SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation can drive melanoma progression, we made use of a zebrafish mitfa

Secretly

Illustration of woman with finger raised; Outline of man looking downward at womanhttps://scholarsjunction.msstate.edu/cht-sheet-music/12167/thumbnail.jp

Fragmentation of Nuclei at Intermediate and High Energies in Modified Cascade Model

The process of nuclear multifragmentation has been implemented, together with evaporation and fission channels of the disintegration of excited remnants in nucleus-nucleus collisions using percolation theory and the intranuclear cascade model. Colliding nuclei are treated as face--centered--cubic lattices with nucleons occupying the nodes of the lattice. The site--bond percolation model is used. The code can be applied for calculation of the fragmentation of nuclei in spallation and multifragmentation reactions.Comment: 19 pages, 10 figure

Importance of individual activated protein C cleavage site regions in coagulation Factor V for Factor Va inactivation and for Factor Xa activation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66371/1/j.1432-1327.1999.00137.x.pd

You Took The Sweet From Sweetheart

[Verse 1] What wonderful pals you and I used to be just as happy and free as the birds in the tree I carried your books to school ev’ry day it was never December ‘twas always May But now you tell me not to hope and that is why I say. [Chorus] There is no warmth in the sunshine The flowers have faded away The days are all dark there’s no song from the lark The world is all work and no play Life is so dull and so bitter I feel like a failure a quitter I’ve been yours from the start When you said we must part You took the sweet from sweetheart. [Verse 2] I’ve met lots of girls since those days back at school those dear days when we both learned the good golden rule But of all the girls that I have known you’re the only girl I wanted for my own What hard luck the world will agree to find your heart was stone. [Chorus

Multiplatform, multidisciplinary investigations of the impacts of Modified Circumpolar Deep Water in the Ross Sea, Antarctica

In 2010-2011, three projects combined to characterize the temporal and spatial distributions of Modified circumpolar Deep Water (MCDW) in the Ross Sea using icebreaker-based sampling, gliders, instrumented seals, and hindcasts from a numerical circulation model. The fieldwork cearly identified MCDW throughout the Ross Sea, and the lata were used to determine its influence on potential heat.md nutrient inputs and biotic distributions. Furthermore, the numerical simulations confirm its apparent trajectory and location. Substantial small-scale variability in oceanographic and biological distributions suggests that such variability may play an important role in biogeochemical cycles. Data from the three projects provide a view of hydrographic variability in the Ross Sea that is impossible to obtain using traditional sampling. Multiplatform investigations are promising approaches to future polar experiments where logistical considerations are of paramount important

A Comparative Study of Efficient Initialization Methods for the K-Means Clustering Algorithm

K-means is undoubtedly the most widely used partitional clustering algorithm. Unfortunately, due to its gradient descent nature, this algorithm is highly sensitive to the initial placement of the cluster centers. Numerous initialization methods have been proposed to address this problem. In this paper, we first present an overview of these methods with an emphasis on their computational efficiency. We then compare eight commonly used linear time complexity initialization methods on a large and diverse collection of data sets using various performance criteria. Finally, we analyze the experimental results using non-parametric statistical tests and provide recommendations for practitioners. We demonstrate that popular initialization methods often perform poorly and that there are in fact strong alternatives to these methods.Comment: 17 pages, 1 figure, 7 table

Lateral tilt during IVC filter placement does not predict the need for advanced filter retrieval techniques

PURPOSEWe aimed to determine if lateral inferior vena cava (IVC) filter tilt at placement predicts the need for subsequent advanced retrieval techniques.METHODSA retrospective chart review was performed of all Gunther Tulip IVC filter placements with subsequent retrievals between February 2015 and October 2017. Chart and imaging review was performed for patient, filter placement, and filter retrieval demographics/characteristics. Degree of agreement between two measurement sets was evaluated with the intraclass correlation (ICC) analysis. Categorical variables were compared with chi-square or Fisher exact test, as appropriate. Kendall rank correlation was used to measure correlation between categorical variables.RESULTSThere was poor agreement between filter tilt angle at the time of placement and retrieval (ICC coefficient, 0.54). Mean difference ± standard deviation between tilt angle at the time of placement and retrieval was 4.6°±4.3° (p = 0.35). Among patient- or procedure-related factors, a common femoral vein access on placement (regression coefficient, -2.90; p = 0.039) was associated with a lower difference between placement and retrieval filter tilt angles compared to internal jugular vein access. Higher filter tilt angle measured at the time of retrieval (OR: 1.19, p = 0.025), hook embedment (OR: 77.3, p < 0.001), and a longer dwell time (OR: 1.25, p = 0.002) were associated with the need for advanced retrieval techniques. However, in univariate and multivariate analysis filter tilt angle at the time of placement was not associated with the subsequent need for advanced retrieval technique (p = 0.16).CONCLUSIONLateral tilt at the time of placement is poorly associated with lateral tilt at the time of retrieval and does not correlate with the need for advanced retrieval technique