Use of a High-Purity Factor X Concentrate in Turkish Subjects with Hereditary Factor X Deficiency: Post Hoc Cohort Subanalysis of a Phase 3 Study

Hereditary factor X (FX) deficiency is a rare bleeding disorder more prevalent in countries with high rates of consanguineous marriage. In a prospective, open-label, multicenter phase 3 study, 25 IU/kg plasma-derived factor X (pdFX) was administered as on-demand treatment or short-term prophylaxis for 6 months to 2 years. In Turkish subjects (n=6), 60.7% of bleeds were minor. A mean of 1.03 infusions were used to treat each bleed, and mean total dose per bleed was 25.38 IU/kg. Turkish subjects rated pdFX efficacy as excellent or good for all 84 assessable bleeds; investigators judged overall pdFX efficacy to be excellent or good for all subjects. Turkish subjects had 51 adverse events; 96% with known severity were mild/moderate, and 1 (infusion-site pain) was possibly pdFX-related. These results demonstrate that 25 IU/kg pdFX is safe and effective in this Turkish cohor

Use of a High-Purity Factor X Concentrate in Turkish Subjects with Hereditary Factor X Deficiency: Post Hoc Cohort Subanalysis of a Phase 3 Study

WOS: 000433166100006PubMed ID: 29545231Hereditary factor X (FX) deficiency is a rare bleeding disorder more prevalent in countries with high rates of consanguineous marriage. In a prospective, open-label, multicenter phase 3 study, 25 IU/kg plasma-derived factor X (pdFX) was administered as on-demand treatment or short-term prophylaxis for 6 months to 2 years. In Turkish subjects (n=6), 60.7% of bleeds were minor. A mean of 1.03 infusions were used to treat each bleed, and mean total dose per bleed was 25.38 IU/kg. Turkish subjects rated pdFX efficacy as excellent or good for all 84 assessable bleeds; investigators judged overall pdFX efficacy to be excellent or good for all subjects. Turkish subjects had 51 adverse events; 96% with known severity were mild/moderate, and 1 (infusion-site pain) was possibly pdFX-related. These results demonstrate that 25 IU/kg pdFX is safe and effective in this Turkish cohortBio Products Laboratory (Elstree, UK)Bio Products Laboratory (Elstree, UK) provided support for this study and funding for medical writing and editorial support in the development of this manuscript. A.F.O.: Received educational support from Pfizer. M.N.: Employee of Bio Products Laboratory. K.K.: Advisory board member for Bayer, Novo Nordisk, Pfizer, and Shire; received educational and investigational support from Bayer, Bio Products Laboratory, CSL Behring, Novo Nordisk, Octapharma, Pfizer, and Shire

Synthesis and electrochemistry of Group 6 tetracarbonyl (N,N '-bis(ferrocenylmethylene)ethylenediamine)metal(0) complexes

Thermal substitution reaction of Cr(CO)4(η2:2-1,5-cyclooctadiene), Mo(CO)4(η2:2-norbornadiene), and W(CO)5(η2-bis(trimethylsilyl)ethyne) with N,N′-bis(ferrocenylmethylene)ethylenediamine (bfeda) yields M(CO)4(bfeda) complexes which could be isolated from the reaction solution and characterized by elemental analysis, MS, IR, and NMR spectroscopy. In the case of tungsten, W(CO)5(bfeda) is formed as intermediate and then undergoes the ring closure reaction yielding the ultimate product W(CO)4(bfeda). The electrochemical behavior of the M(CO)4(bfeda) complexes was studied by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) in dichloromethane with tetrabutylammonium tetrafluoroborate as electrolyte. Constant potential electrolysis of the complexes was performed successively at their peak potentials at 0 °C in their CH2Cl2 solution and the electrolysis was followed by in situ recording the electronic absorption spectra in every 5 mC. In the electrolysis of Cr(CO)4(bfeda), the central Cr(0) is oxidized first and electrolysis continues with oxidations of two ferrocenyl groups until the end of totally three moles of electron passage per mole of complex. In the electrolysis of Mo(CO)4(bfeda) and W(CO)4(bfeda) the first oxidation occurs on the central atom forming a short-lived species which undergoes an intramolecular one-electron transfer and is reduced back to M(0) while one of the ferrocene units is oxidized to the ferrocenium cation at the same time. This indicates that the electron is transferred from iron to the central metal atom

DİYABET SÜRESİ, HBA1C DÜZEYLERİ VE RETİNOPATİ

DİYABET SÜRESİ, HBA1C DÜZEYLERİ VE RETİNOPATİMahmut Gümüş1, Oğuz Urutürk1, Mehmet Sargın1, Ahmet Akın1, Yener Koç1, Mehmet Ali Ustaoğlu1, Birsel Kavaklı1, Ali Yayla1Dr.Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi İç Hastalıkları KliniğiBu çalışmada diabetli hastalarda diabetin mikrovaskuler komplikasyonlarmdan olan retinopati ile HbA1c, arasındaki ilişkiyi ve HbA1c düzeyinin izlenmesinin, diabetin mikrovaskuler komplikasyonlarının ortaya çıkmasını önlemekte ve tedaviyi yönlendirmekteki rolü araştırılmıştır. Hastanemiz diabet polikliniğine 1997-98 yılları arasında başvuran, en az 5 yıllık Tıp 2 DM öyküsü olan 62'si kadın, 22 'si erkek 84 hasta değerlendirildi. Hastaların yaşları, cinsiyetleri, HbA1c düzeyleri, diabet süreleri, tedavi tipleri ve göz dibi bulguları saptandı. Fundus incelemesi normal olan 54 olgunun ortalama HbA1c düzeyi %7,8 iken, retinopati saptanan olgularda bu oran %10'du (p&lt;0,05). Olgularımız diabet süreleri açısından değerlendirildiğinde HbA1c düzeyleri arasında istatistiksel olarak anlamlı fark bulunmadı (p&gt;0,05). Çalışmanın sonuçlan HbA1c'nin diabet süresi ile ilişkili olmadığını, retinopati gözlenen olgularda daha yüksek olduğunu, retinopatinin ise hem HbA1c düzeyi, hem de diabetin süresi ile pozitif ilişkili olduğunu göstermektedir.Anahtar Kelimeler:&nbsp;HBA1C, RETİNOPATİ, DİABETİK MİKROVASKULER KOMPLİKASYODURATION OF DIABETES, HBA1C LEVELS AND RETINOPATHYMahmut Gümüş1, Oğuz Urutürk1, Mehmet Sargın1, Ahmet Akın1, Yener Koç1, Mehmet Ali Ustaoğlu1, Birsel Kavaklı1, Ali Yayla1Dr.Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi İç Hastalıkları KliniğiIn this study, the correlation between HbA1c and retinopathy, one of the microvascular complications of diabetes mellitus; and the effects of HbA1c levels on protection from complications and its effects on treatment were investigated. 84 patients (F/M=62/22) who were admitted to outpatient clinic of diabetes between 1997-1998 and have Type 2 DM for at least 5 years, were evaluated. Age, gender, HbA1c levels, diabetes duration, treatment method and fundus examination of each patient were detected. Mean HbA1c levels of 54 patients whose fundus examination were normal was 7,8%; on the other hand among patients who had retinopathy it was 10% (p&lt; 0,05). There was no statistically significant difference between HbA1c levels when compared according to diabetes duration (p&gt; 0,05). As a result, we found that there was no relation between HbA1c and diabetes duration, HbA1c levels were higher among patients with retinopathy and there was a correlation between retinopathy and both HbA1c levels and diabetes duration.Keywords:&nbsp;HBA1C, RETINOPATHY, MICROVASCULAR COMPLICATIONS OF DIABETES</p

Reconstruction with a patient-specific titanium implant after a wide anterior chest wall resection

The reconstruction of full-thickness chest wall defects is a challenging problem for thoracic surgeons, particularly after a wide resection of the chest wall that includes the sternum. The location and the size of the defect play a major role when selecting the method of reconstruction, while acceptable cosmetic and functional results remain the primary goal. Improvements in preoperative imaging techniques and reconstruction materials have an important role when planning and performing a wide chest wall resection with a low morbidity rate. In this report, we describe the reconstruction of a wide anterior chest wall defect with a patient-specific custom-made titanium implant. An infected mammary tumour recurrence in a 62-year old female, located at the anterior chest wall including the sternum, was resected, followed by a large custom-made titanium implant. Latissimus dorsi flap and split-thickness graft were also used for covering the implant successfully. A titanium custom-made chest wall implant could be a viable alternative for patients who had large chest wall tumours

Oxidative stress in isolated blunt traumatic brain injury

Traumatic brain injury is a common cause of death after trauma. The aim of this study was to investigate the relationship between oxidative stress parameters and, outcomes and clinical findings in patients with isolated traumatic brain injuries. Fifty-four patients who were admitted into the emergency department of Ankara Ataturk Training and Research hospital with isolated blunt traumatic brain injuries and 33 healthy adults as control group, were included in this study. Serum oxidant status was evaluated by measuring Total Oxidant Status (TOS) levels in patients with traumatic brain injury and in healthy individuals. Serum antioxidant status was evaluated by measuring Total Antioxidant Status (TAS) levels. Then, also Oxidative Stress Index (OSI) was calculated. A total of 54 patients with isolated traumatic brain injuries (mean age 36.7 +/- 18.3 years; 60.4% male, 39.6% female) were enrolled. TOS and OSI levels increased in patient group compared to the control group. High levels of OSI, TOS and TAS were observed in patients who finally became dead. A significant correlation between symptoms including nausea, vomitus, loss of consciousness, seizing and TOS, OSI levels of all patients have been observed. Moreover, there was a meaningful correlation between Glaskow Coma Scale (GCS) score, TOS and OSI levels of patients. The oxidative stress parameters may be valuable prognostic markers in traumatic brain injury patients. It can be concluded that oxidative stress parameters may be valuable in the assessment of clinical severity and in predicting outcome of traumatic brain injury patients

Effects of omega-3 essential fatty acids against formaldehyde-induced nephropathy in rats

The aim of this study was to examine the toxicity of formaldehyde ( FA) on the kidney and the protective effects of omega-3 essential fatty acids against these toxic effects. Twenty-one male Wistar rats were divided into three groups. Rats in Group I comprised the controls, while the rats in Group II were injected every other day with FA. Rats in Group III received omega-3 fatty acids daily while exposed to FA. At the end of the 14-day experimental period, all rats were killed by decapitation and the kidneys removed. Some of the kidney tissue specimens were used for determination of superoxide dismutase ( SOD), glutathione peroxidase (GSH-Px) activities, and malondialdehyde (MDA) levels. The remaining kidney tissue specimens were used for light microscopic evaluation. The levels of SOD and GSH-Px were significantly decreased, and MDA levels were significantly increased in rats treated with FA compared with those of the controls. Furthermore, in the microscopic examination of this group, glomerular and tubular degeneration, vascular congestion and tubular dilatation were observed. However, increased SOD and GSH-Px enzyme activities, and decreased MDA levels were detected in the rats administered omega-3 fatty acids while exposed to FA. Additionally, kidney damage caused by FA was decreased and structural appearance was similar to that of the control rats in this group. In conclusion, it was determined that FA-induced kidney damage was prevented by administration of omega-3 essential fatty acids