioral science by providing a rich survey dataset to support and test theories of behavioral change and technology adoption. Second, focus groups were conducted with older adults in Oregon to discuss their arc of technology adoption for grocery shopping. Focus groups were also conducted with two sets of mentors who provide assistance to family members and friends with online food purchases to understand what kinds of interventions might be necessary to broaden access to e-commerce and delivery platforms for vulnerable populations. This report presents high-level descriptive statistics from these surveys comparing results by wave and/or by state. The findings from the focus groups with older adults and mentors are also described. The findings of this research are critical for emergency planning but also for understanding the ever-changing mechanism used to access retail and service opportunities (whether in-person vs. online), and the opportunities for future interventions to remedy barriers to accessing food that are relevant after the pandemic recovery

Multidimensional analysis and therapeutic development using patient iPSC-derived disease models of Wolfram syndrome

Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram syndrome as a spectrum disorder. Therefore, a genotype-phenotype correlation analysis is needed for diagnosis and therapeutic development. Here, we focus on the WFS1 c.1672C\u3eT, p.R558C variant, which is highly prevalent in the Ashkenazi Jewish population. Clinical investigation indicated that patients carrying the homozygous WFS1 c.1672C\u3eT, p.R558C variant showed mild forms of Wolfram syndrome phenotypes. Expression of WFS1 p.R558C was more stable compared with the other known recessive pathogenic variants associated with Wolfram syndrome. Human induced pluripotent stem cell-derived (iPSC-derived) islets (SC-islets) homozygous for WFS1 c.1672C\u3eT variant recapitulated genotype-related Wolfram syndrome phenotypes. Enhancing residual WFS1 function through a combination treatment of chemical chaperones mitigated detrimental effects caused by the WFS1 c.1672C\u3eT, p.R558C variant and increased insulin secretion in SC-islets. Thus, the WFS1 c.1672C\u3eT, p.R558C variant causes a mild form of Wolfram syndrome phenotypes, which can be remitted with a combination treatment of chemical chaperones. We demonstrate that our patient iPSC-derived disease model provides a valuable platform for further genotype-phenotype analysis and therapeutic development for Wolfram syndrome

A pharmacist-driven academic detailing program to increase adult pneumococcal vaccination

Objectives To describe our statewide, pharmacist-led education campaign to increase knowledge and awareness of pneumococcal immunization recommendations. Setting Immunization providers and residents in the state of Rhode Island. Practice description A clinical pathway (i.e., decision-support tool) was developed to educate health professionals about appropriate indications, administration schedules, and frequently asked questions for the 2 different adult pneumococcal vaccines. Academic detailing and distribution of the clinical pathway to health professionals was conducted across Rhode Island. Community outreach activities included radio ads as well as distribution of patient handouts and wallet cards at community events. Practice innovation To our knowledge, this was the first statewide, pharmacist-driven academic detailing and community outreach campaign to promote adult pneumococcal vaccination. Evaluation Academically detailed immunization providers received a 6-question survey. Pneumococcal disease rate differences between the study periods were evaluated with the use of Fisher exact tests, whereas changes in vaccination were assessed with the use of chi-square tests. Results From November 2013 through July 2015, our academic detailers visited and distributed our vaccination pathway materials to more than 400 practice sites across Rhode Island, including 68% of community pharmacies and all adult acute care hospitals. Of the 413 surveys completed, 92% of respondents agreed that their knowledge of the pneumococcal conjugate vaccine, 13-valent and pneumococcal polysaccharide vaccine, 23-valent had improved. Pneumococcal vaccination increased significantly (absolute difference 3.9%, percentage change in proportion 5.4%; P = 0.01), and pneumococcal disease decreased significantly between the preintervention and intervention periods (−2.74/10,000 discharges [95% CI −5.15 to −0.32], P = 0.02). Invasive pneumococcal disease decreased by 21 cases per 1,000,000 population per year between the preintervention and postintervention periods (−42.25 to 0.14, P = 0.05). Conclusion Our statewide, pharmacist-driven pneumococcal vaccination educational outreach program resulted in favorable provider feedback relative to knowledge change and perceptions. Vaccination increased and pneumococcal disease decreased during the study period

Dysfunctional Tissue Correlates of Unrelated Naming Errors in Acute Left Hemisphere Stroke

Most naming error lesion-symptom mapping (LSM) studies have focused on semantic and/or phonological errors. Anomic individuals also produce unrelated word errors, which may be linked to semantic or modality-independent lexical deficits. To investigate the neural underpinnings of rarely-studied unrelated errors, we conducted LSM analyses in 100 individuals hospitalised with a left hemisphere stroke who completed imaging protocols and language assessments. We used least absolute shrinkage and selection operator regression to capture relationships between naming errors and dysfunctional brain tissue metrics (regional damage or hypoperfusion in vascular territories) in two groups: participants with and without impaired single-word auditory comprehension. Hypoperfusion—particularly within the parietal lobe—was an important error predictor, especially for the unimpaired group. In both groups, higher unrelated error proportions were associated with primarily ventral stream damage, the language route critical for processing meaning. Nonetheless, brain metrics implicated in unrelated errors were distinct from semantic error correlates

Compositional and Quantitative Insights Into Bacterial and Archaeal Communities of South Pacific Deep-Sea Sponges (Demospongiae and Hexactinellida)

In the present study, we profiled bacterial and archaeal communities from 13 phylogenetically diverse deep-sea sponge species (Demospongiae and Hexactinellida) from the South Pacific by 16S rRNA-gene amplicon sequencing. Additionally, the associated bacteria and archaea were quantified by real-time qPCR. Our results show that bacterial communities from the deep-sea sponges are mostly host-species specific similar to what has been observed for shallow-water demosponges. The archaeal deep-sea sponge community structures are different from the bacterial community structures in that they are almost completely dominated by a single family, which are the ammonia-oxidizing genera within the Nitrosopumilaceae. Remarkably, the archaeal communities are mostly specific to individual sponges (rather than sponge-species), and this observation applies to both hexactinellids and demosponges. Finally, archaeal 16s gene numbers, as detected by quantitative real-time PCR, were up to three orders of magnitude higher than in shallow-water sponges, highlighting the importance of the archaea for deep-sea sponges in general

Communicating Research Through Comics: Transportation and Land Development

This project created a transportation comic, "Moving From Cars To People," which offers a succinct and fun introduction to a complicated topic: namely, how the built environment in the United States came to be designed for cars and what we can do about it. The comic includes a dialogue, taking place in various urban settings, between characters Kelly and Kristi who are based on the two principal investigators, Kelly Clifton and Kristina Currans. The two have a long history of collaboration around the data, methods, and processes used to plan for multimodal transportation impacts of new development. This short graphic synopsis is an engaging, approachable way for anyone \u2013 no matter their level of expertise in this topic \u2013 to learn about their findings. Illustrated by PSU Master of Fine Arts student Joaquin Golez, the comic was authored by Clifton and Currans and developed in conjunction with Susan Kirtley, director of the Comic Studies Program at Portland State University (PSU), and Portland, OR-based illustrator Ryan Alexander-Tanner, who has worked on academic comics before and drew on his experience to help guide the collaborative process. A Spanish-language version was created with the assistance of Urban Studies PhD student Gabriel Qui\uf1ones-Zambrana