PENGENDALIAN PENCEMARAN LINGKUNGAN AKIBAT LIMBAH PETERNAKAN BABI DI DESA JAGAPATI KECAMATAN ABIANSEMAL KABUPATEN BADUNG

Livestock is any human activity related to raising animals for the purpose of meeting various needs. Pig farming is a popular choice in Jagapati Village, Abiansemal District, Badung Regency. Pig farming produces waste comprising leftover feed, drinking water, urine, feces, and wastewater from cleaning and bathing pigs. Poor disposal of pig waste poses potential environmental pollution. The aim of this study is to determine how environmental pollution due to pig farming waste is controlled in Jagapati Village, as well as to identify associated challenges and solutions. Based on empirical legal research conducted directly with respondents to gather primary data supplemented by secondary data, it was found that various efforts have been made by farmers, the village government, and the district government to control environmental pollution caused by pig farming waste in Jagapati Village. Despite these efforts, the district government should play a more active role in conducting comprehensive data collection of pig farmers in Jagapati Village, particularly in documenting the types and scales of livestock operations that require Registration Certificates, Letters of Registration, and Livestock Business Licenses as stipulated in Regulation of the Minister of Agriculture of the Republic of Indonesia Number 14 of 2020 concerning Registration and Licensing of Livestock Businesses

Hybrid spectrum access with relay assisting both primary and secondary networks under imperfect spectrum sensing

This paper proposes a novel hybrid interweave-underlay spectrum access for a cognitive amplify-and-forward relay network where the relay forwards the signals of both the primary and secondary networks. In particular, the secondary network (SN) opportunistically operates in interweave spectrum access mode when the primary network (PN) is sensed to be inactive and switches to underlay spectrum access mode if the SN detects that the PN is active. A continuous-time Markov chain approach is utilized to model the state transitions of the system. This enables us to obtain the probability of each state in the Markov chain. Based on these probabilities and taking into account the impact of imperfect spectrum sensing of the SN, the probability of each operation mode of the hybrid scheme is obtained. To assess the performance of the PN and SN, we derive analytical expressions for the outage probability, outage capacity, and symbol error rate over Nakagami-m fading channels. Furthermore, we present comparisons between the performance of underlay cognitive cooperative radio networks (CCRNs) and the performance of the considered hybrid interweave-underlay CCRN in order to reveal the advantages of the proposed hybrid spectrum access scheme. Eventually, with the assistance of the secondary relay, performance improvements for the PN are illustrated by means of selected numerical results

Targeted Inactivation of Cerberus Like-2 Leads to Left Ventricular Cardiac Hyperplasia and Systolic Dysfunction in the Mouse

Previous analysis of the Cerberus like 2 knockout (Cerl2(-/-)) mouse revealed a significant mortality during the first day after birth, mostly due to cardiac defects apparently associated with randomization of the left-right axis. We have however, identified Cerl2-associated cardiac defects, particularly a large increase in the left ventricular myocardial wall in neonates that cannot be explained by laterality abnormalities. Therefore, in order to access the endogenous role of Cerl2 in cardiogenesis, we analyzed the embryonic and neonatal hearts of Cerl2 null mutants that did not display a laterality phenotype. Neonatal mutants obtained from the compound mouse line Cer2(-/-)Fundacao para a Ciencia e Tecnologia (FCT); IBB/CBME [PEst-OE/EQB/LA0023/2011]; FCT [SFRH/BD/62081/2009]info:eu-repo/semantics/publishedVersio

Contribution of Transcription Factor Binding Site Motif Variants to Condition-Specific Gene Expression Patterns in Budding Yeast

It is now experimentally well known that variant sequences of a cis transcription factor binding site motif can contribute to differential regulation of genes. We characterize the relationship between motif variants and gene expression by analyzing expression microarray data and binding site predictions. To accomplish this, we statistically detect motif variants with effects that differ among environments. Such environmental specificity may be due to either affinity differences between variants or, more likely, differential interactions of TFs bound to these variants with cofactors, and with differential presence of cofactors across environments. We examine conservation of functional variants across four Saccharomyces species, and find that about a third of transcription factors have target genes that are differentially expressed in a condition-specific manner that is correlated with the nucleotide at variant motif positions. We find good correspondence between our results and some cases in the experimental literature (Reb1, Sum1, Mcm1, and Rap1). These results and growing consensus in the literature indicates that motif variants may often be functionally distinct, that this may be observed in genomic data, and that variants play an important role in condition-specific gene regulation