EPOS: A Novel Use of CERIF for Data-intensive Science

AbstractOne of the key aspects of the approaching data-intensive science era is integration of data through interoperability of systems providing data products or visualization and processing services. Far from being simple, interoperability requires robust and scalable e-infrastructures capable of supporting it. In this work we present the case of EPOS, a plan for data integration in the field of Earth Sciences. We describe the design of its e-infrastructure and show its main characteristics. One of the main elements enabling the system to integrate data, data products and services is the metadata catalogue based on the CERIF metadata model. Such a model, modified to fit into the general e-infrastructure design, is part of a three-layer metadata architecture. CERIF guarantees a robust handling of metadata, which is in this case the key to the interoperability and to one of the feature of the EPOS system: the possibility of carrying on data intensive science orchestrating the distributed resources made available by EPOS data providers and stakeholders

Current Research Information Systems (CRIS): Past, Present and Future

publishedVersio

Limitations in Predicting the Space Radiation Health Risk for Exploration Astronauts

Despite years of research, understanding of the space radiation environment and the risk it poses to long-duration astronauts remains limited. There is a disparity between research results and observed empirical effects seen in human astronaut crews, likely due to the numerous factors that limit terrestrial simulation of the complex space environment and extrapolation of human clinical consequences from varied animal models. Given the intended future of human spaceflight, with efforts now to rapidly expand capabilities for human missions to the moon and Mars, there is a pressing need to improve upon the understanding of the space radiation risk, predict likely clinical outcomes of interplanetary radiation exposure, and develop appropriate and effective mitigation strategies for future missions. To achieve this goal, the space radiation and aerospace community must recognize the historical limitations of radiation research and how such limitations could be addressed in future research endeavors. We have sought to highlight the numerous factors that limit understanding of the risk of space radiation for human crews and to identify ways in which these limitations could be addressed for improved understanding and appropriate risk posture regarding future human spaceflight.Comment: Accepted for publication by Nature Microgravity (2018

Data integration and FAIR data management in Solid Earth Science

Integrated use of multidisciplinary data is nowadays a recognized trend in scientific research, in particular in the domain of solid Earth science where the understanding of a physical process is improved and made complete by different types of measurements – for instance, ground acceleration, SAR imaging, crustal deformation – describing a physical phenomenon. FAIR principles are recognized as a means to foster data integration by providing a common set of criteria for building data stewardship systems for Open Science. However, the implementation of FAIR principles raises issues along dimensions like governance and legal beyond, of course, the technical one. In the latter, in particular, the development of FAIR data provision systems is often delegated to Research Infrastructures or data providers, with support in terms of metrics and best practices offered by cluster projects or dedicated initiatives. In the current work, we describe the approach to FAIR data management in the European Plate Observing System (EPOS), a distributed research infrastructure in the solid Earth science domain that includes more than 250 individual research infrastructures across 25 countries in Europe. We focus in particular on the technical aspects, but including also governance, policies and organizational elements, by describing the architecture of the EPOS delivery framework both from the organizational and technical point of view and by outlining the key principles used in the technical design. We describe how a combination of approaches, namely rich metadata and service-based systems design, are required to achieve data integration. We show the system architecture and the basic features of the EPOS data portal, that integrates data from more than 220 services in a FAIR way. The construction of such a portal was driven by the EPOS FAIR data management approach, that by defining a clear roadmap for compliance with the FAIR principles, produced a number of best practices and technical approaches for complying with the FAIR principles. Such a work, that spans over a decade but concentrates the key efforts in the last 5 years with the EPOS Implementation Phase project and the establishment of EPOS-ERIC, was carried out in synergy with other EU initiatives dealing with FAIR data. On the basis of the EPOS experience, future directions are outlined, emphasizing the need to provide i) FAIR reference architectures that can ease data practitioners and engineers from the domain communities to adopt FAIR principles and build FAIR data systems; ii) a FAIR data management framework addressing FAIR through the entire data lifecycle, including reproducibility and provenance; and iii) the extension of the FAIR principles to policies and governance dimensions.publishedVersio

Methodology to sustain common information spaces for research collaborations

Information and knowledge sharing collaborations are essential for scientific research and innovation. They provide opportunities to pool expertise and resources. They are required to draw on today’s wealth of data to address pressing societal challenges. Establishing effective collaborations depends on the alignment of intellectual and technical capital. In this thesis we investigate implications and influences of socio-technical aspects of research collaborations to identify methods of facilitating their formation and sustained success. We draw on our experience acquired in an international federated seismological context, and in a large research infrastructure for solid-Earth sciences. We recognise the centrality of the users and propose a strategy to sustain their engagement as actors participating in the collaboration. Our approach promotes and enables their active contribution in the construction and maintenance of Common Information Spaces (CISs). These are shaped by conceptual agreements that are captured and maintained to facilitate mutual understanding and to underpin their collaborative work. A user-driven approach shapes the evolution of a CIS based on the requirements of the communities involved in the collaboration. Active users’ engagement is pursued by partitioning concerns and by targeting their interests. For instance, application domain experts focus on scientific and conceptual aspects; data and information experts address knowledge representation issues; and architects and engineers build the infrastructure that populates the common space. We introduce a methodology to sustain CIS and a conceptual framework that has its foundations on a set of agreed Core Concepts forming a Canonical Core (CC). A representation of such a CC is also introduced that leverages and promotes reuse of existing standards: EPOS-DCAT-AP. The application of our methodology shows promising results with a good uptake and adoption by the targeted communities. This encourages us to continue applying and evaluating such a strategy in the future

Data Management in Distributed, Federated Research Infrastructures: The Case of EPOS

Data management is a key activity when Open Data stewardship through services complying with the FAIR principles is required, as it happens in many National and European initiatives. Existing guidelines and tools facilitate the drafting of Data Management Plans by focusing on a set of common parameters or questions. In this paper we describe how data management is carried out in EPOS, the European Research Infrastructure for providing access to integrated data and services in the solid Earth domain. EPOS relies on a federated model and is committed to remain operational in the long term. In EPOS, five key dimensions were identified for the Federated Data Management, namely the management of: thematic data; e-infrastructure for data integration; community of data providers committed to data provision processes; sustainability; and policies. On the basis of the EPOS experience, which is to some extent applicable to other research infrastructures, we propose additional components that may extend the EU Horizon 2020 Data Management Guidelines template, thus comprehensively addressing the Federated Data Management in the context of distributed Research Infrastructures

Coherent matter wave inertial sensors for precision measurements in space

We analyze the advantages of using ultra-cold coherent sources of atoms for matter-wave interferometry in space. We present a proof-of-principle experiment that is based on an analysis of the results previously published in [Richard et al., Phys. Rev. Lett., 91, 010405 (2003)] from which we extract the ratio h/m for 87Rb. This measurement shows that a limitation in accuracy arises due to atomic interactions within the Bose-Einstein condensate

The inflammatory microenvironment in colorectal neoplasia

Peer reviewedPublisher PD

Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science

Abstract Background Many interventions found to be effective in health services research studies fail to translate into meaningful patient care outcomes across multiple contexts. Health services researchers recognize the need to evaluate not only summative outcomes but also formative outcomes to assess the extent to which implementation is effective in a specific setting, prolongs sustainability, and promotes dissemination into other settings. Many implementation theories have been published to help promote effective implementation. However, they overlap considerably in the constructs included in individual theories, and a comparison of theories reveals that each is missing important constructs included in other theories. In addition, terminology and definitions are not consistent across theories. We describe the Consolidated Framework For Implementation Research (CFIR) that offers an overarching typology to promote implementation theory development and verification about what works where and why across multiple contexts. Methods We used a snowball sampling approach to identify published theories that were evaluated to identify constructs based on strength of conceptual or empirical support for influence on implementation, consistency in definitions, alignment with our own findings, and potential for measurement. We combined constructs across published theories that had different labels but were redundant or overlapping in definition, and we parsed apart constructs that conflated underlying concepts. Results The CFIR is composed of five major domains: intervention characteristics, outer setting, inner setting, characteristics of the individuals involved, and the process of implementation. Eight constructs were identified related to the intervention (e.g., evidence strength and quality), four constructs were identified related to outer setting (e.g., patient needs and resources), 12 constructs were identified related to inner setting (e.g., culture, leadership engagement), five constructs were identified related to individual characteristics, and eight constructs were identified related to process (e.g., plan, evaluate, and reflect). We present explicit definitions for each construct. Conclusion The CFIR provides a pragmatic structure for approaching complex, interacting, multi-level, and transient states of constructs in the real world by embracing, consolidating, and unifying key constructs from published implementation theories. It can be used to guide formative evaluations and build the implementation knowledge base across multiple studies and settings.http://deepblue.lib.umich.edu/bitstream/2027.42/78272/1/1748-5908-4-50.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/2/1748-5908-4-50-S1.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/3/1748-5908-4-50-S3.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/4/1748-5908-4-50-S4.PDFhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/5/1748-5908-4-50.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78272/6/1748-5908-4-50-S2.PDFPeer Reviewe

Public Health and Cost Benefits of Successful Reperfusion After Thrombectomy for Stroke

Background and Purpose- The benefit that endovascular thrombectomy offers to patients with stroke with large vessel occlusions depends strongly on reperfusion grade as defined by the expanded Thrombolysis in Cerebral Infarction (eTICI) scale. Our aim was to determine the lifetime health and cost consequences of the quality of reperfusion for patients, healthcare systems, and society. Methods- A Markov model estimated lifetime quality-adjusted life years (QALY) and lifetime costs of endovascular thrombectomy-treated patients with stroke based on eTICI grades. The analysis was performed over a lifetime horizon in a United States setting, adopting healthcare and societal perspectives. The reference case analysis was conducted for stroke at 65 years of age. National health and cost consequences of improved eTICI 2c/3 reperfusion rates were estimated. Input parameters were based on best available evidence. Results- Lifetime QALYs increased for every grade of improved reperfusion (median QALYs for eTICI 0/1: 2.62; eTICI 2a: 3.46; eTICI 2b: 5.42; eTICI 2c: 5.99; eTICI 3: 6.73). Achieving eTICI 3 over eTICI 2b reperfusion resulted on average in 1.31 incremental QALYs as well as healthcare and societal cost savings of $10 327 and$20 224 per patient. A 10% increase in the eTICI 2c/3 reperfusion rate of all annually endovascular thrombectomy-treated patients with stroke in the United States is estimated to yield additional 3656 QALYs and save $21.0 million and$36.8 million for the healthcare system and society, respectively. Conclusions- Improved reperfusion grants patients with stroke additional QALYs and leads to long-term cost savings. Procedural strategies to achieve complete reperfusion should be assessed for safety and feasibility, even when initial reperfusion seems to be adequate