The Assessment of Knowledge and Attitudes of Personnels working in a Training and Research Hospital located in Central Anatolia on Rational Drug Use

AMAÇ: Akılcı ilaç kullanımı süreci, hastanın probleminin tanımlanmasından, tedavinin sonuçlandırılması ve izlenmesini kapsayan sistematik bir yaklaşımdır. Hastane çalışanlarının AİK ilkelerine uygun davranmaması akılcı olmayan ilaç kullanımı sorununu doğuracak ve ilaçların akılcı ilaç kullanım döngüsünü sekteye uğratacaktır. Bu çalışmanın amacı; İç Anadolu bölgesinde hizmet vermekte olan bir eğitim araştırma hastanesinin çalışanlarının AİK ile ilgili farkındalık düzeylerini belirlemektir. YÖNTEM ve GEREÇLER: Çalışmanın evrenini, Eğitim ve Araştırma Hastanesi'nde çalışan hekim (n=130), hemşire (n=310) oluşturmuştur. Anket formunun uygulandığı günlerde izinde olan ve çalışmaya katılmak istemeyenler nedeniyle 64 hekim, 148 hemşire çalışmaya dahil edilmiştir. Veriler, Türkiye İlaç ve Tıbbi Cihaz Kurumu(Ankara/Türkiye), Akılcı İlaç Kullanımı biriminin hazırlamış olduğu anketler kullanılarak toplanmıştır. BULGULAR: Çalışmaya katılan hekimlerin %29,7'si hastalar tarafından talep edilen ilaçları hiçbir zaman muayene etmeden ilaç reçete etmediklerini bildirirken, %40.6'sı sadece kronik hastalıkların ilaçlarını reçete ettiklerini, %18,8'i ise reçete etmedikleri takdirde tartışma çıktığını belirtmişlerdir. %50,0'ı ilaçların uygulama şeklini, %48,4'ü ilaçların günlük dozunu ve %42,2'si tedavi süresini her zaman bilgisini verdiklerini belirtmişlerdir. Çalışmaya katılan hemşirelerin karşılaştıkları ilaç uygulama hatalarına bakıldığında, %53,4'ü ilaçların atlanması, uygulanmaması, %49,3'ü ilacın yanlış zamanda uygulandığını ve %18,9'u ilacın yanlış hastaya uygulandığını belirtmişlerdir. SONUÇ: Hekim ve hemşirelerin bilgi ve tutumlarını artırmak amacı ile çalışmanın yapıldığı hastanede AİK ile ilgili her iki gruba yönelik çalışmalar yapılması, bilgi ve tutumların eğitimlerle desteklenmesi uygun olacaktırINTRODUCTION: Rational drug use(RDU) period is a systematic approach which consists identifying the problem of the patient, concluding and monitoring the treatment. The failure of hospital staff to comply with the principles of RDU will lead to the problem of unethical drug use and to the RDU. The aim of the study is, to determine the awareness level of employees in a Training and Research Hospital located in Central Anatolia which study is held regarding to RDU. METHODS: Nurses and Physicians working at the Hospital formed the population of the study. 64 physicians and 148 nurses were included in the study. Because they were on the day of the survey form and didn’t participate in the study. Data were collected by using surveys which were prepared by Turkey Medicines and Medical Devices Agency (Ankara/Turkey), RDU Unit. RESULTS: 29,7% of physicians reported that they did not prescribe medicines demanded by the patients without ever examining the patients. 18,8% of physicians stated that they had a discussion with patients if they did not prescribe. According to this, 50% of physicians stated that they always inform their patients about drug application method, 48.4% of physicians always inform about daily dosage of drugs and 42.2% of them always inform about treatment period. For medicine application errors which participating nurses most frequently encounter, they said skipping medicines (53.4%), applying medicines at wrong times (49.3%) and applying medicine to wrong patients (18.9%). CONCLUSION: In order to increase the knowledge and attitudes of physicians and nurses, it will be appropriate to carry out studies and knowledge and attitudes towards training for both groups related to RDU in the hospital where the work is don

Do Resveratrol and Dehydroepiandrosterone Increase Diminished Ovarian Reserve?

Objective: In this study, the aim is to observe changes induced by dehydroepiandrosterone (DHEA) and resveratrol (RES) in diminished ovarian follicles that was induced by 4-vinylcyclohexenediepoxide (VCD)

A novel proton transfer salt of 2-amino-6-sulfamoylbenzothiazole and its metal complexes: the evaluation of their inhibition effects on human cytosolic carbonic anhydrases

WOS: 000392591100016PubMed: 28100079A novel proton transfer compound (SMHABT) (+)(HDPC)(-) (1) obtained from 2-amino-6-sulfamoylbenzothiazole (SMABT) and 2,6-pyridinedicarboxylic acid (H2DPC) and its Fe(III), Co(II), Ni(II) complexes (2-4), and Fe(II) complex of SMABT (5) have been prepared and characterized by spectroscopic techniques. Additionally, single crystal X-ray diffraction techniques were applied to complexes (2-4). All complexes (2-4) have distorted octahedral conformations and the structure of 5 might be proposed as octahedral according to spectral and analytical results. All compounds, including acetazolamide (AAZ) as the control compound, were also evaluated for their in vitro inhibition effects on human hCA I and hCA II for their hydratase and esterase activities. The synthesized compounds have remarkable inhibitory activities on hCA I and hCA II. Especially, the inhibition potentials of the salt and the metal complexes (1-5) are comparable with AAZ. Inhibition data have been analyzed by using a one-way analysis of variance for multiple comparisons (p < .0001).Dumlupinar University Research Fund [2014/18]This work was supported by the Dumlupinar University Research Fund [(grant No. 2014/18)]