Cal Poly Microgrid Fixed PV Array

The Mechanical Engineering Department at California Polytechnic State University of San Luis Obispo would like an adjustable, fixed angle solar panel mount to help educate students on basic solar energy principles. Our team has developed a unique sawhorse design utilizing ideation techniques and design selection tools. The selected design allows for multiple panel adjustability and control of both azimuth and tilt angle. Safety concerns are addressed with action plans to mitigate risk. Concept prototypes to justify gearbox functionality and subsystem cohesion was utilized to reduce manufacturing issues. Manufacturing began in March 2020 and proceed through until the end of the month. The manufacturing of the mount was halted due to COVID-19, forcing the design to end strictly in a what-if manufacturing procedure to allow the construction of it to be done in future time

Simulative Investigations of the Influence of Surface Indentations on Residual Stresses on Inner Raceways for Roller Element Bearings

Resource-efficient machine elements are in the focus of current research. One of the most widely used machine elements are roller bearings. Thus, the optimization of bearings and their tribological properties promises to result in significant resource savings. Special focus is set on the bearing fatigue life, which may be significantly reduced by indentations on the raceways. The reduction in fatigue life can be caused by processes such as rolling over particles or by brinelling. These processes induce local stress peaks and lead to elastic-plastic deformations of the raceways. During the subsequent operation, the pile up of material around the indentations is flattened and hence the residual stresses change. Inside these so called shoulders stress pealcs, residual stresses and hardening effects occur possibly resulting in crack initiation, crack growth under cyclic loading, and eventually spalling of material. For deeper and more sharp-edged indentations the bearing fatigue life is reduced more. To quantify the influence of an indentation on the bearing rating life a calculation model was developed based on the approach of IOANNIDES, BERGLING and GABELLI. For this, a 3D-FE model is used to calculate the three dimensional stress fields by superposition of residual and load stresses

Mechanism of Preconditioning by Isoflurane in Rabbits: A Direct Role for Reactive Oxygen Species

LARGE quantities of reactive oxygen species (ROS) released during reperfusion after coronary artery occlusion damage proteins responsible for intracellular homeostasis, produce tissue injury, depress contractile function, and increase myocardial infarct size. In contrast, small quantities of ROS may exert beneficial effects during ischemia and reperfusion when released before a prolonged ischemic event. ROS derived from mitochondria during a brief ischemic episode produce preconditioning. Free radical scavengers administered during ischemic preconditioning (IPC) markedly attenuate the protective effect of the preconditioning stimulus on infarct size. These data suggest that IPC is mediated in part by small quantities of ROS released during preconditioning. Volatile anesthetics protect myocardium against infarction through a signal transduction pathway that includes adenosine type 1 receptors, protein kinase C, inhibitory guanine regulatory proteins, and mitochondrial and sarcolemmal adenosine triphosphate-regulated potassium (KATP) channels. A recent investigation by Müllenheim et al . provides compelling evidence that ROS also mediate myocardial protection produced by volatile anesthetics. We sought to confirm and extend these important results by examining the hypothesis that ROS scavengers inhibit isoflurane-induced protection against irreversible ischemic injury. We further tested the hypothesis that isoflurane directly generates ROS in rabbit ventricular myocardium in vivo using a confocal microscopic technique combined with the superoxide anion-specific fluorescent probe dihydroethidium

Exploiting transient protein states for the design of small-molecule stabilizers of mutant p53

The destabilizing p53 cancer mutation Y220C creates an extended crevice on the surface of the protein that can be targeted by small-molecule stabilizers. Here, we identify different classes of small molecules that bind to this crevice and determine their binding modes by X-ray crystallography. These structures reveal two major conformational states of the pocket and a cryptic, transiently open hydrophobic subpocket that is modulated by Cys220. In one instance, specifically targeting this transient protein state by a pyrrole moiety resulted in a 40-fold increase in binding affinity. Molecular dynamics simulations showed that both open and closed states of this subsite were populated at comparable frequencies along the trajectories. Our data extend the framework for the design of high-affinity Y220C mutant binders for use in personalized anticancer therapy and, more generally, highlight the importance of implementing protein dynamics and hydration patterns in the drug-discovery process

Avalanches and micrometeorology driving mass and energy balance of the lowest perennial ice field of the Alps: a case study

The mass balance of very small glaciers is often governed by anomalous snow accumulation, winter precipitation being multiplied by snow redistribution processes (gravitationally or wind driven), or suppressed snow ablation driven by micrometeorological effects lowering net radiation and/or turbulent heat exchange. In this case study, we analysed the relative contribution of snow accumulation and ablation processes governing the long- and short-term mass balance of the lowest perennial ice field of the Alps, the Ice Chapel, located at 870&thinsp;m&thinsp;a.s.l. in the Berchtesgaden National Park (Germany). This study emphasizes the importance of the local topographic setting for the survival of a perennial ice field located far below the climatic snow line. Although long-term mass balance measurements of the ice field surface showed a dramatic mass loss between 1973 and 2014, the ice field mass balance was rather stable between 2014 and 2017 and even showed a strong mass gain in 2017/2018 with an increase in surface height by 50&thinsp;%–100&thinsp;% relative to the ice field thickness. Measurements suggest that the winter mass balance clearly dominated the annual mass balance. At the Ice Chapel surface, 92&thinsp;% of snow accumulation was gained by snow avalanching, thus clearly governing the 2017/2018 winter mass balance of the ice field with mean snow depths of 32&thinsp;m at the end of the accumulation period. Avalanche deposition was amplified by preferential deposition of snowfall in the wind-sheltered rock face surrounding the ice field. Detailed micrometeorological measurements combined with a numerical analysis of the small-scale near-surface atmospheric flow field identified the micrometeorological processes driving the energy balance of the ice field. Measurements revealed a katabatic flow system draining down the ice field throughout the day, showing strong temporal and spatial dynamics. The spatial origin of the thermal flow system was shown to be of particular importance for the ice field surface energy balance. Numerical simulation indicates that deep katabatic flows, which developed at higher-elevation shaded areas of the rock face and drained down the ice field, enhance sensible heat exchange towards the ice field surface by enhancing turbulence close to the ice surface. Conversely, the shallow katabatic flow developing at the ice field surface appeared to laterally decouple the local near-surface atmosphere from the warmer adjacent air suppressing heat exchange. Numerical results thus suggest that shallow katabatic flows driven by the cooling effect of the ice field surface are especially efficient in lowering the climatic sensitivity of the ice field to the surrounding rising air temperatures. Such micrometeorological phenomena must be taken into account when calculating mass and energy balances of very small glaciers or perennial ice fields at elevations far below the climatic snow line.</p

Characterization and Source Term Assessments of Radioactive Particles from Marshall Islands Using Non-Destructive Analytical Techniques

A considerable fraction of radioactivity entering the environment from different nuclear events is associated with particles. The impact of these events can only be fully assessed where there is some knowledge about the mobility of particle bound radionuclides entering the environment. The behavior of particulate radionuclides is dependent on several factors, including the physical, chemical and redox state of the environment, the characteristics of the particles (e.g., the chemical composition, crystallinity and particle size) and on the oxidative state of radionuclides contained in the particles. Six plutonium-containing particles stemming from Runit Island soil (Marshall Islands) were characterized using non-destructive analytical and microanalytical methods. By determining the activity of {sup 239,240}Pu and {sup 241}Am isotopes from their gamma peaks structural information related to Pu matrix was obtained, and the source term was revealed. Composition and elemental distribution in the particles were studied with synchrotron radiation based micro X-ray fluorescence (SR-{mu}-XRF) spectrometry. Scanning electron microscope equipped with energy dispersive X-ray detector (SEMEDX) and secondary ion mass spectrometer (SIMS) were used to examine particle surfaces. Based on the elemental composition the particles were divided into two groups; particles with plain Pu matrix, and particles where the plutonium is included in Si/O-rich matrix being more heterogeneously distributed. All of the particles were identified as fragments of initial weapons material. As containing plutonium with low {sup 240}Pu/{sup 239}Pu atomic ratio, {approx}2-6%, which corresponds to weapons grade plutonium, the source term was identified to be among the safety tests conducted in the history of Runit Island

The PyCBC search for gravitational waves from compact binary coalescence

We describe the PyCBC search for gravitational waves from compact-object binary coalescences in advanced gravitational-wave detector data. The search was used in the first Advanced LIGO observing run and unambiguously identified two black hole binary mergers, GW150914 and GW151226. At its core, the PyCBC search performs a matched-filter search for binary merger signals using a bank of gravitational-wave template waveforms. We provide a complete description of the search pipeline including the steps used to mitigate the effects of noise transients in the data, identify candidate events and measure their statistical significance. The analysis is able to measure false-alarm rates as low as one per million years, required for confident detection of signals. Using data from initial LIGO's sixth science run, we show that the new analysis reduces the background noise in the search, giving a 30% increase in sensitive volume for binary neutron star systems over previous searches.Comment: 29 pages, 7 figures, accepted by Classical and Quantum Gravit

First modern human settlement recorded in the Iberian hinterland occurred during Heinrich Stadial 2 within harsh environmental conditions

As the south-westernmost region of Europe, the Iberian Peninsula stands as a key area for understanding the process of modern human dispersal into Eurasia. However, the precise timing, ecological setting and cultural context of this process remains controversial concerning its spatiotemporal distribution within the different regions of the peninsula. While traditional models assumed that the whole Iberian hinterland was avoided by modern humans due to ecological factors until the retreat of the Last Glacial Maximum, recent research has demonstrated that hunter-gatherers entered the Iberian interior at least during Solutrean times. We provide a multi-proxy geoarchaeological, chronometric and paleoecological study on human–environment interactions based on the key site of Peña Capón (Guadalajara, Spain). Results show (1) that this site hosts the oldest modern human presence recorded to date in central Iberia, associated to pre-Solutrean cultural traditions around 26, 000 years ago, and (2) that this presence occurred during Heinrich Stadial 2 within harsh environmental conditions. These findings demonstrate that this area of the Iberian hinterland was recurrently occupied regardless of climate and environmental variability, thus challenging the widely accepted hypothesis that ecological risk hampered the human settlement of the Iberian interior highlands since the first arrival of modern humans to Southwest Europe. © 2021, The Author(s)

First modern human settlement recorded in the Iberian hinterland occurred during Heinrich Stadial 2 within harsh environmental conditions

As the south-westernmost region of Europe, the Iberian Peninsula stands as a key area for understanding the process of modern human dispersal into Eurasia. However, the precise timing, ecological setting and cultural context of this process remains controversial concerning its spatiotemporal distribution within the different regions of the peninsula. While traditional models assumed that the whole Iberian hinterland was avoided by modern humans due to ecological factors until the retreat of the Last Glacial Maximum, recent research has demonstrated that hunter-gatherers entered the Iberian interior at least during Solutrean times. We provide a multi-proxy geoarchaeological, chronometric and paleoecological study on human?environment interactions based on the key site of Peña Capón (Guadalajara, Spain). Results show (1) that this site hosts the oldest modern human presence recorded to date in central Iberia, associated to pre-Solutrean cultural traditions around 26,000 years ago, and (2) that this presence occurred during Heinrich Stadial 2 within harsh environmental conditions. These findings demonstrate that this area of the Iberian hinterland was recurrently occupied regardless of climate and environmental variability, thus challenging the widely accepted hypothesis that ecological risk hampered the human settlement of the Iberian interior highlands since the first arrival of modern humans to Southwest Europe.Tis research was carried out in the context of the ERC MULTIPALEOIBERIA project, funded by the European Research Council (ERC-2018-STG-805478), and the PALEOINTERIOR project, funded by the Spanish Ministry of Science and Innovation (HAR2017-82483-C3-3-P)