The impact of the internal organisational environment on NSD knowledge management and NSD performance.

Building on a diverse stream of literature, knowledge strategy and NSD in particular, the theory investigated in this research is that service firms can use knowledge strategy to improve the innovation performance of their business. Although scholars are now beginning to organise their research agendas around a set of explicit hypotheses concerning the causes and effects of knowledge intensive environments, knowledge management has only recently emerged as an explicit area of pursuit for managing firms. This research empirically investigated knowledge management activity in the context of NSD, and as such provides insight into a subject area previously lacking in rigorous empirical studies. Previous research in the field of NSD has tended to concentrate its focus on the financial services market. In contrast, this research drew its sample from a wider population and identified that many of the findings appear to be generalisable across a number of business markets, both in a consumer and business context. In adopting a knowledge-based view of a service business, this research conceptualised a notion of NSD Knowledge Environment( NKE) to represent the way in which knowledge supports the business' ability to develop new services across a NSD programme. The nine unique bundles of resources which comprise the NKE (knowledge depth; knowledge dispersion; NSD memory, personal interaction; climate of learning; creative climate; entrepreneurial climate; collaborative climate; goal climate) were found to be capable of yielding sustainable, above-normal business performance. The NKE was discovered to have a significant impact on the service business' overall NSD programme performance across four distinct measures: financial; new opportunities; customer responsiveness innovation. Whilst service firms were found to be aware of the importance of knowledge resources to their business, few had embraced a business-wide' framework, for managing- particular knowledge 'assets.' This research therefore indicates the importance of addressing the need for. a knowledge management framework targets specifically at NSD success. Whilst the NKE was discovered to have a'significant impact on the service business' overall ability to develop innovative new products supports the findings of previous research, interestingly, this research identified a multi-dimensional concept of innovativeness, comprising both measures of innovative outcomes and innovative processes. The more innovative NSD programmes were found to be more successful on many' other performance dimensions (financial'and nonfinancial) than their counterparts,i. e. innovative NSD programmes were more successful than their competition on all dimensions, aswell as having a very high percentage of sales and profits originating from new services introduced in the last three years. The overall implication of this research is that if a firm's scarcer resources are the source of improved economic performance, it follows that supportive knowledge practices and a supportive internal knowledge environment must be created to ensure these assets are leveraged successfully

Long Range Physics in a Hot Non-Abelian Plasma

We derive a set of equations describing the real time dynamics of modes with spatial momentum of order g^2 T in a high temperature gauge theory, where g is the coupling constant and T is the temperature. This dynamics is stochastic in nature. Important implications for baryon number violation at high temperature and for the physics at the electroweak phase transition, are discussed.Comment: 14 pages, uses LaTeX; Typographical errors corrected and references adde

Outsiders: an exploratory history of IS in corporations

This paper is an exploratory study that provides a brief history of information systems (IS) in corporations that are not part of the Information Technology sector, such as retailers, banks, government agencies and so on. It looks at the development of the IS function and the changing roles of IS practitioners in such organisations over the past 60 years, and assesses how they perceived themselves and were perceived by their peers, by business colleagues and by others. It uses the testimony of successful IS practitioners to provide a grounded perspective on the history of the IS worker over this time. The research identifies a trajectory of a gradual diminishment in the role and status of the IS worker in the corporation over the lifetime of the discipline. It observes that the IS worker has experienced changed fortunes: from a position of influence at the outset, leading to a peak of status and reward in the years up to the millennium; and to the present day where the occupation has a much lower profile. It ascribes this to the increasing commoditisation of IS, manifested by phenomena such as end-user computing, outsourcing and cloud computing. The paper is of relevance to academics who are interested in IS in the corporate organisation; to business professionals, who are sometimes bewildered by their IS colleagues; and to those who work in IS. The research is presented as an interpretative study and is intended to help future researchers frame questions and design research projects. It also aims to inform and witness, and provide a perspective on a currently neglected part of the business world

Association between non-medical cannabis legalization and emergency department visits for cannabis-induced psychosis

A major public health concern of cannabis legalization is that it may result in an increase in psychotic disorders. We examined changes in emergency department (ED) visits for cannabis-induced psychosis following the legalization and subsequent commercialization (removal of restrictions on retail stores and product types) of non-medical cannabis in Ontario, Canada (population of 14.3 million). We used health administrative data containing the cause of all ED visits to examine changes over three periods; 1) pre-legalization (January 2014–September 2018); 2) legalization with restrictions (October 2018 – February 2020); and 3) commercialization (March 2020 – September 2021). We considered subgroups stratified by age and sex and examined cocaine- and methamphetamine-induced psychosis ED visits as controls. During our study, there were 6300 ED visits for cannabis-induced psychosis. The restricted legalization period was not associated with changes in rates of ED visits for cannabis-induced psychosis relative to pre-legalization. The commercialization period was associated with an immediate increase in rates of ED visits for cannabis-induced psychosis (IRR 1.30, 95% CI 1.02–1.66) and no gradual monthly change; immediate increases were seen only for youth above (IRR 1.63, 1.27–2.08, ages 19–24) but not below (IRR 0.73 95%CI 0.42–1.28 ages, 15–18) the legal age of purchase, and similar for men and women. Commercialization was not associated with changes in rates of ED visits for cocaine- or methamphetamine-induced psychosis. This suggests that legalization with store and product restrictions does not increase ED visits for cannabis-induced psychosis. In contrast, cannabis commercialization may increase cannabis-induced psychosis presentations highlighting the importance of preventive measures in regions considering legalization

Facilitating the analysis of a UK national blood service supply chain using distributed simulation

In an attempt to investigate blood unit ordering policies, researchers have created a discrete-event model of the UK National Blood Service (NBS) supply chain in the Southampton area of the UK. The model has been created using Simul8, a commercial-off-the-shelf discrete-event simulation package (CSP). However, as more hospitals were added to the model, it was discovered that the length of time needed to perform a single simulation severely increased. It has been claimed that distributed simulation, a technique that uses the resources of many computers to execute a simulation model, can reduce simulation runtime. Further, an emerging standardized approach exists that supports distributed simulation with CSPs. These CSP Interoperability (CSPI) standards are compatible with the IEEE 1516 standard The High Level Architecture, the defacto interoperability standard for distributed simulation. To investigate if distributed simulation can reduce the execution time of NBS supply chain simulation, this paper presents experiences of creating a distributed version of the CSP Simul8 according to the CSPI/HLA standards. It shows that the distributed version of the simulation does indeed run faster when the model reaches a certain size. Further, we argue that understanding the relationship of model features is key to performance. This is illustrated by experimentation with two different protocols implementations (using Time Advance Request (TAR) and Next Event Request (NER)). Our contribution is therefore the demonstration that distributed simulation is a useful technique in the timely execution of supply chains of this type and that careful analysis of model features can further increase performance

Quark Imaging in the Proton Via Quantum Phase-Space Distributions

We develop the concept of quantum phase-space (Wigner) distributions for quarks and gluons in the proton. To appreciate their physical content, we analyze the contraints from special relativity on the interpretation of elastic form factors, and examine the physics of the Feynman parton distributions in the proton's rest frame. We relate the quark Wigner functions to the transverse-momentum dependent parton distributions and generalized parton distributions, emphasizing the physical role of the skewness parameter. We show that the Wigner functions allow to visualize quantum quarks and gluons using the language of the classical phase space. We present two examples of the quark Wigner distributions and point out some model-independent features.Comment: 20 pages with 3 fiture

Identifying Recent Cholera Infections Using a Multiplex Bead Serological Assay

Estimates of incidence based on medically attended cholera can be severely biased. Vibrio cholerae O1 leaves a lasting antibody signal and recent advances showed that these can be used to estimate infection incidence rates from cross-sectional serologic data. Current laboratory methods are resource intensive and challenging to standardize across laboratories. A multiplex bead assay (MBA) could efficiently expand the breadth of measured antibody responses and improve seroincidence accuracy. We tested 305 serum samples from confirmed cholera cases (4 to 1083 d postinfection) and uninfected contacts in Bangladesh using an MBA (IgG/IgA/IgM for 7 Vibrio cholerae O1-specific antigens) as well as traditional vibriocidal and enzyme-linked immunosorbent assays (2 antigens, IgG, and IgA). While postinfection vibriocidal responses were larger than other markers, several MBA-measured antibodies demonstrated robust responses with similar half-lives. Random forest models combining all MBA antibody measures allowed for accurate identification of recent cholera infections (e.g., past 200 days) including a cross-validated area under the curve (cvAUC200) of 92%, with simpler 3 IgG antibody models having similar accuracy. Across infection windows between 45 and 300 days, the accuracy of models trained on MBA measurements was non-inferior to models based on traditional assays. Our results illustrated a scalable cholera serosurveillance tool that can be incorporated into multipathogen serosurveillance platforms. IMPORTANCE Reliable estimates of cholera incidence are challenged by poor clinical surveillance and health-seeking behavior biases. We showed that cross-sectional serologic profiles measured with a high-throughput multiplex bead assay can lead to accurate identification of those infected with pandemic Vibrio cholerae O1, thus allowing for estimates of seroincidence. This provides a new avenue for understanding the epidemiology of cholera, identifying priority areas for cholera prevention/control investments, and tracking progress in the global fight against this ancient disease

Early- Onset Stroke and Vasculopathy Associated with Mutations in ADA2

Adenosine deaminase 2 (ADA2) is an enzyme involved in purine metabolism and a growth factor that influences the development of endothelial cells and leukocytes. This study shows that defects in ADA2 cause recurrent fevers, vascular pathologic features, and mild immunodeficiency. Patients with autoinflammatory disease sometimes present with clinical findings that encompass multiple organ systems.(1) Three unrelated children presented to the National Institutes of Health (NIH) Clinical Center with intermittent fevers, recurrent lacunar strokes, elevated levels of acute-phase reactants, livedoid rash, hepatosplenomegaly, and hypogammaglobulinemia. Collectively, these findings do not easily fit with any of the known inherited autoinflammatory diseases. Hereditary or acquired vascular disorders can have protean manifestations yet be caused by mutations in a single gene. Diseases such as the Aicardi-Goutieres syndrome,(2),(3) polypoidal choroidal vasculopathy,(4) sickle cell anemia,(5) livedoid vasculopathy,(6) and the small-vessel vasculitides(7),(8) are examples of systemic ...</p

Q

The Qweak experiment, which took data at Jefferson Lab in the period 2010 - 2012, will precisely determine the weak charge of the proton by measuring the parity-violating asymmetry in elastic e-p scattering at 1.1 GeV using a longitudinally polarized electron beam and a liquid hydrogen target at a low momentum transfer of Q2 = 0.025 (GeV/c)2. The weak charge of the proton is predicted by the Standard Model and any significant deviation would indicate physics beyond the Standard Model. The technical challenges and experimental apparatus for measuring the weak charge of the proton will be discussed, as well as the method of extracting the weak charge of the proton. The results from a small subset of the data, that has been published, will also be presented. Furthermore an update will be given of the current status of the data analysis