Sex and age incentives in sport

This investigation assessed the hierarchical structure of athletes\u27 incentive systems across age and sex. The Birch and Veroff (1966) model of incentive motivation provided the theoretical framework for this study. [This is an excerpt from the abstract. For the complete abstract, please see the document.

Targeting of Rac GTPases blocks the spread of intact human breast cancer

High expression of Rac small GTPases in invasive breast ductal carcinoma is associated with poor prognosis, but its therapeutic value in human cancers is not clear. The aim of the current study was to determine the response of human primary breast cancers to Rac-based drug treatments ex vivo. Three-dimensional organotypic cultures were used to assess candidate therapeutic avenues in invasive breast cancers. Uniquely, in these primary cultures, the tumour is not disaggregated, with both epithelial and mesenchymal components maintained within a three-dimensional matrix of type I collagen. EHT 1864, a small molecule inhibitor of Rac GTPases, prevents spread of breast cancers in this setting, and also reduces proliferation at the invading edge. Rac1+ epithelial cells in breast tumours also contain high levels of the phosphorylated form of the transcription factor STAT3. The small molecule Stattic inhibits activation of STAT3 and induces effects similar to those seen with EHT 1864. Pan-Rac inhibition of proliferation precedes down-regulation of STAT3 activity, defining it as the last step in Rac activation during human breast cancer invasion. Our data highlights the potential use of Rac and STAT3 inhibition in treatment of invasive human breast cancer and the benefit of studying novel cancer treatments using three-dimensional primary tumour tissue explant cultures

Motivation to study in Higher Education:a comparison between Germany and Great Britain

This article deals with reasons for the motivation to study in higher education. To find out about motives, around 200 A-level students in Germany and Great Britain were asked about their plans for the time after completion of their A-levels. Through socio-demographic data the authors could deploy facts about social backgrounds and the affiliations to socio-economic classes. There are some expected findings (e.g., British A-level students are more likely to study than their German comrades) and some pretty unexpected results (e.g., social classes do not seem to divide students into choosing university or not)

Reducing gender bias in household consumption data: Implications for food fortification policy.

Household Consumption Expenditure Survey (HCES) data are increasingly used to inform nutrition policy around the world, most prominently for food fortification programs. However, they risk providing incorrect and gender-biased estimates of dietary intakes. We use both 7-day HCES and 24-hour dietary recall (24HR) data on all members of 5604 households in rural Bangladesh to disentangle the two main sources of error: 1) mismeasurement of household consumption, and 2) intra-household allocation assumptions used to individualize household consumption. We show that, relative to 24HR, HCES overestimate household-level quantities and underestimate women’s share of household foods. Errors from modeling the potential benefits and risks of fortification depend on the food – better measurement is needed for foods consumed episodically (e.g. wheat flour or sugar) or in small quantities (e.g. salt and oil). Beyond mean bias, we find poor and heteroskedastic agreement between HCES and 24HR methods, which is more driven by mismeasurement of food quantities than the application of flawed assumptions about food allocation – at least in the Bangladeshi context. We demonstrate a novel generalizable method for improving HCES intake estimates by drawing on the advantages of both HCES and 24HR data. Using a small sample of 24HR data to generate context- and food-specific quantity and allocation corrections, we can almost eliminate mean bias. With further validation, we hope our proposed method can be used to ensure that HCES estimates account for locally-specific measurement error and gender norms, and that nutrition policy based on these data will be safer and more gender-sensitive

TV Wars: Exclusive Content and Platform Competition in Pay TV

The article examines incentives for exclusive distribution of premium television programming. Static analysis shows that a vertically integrated operator with premium programming always supplies this content to the rival distributor, using per-subscriber fees to soften competition. In a dynamic setting with switching costs exclusivity confers a market share advantage, benefiting the operator in the future. Under certain conditions this future benefit outweighs the opportunity cost of forgone wholesale fees, making exclusivity the preferred choice. Alternative dynamic mechanisms are explored, identifying essential features. The analysis explains the observed incidence of content exclusivity in pay TV and provides guidance for policymakers

Investment, uncertainty and pre-emption

Author's pre-print draft dated 7 September 2009. updated version of CEPR discussion paper 3013. Final version published by Elsevier; available online at http://www.sciencedirect.com/This paper examines irreversible investment in a project with uncertain returns, when there is an advantage to being the first to Invest and externalities to investing when others also do so We show that the possibility of pre-emption can have significant qualitative and quantitative effects on the relationship between uncertainty and investment In a single-agent real options model, the trigger threshold for investment increases without bound as uncertainty grows In contrast, the investment trigger of a leader faced with pre-emption is bounded above as uncertainty increases In fact, we show that under certain parameter values, greater uncertainty can lead the leader to invest earlier These findings reinforce the importance of extending real options analysis to include strategic interactions between players Applications to industry situations are also discussed (C) 2009 Elsevier B V All rights reserve

Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial.

Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza

Febrile Rhinovirus Illness During Pregnancy Is Associated With Low Birth Weight in Nepal.

BACKGROUND: Adverse birth outcomes, including low birth weight (LBW), defined as \u3c2500 \u3egrams, small-for-gestational-age (SGA), and prematurity, contribute to 60%-80% of infant mortality worldwide and may be related to infections during pregnancy. The aim of this study was to assess whether febrile human rhinovirus (HRV) illness is associated with adverse birth outcomes. METHODS: Active household-based weekly surveillance was performed for respiratory illness episodes in pregnant women as part of a community-based, prospective, randomized trial of maternal influenza immunization in rural Nepal. Rhinovirus (HRV) febrile illness episodes were defined as fever plus cough, sore throat, runny nose, and/or myalgia with HRV detected on mid-nasal swab. Multivariate regression analysis evaluated the association between febrile HRV respiratory illness and adverse birth outcomes. RESULTS: Overall, 96 (3%) of 3693 pregnant women had HRV-positive febrile respiratory illnesses. Infants born to pregnant women with HRV febrile illness had a 1.6-fold increased risk of being LBW compared with those with non-HRV febrile illness (28 of 96 [38%] vs 109 of 458 [24%]; relative risk [RR], 1.6; 95% confidence interval [CI], 1.1-2.3). No difference in risk of LBW was observed between infants born to mothers with non-HRV febrile respiratory illness and those without respiratory illness during pregnancy (109 of 458 [24%] vs 552 of 2220 [25%], respectively; RR, 1.0; 95% CI, 0.8-1.2). CONCLUSIONS: Febrile illness due to rhinovirus during pregnancy was associated with increased risk of LBW in a rural South Asian population. Interventions to reduce the burden of febrile respiratory illness due to rhinovirus during pregnancy may have a significant impact on LBW and subsequent infant mortality