494 research outputs found
Canonical quantization of non-commutative holonomies in 2+1 loop quantum gravity
In this work we investigate the canonical quantization of 2+1 gravity with
cosmological constant in the canonical framework of loop quantum
gravity. The unconstrained phase space of gravity in 2+1 dimensions is
coordinatized by an SU(2) connection and the canonically conjugate triad
field . A natural regularization of the constraints of 2+1 gravity can be
defined in terms of the holonomies of . As a first step
towards the quantization of these constraints we study the canonical
quantization of the holonomy of the connection on the
kinematical Hilbert space of loop quantum gravity. The holonomy operator
associated to a given path acts non trivially on spin network links that are
transversal to the path (a crossing). We provide an explicit construction of
the quantum holonomy operator. In particular, we exhibit a close relationship
between the action of the quantum holonomy at a crossing and Kauffman's
q-deformed crossing identity. The crucial difference is that (being an operator
acting on the kinematical Hilbert space of LQG) the result is completely
described in terms of standard SU(2) spin network states (in contrast to
q-deformed spin networks in Kauffman's identity). We discuss the possible
implications of our result.Comment: 19 pages, references added. Published versio
Resummation of transverse energy in vector boson and Higgs boson production at hadron colliders
We compute the resummed hadronic transverse energy (E_T) distribution due to
initial-state QCD radiation in vector boson and Higgs boson production at
hadron colliders. The resummed exponent, parton distributions and coefficient
functions are treated consistently to next-to-leading order. The results are
matched to fixed-order calculations at large E_T and compared with
parton-shower Monte Carlo predictions at Tevatron and LHC energies.Comment: 24 pages, 15 figure
A Formalism for the Systematic Treatment of Rapidity Logarithms in Quantum Field Theory
Many observables in QCD rely upon the resummation of perturbation theory to
retain predictive power. Resummation follows after one factorizes the cross
section into the rele- vant modes. The class of observables which are sensitive
to soft recoil effects are particularly challenging to factorize and resum
since they involve rapidity logarithms. In this paper we will present a
formalism which allows one to factorize and resum the perturbative series for
such observables in a systematic fashion through the notion of a "rapidity
renormalization group". That is, a Collin-Soper like equation is realized as a
renormalization group equation, but has a more universal applicability to
observables beyond the traditional transverse momentum dependent parton
distribution functions (TMDPDFs) and the Sudakov form factor. This formalism
has the feature that it allows one to track the (non-standard) scheme
dependence which is inherent in any scenario where one performs a resummation
of rapidity divergences. We present a pedagogical introduction to the formalism
by applying it to the well-known massive Sudakov form factor. The formalism is
then used to study observables of current interest. A factorization theorem for
the transverse momentum distribution of Higgs production is presented along
with the result for the resummed cross section at NLL. Our formalism allows one
to define gauge invariant TMDPDFs which are independent of both the hard
scattering amplitude and the soft function, i.e. they are uni- versal. We
present details of the factorization and resummation of the jet broadening
cross section including a renormalization in pT space. We furthermore show how
to regulate and renormalize exclusive processes which are plagued by endpoint
singularities in such a way as to allow for a consistent resummation.Comment: Typos in Appendix C corrected, as well as a typo in eq. 5.6
Loop Quantum Gravity
The problem of finding the quantum theory of the gravitational field, and
thus understanding what is quantum spacetime, is still open. One of the most
active of the current approaches is loop quantum gravity. Loop quantum gravity
is a mathematically well-defined, non-perturbative and background independent
quantization of general relativity, with its conventional matter couplings. The
research in loop quantum gravity forms today a vast area, ranging from
mathematical foundations to physical applications. Among the most significative
results obtained are: (i) The computation of the physical spectra of
geometrical quantities such as area and volume; which yields quantitative
predictions on Planck-scale physics. (ii) A derivation of the
Bekenstein-Hawking black hole entropy formula. (iii) An intriguing physical
picture of the microstructure of quantum physical space, characterized by a
polymer-like Planck scale discreteness. This discreteness emerges naturally
from the quantum theory and provides a mathematically well-defined realization
of Wheeler's intuition of a spacetime ``foam''. Long standing open problems
within the approach (lack of a scalar product, overcompleteness of the loop
basis, implementation of reality conditions) have been fully solved. The weak
part of the approach is the treatment of the dynamics: at present there exist
several proposals, which are intensely debated. Here, I provide a general
overview of ideas, techniques, results and open problems of this candidate
theory of quantum gravity, and a guide to the relevant literature.Comment: Review paper written for the electronic journal `Living Reviews'. 34
page
A Minimal Model of Metabolism Based Chemotaxis
Since the pioneering work by Julius Adler in the 1960's, bacterial chemotaxis has been predominantly studied as metabolism-independent. All available simulation models of bacterial chemotaxis endorse this assumption. Recent studies have shown, however, that many metabolism-dependent chemotactic patterns occur in bacteria. We hereby present the simplest artificial protocell model capable of performing metabolism-based chemotaxis. The model serves as a proof of concept to show how even the simplest metabolism can sustain chemotactic patterns of varying sophistication. It also reproduces a set of phenomena that have recently attracted attention on bacterial chemotaxis and provides insights about alternative mechanisms that could instantiate them. We conclude that relaxing the metabolism-independent assumption provides important theoretical advances, forces us to rethink some established pre-conceptions and may help us better understand unexplored and poorly understood aspects of bacterial chemotaxis
Signatures of arithmetic simplicity in metabolic network architecture
Metabolic networks perform some of the most fundamental functions in living
cells, including energy transduction and building block biosynthesis. While
these are the best characterized networks in living systems, understanding
their evolutionary history and complex wiring constitutes one of the most
fascinating open questions in biology, intimately related to the enigma of
life's origin itself. Is the evolution of metabolism subject to general
principles, beyond the unpredictable accumulation of multiple historical
accidents? Here we search for such principles by applying to an artificial
chemical universe some of the methodologies developed for the study of genome
scale models of cellular metabolism. In particular, we use metabolic flux
constraint-based models to exhaustively search for artificial chemistry
pathways that can optimally perform an array of elementary metabolic functions.
Despite the simplicity of the model employed, we find that the ensuing pathways
display a surprisingly rich set of properties, including the existence of
autocatalytic cycles and hierarchical modules, the appearance of universally
preferable metabolites and reactions, and a logarithmic trend of pathway length
as a function of input/output molecule size. Some of these properties can be
derived analytically, borrowing methods previously used in cryptography. In
addition, by mapping biochemical networks onto a simplified carbon atom
reaction backbone, we find that several of the properties predicted by the
artificial chemistry model hold for real metabolic networks. These findings
suggest that optimality principles and arithmetic simplicity might lie beneath
some aspects of biochemical complexity
Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair
Jaagsiekte sheep retrovirus (JSRV) is a unique oncogenic virus with distinctive biological properties. JSRV is the only virus causing a naturally occurring lung cancer (ovine pulmonary adenocarcinoma, OPA) and possessing a major structural protein that functions as a dominant oncoprotein. Lung cancer is the major cause of death among cancer patients. OPA can be an extremely useful animal model in order to identify the cells originating lung adenocarcinoma and to study the early events of pulmonary carcinogenesis. In this study, we demonstrated that lung adenocarcinoma in sheep originates from infection and transformation of proliferating type 2 pneumocytes (termed here lung alveolar proliferating cells, LAPCs). We excluded that OPA originates from a bronchioalveolar stem cell, or from mature post-mitotic type 2 pneumocytes or from either proliferating or non-proliferating Clara cells. We show that young animals possess abundant LAPCs and are highly susceptible to JSRV infection and transformation. On the contrary, healthy adult sheep, which are normally resistant to experimental OPA induction, exhibit a relatively low number of LAPCs and are resistant to JSRV infection of the respiratory epithelium. Importantly, induction of lung injury increased dramatically the number of LAPCs in adult sheep and rendered these animals fully susceptible to JSRV infection and transformation. Furthermore, we show that JSRV preferentially infects actively dividing cell in vitro. Overall, our study provides unique insights into pulmonary biology and carcinogenesis and suggests that JSRV and its host have reached an evolutionary equilibrium in which productive infection (and transformation) can occur only in cells that are scarce for most of the lifespan of the sheep. Our data also indicate that, at least in this model, inflammation can predispose to retroviral infection and cancer
The interpretations and uses of fitness landscapes in the social sciences
__Abstract__
This working paper precedes our full article entitled “The evolution of Wright’s (1932) adaptive field to contemporary interpretations and uses of fitness landscapes in the social sciences” as published in the journal Biology & Philosophy (http://link.springer.com/article/10.1007/s10539-014-9450-2). The working paper features an extended literature overview of the ways in which fitness landscapes have been interpreted and used in the social sciences, for which there was not enough space in the full article. The article features an in-depth philosophical discussion about the added value of the various ways in which fitness landscapes are used in the social sciences. This discussion is absent in the current working paper. Th
- …