Performance considerations for the application of the lossless browse and residual model

A hybrid lossless compression model employing both the (lossy) JPEG DCT algorithm and one of a selection of lossless image compression methods has been tested. The hybrid model decomposes the original image into a low-loss quick-look browse and a residual image. The lossless compression methods tested in the model are Huffman, arithmetic, LZW, lossless JPEG, and diagonal coding. For both the direct and the hybrid application of these lossless methods, the compression ratios (CR's) are calculated and compared on three test images. For each lossless method tested, the hybrid model had no more than a nominal loss in compression efficiency relative to the direct approach. In many cases, the hybrid model provided a significant compression gain. When used in the hybrid model, lossless JPEG outperformed the other lossless methods over a broad range of browse image qualities

Performance considerations for the application of the lossless browse and residual model

A hybrid lossless compression model employing both the (lossy) JPEG DCT algorithm and one of a selection of lossless image compression methods has been tested. The hybrid model decomposes the original image into a low-loss quick-look browse and a residual image. The lossless compression methods tested in the model are Huffman, arithmetic, LZW, lossless JPEG, and diagonal coding. For both the direct and the hybrid application of these lossless methods, the compression ratios (CR's) are calculated and compared on three test images. For each lossless method tested, the hybrid model had no more than a nominal loss in compression efficiency relative to the direct approach. In many cases, the hybrid model provided a significant compression gain. When used in the hybrid model, lossless JPEG outperformed the other lossless methods over a broad range of browse image qualities.Approved for public release; distribution is unlimited

Differential Susceptibility of SD and CD Rats to a Novel Rat Theilovirus

Antibodies to rat theilovirus (RTV) have been detected in rats for many years because of their serologic crossreactivity with strains of Theiler murine encephalomyelitis virus (TMEV) of mice. Little information exists regarding this pathogen, yet it is among the most common viruses detected in serologic surveys of rats used in research. In the study reported here, a novel isolate of RTV, designated RTV1, was cultured from the feces of infected rats. The RTV1 genome contained 8094 nucleotides and had approximately 95% identity with another rat theilovirus, NSG910, and 73% identity with TMEV strains. In addition, the genome size of RTV1 was similar to those of TMEV strains but larger than that reported for NSG910. Oral inoculation of Sprague-Dawley (SD) and CD male rats (n = 10 each group) with RTV1 revealed that SD rats were more susceptible than CD rats to RTV1 infection. At 14 d postinoculation, 100% of SD rats shed virus in the feces, and 70% were positive for RTV serum antibodies. By 56 d postinoculation 30% of SD rats continued to have detectable virus in the feces, and 90% had seroconverted. In contrast, in inoculated CD rats RTV was detected only in the feces at 14 d postinoculation, at which time 40% of CD rats were fecal positive. By 56 d postinoculation only 20% of CD rats had detectable RTV serum antibodies. Our data provide additional sequence information regarding a rat-specific Cardiovirus and indicate that SD rats are more susceptible than CD rats to RTV1 infection.This work was supported by funds from a National Institutes ofHealth Postdoctoral Training in Comparative Medicine grant (T32-RR07004) and the Research Animal Diagnostic Laboratory (RADIL)

The XMM Cluster Survey: The Dynamical State of XMMXCS J2215.9-1738 at z=1.457

We present new spectroscopic observations of the most distant X-ray selected galaxy cluster currently known, XMMXCS J2215.9-1738 at z=1.457, obtained with the DEIMOS instrument at the W. M. Keck Observatory, and the FORS2 instrument on the ESO Very Large Telescope. Within the cluster virial radius, as estimated from the cluster X-ray properties, we increase the number of known spectroscopic cluster members to 17 objects, and calculate the line of sight velocity dispersion of the cluster to be 580+/-140 km/s. We find mild evidence that the velocity distribution of galaxies within the virial radius deviates from a single Gaussian. We show that the properties of J2215.9-1738 are inconsistent with self-similar evolution of local X-ray scaling relations, finding that the cluster is underluminous given its X-ray temperature, and that the intracluster medium contains ~2-3 times the kinetic energy per unit mass of the cluster galaxies. These results can perhaps be explained if the cluster is observed in the aftermath of an off-axis merger. Alternatively, heating of the intracluster medium through supernovae and/or Active Galactic Nuclei activity, as is required to explain the observed slope of the local X-ray luminosity-temperature relation, may be responsible.Comment: 13 pages, 6 figures, accepted for publication in Ap

The XMM Cluster Survey: a massive galaxy cluster at z = 1.45

We report the discovery of XMMXCS J2215.9-1738, a massive galaxy cluster at z=1.45, which was found in the XMM Cluster Survey. The cluster candidate was initially identified as an extended X-ray source in archival XMM data. Optical spectroscopy shows that six galaxies within a ~60" diameter region lie at z=1.45+/-0.01. Model fits to the X-ray spectra of the extended emission yield kT=7.4+2.7-1.8 keV (90% confidence); if there is an undetected central X-ray point source, then kT=6.5+2.6-1.8 keV. The bolometric X-ray luminosity is LX=4.4+0.8-0.6C 1044 ergs s-1 over a 2 Mpc radial region. The measured TX, which is the highest for any known cluster at z>1, suggests that this cluster is relatively massive for such a high redshift. The redshift of XMMXCS J2215.9-1738 is the highest currently known for a spectroscopically confirmed cluster of galaxies

Baseline anticholinergic burden from medications predicts incident fatal and non-fatal stroke in the EPIC-Norfolk general population.

BACKGROUND: Stroke is primarily a disease of older age, with a substantial impact on global mortality and morbidity. Medications with anticholinergic effects are widely used, but no studies have been conducted to examine the relationship between anticholinergic burden (ACB) and stroke in a general population. METHOD: The sample was drawn from the EPIC-Norfolk cohort. Baseline assessments were carried out during 1993-97 and participants were followed up until March 2016. Participants were divided into four groups according to their total ACB score at baseline; these groups were those with a total ACB score of 0, 1, 2-3 and >3. After exclusion, Cox proportional hazards models were constructed to determine the associations between the ACB score groups and the risk of incident stroke and stroke mortality. Sensitivity analysis and propensity score matched analyses were performed. RESULTS: In total 25 639 participants attended the first health check; 3917 participants were excluded, leaving 21 722 participants to be included. Participants had a mean age [standard deviation (SD)] of 58.9 (9.2) years (54.4% women). Of these, 2131 suffered incident stroke and 562 died from stroke. Mean follow-up was approximately 18 years for both outcomes. In the fully adjusted model, those with an ACB of >3 had 59% relative risk of incident stroke {hazard ratio [HR] [95% confidence interval (CI) 1.59 [1.34-1.89]} and 86% relative risk of stroke mortality [1.86 (1.37-2.53)] compared with those in ACB 0 category. Sensitivity analyses and propensity score matched analyses showed similar results. CONCLUSIONS: Our results provide an incentive for the cautious use of medications with anticholinergic properties, to help reduce the global burden of stroke

Ambiguity, multiple streams, and EU policy

The multiple streams framework draws insight from interactions between agency and institutions to explore the impact of context, time, and meaning on policy change and to assess the institutional and issue complexities permeating the European Union (EU) policy process. The authors specify the assumptions and structure of the framework and review studies that have adapted it to reflect more fully EU decision-making processes. The nature of policy entrepreneurship and policy windows are assessed to identify areas of improvement. Finally, the authors sketch out a research agenda that refines the logic of political manipulation which permeates the lens and the institutional complexity which frames the EU policy process

The "physical process" version of the first law and the generalized second law for charged and rotating black holes

We investigate both the ``physical process'' version of the first law and the second law of black hole thermodynamics for charged and rotating black holes. We begin by deriving general formulas for the first order variation in ADM mass and angular momentum for linear perturbations off a stationary, electrovac background in terms of the perturbed non-electromagnetic stress-energy, $\delta T_{ab}$, and the perturbed charge current density, $\delta j^a$. Using these formulas, we prove the "physical process version" of the first law for charged, stationary black holes. We then investigate the generalized second law of thermodynamics (GSL) for charged, stationary black holes for processes in which a box containing charged matter is lowered toward the black hole and then released (at which point the box and its contents fall into the black hole and/or thermalize with the ``thermal atmosphere'' surrounding the black hole). Assuming that the thermal atmosphere admits a local, thermodynamic description with respect to observers following orbits of the horizon Killing field, and assuming that the combined black hole/thermal atmosphere system is in a state of maximum entropy at fixed mass, angular momentum, and charge, we show that the total generalized entropy cannot decrease during the lowering process or in the ``release process''. Consequently, the GSL always holds in such processes. No entropy bounds on matter are assumed to hold in any of our arguments.Comment: 35 pages; 1 eps figur