Strength analysis of the plated clavicle

This paper discusses the methods of fastening a clavicle reinforcement plate to the bone. In order to identify the advantages and disadvantages of different types of plates, computer modeling and strength analysis was performed for two plates, which were manufactured from different materials and which employed different mounting design element

Strength analysis of the plated clavicle

This paper discusses the methods of fastening a clavicle reinforcement plate to the bone. In order to identify the advantages and disadvantages of different types of plates, computer modeling and strength analysis was performed for two plates, which were manufactured from different materials and which employed different mounting design element

Innovative teacher education through personalised learning: designing teaching and learning scenarios

The growing diversity of the student population twinned with a shift towards more learner-centred education provides the impetus to develop innovative teaching approaches. Imagined as personalised learning (PL), this approach argues for greater flexibility for the learner and more opportunities to include students' voice in the design and enactment of learning. This paper distils the learning from the members of the INTERPEARL project consortium including Lithuanian Universities Siauliai University (SU), Vytautas Magnus University (VMU), and Vilnius University (VU) together with their international partners University of Iceland (UI), and University College Cork, Ireland (UCC). The paper is based on the theoretical assumptions of social construction and takes mixed method approach to uncover the learning from implementing a personalised learning process to encourage greater learner agency and co-creation of learning. This paper will introduce the PL framework developed by the INTERPEARL consortium and two related concepts, namely Learning Scenarios and Learning Design. The learning from the implementation of the PL Framework in Iceland, Ireland, and Lithuanian is uncovered, with a methodology of self-study of teaching and teacher education practices (S-STEP), and student-teachers surveys providing a strong rationale for more PL approach

Ring nucleases deactivate Type III CRISPR ribonucleases by degrading cyclic oligoadenylate

This work was funded by grants from the Biotechnology and Biological Sciences Research Council (REF BB/M000400/1 and BB/M021017/1). MFW is a Wolfson Research Merit Award holder.The CRISPR system provides adaptive immunity against mobile genetic elements in prokaryotes, using small CRISPR RNAs that direct effector complexes to degrade invading nucleic acids1,2,3. Type III effector complexes were recently demonstrated to synthesize a  novel second messenger, cyclic oligoadenylate, on binding target RNA4,5. Cyclic oligoadenylate, in turn, binds to and activates ribonucleases  and other factors—via a CRISPR-associated Rossman-fold domain—and thereby induces in the cell an antiviral state that is important for immunity. The mechanism of the ‘off-switch’ that resets the system is not understood. Here we identify the nuclease that degrades these cyclic oligoadenylate ring molecules. This ‘ring nuclease’ is itself a protein of the CRISPR-associated Rossman-fold family, and has a metal-independent mechanism that cleaves cyclic tetraadenylate rings to generate linear diadenylate species and switches off the antiviral state. The identification of ring nucleases adds an important insight tothe CRISPR system.PostprintPeer reviewe

Manifestation of Parental Support for Primary Form Students Learning at Home

The research deals with the parental support for primary form student learning at home. The following problem questions were raised: what are the types of parental involvement in children's learning and how does parental support manifest in practice of children learning at home. The problem is also relevant because the primary form students' age is the time when parent support has the highest value and creates conditions for comprehensive personality growth: academic skills, children's future prospects, mental health and formation of social relationships. By applying the data collection method of in-depth interview, the conditions to understand what types of parental involvement in children's learning manifest while providing learning support at home have been created. The method of content analysis helped to reveal the following types of parental involvement in children's learning: control and autonomy supportive practice. Expression of the said roles manifested during the following parents' initiatives/ actions: collaboration, motivation, intrusion of rules, instructions of parents, preaching, continuous observation