Where do Innovations Come From? Transformations in the U.S. Economy, 1970-2006

This article brings to bear new data on the issue of structuring national innovation systems. Drawing on a unique data set of prize winning innovations between 1971 and 2006, we document three key changes in the U.S. economy. The first is an expanding role of interorganizational collaborations in producing award winning innovations. The second is the diminishing role of the largest corporations as sources of innovation. The third is the expanded role of public institutions and public funding in the innovation process. This leads us to the surprising conclusion that the U.S. increasingly resembles a Developmental Network State in which government initiatives are critical in overcoming network failures and in providing critical funding for the innovation process. The paper concludes by addressing the implications of these finding for debates over the appropriate regime for intellectual property rights.

Quantifying inbreeding avoidance through extra-pair reproduction

© 2014 The Author(s). Evolution © 2014 The Society for the Study of Evolution.Peer reviewedPublisher PD

Large-scale genomics unveils the genetic architecture of psychiatric disorders

Family study results are consistent with genetic effects making substantial contributions to risk of psychiatric disorders such as schizophrenia, yet robust identification of specific genetic variants that explain variation in population risk had been disappointing until the advent of technologies that assay the entire genome in large samples. We highlight recent progress that has led to a better understanding of the number of risk variants in the population and the interaction of allele frequency and effect size. The emerging genetic architecture implies a large number of contributing loci (that is, a high genome-wide mutational target) and suggests that genetic risk of psychiatric disorders involves the combined effects of many common variants of small effect, as well as rare and de novo variants of large effect. The capture of a substantial proportion of genetic risk facilitates new study designs to investigate the combined effects of genes and the environment

Increased incidence and risk of septicemia and urinary tract infection after Clostridioides difficile infection

BACKGROUND: Although increased occurrence of septicemia in persons with METHODS: The first episode of CDI was identified using 2011-2017 MarketScan and CMS Medicare data and CDI cases categorized by standard surveillance definitions. Uninfected persons were frequency matched 4:1 to cases by the CDI case surveillance definition. Multivariable Cox proportional hazards models were used to identify risk factors for septicemia and UTI within 90 days of CDI onset, accounting for the competing risk of death in the Medicare population. RESULTS: The incidence of septicemia was highest after hospital-onset CDI in the Medicare, younger commercial, and younger Medicaid populations (25.5%, 15.7%, and 19.5%, respectively) and lowest in those with community-associated CDI (3.8%, 4.3%, and 8.3%, respectively). In contrast, the incidence of UTI was highest in those with other healthcare facility onset CDI in all 3 populations (32.1%, 24.2%, and 18.1%, respectively). Hospital-onset CDI was associated with highest risk of septicemia compared with uninfected controls in all 3 populations. In the younger populations, risk of septicemia was more uniform across the CDI surveillance definitions. The risk of UTI was significantly higher in all CDI surveillance categories compared to uninfected controls, and among CDI cases it was lowest in those with community-associated CDI. CONCLUSIONS: The incidence of septicemia is high after CDI, particularly after hospital-onset infection. Additional preventive measures are needed to reduce infectious complications of CDI

Healthcare costs of Clostridioides difficile infection in commercially insured younger adults

In a US adult population aged \u3c65 years, attributable costs due t

Como se dá a inovação dentro do Estado Desenvolvimentista em Rede? Novos dados sobre acordos público-privados em um laboratório do Departamento de Energia dos Estados Unidos

A importância dos laboratórios nacionais do Department of Energy (DOE) para o sistema nacional de inovação dos EUA há muito tem sido tema de debate. Seus defensores destacam o papel central dos laboratórios no desenvolvimento de tecnologias como baterias avançadas, e os grandes progressos em energia solar, tecnologias de imagem e diversos empreendimentos em TI, entre outros. Seus críticos têm sugerido reiteradamente que a capacidade de inovação dos laboratórios vem se deteriorando por falta de parcerias com empresas comerciais e de táticas de gestão. O que – surpreendentemente, talvez - tem faltado nesse debate é uma revisão meticulosa dos dados sobre parcerias público-privadas entre os laboratórios e empresas privadas. Este artigo baseia-se em dados não públicos sobre um tipo de acordo contratual – os acordos Work-For-Others (WFO) (Trabalho-Para-Outros) – através dos quais o laboratório realiza um contrato de trabalho com empresas privadas. Revisamos 10 anos de dados dos WFO de um único laboratório do DOE. Nossa análise proporciona um panorama inicial da geografia surpreendentemente diversa e da gama de empresas que contrataram o laboratório como fornecedor de P&D, bem como de características chave desses acordos. Apesar de nossa coleta de dados compreender acordos de apenas um laboratório, os achados reforçam a importância de olhar a complexa e sobreposta rede de programas no sistema federal Americano que apoia a inovação no setor privado

huSync : a model and system for the measure of synchronization in small groups : a case study on musical joint action

Human communication entails subtle non-verbal modes of expression, which can be analyzed quantitatively using computational approaches and thus support human sciences. In this paper we present huSync, a computational framework and system that utilizes trajectory information extracted using pose estimation algorithms from video sequences to quantify synchronization between individuals in small groups. The system is exploited to study interpersonal coordination in musical ensembles. Musicians communicate with each other through sounds and gestures, providing nonverbal cues that regulate interpersonal coordination. huSync was applied to recordings of concert performances by a professional instrumental ensemble playing two musical pieces. We examined effects of different aspects of musical structure (texture and phrase position) on interpersonal synchronization, which was quantified by computing phase locking values of head motion for all possible within-group pairs. Results indicate that interpersonal coupling was stronger for polyphonic textures (ambiguous leadership) than homophonic textures (clear melodic leader), and this difference was greater in early portions of phrases than endings (where coordination demands are highest). Results were cross-validated against an analysis of audio features, showing links between phase locking values and event density. This research produced a system, huSync, that can quantify synchronization in small groups and is sensitive to dynamic modulations of interpersonal coupling related to ambiguity in leadership and coordination demands, in standard video recordings of naturalistic human group interaction. huSync enabled a better understanding of the relationship between interpersonal coupling and musical structure, thus enhancing collaborations between human and computer scientists

Hubble Space Telescope Observations of Comet 9P/Tempel 1 during the Deep Impact Encounter

We report on the Hubble Space Telescope program to observe periodic comet 9P/Tempel 1 in conjunction with NASA's Deep Impact mission. Our objectives were to study the generation and evolution of the coma resulting from the impact and to obtain wide-band images of the visual outburst generated by the impact. Two observing campaigns utilizing a total of 17 HST orbits were carried out: the first occurred on 2005 June 13-14 and fortuitously recorded the appearance of a new, short-lived fan in the sunward direction on June 14. The principal campaign began two days before impact and was followed by contiguous orbits through impact plus several hours and then snapshots one, seven, and twelve days later. All of the observations were made using the Advanced Camera for Surveys (ACS). For imaging, the ACS High Resolution Channel (HRC) provides a spatial resolution of 36 km (16 km/pixel) at the comet at the time of impact. Baseline images of the comet, made prior to impact, photometrically resolved the comet's nucleus. The derived diameter, 6.1 km, is in excellent agreement with the 6.0 +/- 0.2 km diameter derived from the spacecraft imagers. Following the impact, the HRC images illustrate the temporal and spatial evolution of the ejecta cloud and allow for a determination of its expansion velocity distribution. One day after impact the ejecta cloud had passed out of the field-of-view of the HRC.Comment: 15 pages, 14 postscript figures. Accepted for publication in Icarus special issue on Deep Impac