Discovery of a Metal-Line Absorber Associated with a Local Dwarf Starburst Galaxy

We present optical and near-infrared images, H I 21 cm emission maps, optical spectroscopy, and Hubble Space Telescope/Space Telescope Imaging Spectrograph ultraviolet spectroscopy of the QSO/galaxy pair SBS 1122+594/IC 691. The QSO sight line lies at a position angle of 27 degrees from the minor axis of the nearby dwarf starburst galaxy IC 691 (cz_gal = 1204+-3 km/s, L_B ~ 0.09 L*, current star formation rate = 0.08-0.24 solar masses per year) and 33 kpc (6.6 arcmin) from its nucleus. We find that IC 691 has an H I mass of M_HI = (3.6+-0.1) x 10^8 solar masses and a dynamical mass of M_dyn = (3.1+-0.5) x 10^10 solar masses. The UV spectrum of SBS 1122+594 shows a metal-line (Ly-alpha + C IV) absorber near the redshift of IC 691 at cz_abs = 1110+-30 km/s. Since IC 691 is a dwarf starburst and the SBS 1122+594 sight line lies in the expected location for an outflowing wind, we propose that the best model for producing this metal-line absorber is a starburst wind from IC 691. We place consistent metallicity limits on IC 691 ([Z/Zsun] ~ -0.7) and the metal-line absorber ([Z/Zsun] < -0.3). We also find that the galaxy's escape velocity at the absorber location is v_esc = 80+-10 km/s and derive a wind velocity of v_w = 160+-50 km/s. Thus, the evidence suggests that IC 691 produces an unbound starburst wind that escapes from its gravitational potential to transport metals and energy to the surrounding intergalactic medium.Comment: 31 pages, 8 figures; AJ in press; a version with high resolution figures can be downloaded from http://casa.colorado.edu/~keeney/research/papers/IC691.pd

Optimal percolation in correlated multilayer networks with overlap

Multilayer networks have been found to be prone to abrupt cascading failures under random and targeted attacks, but most of the targeting algorithms proposed so far have been mainly tested on uncorrelated systems. Here we show that the size of the critical percolation set of a multilayer network is substantially affected by the presence of inter-layer degree correlations and edge overlap. We provide extensive numerical evidence which confirms that the state-of-the-art optimal percolation strategies consistently fail to identify minimal percolation sets in synthetic and real-world correlated multilayer networks, thus overestimating their robustness. We propose two new targeting algorithms, based on the local estimation of path disruptions away from a given node, and a family of Pareto-efficient strategies that take into account both intra-layer and inter-layer heuristics, and can be easily extended to multiplex networks with an arbitrary number of layers. We show that these strategies consistently outperform existing attacking algorithms, on both synthetic and real-world multiplex networks, and provide some interesting insights about the interplay of correlations and overlap in determining the hyperfragility of real-world multilayer networks. Overall, the results presented in the paper suggest that we are still far from having fully identified the salient ingredients determining the robustness of multiplex networks to targeted attacks.Comment: 14 pages, 9 figures, 1 tabl

Relationships among pro-inflammatory and degradation-related biomarkers released by articular cartilage from osteoarthritic knees

"Orthpaedic Surgery, School of Medicine."Introduction: Osteoarthritis (OA) is a multifactorial disease often progressing from an initial insult or injury to whole-joint inflammation and degeneration causing pain and dysfunction ; Previous studies have indicated moderate to weak linear correlations between inflammatory and degradation related biomarker production levels by OA cartilage during culture ; This study was designed to characterize non-linear relationships among pro-inflammatory and degradation- related biomarkers produced by articular cartilage recovered from patients with knee OA."This study was funded by the Thompson Laboratory for Regenerative Orthopaedics."Neurological Surgery, University of Missouri School of Medicin

A z=0.9 supercluster of X-ray luminous, optically-selected, massive galaxy clusters

We report the discovery of a compact supercluster structure at z=0.9. The structure comprises three optically-selected clusters, all of which are detected in X-rays and spectroscopically confirmed to lie at the same redshift. The Chandra X-ray temperatures imply individual masses of ~5x10^14 Msun. The X-ray masses are consistent with those inferred from optical--X-ray scaling relations established at lower redshift. A strongly-lensed z~4 Lyman break galaxy behind one of the clusters allows a strong-lensing mass to be estimated for this cluster, which is in good agreement with the X-ray measurement. Optical spectroscopy of this cluster gives a dynamical mass in good agreement with the other independent mass estimates. The three components of the RCS2319+00 supercluster are separated from their nearest neighbor by a mere <3 Mpc in the plane of the sky and likely <10 Mpc along the line-of-sight, and we interpret this structure as the high-redshift antecedent of massive (~10^15 Msun) z~0.5 clusters such as MS0451.5-0305.Comment: ApJ Letters accepted. 5 pages in emulateapj, 3 figure

Vegetation and peat characteristics of restiad bogs on Chatham Island (Rekohu), New Zealand

Restiad bogs dominated by Sporadanthus traversii on Chatham Island, New Zealand, were sampled to correlate vegetation patterns and peat properties, and to compare with restiad systems dominated by Sporadanthus ferrugineus and Empodisma minus in the Waikato region, North Island, New Zealand. Classification and ordination resulted in five groups that reflected a disturbance gradient. The largest S. traversii group, which comprised plots from central, relatively intact bogs, had the lowest levels of total nitrogen (mean 1.20 mg cm-3), total phosphorus (mean 0.057 mg cm-3), total potassium (mean 0.083 mg cm-3), and available phosphorus (mean 18.6 μg cm-3). Modification by drainage, stock, and fires resulted in a decline of S. traversii and an increase of Gleichenia dicarpa fern cover, together with elevated peat nutrient levels and higher bulk density. Compared with peat dominated by Sporadanthus ferrugineus or Empodisma minus in relatively unmodified Waikato restiad bogs, Chatham Island peat under S. traversii has significantly higher total potassium, total nitrogen, available phosphorus, bulk density, and von Post decomposition indices, and significantly lower pH. Sporadanthus traversii and Empodisma minus have similar ecological roles in restiad bog development, occupying a relatively wide nutrient range, and regenerating readily from seed after fire. Despite differences in root morphology, S. traversii and E. minus are the major peat formers in raised restiad bogs on Chatham Island and in Waikato, respectively, and could be regarded as ecological equivalents

The Cosmic Background Imager

Design and performance details are given for the Cosmic Background Imager (CBI), an interferometer array that is measuring the power spectrum of fluctuations in the cosmic microwave background radiation (CMBR) for multipoles in the range 400 < l < 3500. The CBI is located at an altitude of 5000 m in the Atacama Desert in northern Chile. It is a planar synthesis array with 13 0.9-m diameter antennas on a 6-m diameter tracking platform. Each antenna has a cooled, low-noise receiver operating in the 26-36 GHz band. Signals are cross-correlated in an analog filterbank correlator with ten 1 GHz bands. This allows spectral index measurements which can be used to distinguish CMBR signals from diffuse galactic foregrounds. A 1.2 kHz 180-deg phase switching scheme is used to reject cross-talk and low-frequency pick-up in the signal processing system. The CBI has a 3-axis mount which allows the tracking platform to be rotated about the optical axis, providing improved (u,v) coverage and a powerful discriminant against false signals generated in the receiving electronics. Rotating the tracking platform also permits polarization measurements when some of the antennas are configured for the orthogonal polarization.Comment: 14 pages. Accepted for publication in PASP. See also http://www.astro.caltech.edu/~tjp/CBI

A holistic multi-methodology for sustainable renovation

A review of the barriers for building renovation has revealed a lack of methodologies, which can promote sustainability objectives and assist various stakeholders during the design stage of building renovation/retrofitting projects. The purpose of this paper is to develop a Holistic Multi-methodology for Sustainable Renovation, which aims to deal with complexity of renovation projects. It provides a framework through which to involve the different stakeholders in the design process to improve group learning and group decision-making, and hence make the building renovation design process more robust and efficient. Therefore, the paper discusses the essence of multifaceted barriers in building renovation regarding cultural changes and technological/physical changes. The outcome is a proposal for a multi-methodology framework, which is developed by introducing, evaluating and mixing methods from Soft Systems Methodologies (SSM) with Multiple Criteria Decision Making (MCDM). The potential of applying the proposed methodology in renovation projects is demonstrated through a case study

Measuring organisational readiness for patient engagement (MORE) : an international online Delphi consensus study

Date of Acceptance: 28/01/2015. © 2015 Oostendorp et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise statedWidespread implementation of patient engagement by organisations and clinical teams is not a reality yet. The aim of this study is to develop a measure of organisational readiness for patient engagement designed to monitor and facilitate a healthcare organisation’s willingness and ability to effectively implement patient engagement in healthcarePeer reviewedFinal Published versio

Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast

Meiotic recombination plays an essential role in the proper segregation of chromosomes at meiosis I in many sexually reproducing organisms. Meiotic recombination is initiated by the scheduled formation of genome-wide DNA double-strand breaks (DSBs). The timing of DSB formation is strictly controlled because unscheduled DSB formation is detrimental to genome integrity. Here, we investigated the role of DNA damage checkpoint mechanisms in the control of meiotic DSB formation using budding yeast. By using recombination defective mutants in which meiotic DSBs are not repaired, the effect of DNA damage checkpoint mutations on DSB formation was evaluated. The Tel1 (ATM) pathway mainly responds to unresected DSB ends, thus the sae2 mutant background in which DSB ends remain intact was employed. On the other hand, the Mec1 (ATR) pathway is primarily used when DSB ends are resected, thus the rad51 dmc1 double mutant background was employed in which highly resected DSBs accumulate. In order to separate the effect caused by unscheduled cell cycle progression, which is often associated with DNA damage checkpoint defects, we also employed the ndt80 mutation which permanently arrests the meiotic cell cycle at prophase I. In the absence of Tel1, DSB formation was reduced in larger chromosomes (IV, VII, II and XI) whereas no significant reduction was found in smaller chromosomes (III and VI). On the other hand, the absence of Rad17 (a critical component of the ATR pathway) lead to an increase in DSB formation (chromosomes VII and II were tested). We propose that, within prophase I, the Tel1 pathway facilitates DSB formation, especially in bigger chromosomes, while the Mec1 pathway negatively regulates DSB formation. We also identified prophase I exit, which is under the control of the DNA damage checkpoint machinery, to be a critical event associated with down-regulating meiotic DSB formation

A Model of User Preferences for Semantic Services Discovery and Ranking

Current proposals on Semantic Web Services discovery and ranking are based on user preferences descriptions that often come with insufficient expressiveness, consequently making more difficult or even preventing the description of complex user desires. There is a lack of a general and comprehensive preference model, so discovery and ranking proposals have to provide ad hoc preference descriptions whose expressiveness depends on the facilities provided by the corresponding technique, resulting in user preferences that are tightly coupled with the underlying formalism being used by each concrete solution. In order to overcome these problems, in this paper an abstract and sufficiently expressive model for defining preferences is presented, so that they may be described in an intuitively and user-friendly manner. The proposed model is based on a well-known query preference model from database systems, which provides highly expressive constructors to describe and compose user preferences semantically. Furthermore, the presented proposal is independent from the concrete discovery and ranking engines selected, and may be used to extend current Semantic Web Service frameworks, such as wsmo, sawsdl, or owl-s. In this paper, the presented model is also validated against a complex discovery and ranking scenario, and a concrete implementation of the model in wsmo is outlined.Comisión Interministerial de Ciencia y Tecnología TIN2006-00472Comisión Interministerial de Ciencia y Tecnología TIN2009-07366Junta de Andalucía TIC-253