Monetary costs of agitation in older adults with Alzheimer's disease in the UK: prospective cohort study

While nearly half of all people with Alzheimer's disease (AD) have agitation symptoms every month, little is known about the costs of agitation in AD. We calculated the monetary costs associated with agitation in older adults with AD in the UK from a National Health Service and personal social services perspective

The optimal pebbling number of staircase graphs

Let G be a graph with a distribution of pebbles on its vertices. A pebbling move consists of removing two pebbles from one vertex and placing one pebble on an adjacent vertex. The optimal pebbling number of G is the smallest number of pebbles which can be placed on the vertices of G such that, for any vertex v of G, there is a sequence of pebbling moves resulting in at least one pebble on v. We determine the optimal pebbling number for several classes of induced subgraphs of the square grid, which we call staircase graphs. © 2018 Elsevier B.V

Calderón de la Barca en Hungría desde fines del siglo XVIII hasta la actualidad

Nuestro proyecto de investigación tiene el objetivo de cubrir los hiatos en las investigaciones de las relaciones culturales entre España y Hungría, abarcando y examinando en profundidad la presencia del teatro español en Hungría desde los siglos xviii-xix hasta nuestros días. Junto con dar un repertorio de las traducciones húngaras y los estrenos de las obras teatrales españolas en nuestro país queremos ofrecer también un análisis más complejo y un resumen exhaustivo sobre los aspectos más importantes de la recepción del teatro español en Hungría en los últimos dos siglos. Uno de los hitos importantes ha sido el examen de la presencia y la popularidad de los dramas de Calderón de la Barca en Hungría. Hemos buscado la primera huella de su nombre, el nacimiento de las traducciones —primero del alemán y luego directamente del español—, sus estrenos desde 1795 hasta nuestros días, y su resonancia crítica en la prensa teatral húngara. Este artículo tiene el objetivo de resumir los resultados de esta investigación, destacando a algunos traductores literarios y directores teatrales que hicieron memorable el nombre de Calderón de la Barca ante el público húngaro.My research project aims to investigate the cultural relations between Spain and Hungary, through an in-depth analysis of the presence of Spanish theatre in Hungary, from the 18th-19th century until today. Apart from compiling a data base comprising the Hungarian translations and the Hungarian performances of Spanish dramas, I also examine in detail the most important aspects of the reception of Spanish theatre in Hungary. The analysis of the popularity and the presence of the dramas of Calderón de la Barca was especially important. I have traced the first appearance of his name, the translations of his dramas (first these were translated from German, later directly from Spanish), the performances of his plays from 1795 until today, and also their critical reception in the Hungarian press. The goal of the present article is to summarise the findings of this research, emphasising the role of certain Hungarian translators and directors, thanks to whom the Hungarian public became familiar with the name of Calderón de la Barca

Comparative in vitro studies on native and recombinant human cationic trypsins - Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis

Hereditary pancreatitis, an autosomal dominant disease is believed to be caused by mutation in the human trypsinogen gene. The role of mutations has been investigated by in vitro studies using recombinant rat and human trypsinogen (TG), In this study we compare the enzymatic properties and inhibition by human pancreatic secretory trypsin inhibitor (hPSTI) of the native, postsynthetically modified and recombinant cationic trypsin, and found these values practically identical, We also determined the autolytic stability of recombinant wild type (Hu1Asn21) and pancreatitis-associated (Hu1Ile21) trypsin, Both forms were equally stable. Similarly, we found no difference in the rate of activation of the two zymogens by human cationic and anionic trypsin. Mesotrypsin did not activate either form. The rate of autocatalytic activation of Hu1Asn21 TG and Hu1Ile21 TG was also identical at pH 8 both in the presence and absence of Ca2+. At pH 5 Hu1Ile21 TG autoactivated about twice as fast as HulAsn21 TG, The presence of physiological amount of hPSTI completely prevented autoactivation of both zymogens at pH 8 and at pH 5 as well. Cathepsin B readily activated both zymogens although Hu1Ile21 TG was activated about 2.5-3 times as fast as Hu1Asn21 TG, The presence of hPSTI did not prevent the activation of zymogens by cathepsin B, Our results underlie the central role of cathepsin B in the development of different forms of pancreatitis

Spacelab Charcoal Analyses

This report describes analytical methods and results obtained from chemical analysis of 31 charcoal samples in five sets. Each set was obtained from a single scrubber used to filter ambient air on board a Spacelab mission. Analysis of the charcoal samples was conducted by thermal desorption followed by gas chromatography/mass spectrometry (GC/MS). All samples were analyzed using identical methods. The method used for these analyses was able to detect compounds independent of their polarity or volatility. In addition to the charcoal samples, analyses of three Environmental Control and Life Support System (ECLSS) water samples were conducted specifically for trimethylamine

The effects of bracket, wire conformation and size on the load systems during orthodontic sliding mechanics

Objective: The purpose of this laboratory study was to compare all 6 load components (3 force and 3 moment) acting on 2 different stainless steel brackets as they slide along 3 sizes of stainless steel archwires with 3 different conformations. Materials and Methods: Brackets were attached to a load cell and elastomeric ligated to the wires. As the load cell was pulled along a precision track, the 6 load components (forces and moments in the 3 orthogonal coordinate system) acting on the bracket were recorded. ANOVA was applied to the data. Results: Overall, there were significant differences for all effects (bracket, wire size and wire configuration), for all outcomes (the loads), except the effect of bracket on the force of friction and one of the moment components. Conclusion: The results demonstrate that the force of friction associated with sliding mechanics should not be considered in isolation, because factors that affect it also affect the other 5 load components