16 research outputs found
The Susceptibility Analysis of Fungal Strains to Posaconasole in vitro Isolated from Cinical Specimens of Patients Hospitalized in Warsaw Medical University Central Clinical Hospital
Consensus on methods of development of clinical practice guidelines in oncology under the auspices of Maria Sklodowska-Curie National Research Institute of Oncology and the Agency for Health Technology Assessment and Tariff System
Introduction.As the changes leading to improvement of cancer care in Poland have shown the need to introduce clinical practice guidelines into the health care system, it has become clear that no methodological standard of the process for guidelines preparation has been established so far. The following process aims to present a unified and comprehensive clinical practice guidelines (CPGs) development methodology.
Materials and methods.A review of globally recognised methods used by guideline development groups was prepared, informing the discussion during three plenary meetings and extensive consultations in writing. The resulting document was unanimously approved by a group of 24 methodologists and clinical experts, and has been formally recognized as a standard for CPGs development by the management of the National Institute of Oncology and the Agency for Health Technology Assessment and Tariff System.
Results.Within the process, 43 recommendations were formulated to create unified and comprehensive rules for guideline development within the Polish healthcare system.
Conclusions.The presented methods are consistent with the globally recognized tools and methods of guideline development, such as GRADE and ADAPTE, and follow quality criteria described by AGREE II. The process supports the development of high-quality guidelines within a resource-constrained setting by allowing to choose between adoption, adaptation, or de novo development of either the whole document of guidelines or particular recommendations
Cryoconite – from minerals and organic matter to bioengineeredsediments on glacier's surfaces
Cryoconite is a mixture of mineral and organic material covering glacial ice, playing important roles in biogeochemical
cycles and lowering the albedo of a glacier surface. Understanding the differences in structure of
cryoconite across the globe can be important in recognizing past and future changes in supraglacial environments
and ice-organisms-minerals interactions. Despite the worldwide distribution and over a century of studies, the
basic characteristics of cryoconite, including its forms and geochemistry, remain poorly studied. The major purpose
of our study is the presentation and description of morphological diversity, chemical and photoautotrophs
composition, and organic matter content of cryoconite sampled from 33 polar and mountain glaciers around the
globe. Observations revealed that cryoconite is represented by various morphologies including loose and granular
forms. Granular cryoconite includes smooth, rounded, or irregularly shaped forms; with some having their
surfaces covered by cyanobacteria filaments. The occurrence of granules increased with the organic matter content
in cryoconite.Moreover, amajor driver of cryoconite colouringwas the concentration of organicmatter and
its interplay with minerals. The structure of cyanobacteria and algae communities in cryoconite differs between
glaciers, but representatives of cyanobacteria families Pseudanabaenaceae and Phormidiaceae, and algae families
Mesotaeniaceae and Ulotrichaceaewere themost common. Themost of detected cyanobacterial taxa are known
to produce polymeric substances (EPS) that may cement granules. Organic matter content in cryoconite varied
between glaciers, ranging from 1% to 38%. The geochemistry of all the investigated samples reflected local sediment
sources, except of highly concentrated Pb andHg in cryoconite collected fromEuropean glaciers near industrialized
regions, corroborating cryoconite as element-specific collector and potential environmental indicator of
anthropogenic activity. Our work supports a notion that cryoconite may bemore than just simple sediment and
instead exhibits complex structure with relevance for biodiversity and the functioning of glacial ecosystem
Weltimmo, Schrems and the reinforcement of cooperation between European data protection authorities
While the work on the General Data Protection Regulation slowly comes to an end, recently causing both self-reflection and worldwide heated debates on its prospects, there is no doubt two particular judgments of the Court of Justice of the European Union from October 2015 gained no less attention. Obviously we have in mind judgements in widely-debated Schrems and in yet-not-so-popular Weltimmo cases, whose influence on the regulation of personal data protection in Europe and beyond is unprecedented. This influence is at least twofold