Audio-visual detection benefits in the rat

Human psychophysical studies have described multisensory perceptual benefits such as enhanced detection rates and faster reaction times in great detail. However, the neural circuits and mechanism underlying multisensory integration remain difficult to study in the primate brain. While rodents offer the advantage of a range of experimental methodologies to study the neural basis of multisensory processing, rodent studies are still limited due to the small number of available multisensory protocols. We here demonstrate the feasibility of an audio-visual stimulus detection task for rats, in which the animals detect lateralized uni- and multi-sensory stimuli in a two-response forced choice paradigm. We show that animals reliably learn and perform this task. Reaction times were significantly faster and behavioral performance levels higher in multisensory compared to unisensory conditions. This benefit was strongest for dim visual targets, in agreement with classical patterns of multisensory integration, and was specific to task-informative sounds, while uninformative sounds speeded reaction times with little costs for detection performance. Importantly, multisensory benefits for stimulus detection and reaction times appeared at different levels of task proficiency and training experience, suggesting distinct mechanisms inducing these two multisensory benefits. Our results demonstrate behavioral multisensory enhancement in rats in analogy to behavioral patterns known from other species, such as humans. In addition, our paradigm enriches the set of behavioral tasks on which future studies can rely, for example to combine behavioral measurements with imaging or pharmacological studies in the behaving animal or to study changes of integration properties in disease models

Eccentricity dependent auditory enhancement of visual stimulus detection but not discrimination

Sensory perception is enhanced by the complementary information provided by our different sensory modalities and even apparently task irrelevant stimuli in one modality can facilitate performance in another. While perception in general comprises both, the detection of sensory objects as well as their discrimination and recognition, most studies on audio-visual interactions have focused on either of these aspects. However, previous evidence, neuroanatomical projections between early sensory cortices and computational mechanisms suggest that sounds might differentially affect visual detection and discrimination and differentially at central and peripheral retinal locations. We performed an experiment to directly test this by probing the enhancement of visual detection and discrimination by auxiliary sounds at different visual eccentricities and within the same subjects. Specifically, we quantified the enhancement provided by sounds that reduce the overall uncertainty about the visual stimulus beyond basic multisensory co-stimulation. This revealed a general trend for stronger enhancement at peripheral locations in both tasks, but a statistically significant effect only for detection and only at peripheral locations. Overall this suggests that there are topographic differences in the auditory facilitation of basic visual processes and that these may differentially affect basic aspects of visual recognition

Neurophysiological correlates of the rubber hand illusion in late evoked and alpha/beta band activity

The rubber hand illusion (RHI) allows insights into how the brain resolves conflicting multisensory information regarding body position and ownership. Previous neuroimaging studies have reported a variety of neurophysiological correlates of illusory hand ownership, with conflicting results likely originating from differences in experimental parameters and control conditions. Here, we overcome these limitations by using a fully automated and precisely-timed visuo-tactile stimulation setup to record evoked responses and oscillatory responses in participants who felt the RHI. Importantly, we relied on a combination of experimental conditions to rule out confounds of attention, body-stimulus position and stimulus duration and on the combination of two control conditions to identify neurophysiological correlates of illusory hand ownership. In two separate experiments we observed a consistent illusion-related attenuation of ERPs around 330 ms over frontocentral electrodes, as well as decreases of frontal alpha and beta power during the illusion that could not be attributed to changes in attention, body-stimulus position or stimulus duration. Our results reveal neural correlates of illusory hand ownership in late and likely higher-order rather than early sensory processes, and support a role of premotor and possibly intraparietal areas in mediating illusory body ownership

Neural codes formed by small and temporally precise populations in auditory cortex

The encoding of sensory information by populations of cortical neurons forms the basis for perception but remains poorly understood. To understand the constraints of cortical population coding we analyzed neural responses to natural sounds recorded in auditory cortex of primates (Macaca mulatta). We estimated stimulus information while varying the composition and size of the considered population. Consistent with previous reports we found that when choosing subpopulations randomly from the recorded ensemble, the average population information increases steadily with population size. This scaling was explained by a model assuming that each neuron carried equal amounts of information, and that any overlap between the information carried by each neuron arises purely from random sampling within the stimulus space. However, when studying subpopulations selected to optimize information for each given population size, the scaling of information was strikingly different: a small fraction of temporally precise cells carried the vast majority of information. This scaling could be explained by an extended model, assuming that the amount of information carried by individual neurons was highly nonuniform, with few neurons carrying large amounts of information. Importantly, these optimal populations can be determined by a single biophysical marker—the neuron's encoding time scale—allowing their detection and readout within biologically realistic circuits. These results show that extrapolations of population information based on random ensembles may overestimate the population size required for stimulus encoding, and that sensory cortical circuits may process information using small but highly informative ensembles

Flavor and chiral oscillations with Dirac wave packets

We report about recent results on Dirac wave packets in the treatment of neutrino flavor oscillation where the initial localization of a spinor state implies an interference between positive and negative energy components of mass-eigenstate wave packets. A satisfactory description of fermionic particles requires the use of the Dirac equation as evolution equation for the mass-eigenstates. In this context, a new flavor conversion formula can be obtained when the effects of chiral oscillation are taken into account. Our study leads to the conclusion that the fermionic nature of the particles, where chiral oscillations and the interference between positive and negative frequency components of mass-eigenstate wave packets are implicitly assumed, modifies the standard oscillation probability. Nevertheless, for ultra-relativistic particles and sharply peaked momentum distributions, we can analytically demonstrate that these modifications introduce correction factors proportional to (m12/p0) square which are practically un-detectable by any experimental analysisComment: 16 pages, 2 figure

Dopamine, time perception, and future time perspective.

RationaleImpairment in time perception, a critical component of decision-making, represents a risk factor for psychiatric conditions including substance abuse. A therapeutic that ameliorates this impairment could be advantageous in the treatment of impulsivity and decision-making disorders.ObjectivesHere we hypothesize that the catechol-O-methyltransferase (COMT) inhibitor tolcapone, which increases dopamine tone in frontal cortex (Ceravolo et al Synapse 43:201-207, 2002), improves time perception, with predictive behavioral, genetic, and neurobiological components.MethodsSubjects (n = 66) completed a duration estimation task and other behavioral testing in each of two sessions after receiving a single oral dose of tolcapone (200 mg) or placebo in randomized, double-blind, counterbalanced, crossover fashion. Resting state fMRI data were obtained in a subset of subjects (n = 40). Subjects were also genotyped for the COMT (rs4680) polymorphism.ResultsTime perception was significantly improved across four proximal time points ranging from 5 to 60 s (T(524) = 2.04, p = 0.042). The degree of this improvement positively correlated with subjective measures of stress, depression, and alcohol consumption and was most robust in carriers of the COMT Val158 allele. Using seed regions defined by a previous meta-analysis (Wiener et al Neuroimage 49:1728-1740, 2010), we found not only that a connection from right inferior frontal gyrus (RIFG) to right putamen decreases in strength on tolcapone versus placebo (p < 0.05, corrected), but also that the strength of this decrease correlates inversely with the increase in duration estimation on tolcapone versus placebo (r = - 0.37, p = 0.02).ConclusionsCompressed time perception can be ameliorated by administration of tolcapone. Additional studies should be conducted to determine whether COMT inhibitors may be effective in treating decision-making disorders and addictive behaviors

Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung cancer

Objective: To determine the expression of endogenous adhesion/growth-regulatory lectins and their binding sites using labeled tissue lectins as well as the binding profile of hyaluronic acid as an approach to define new prognostic markers. Methods: Sections of paraffin-embedded histological material of 481 lungs from lung tumor patients following radical lung excision processed by a routine immunohistochemical method (avidin-biotin labeling, DAB chromogen). Specific antibodies against galectins-1 and - 3 and the heparin-binding lectin were tested. Staining by labeled galectins and hyaluronic acid was similarly visualized by a routine protocol. After semiquantitative assessment of staining, the results were compared with the pT and pN stages and the histological type. Survival was calculated by univariate and multivariate methods. Results: Binding of galectin-1 and its expression tended to increase, whereas the parameters for galectin-3 decreased in advanced pT and pN stages at a statistically significant level. The number of positive cases was considerably smaller among the cases with small cell lung cancer than in the group with non-small-cell lung cancer, among which adenocarcinomas figured prominently with the exception of galectin-1 expression. Kaplan-Meier computations revealed that the survival rate of patients with galectin-3-binding or galectin-1-expressing tumors was significantly poorer than that of the negative cases. In the multivariate calculations of survival lymph node metastases ( p < 0.0001), histological type ( p = 0.003), galectin-3-binding capacity ( p = 0.01), galectin-3 expression ( p = 0.03) and pT status ( p = 0.003) proved to be independent prognostic factors, not correlated with the pN stage. Conclusion: The expression and the capacity to bind the adhesion/growth regulatory galectin-3 is defined as an unfavorable prognostic factor not correlated with the pTN stage. Copyright (C) 2005 S. Karger AG, Basel

Resolving a Discrete Ambiguity in the CKM Angle β\beta through Bu,d→J/ψK∗B_{u,d} \to J/\psi K^\ast and Bs→J/ψϕB_s \to J/\psi \phi Decays

It is well known that $\sin(2\beta)$, where $\beta$ is one of the angles of the unitarity triangle of the CKM matrix, can be determined in a theoretically clean way by measuring mixing-induced CP violation in the decay $B_d \to J/\psi K_S$. Another clean extraction of this CKM angle is provided by the time-dependent angular distribution for the decay products of $B_d \to J/\psi(\to l^+l^-) K^{\ast0}(\to \pi^0 K_S)$, where we have more observables at our disposal than in the case of $B_d \to J/\psi K_S$, so that in addition to $\sin(2\beta)$ also $\cos(2\beta)$ can be probed in a direct way. Unfortunately a sign ambiguity remains in $\cos(2\beta)$. If it could be resolved, a discrete ambiguity in the extraction of the CKM angle $\beta$ could be resolved as well, which would allow a more incisive test of the CKM model of CP violation. This note shows that detailed time-dependent studies of $B_{u,d} \to J/\psi K^{\ast}$ and $B_s \to J/\psi \phi$ decay processes can determine the sign of $\cos(2\beta)$, thereby removing the corresponding ambiguity in the extraction of the CKM angle $\beta$.Comment: 5 pages, LaTeX, no figure

Flavor Neutrino Oscillations and Time-Energy Uncertainty Relation

We consider neutrino oscillations as non stationary phenomenon based on Schrodinger evolution equation and mixed states of neutrinos with definite flavors. We show that time-energy uncertainty relation plays a crucial role in neutrino oscillations. We compare neutrino oscillations with $B_{d}^{0}\leftrightarrows\bar B_{d}^{0}$ oscillations.Comment: A report at the 2nd Scandinavian Neutrino Workshop, SNOW 2006, Stockholm, May 2-6, 200

Digital Start-Up Ecosystems: A Systematic Literature Review and Model Development for South Africa

Digital start-ups play a crucial role in boosting the economies of many countries through technological innovations. Several studies have been conducted assessing digital start-ups or digital entrepreneurship, mainly from the perspective of the Global North. However, gaps exist in the literature regarding digital ecosystems, especially in the context of developing countries (the Global South), such as South Africa. This study fills this gap by exploring the structure as well as highlighting the hindering factors of the start-up ecosystem in South Africa. In addition, the study explores the influential factors of the digital start-up ecosystem and models that can be used to assess upscaling for the growth of new digital start-up ventures. The study conducted a systematic literature review using the PRISMA framework. The Scopus-indexed database was used to source published peer-reviewed papers on digital ecosystems between 2017 and 2023. Key findings of the study pertaining to South Africa’s start-up ecosystem revealed that the country is producing thriving digital start-ups. The current study also identified several challenges that affect the development of digital start-ups in South Africa. Some of the challenges include regulatory barriers, skills shortages, a lack of funding, and a digital infrastructure gap, among others. Furthermore, work is being conducted by ecosystem stakeholders to address these challenges, with a greater collective and cohesive effort needed to effectively address the hindering factors. The study advocates for intervention as well as policy and practitioner implications that could be utilised by ecosystem stakeholders, particularly entrepreneurs in the digital market. The research findings pertain to the South African start-up ecosystem but have greater appeal and relevancy for many developing start-up ecosystems globally, especially in the Global South