100 research outputs found
Detection of Polarized Broad Emission in the Seyfert 2 Galaxy Mrk 573
We report the discovery of the scattered emission from a hidden broad-line
region (BLR) in a Seyfert 2 galaxy, Mrk 573, based on our recent
spectropolarimetric observation performed at the Subaru Telescope. This object
has been regarded as a type 2 AGN without a hidden BLR by the previous
observations. However, our high quality spectrum of the polarized flux of Mrk
573 shows prominent broad (~3000 km/s) H_alpha emission, broad weak H_beta
emission, and subtle Fe II multiplet emission. Our new detection of these
indications for the presence of the hidden BLR in the nucleus of Mrk 573 is
thought to be owing to the high signal-to-noise ratio of our data, but the
possibility of a time variation of the scattered BLR emission is also
mentioned. Some diagnostic quantities such as the IRAS color, the radio power,
and the line ratio of the emission from the narrow-line region of Mrk 573 are
consistent with the distributions of such quantities of type 2 AGNs with a
hidden BLR. Mrk 573 is thought to be an object whose level of the AGN activity
is the weakest among the type 2 AGNs with a hidden BLR. In terms of the
systematic differences between the type 2 AGNs with and without a hidden BLR,
we briefly comment on an interesting Seyfert 2 galaxy, Mrk 266SW, which may
possess a hidden BLR but has been treated as a type 2 AGNs without a hidden
BLR.Comment: 9 pages including 6 figures, to appear in The Astronomical Journa
Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation
Optineurin has been shown to be involved in primary open-angle glaucoma. We recently found that optineurin is involved in familial amyotrophic lateral sclerosis (ALS). On the other hand, optineurin has been shown to inhibit transcription factors related to innate immunity such as NF-kappa B and interferon regulatory factor-3 (IRF3). In the present study, the effect of ALS-associated optineurin mutations on IRF3 activation was investigated. Optineurin inhibited IRF3 activation induced by melanoma differentiation-associated gene 5 or Toll-IL-1 receptor domain-containing adaptor-inducing interferon-beta. The inhibition was abrogated by mutations related to ALS but not by a mutation related to glaucoma. Reporter assay indicated that the JAK-STAT signaling pathway was not affected by optineurin. These results show that ALS-related optineurin is involved in the IRF3 activation pathway. Pathogenesis of ALS may be associated with some kind of innate immunity, especially that against virus infection, through IRF3 activation
Inactivation of the Influenza Virus by a Supplemental Fermented Plant Product (Manda Koso)
Manda Koso is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that are fermented for more than 3 years. We hypothesized that the FPP can prevent infection by influenza virus and human norovirus. Therefore, we investigated the effects of the FPP on influenza virus and feline calicivirus, a surrogate of human norovirus. We found that 10% FPP inactivated the influenza virus but not the feline calicivirus. Inhibition of the influenza virus was highly concentration-dependent: 1% and 0.3% FPP showed reduced inactivation efficacy. The effects of the FPP on the influenza virus-infected cells were investigated by addition of the FPP to the culture medium after virus infection. No suppressive effect of the FPP on influenza replication in MDCK cells was observed. The results showed that the FPP could inactivate influenza virus by affecting the virus particles
The 2006 November outburst of EG Aquarii: the SU UMa nature revealed
We report time-resolved CCD photometry of the cataclysmic variable EG Aquarii
during the 2006 November outburst During the outburst, superhumps were
unambiguously detected with a mean period of 0.078828(6) days, firstly
classifying the object as an SU UMa-type dwarf nova. It also turned out that
the outburst contained a precursor. At the end of the precursor, immature
profiles of humps were observed. By a phase analysis of these humps, we
interpreted the features as superhumps. This is the second example that the
superhumps were shown during a precursor. Near the maximum stage of the
outburst, we discovered an abrupt shift of the superhump period by
0.002 days. After the supermaximum, the superhump period decreased at the rate
of =, which is typical for SU UMa-type dwarf
novae. Although the outburst light curve was characteristic of SU UMa-type
dwarf novae, long-term monitoring of the variable shows no outbursts over the
past decade. We note on the basic properties of long period and inactive SU
UMa-type dwarf novae.Comment: 9 pages, 7 figures, accepted for PAS
Subaru Spectropolarimetry of Mrk 573: The Hidden High-Ionization Nuclear Emission-Line Region inside the Dusty Torus
We report on the result of our high quality spectropolarimetric observation
for the narrow-line region in a nearby Seyfert 2 galaxy, Mrk 573, by the Subaru
Telescope. The polarized flux spectrum of Mrk 573 shows not only prominent
scattered broad H emission but also various narrow forbidden emission
lines. We find that the measured polarization degree of the observed forbidden
emission lines is positively correlated with the ionization potential of the
corresponding ions and the critical density of the corresponding transitions.
We discuss some possible origins of these correlations, and then we point out
that the correlations are caused due to the obscuration of the stratified
narrow-line region in Mrk 573 by the optically and geometrically thick dusty
torus, just similar to the previous study on NGC 4258.Comment: 10 pages including 8 figures, to appear in The Astronomical Journa
SLPI is a critical mediator that controls PTH-induced bone formation
Osteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although it is unclear how these cells are coordinately regulated by PTH. Here, we identify a serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI), as a critical mediator that is involved in the PTH-mediated shift to the osteoblastic phase. Slpi is highly upregulated in osteoblasts by PTH, while genetic ablation of Slpi severely impairs PTH-induced bone formation. Slpi induction in osteoblasts enhances its differentiation, and increases osteoblast–osteoclast contact, thereby suppressing osteoclastic function. Intravital bone imaging reveals that the PTH-mediated association between osteoblasts and osteoclasts is disrupted in the absence of SLPI. Collectively, these results demonstrate that SLPI regulates the communication between osteoblasts and osteoclasts to promote PTH-induced bone anabolism.Morimoto A., Kikuta J., Nishikawa K., et al. SLPI is a critical mediator that controls PTH-induced bone formation. Nature Communications 12, 2136 (2021); https://doi.org/10.1038/s41467-021-22402-x
Missing western half of the Pacific Plate: Geochemical nature of the Izanagi-Pacific Ridge interaction with a stationary boundary between the Indian and Pacific mantles
The source mantle of the basaltic ocean crust on the western half of the Pacific Plate was examined using Pb–Nd–Hf isotopes. The results showed that the subducted Izanagi–Pacific Ridge (IPR) formed from both Pacific (180–∼80 Ma) and Indian (∼80–70 Ma) mantles. The western Pacific Plate becomes younger westward and is thought to have formed from the IPR. The ridge was subducted along the Kurile–Japan–Nankai–Ryukyu (KJNR) Trench at 60–55 Ma and leading edge of the Pacific Plate is currently stagnated in the mantle transition zone. Conversely, the entire eastern half of the Pacific Plate, formed from isotopically distinct Pacific mantle along the East Pacific Rise and the Juan de Fuca Ridge, largely remains on the seafloor. The subducted IPR is inaccessible; therefore, questions regarding which mantle might be responsible for the formation of the western half of the Pacific Plate remain controversial. Knowing the source of the IPR basalts provides insight into the Indian–Pacific mantle boundary before the Cenozoic. Isotopic compositions of the basalts from borehole cores (165–130 Ma) in the western Pacific show that the surface oceanic crust is of Pacific mantle origin. However, the accreted ocean floor basalts (∼80–70 Ma) in the accretionary prism along the KJNR Trench have Indian mantle signatures. This indicates the younger western Pacific Plate of IPR origin formed partly from Indian mantle and that the Indian–Pacific mantle boundary has been stationary in the western Pacific at least since the Cretaceous
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