Diabetes mellitus itself increases cardio- cerebrovascular risk and renal complications in primary aldosteronism

This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Aya Saiki, Michio Otsuki, Daisuke Tamada, Tetsuhiro Kitamura, Iichiro Shimomura, Isao Kurihara, Takamasa Ichijo, Yoshiyu Takeda, Takuyuki Katabami, Mika Tsuiki, Norio Wada, Toshihiko Yanase, Yoshihiro Ogawa, Junji Kawashima, Masakatsu Sone, Nobuya Inagaki, Takanobu Yoshimoto, Ryuji Okamoto, Katsutoshi Takahashi, Hiroki Kobayashi, Kouichi Tamura, Kohei Kamemura, Koichi Yamamoto, Shoichiro Izawa, Miki Kakutani, Masanobu Yamada, Akiyo Tanabe, Mitsuhide Naruse, Diabetes Mellitus Itself Increases Cardio-Cerebrovascular Risk and Renal Complications in Primary Aldosteronism, The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 7, July 2020, Pages e2531–e2537 is available online at: https://doi.org/10.1210/clinem/dgaa177

Rapid and large-scale formation of porcine hepatocyte spheroids

肝不全ブタ用のハイブリッド型人工肝臓モジュールに必要とされる細胞数の1/4(2.5×10(10)cells)に相当する初代培養ブタ肝細胞の高機能凝集体(スフェロイド)を, 浮遊培養によって形成させることができた. 形成されたスフェロイドをそのまま浮遊培養しても良好に高機能を発現したたことより, スフェロイド/浮遊培養槽は, 実用人工肝モジュールとして期待される培養形態であると考えられた.小特集 バイオテクノロジ