Putting self-regulation theory into practice: A user's manual

Cervone, Shadel, Smith, and Fiori (2006) propose that theories of personality architecture may provide an integrative theoretical framework for self-regulation research. Building further on this argument, the present paper considers one comprehensive modern approach to personality architecture, personality systems interactions (PSI) theory. The authors provide a brief overview of PSI theory and discuss a simple, three-step "user's manual" that has guided applications of the theory to real-life behavior. Work on PSI theory highlights some of the integrative potential of personality science in the field of self-regulation. The authors conclude that theories of personality architecture may improve the quality and precision of the counselling, coaching, and training that psychologists in many diverse areas provide. © 2006 International Association for Applied Psychology

Exclusion of BMP6 as a candidate gene for cleidocranial dysplasia

Cleidocranial dysplasia (CCD) is an autosomal dominant, generalized skeletal dysplasia in humans that has been mapped to the short arm of chromosome 6. We report linkage of a CCD mutation to 6p21 in a large family and exclude the bone morphogenetic protein 6 gene (BMP6) as a candidate for the disease by cytogenetic localization and genetic recombination. CCD was linked with a maximal two-point LOD score of 7.22 with marker D6S452 at θ = 0. One relative with a recombination between D6S451 and D6S459 and another individual with a recombination between D6S465 and CCD places the mutation within a 7 cM region between D6S451 and D6S465 at 6p21. A phage P1 genomic clone spanning most of the BMP6 gene hybridized to chromosome 6 in band region p23–p24 using FISH analysis, placing this gene cytogenetically more distal than the region of linkage for CCD. We derived a new polymorphic marker from this same P1 clone and found recombinations between the marker and CCD in this family. The results confirm the map position of CCD on 6p21, further refine the CCD genetic interval by identifying a recombination between D6S451 and D6S459, and exclude BMP6 as a candidate gene. Am. J. Med. Genet. 71:292–297, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38269/1/9_ftp.pd

Mechanisms of noncovalent β subunit regulation of NaV channel gating

Voltage-gated Na(+) (NaV) channels comprise a macromolecular complex whose components tailor channel function. Key components are the non-covalently bound β1 and β3 subunits that regulate channel gating, expression, and pharmacology. Here, we probe the molecular basis of this regulation by applying voltage clamp fluorometry to measure how the β subunits affect the conformational dynamics of the cardiac NaV channel (NaV1.5) voltage-sensing domains (VSDs). The pore-forming NaV1.5 α subunit contains four domains (DI-DIV), each with a VSD. Our results show that β1 regulates NaV1.5 by modulating the DIV-VSD, whereas β3 alters channel kinetics mainly through DIII-VSD interaction. Introduction of a quenching tryptophan into the extracellular region of the β3 transmembrane segment inverted the DIII-VSD fluorescence. Additionally, a fluorophore tethered to β3 at the same position produced voltage-dependent fluorescence dynamics strongly resembling those of the DIII-VSD. Together, these results provide compelling evidence that β3 binds proximally to the DIII-VSD. Molecular-level differences in β1 and β3 interaction with the α subunit lead to distinct activation and inactivation recovery kinetics, significantly affecting NaV channel regulation of cell excitability

You can’t always remember what you want: The role of cortisol in self-ascription of assigned goals

Past work indicates that persistent stress leads people to misremember assigned tasks as self-selected, a phenomenon known as self-infiltration [Baumann, N., & Kuhl, J. (2003). Self-infiltration: Confusing assigned tasks as self-selected in memory. Personality and Social Psychology Bulletin, 29, 487-497; Kazén, M., Baumann, N., & Kuhl, J. (2003). Self-infiltration vs. self-compatibility checking in dealing with unattractive tasks and unpleasant items: The moderating influence of state vs. action-orientation. Motivation & Emotion, 27, 157-197; Kuhl, J., & Kazén, M. (1994). Self-discrimination and memory: State orientation and false-self-ascription of assigned activities. Journal of Personality & Social Psychology, 66, 1103-1115]. The present research examined the link between self-infiltration and cortisol, a well-established stress hormone. Participants selected simple office tasks for later enactment and were assigned to do an additional set of office tasks by an instructor. After an 8-min stress induction, participants were unexpectedly asked to recognize which tasks were self-selected or assigned. Cortisol was assessed before and after the stress induction. As expected, self-infiltration was predicted both by pre- and by post-manipulation cortisol levels. These results point to some of the neuroendocrine functions that underlie the self. © 2009 Elsevier Inc. All rights reserved

Early detection of rifampin in human nerve tissue after an oral dose of 600 milligrams.

Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue